Entry status  (1)

REL

(12)

Experimental methods  (2)

X-ray diffraction

(10)

Solution NMR

(2)

Authors  (91)

Arrowsmith CH

(5)

Filippakopoulos P

(5)

Knapp S

(5)

Salah E

(5)

Structural Genomics Consortium (SGC)

(5)

Weigelt J

(5)

von Delft F

(5)

Cooper C

(4)

Edwards AM

(4)

Bountra C

(3)

Gish GD

(3)

Grebien F

(3)

Hantschel O

(3)

Kay LE

(3)

Kofler M

(3)

Neudecker P

(3)

Pawson T

(3)

Superti-Furga G

(3)

Turk BE

(3)

Baba D

(2)

Elkins JM

(2)

Fedorov O

(2)

Gish G

(2)

Guntert P

(2)

Güntert P

(2)

Hanzawa H

(2)

Imaoka T

(2)

Inagaki H

(2)

Kaneta Y

(2)

Kurinov I

(2)

Kusebauch U

(2)

Manczyk N

(2)

Martyn GD

(2)

Moran MF

(2)

Moritz RL

(2)

Morrone SR

(2)

Nakayama K

(2)

Odagiri T

(2)

Picaud SS

(2)

Sicheri F

(2)

Sidhu SS

(2)

Singer AU

(2)

Sun Z

(2)

Taniguchi T

(2)

Tong J

(2)

Toyota A

(2)

Ugochukwu E

(2)

Veggiani G

(2)

Yasumatsu I

(2)

Yates BP

(2)

Barr A

(1)

Cheng W

(1)

Choi HG

(1)

Deng X

(1)

Edwards A

(1)

Elkins J

(1)

Gray NS

(1)

Hellwig S

(1)

Hur W

(1)

Iimura S

(1)

Inoue M

(1)

Kanda S

(1)

Kawai J

(1)

Kiga M

(1)

Kigawa T

(1)

Koshiba S

(1)

Krojer T

(1)

Lin D

(1)

Lopez-Mendez B

(1)

López-Méndez B

(1)

Miduturu CV

(1)

Momose T

(1)

Pan W

(1)

Pantoja-Uceda D

(1)

Pike ACW

(1)

RIKEN Structural Genomics/Proteomics Initiative (RSGI)

(1)

Scott A

(1)

Seo M

(1)

Shibata Y

(1)

Shimizu H

(1)

Shirouzu M

(1)

Smithgall TE

(1)

Sugano S

(1)

Tanaka A

(1)

Terada T

(1)

Ueda K

(1)

Wang F

(1)

Yokoyama S

(1)

Yuan Z

(1)

Zhang J

(1)

Zhou W

(1)

Homo / hetero assembly  (2)

homo

(8)

hetero

(4)

Assembly composition  (2)

protein structure

(8)

protein/protein complex

(4)

Assembly polymer count  (2)

dimer

(6)

monomer

(6)

Resolution distribution

1.0 - 1.5

(2)

1.5 - 2

(5)

2.0 - 2.5

(2)

2.5 - 3

(1)

Release year distribution

2000 - 2005

(1)

2005 - 2010

(5)

2010 - 2015

(2)

2015 - 2020

(1)

2020 - 2025

(4)

2025 - 2030

(1)

Journal  (7)

Cell

(3)

ACS Chem Biol

(2)

ACS Med Chem Lett

(2)

To be published

(2)

Chem Biol

(1)

J Am Chem Soc

(1)

J Biomol NMR

(1)

Organism superkingdom  (1)

Eukaryota

(12)

Organism name  (1)

Homo sapiens

(12)

Molecule name  (5)

Feline sarcoma/Fujinami avian sarcoma oncogene homolog

(12)

Proto-oncogene c-Fes

(12)

Proto-oncogene c-Fps

(12)

Tyrosine-protein kinase Fes/Fps

(12)

p93c-fes

(12)

Molecule type  (1)

Protein

(12)

Gene names  (2)

FES

(12)

FPS

(12)

Interacting Molecules  (2)

Ezrin

(2)

Synthetic peptide

(2)

Interacting ligands  (9)

SO4 : SULFATE ION

(3)

STU : STAUROSPORINE

(3)

CL : CHLORIDE ION

(2)

EDO : 1,2-ETHANEDIOL

(2)

NA : SODIUM ION

(2)

9FC : 6-{[(1R,2S)-2-aminocyclohexyl]amino}-5-cyano-2-[(3-methylphenyl)amino]pyridine-3-carboxamide

(1)

A1LWS : 7-[[(1R,2S)-2-azanylcyclohexyl]amino]-5-[[3-[(2S,6R)-2,6-dimethylmorpholin-4-yl]phenyl]amino]-4-oxidanylidene-3H-pyrido[3,4-d]pyridazine-8-carbonitrile

(1)

GUI : 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE

(1)

MLI : MALONATE ION

(1)

EC number / name  (1)

2.7.10.2 : Non-specific protein-tyrosine kinase

(12)

Biological function  (3)

ATP binding

(5)

protein kinase activity

(5)

protein tyrosine kinase activity

(5)

Biological process  (1)

protein phosphorylation

(5)

CATH class  (2)

Alpha Beta

(6)

Mainly Alpha

(5)

CATH topology  (5)

SHC Adaptor Protein

(6)

Phosphorylase Kinase; domain 1

(4)

Transferase(Phosphotransferase); domain 1

(4)

Helix Hairpins

(1)

Substrate Binding Domain Of Dnak; Chain:A; Domain 2

(1)

Pfam accession / name  (3)

PF00017 : SH2

(10)

PF07714 : PK_Tyr_Ser-Thr

(6)

PF00611 : FCH

(2)

Diffraction protocol  (2)

Single wavelength

(9)

MAD

(1)

Diffraction radiation source type  (2)

Synchrotron

(7)

Rotating anode

(3)

Diffraction source  (8)

APS BEAMLINE 24-ID-E

(2)

RIGAKU FR-E+ SUPERBRIGHT

(2)

CLSI BEAMLINE 08ID-1

(1)

DIAMOND BEAMLINE I24

(1)

PHOTON FACTORY BEAMLINE AR-NW12A

(1)

PHOTON FACTORY BEAMLINE BL-1A

(1)

RIGAKU FR-E SUPERBRIGHT

(1)

SLS BEAMLINE X10SA

(1)

Synchrotron site  (5)

APS

(2)

Photon Factory

(2)

CLSI

(1)

Diamond

(1)

SLS

(1)

Diffraction detector type  (3)

Pixel

(5)

Image plate

(3)

CCD

(2)

Refinement software  (2)

REFMAC

(8)

PHENIX

(2)

NMR software packages  (5)

CYANA

(2)

OPALp

(2)

FLYA

(1)

NMRPipe

(1)

NMRView

(1)

NMR Field Strength

500.0 - 600

(2)

600.0 - 700

(2)

700.0 - 800

(2)

800.0 - 900

(2)

Representative Structures

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