Uniprot accession / id : (P13645)
 
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Entry Information
Entry status  (1)
REL
(6)
 
Experimental methods  (1)
X-ray diffraction
(6)
 
Authors  (29)
Bunick CG
(4)
Eldirany SA
(3)
Hinbest AJ
(3)
Ho M
(3)
Lomakin IB
(3)
Anderson A
(1)
Barbu EM
(1)
Chen Y
(1)
Chen YG
(1)
Deivanayagam CCS
(1)
Deng X
(1)
Deng XM
(1)
Feng Y
(1)
Foster TJ
(1)
Ganesh VK
(1)
Hook M
(1)
Le B
(1)
Lin SL
(1)
Liu B
(1)
Liu L
(1)
Matsuka Y
(1)
Milstone LM
(1)
Narayana SVL
(1)
Steitz TA
(1)
Wang J
(1)
Wang JW
(1)
Xiang H
(1)
Yang M
(1)
Yang MJ
(1)
 
Homo / hetero assembly  (1)
hetero
(6)
 
Assembly composition  (1)
protein/protein complex
(6)
 
Assembly polymer count  (2)
dimer
(4)
tetramer
(2)
 
Resolution distribution
2.0 - 2.5
(3)
2.5 - 3
(2)
3.0 - 3.5
(1)
 
Release year distribution
2010 - 2015
(2)
2015 - 2020
(4)
 
Journal  (5)
EMBO J
(2)
J Invest Dermatol
(1)
PLoS Pathog
(1)
To be published
(1)
Yale J Biol Med
(1)
 
Macromolecules
Organism superkingdom  (2)
Eukaryota
(6)
Bacteria
(2)
 
Organism name  (3)
Homo sapiens
(6)
Staphylococcus aureus subsp. aureus MRSA252
(1)
Staphylococcus aureus subsp. aureus N315
(1)
 
Molecule name  (17)
CK-10
(6)
Cytokeratin-10
(6)
K10
(6)
Keratin, type I cytoskeletal 10
(6)
Keratin-10
(6)
Cytokeratin-1
(4)
Keratin, type II cytoskeletal 1
(4)
Keratin-1
(4)
Type-II keratin Kb1
(4)
67 kDa cytokeratin
(3)
CK-1
(3)
Hair alpha protein
(3)
K1
(3)
Clumping factor B
(2)
Fibrinogen receptor B
(2)
Fibrinogen-binding protein B
(2)
Keratin 1
(1)
 
Molecule type  (1)
Protein
(6)
 
Gene names  (7)
KPP
(6)
KRT10
(6)
KRT1
(4)
KRTA
(3)
clfB
(2)
SA2423
(1)
SAR2709
(1)
 
Interacting Molecules  (3)
Keratin, type I cytoskeletal 10
(6)
Keratin, type II cytoskeletal 1
(4)
Clumping factor B
(2)
 
Interacting ligands  (5)
BOG : octyl beta-D-glucopyranoside
(1)
CD : CADMIUM ION
(1)
CO : COBALT (II) ION
(1)
NI : NICKEL (II) ION
(1)
SO4 : SULFATE ION
(1)
 
Function and Biology
Biological function  (1)
structural molecule activity
(4)
 
Biological process  (1)
cell adhesion
(2)
 
Biological cell component  (2)
cell wall
(2)
keratin filament
(2)
 
Sequence and Structure classification
CATH class  (1)
Mainly Beta
(2)
 
CATH topology  (1)
Immunoglobulin-like
(2)
 
Pfam accession / name  (3)
PF00038 : Filament
(4)
PF10425 : SdrG_C_C
(2)
PF17961 : Big_8
(2)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(6)
 
Diffraction radiation source type  (2)
Synchrotron
(5)
Rotating anode
(1)
 
Diffraction source  (4)
APS BEAMLINE 24-ID-C
(3)
NSLS BEAMLINE X25
(1)
RIGAKU RU300
(1)
SSRF BEAMLINE BL17U
(1)
 
Synchrotron site  (3)
APS
(3)
NSLS
(1)
SSRF
(1)
 
Diffraction detector type  (2)
Pixel
(4)
CCD
(1)
 
Refinement software  (2)
PHENIX
(5)
REFMAC
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 6 of 6
Entries 1 to 6 of 6
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Crystal structure of the heterocomplex between coil 2B domains of human intermediate filament proteins keratin 1 (KRT1) and keratin 10 (KRT10)
Bunick CG, Steitz TA
J Invest Dermatol (2017) [PMID: 27595935  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Keratin-1 - Keratin-10 dimer complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-137542 (Preferred)   search this ID
PDBe-KB: P04264    P13645   
X-ray diffraction
3.3001251Å resolution
Released: 18 May 2016
Model geometry
Fit model/data
4zry
4zry
4zry
Crystal structure of the heterocomplex between human keratin 1 coil 1B containing S233L mutation and wild-type human keratin 10 coil 1B
Eldirany SA, Lomakin IB, Bunick CG
EMBO J (2019) [PMID: 31036554  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Keratin, type II cytoskeletal 1 and Keratin, type I cytoskeletal 10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-137543 (Preferred)   search this ID
PDBe-KB: P04264    P13645   
X-ray diffraction
2.386Å resolution
Released: 15 May 2019
Model geometry
Fit model/data
6e2j
6e2j
6e2j
Structural and biochemical characterization of ClfB:ligand interactions
Ganesh VK
To be published
Assembly composition: protein/protein complex
Assembly name: Clumping factor B and Keratin, type I cytoskeletal 10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146683 (Preferred)   search this ID
PDBe-KB: Q7A382    P13645   
X-ray diffraction
2.6Å resolution
Released: 4 May 2011
Model geometry
Fit model/data
3asw
3asw
3asw
Crystal structures reveal the multi-ligand binding mechanism of the Staphylococcus aureus ClfB
Yang MJ, Xiang H, Wang JW, Liu B, Chen YG, Liu L, Deng XM, Feng Y
PLoS Pathog (2012) [PMID: 22719251  ]
Assembly composition: protein/protein complex
Bound ligands: MG    MG   
Assembly name: Clumping factor B and Keratin, type I cytoskeletal 10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146682 (Preferred)   search this ID
PDBe-KB: Q6GDH2    P13645   
X-ray diffraction
2.3Å resolution
Released: 8 Aug 2012
Model geometry
Fit model/data
4f1z
4f1z
4f1z
Crystal structure of the wild-type heterocomplex between coil 1B domains of human intermediate filament proteins keratin 1 (KRT1) and keratin 10 (KRT10)
Eldirany SA, Lomakin IB, Bunick CG
EMBO J (2019) [PMID: 31036554  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: NI    CO    CO    NI    CD    CD   
Assembly name: Keratin, type II cytoskeletal 1 and Keratin, type I cytoskeletal 10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-124846 (Preferred)   search this ID
PDBe-KB: H6VRG1    P13645   
X-ray diffraction
2.983Å resolution
Released: 15 May 2019
Model geometry
Fit model/data
6ec0
6ec0
6ec0
Crystal structure of the heterocomplex between coil 2B domains of wild-type keratin 1 (KRT1) and keratin 10 (KRT10) containing mutation Cys401Ala
Lomakin IB, Bunick CG
Yale J Biol Med (2020) [PMID: 32226330  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: BOG    GOL    BOG   
Assembly name: Keratin-1 - Keratin-10 dimer complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-137542 (Preferred)   search this ID
PDBe-KB: P04264    P13645   
X-ray diffraction
2.069Å resolution
Released: 13 Nov 2019
Model geometry
Data not analysed
Fit model/data
Data not analysed
6uui
6uui
6uui
Entries 1 to 6 of 6
Entries 1 to 6 of 6