Entry status  (1)

REL

(11)

Experimental methods  (2)

X-ray diffraction

(8)

Electron Microscopy

(3)

Authors  (86)

Hinck AP

(4)

Hinck CS

(4)

Taylor AB

(4)

Gruetter MG

(3)

Grütter MG

(3)

Baron JL

(2)

Bernard DJ

(2)

Byeon CH

(2)

Cai G

(2)

Campbell MG

(2)

Carey ND

(2)

Cerletti N

(2)

Cheng Y

(2)

Cherepanov P

(2)

Coleman JA

(2)

Conway IO

(2)

Cormier A

(2)

Cossio P

(2)

Cox DA

(2)

Grutter MG

(2)

Hill CS

(2)

Ishima R

(2)

Ito S

(2)

Jespersen JM

(2)

Jin M

(2)

Krzysiak T

(2)

Lin YF

(2)

Lopez-Casillas F

(2)

Lou J

(2)

López-Casillas F

(2)

Marks J

(2)

McMaster G

(2)

Mittl PR

(2)

Mittl PRE

(2)

Nishimura SL

(2)

Priestle JP

(2)

Punch E

(2)

Seed RI

(2)

Shing T

(2)

Tang PK

(2)

Wang L

(2)

Wankowicz SA

(2)

Wen W

(2)

Wieteska L

(2)

Wieteska Ł

(2)

Yu Z

(2)

Arron JR

(1)

Bender HS

(1)

Brightbill HD

(1)

Deep S

(1)

Dong X

(1)

Finch D

(1)

Gao X

(1)

Groppe J

(1)

Gruetter C

(1)

Grütter C

(1)

Halpern W

(1)

Hart PJ

(1)

Huang Z

(1)

Hudson NE

(1)

Jermutus L

(1)

Jia G

(1)

Liang WC

(1)

Loning S

(1)

Lu C

(1)

Lupardus P

(1)

Lupardus PJ

(1)

McCourt M

(1)

Mitra M

(1)

Podichetty S

(1)

Ramalingam T

(1)

Samavarchi-Tehrani P

(1)

Schuermann JP

(1)

Schwarz PM

(1)

Shu Z

(1)

Springer TA

(1)

Sun T

(1)

Turner R

(1)

Uttarwar S

(1)

Vander Heiden JA

(1)

Wilkinson T

(1)

Wrana JL

(1)

Wu Y

(1)

Yadav R

(1)

Yin J

(1)

Zubieta C

(1)

Homo / hetero assembly  (2)

hetero

(9)

homo

(2)

Assembly composition  (2)

protein/protein complex

(9)

protein structure

(2)

Assembly polymer count  (5)

hexamer

(3)

trimer

(3)

dimer

(2)

pentamer

(2)

tetramer

(1)

Resolution distribution

1.5 - 2

(1)

2.0 - 2.5

(3)

2.5 - 3

(4)

3.0 - 3.5

(2)

4.0 - 4.5

(1)

Release year distribution

1995 - 2000

(2)

2000 - 2005

(1)

2005 - 2010

(2)

2010 - 2015

(1)

2020 - 2025

(5)

2025 - 2030

(2)

Journal  (8)

Cell

(2)

Nat Commun

(2)

Protein Sci

(2)

Med

(1)

Mol Cell

(1)

Nat Struct Biol

(1)

Nat Struct Mol Biol

(1)

Proc Natl Acad Sci U S A

(1)

Organism superkingdom  (1)

Eukaryota

(11)

Organism name  (1)

Homo sapiens

(11)

Molecule name  (5)

LAP

(11)

Latency-associated peptide

(11)

TGF-beta-3

(11)

Transforming growth factor beta-3

(11)

Transforming growth factor beta-3 proprotein

(11)

Molecule type  (1)

Protein

(11)

Gene names  (1)

TGFB3

(11)

Interacting Molecules  (13)

TGF-beta receptor type-2

(4)

TGF-beta receptor type-1

(3)

Transforming growth factor beta-3

(2)

ZP domain-containing protein

(2)

2A10 Fab Heavy Chain

(1)

2A10 Fab Light chain

(1)

GC-1008 Fab Light Chain

(1)

Immunoglobulin heavy constant gamma 4

(1)

Integrin alpha-V

(1)

Integrin alpha-V heavy chain

(1)

Integrin beta-6

(1)

Integrin beta-8

(1)

Transforming growth factor beta activator LRRC32

(1)

Interacting ligands  (2)

MG : MAGNESIUM ION

(2)

DIO : 1,4-DIETHYLENE DIOXIDE

(1)

Biological function  (9)

growth factor activity

(8)

cytokine activity

(2)

identical protein binding

(2)

protein binding

(2)

transforming growth factor beta binding

(2)

transforming growth factor beta receptor binding

(2)

type I transforming growth factor beta receptor binding

(2)

type II transforming growth factor beta receptor binding

(2)

type III transforming growth factor beta receptor binding

(2)

Biological process  (31)

cell-cell junction organization

(2)

detection of hypoxia

(2)

face morphogenesis

(2)

in utero embryonic development

(2)

lung alveolus development

(2)

mammary gland development

(2)

negative regulation of cell population proliferation

(2)

negative regulation of macrophage cytokine production

(2)

negative regulation of neuron apoptotic process

(2)

negative regulation of vascular associated smooth muscle cell proliferation

(2)

odontogenesis

(2)

positive regulation of DNA-templated transcription

(2)

positive regulation of SMAD protein signal transduction

(2)

positive regulation of apoptotic process

(2)

positive regulation of cell division

(2)

positive regulation of cell population proliferation

(2)

positive regulation of collagen biosynthetic process

(2)

positive regulation of epithelial to mesenchymal transition

(2)

positive regulation of filopodium assembly

(2)

positive regulation of protein secretion

(2)

positive regulation of stress fiber assembly

(2)

positive regulation of tight junction disassembly

(2)

positive regulation of transcription by RNA polymerase II

(2)

regulation of cell population proliferation

(2)

regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

(2)

response to hypoxia

(2)

response to progesterone

(2)

salivary gland morphogenesis

(2)

secondary palate development

(2)

transforming growth factor beta receptor signaling pathway

(2)

uterine wall breakdown

(2)

Biological cell component  (6)

extracellular region

(8)

collagen-containing extracellular matrix

(2)

extracellular space

(2)

intracellular membrane-bounded organelle

(2)

plasma membrane

(2)

platelet alpha granule lumen

(2)

SCOP fold  (1)

Cystine-knot cytokines

(4)

SCOP family  (1)

Transforming growth factor (TGF)-beta

(4)

CATH class  (1)

Mainly Beta

(5)

CATH topology  (1)

Cystine Knot Cytokines, subunit B

(5)

Pfam accession / name  (2)

PF00019 : TGF_beta

(10)

PF00688 : TGFb_propeptide

(2)

Diffraction protocol  (1)

Single wavelength

(6)

Diffraction radiation source type  (2)

Synchrotron

(6)

Rotating anode

(1)

Diffraction source  (6)

APS BEAMLINE 24-ID-C

(2)

APS BEAMLINE 23-ID-D

(1)

ENRAF-NONIUS FR571

(1)

NSLS BEAMLINE X8C

(1)

SLS BEAMLINE X06SA

(1)

SSRL BEAMLINE BL11-1

(1)

Synchrotron site  (4)

APS

(3)

NSLS

(1)

SLS

(1)

SSRL

(1)

Diffraction detector type  (3)

CCD

(4)

Diffractometer

(2)

Pixel

(2)

Refinement software  (5)

CNS

(2)

PHENIX

(2)

X-PLOR

(2)

BUSTER

(1)

REFMAC

(1)

EM microscope model  (2)

FEI TITAN KRIOS

(2)

TFS KRIOS

(1)

EM detector name  (3)

FEI FALCON IV (4k x 4k)

(1)

GATAN K2 SUMMIT (4k x 4k)

(1)

GATAN K3 (6k x 4k)

(1)

Representative Structures

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