Uniprot accession / id : P17918  OR   Uniprot accession / id : P12004
 
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Entry Information
Entry status  (1)
REL
(91)
 
Experimental methods  (2)
X-ray diffraction
(49)
Electron Microscopy
(42)
 
Authors  (343)
De Biasio A
(15)
Li H
(14)
Blanco FJ
(12)
He Q
(12)
O'Donnell ME
(12)
Wang F
(12)
Bruning JB
(10)
Hamdan SM
(10)
Lancey C
(10)
Merino N
(10)
Raducanu VS
(10)
Tehseen M
(10)
Gao N
(9)
Li N
(9)
Li Q
(9)
Tian Y
(9)
Rashid F
(8)
Ragan TJ
(7)
Abell AD
(6)
Hashimoto H
(6)
Hishiki A
(6)
Scanlon DB
(6)
Yao NY
(6)
Blair K
(5)
Crehuet R
(5)
Horsfall AJ
(5)
Kelch BA
(5)
Savva CG
(5)
Shirbini A
(5)
Vandborg BA
(5)
Zaher MS
(5)
Anna P
(4)
Fenglin L
(4)
Onesti S
(4)
Sato M
(4)
Shimizu T
(4)
Ahel D
(3)
Ariza A
(3)
Barrera-Vilarmau S
(3)
Carnie CJ
(3)
Creuhet R
(3)
Cruehet R
(3)
De March M
(3)
Duffy CM
(3)
Fischer P
(3)
Fischer PM
(3)
Gonzalez-Magana A
(3)
Gonzalez-Magaña A
(3)
Hamdan S
(3)
Hanafusa T
(3)
Hickey TE
(3)
Hilbert BJ
(3)
Kamei K
(3)
Kikhtyak Z
(3)
Kontopidis G
(3)
Lane D
(3)
Lane DP
(3)
McInnes C
(3)
Mcinnes C
(3)
Ohashi E
(3)
Ohmori H
(3)
Romano-Moreno M
(3)
Roske JJ
(3)
Sebesta M
(3)
Shahid T
(3)
Taylor P
(3)
Tilley WD
(3)
Walkinshaw MD
(3)
Wu S
(3)
Wu SY
(3)
Yeeles JTP
(3)
Zheleva D
(3)
Zheleva DI
(3)
Aboody KS
(2)
Actis M
(2)
Aretz J
(2)
Bakshi S
(2)
Benarafa C
(2)
Boudet J
(2)
Burgener SS
(2)
Caillat C
(2)
Candalh C
(2)
Chatfield S
(2)
Chav T
(2)
Chung V
(2)
Cooper CDO
(2)
Crespan E
(2)
Dang PM
(2)
De Chiara A
(2)
Desplancq D
(2)
El-Benna J
(2)
Favier M
(2)
Felsenfeld D
(2)
Finley M
(2)
Flores L
(2)
Frachet P
(2)
Fujii N
(2)
Gaubitz C
(2)
Giakoumakis NN
(2)
Gu L
(2)
 
More...
 
Homo / hetero assembly  (2)
hetero
(76)
homo
(15)
 
Assembly composition  (3)
protein/protein complex
(42)
DNA/protein complex
(34)
protein structure
(15)
 
Assembly polymer count  (10)
hexamer
(34)
octamer
(15)
trimer
(14)
decamer
(6)
heptamer
(5)
pentamer
(5)
nonamer
(4)
tetramer
(4)
dimer
(3)
monomer
(1)
 
Resolution distribution
1.5 - 2
(4)
2.0 - 2.5
(14)
2.5 - 3
(27)
3.0 - 3.5
(20)
3.5 - 4
(14)
4.0 - 4.5
(5)
4.5 - 5
(2)
5.0 - 5.5
(2)
6.0 - 6.5
(1)
8.0 - 8.5
(1)
21.5 - 22
(1)
 
Release year distribution
1995 - 2000
(1)
2000 - 2005
(6)
2005 - 2010
(7)
2010 - 2015
(8)
2015 - 2020
(30)
2020 - 2025
(48)
2025 - 2030
(6)
 
Journal  (24)
Nat Commun
(16)
EMBO J
(10)
J Biol Chem
(9)
Proc Natl Acad Sci U S A
(9)
Nat Struct Mol Biol
(7)
Nucleic Acids Res
(5)
To be published
(5)
Biochem Biophys Res Commun
(3)
Biorxiv
(3)
J Mol Biol
(3)
RSC Chem Biol
(3)
Structure
(3)
Cell Chem Biol
(2)
J Exp Med
(2)
Life Sci Alliance
(2)
Acta Crystallogr F Struct Biol Commun
(1)
Biochemistry
(1)
Cell
(1)
Cell Cycle
(1)
Cell Rep
(1)
Chemistry
(1)
DNA Repair (Amst)
(1)
J Cell Biol
(1)
Sci Rep
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(91)
 
Organism name  (1)
Homo sapiens
(91)
 
Molecule name  (3)
Cyclin
(91)
PCNA
(91)
Proliferating cell nuclear antigen
(91)
 
Molecule type  (1)
Protein
(91)
 
Gene names  (1)
PCNA
(91)
 
Interacting Molecules  (75)
Flap endonuclease 1
(14)
Replication factor C subunit 2
(11)
Replication factor C subunit 3
(11)
Replication factor C subunit 4
(11)
Replication factor C subunit 5
(11)
downstream DNA
(8)
upstream DNA
(8)
5 prime flap DNA
(6)
Chromosome transmission fidelity protein 18 homolog
(6)
Cyclin-dependent kinase inhibitor 1
(6)
DNA (40-MER)
(6)
DNA polymerase delta subunit 3
(6)
DNA polymerase delta subunit 4
(6)
Fanconi-associated nuclease 1
(6)
DNA polymerase delta catalytic subunit
(5)
DNA polymerase delta subunit 2
(5)
DNA polymerase epsilon catalytic subunit A
(5)
DNA primer
(5)
DNA template
(5)
parent strand DNA
(5)
ATPase family AAA domain-containing protein 5
(4)
DNA (20-MER)
(4)
DNA ligase 1
(3)
DNA nascent strand
(3)
DNA polymerase kappa
(3)
DNA template strand
(3)
PCNA-associated factor
(3)
Peptide mimetic (ACE)RQCSMTCFYHSK(NH2) with linker
(3)
5 prime DNA
(2)
DNA (46-MER) with (CAG)2 extrusion
(2)
DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3')
(2)
DNA (5'-D(P*CP*CP*CP*AP*TP*CP*GP*TP*AP*T)-3')
(2)
DNA Primer
(2)
DNA Template
(2)
Oligo13P
(2)
Oligo19ddC
(2)
Oligo32
(2)
Ribonuclease H2 subunit B
(2)
parent strand
(2)
ALA-GLY-ALA-GLY-ALA
(1)
Adenine DNA glycosylase
(1)
DNA (5'-D(P*AP*AP*AP*GP*TP*GP*AP*AP*AP*AP*AP*TP*CP*TP*AP*AP*AP*GP*CP*AP*TP*CP*AP*C)-3')
(1)
DNA (5'-D(P*AP*TP*CP*TP*CP*GP*AP*GP*TP*CP*TP*AP*GP*AP*AP*AP*TP*TP*CP*G)-3')
(1)
DNA (5'-D(P*CP*GP*AP*AP*TP*TP*TP*CP*TP*AP*GP*AP*CP*TP*CP*GP*AP*GP*AP*TP*CP*AP*G)-3')
(1)
DNA (5'-D(P*GP*TP*GP*AP*TP*GP*CP*TP*TP*TP*AP*GP*AP*TP*TP*TP*TP*TP*C)-3')
(1)
DNA (Continuous)
(1)
DNA (Post-Nick)
(1)
DNA (Pre-Nick)
(1)
DNA (continuous)
(1)
DNA (cytosine-5)-methyltransferase 1
(1)
DNA (post-nick)
(1)
DNA (pre-nick)
(1)
DNA annealing helicase and endonuclease ZRANB3
(1)
DNA excision repair protein ERCC-6-like 2
(1)
DNA polymerase eta
(1)
DNA polymerase iota
(1)
DNA replication factor Cdt1
(1)
DNA-dependent metalloprotease SPRTN
(1)
Denticleless protein homolog
(1)
E3 ubiquitin-protein ligase TRAIP
(1)
E3 ubiquitin-protein ligase UHRF2
(1)
F-box DNA helicase 1
(1)
Primer DNA
(1)
Proliferating cell nuclear antigen
(1)
Replication factor C subunit 1
(1)
Ribonuclease H2 subunit A
(1)
Ribonuclease H2 subunit C
(1)
SMALL PEPTIDE SAVLQKKITDYFHPKK
(1)
Template DNA
(1)
Ubiquitin
(1)
downstream DNA chain F
(1)
parent DNA
(1)
parent strand chain E
(1)
poly(ADP-ribose) glycohydrolase
(1)
upstream DNA chain J
(1)
 
Interacting ligands  (9)
SO4 : SULFATE ION
(7)
CL : CHLORIDE ION
(3)
GOL : GLYCEROL
(1)
NA : SODIUM ION
(1)
T2B : 4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol
(1)
T3 : 3,5,3'TRIIODOTHYRONINE
(1)
ZN : ZINC ION
(1)
ZQW : N~2~-(naphthalene-1-carbonyl)-N-(2-phenoxyphenyl)-L-alpha-glutamine
(1)
ZQZ : N-[2-(3-methoxyphenoxy)phenyl]-N~2~-(naphthalene-1-carbonyl)-L-alpha-glutamine
(1)
 
Function and Biology
Biological function  (15)
DNA binding
(91)
DNA polymerase binding
(91)
DNA polymerase processivity factor activity
(91)
MutLalpha complex binding
(91)
chromatin binding
(91)
damaged DNA binding
(91)
dinucleotide insertion or deletion binding
(91)
enzyme binding
(91)
histone acetyltransferase binding
(91)
identical protein binding
(91)
nuclear estrogen receptor binding
(91)
protein binding
(91)
protein-containing complex binding
(91)
purine-specific mismatch base pair DNA N-glycosylase activity
(91)
receptor tyrosine kinase binding
(91)
 
Biological process  (29)
DNA damage response
(91)
DNA repair
(91)
DNA replication
(91)
base-excision repair, gap-filling
(91)
cellular response to UV
(91)
cellular response to hydrogen peroxide
(91)
cellular response to xenobiotic stimulus
(91)
chromatin organization
(91)
epithelial cell differentiation
(91)
estrous cycle
(91)
heart development
(91)
leading strand elongation
(91)
liver regeneration
(91)
mismatch repair
(91)
mitotic telomere maintenance via semi-conservative replication
(91)
negative regulation of transcription by RNA polymerase II
(91)
positive regulation of DNA repair
(91)
positive regulation of DNA replication
(91)
positive regulation of DNA-directed DNA polymerase activity
(91)
positive regulation of deoxyribonuclease activity
(91)
replication fork processing
(91)
response to L-glutamate
(91)
response to cadmium ion
(91)
response to dexamethasone
(91)
response to estradiol
(91)
response to lipid
(91)
response to oxidative stress
(91)
translesion synthesis
(91)
regulation of DNA replication
(85)
 
Biological cell component  (15)
PCNA complex
(91)
PCNA-p21 complex
(91)
centrosome
(91)
chromatin
(91)
chromosome, telomeric region
(91)
cyclin-dependent protein kinase holoenzyme complex
(91)
extracellular exosome
(91)
male germ cell nucleus
(91)
nuclear body
(91)
nuclear lamina
(91)
nuclear replication fork
(91)
nucleoplasm
(91)
nucleus
(91)
replication fork
(91)
replisome
(91)
 
Sequence and Structure classification
SCOP fold  (1)
DNA clamp
(7)
 
SCOP family  (1)
DNA polymerase processivity factor
(7)
 
CATH class  (1)
Alpha Beta
(36)
 
CATH topology  (1)
Proliferating Cell Nuclear Antigen
(36)
 
Pfam accession / name  (2)
PF00705 : PCNA_N
(91)
PF02747 : PCNA_C
(91)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(48)
 
Diffraction radiation source type  (2)
Synchrotron
(47)
Rotating anode
(2)
 
Diffraction source  (30)
AUSTRALIAN SYNCHROTRON BEAMLINE MX1
(6)
DIAMOND BEAMLINE I03
(3)
ESRF BEAMLINE ID29
(3)
ESRF BEAMLINE MASSIF-1
(3)
APS BEAMLINE 23-ID-B
(2)
CHESS BEAMLINE A1
(2)
PHOTON FACTORY BEAMLINE AR-NW12A
(2)
PHOTON FACTORY BEAMLINE BL-17A
(2)
RIGAKU MICROMAX-007 HF
(2)
SLS BEAMLINE X06SA
(2)
SPRING-8 BEAMLINE BL38B1
(2)
SSRL BEAMLINE BL9-2
(2)
ALBA BEAMLINE XALOC
(1)
ALS BEAMLINE 12.3.1
(1)
ALS BEAMLINE 4.2.2
(1)
APS BEAMLINE 19-ID
(1)
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
(1)
DIAMOND BEAMLINE I04
(1)
ELETTRA BEAMLINE 5.2R
(1)
EMBL/DESY, HAMBURG BEAMLINE BW7A
(1)
ESRF BEAMLINE ID23-2
(1)
ESRF BEAMLINE MASSIF-3
(1)
NSLS BEAMLINE X25
(1)
PHOTON FACTORY BEAMLINE AR-NE3A
(1)
PHOTON FACTORY BEAMLINE BL-1A
(1)
PHOTON FACTORY BEAMLINE BL-5A
(1)
SRS BEAMLINE PX14.1
(1)
SRS BEAMLINE PX9.6
(1)
SSRF BEAMLINE BL17U1
(1)
SSRF BEAMLINE BL18U1
(1)
 
Synchrotron site  (16)
ESRF
(8)
Australian Synchrotron
(7)
Photon Factory
(7)
Diamond
(4)
APS
(3)
ALS
(2)
CHESS
(2)
SLS
(2)
SPring-8
(2)
SRS
(2)
SSRF
(2)
SSRL
(2)
ALBA
(1)
ELETTRA
(1)
EMBL/DESY, Hamburg
(1)
NSLS
(1)
 
Diffraction detector type  (4)
Pixel
(26)
CCD
(17)
CMOS
(1)
Image plate
(1)
 
Refinement software  (6)
PHENIX
(29)
REFMAC
(20)
CNS
(3)
BUSTER
(1)
X-PLOR
(1)
phenix.real_space_refine
(1)
 
EM microscope model  (5)
FEI TITAN KRIOS
(31)
FEI TITAN
(4)
TFS KRIOS
(4)
TFS GLACIOS
(2)
JEOL 2010
(1)
 
EM detector name  (5)
GATAN K3 (6k x 4k)
(26)
GATAN K3 BIOQUANTUM (6k x 4k)
(10)
FEI FALCON III (4k x 4k)
(3)
FEI FALCON IV (4k x 4k)
(2)
GATAN ULTRASCAN 4000 (4k x 4k)
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 91
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Co-crystal structure of caPCNA bound to AOH1160 derivative 1LE
Jossart J, Kenjic N, Malkas LH, Hickey RJ, Perry JJ
Cell Chem Biol (2023) [PMID: 37531956  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZQW    ZQW    CL   
Assembly name: PCNA homotrimer (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146041 (Preferred)   search this ID
PDBe-KB: P12004   
X-ray diffraction
2.81Å resolution
Released: 26 Jul 2023
Model geometry
Fit model/data
8gl9
8gl9
8gl9
PCNA
Vandborg BC, Bruning JB
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: PCNA homotrimer (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146041 (Preferred)   search this ID
PDBe-KB: P12004   
X-ray diffraction
2.85Å resolution
Released: 29 May 2024
Model geometry
Fit model/data
8gcj
8gcj
8gcj
Structure of the human endogenous PCNA-FEN1 complex - State C
Tian Y, Gao N
EMBO J (2024) [PMID: 39578540  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: PCNA homotrimer and Flap endonuclease 1 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-281321 (Preferred)   search this ID
PDBe-KB: P12004    P39748   
Electron Microscopy
3.51Å resolution
Released: 4 Dec 2024
Model geometry
Fit model/data
Data not analysed
8yjq
8yjq
8yjq
Structure of the human endogenous PCNA-FEN1 complex - State D
Tian Y, Gao N
EMBO J (2024) [PMID: 39578540  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: PCNA homotrimer and Flap endonuclease 1 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-281322 (Preferred)   search this ID
PDBe-KB: P12004    P39748   
Electron Microscopy
3.51Å resolution
Released: 4 Dec 2024
Model geometry
Fit model/data
Data not analysed
8yjr
8yjr
8yjr
Structure of the human endogenous PCNA-FEN1 complex - State H
Tian Y, Gao N
EMBO J (2024) [PMID: 39578540  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: PCNA homotrimer and Flap endonuclease 1 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-281326 (Preferred)   search this ID
PDBe-KB: P12004    P39748   
Electron Microscopy
3.55Å resolution
Released: 4 Dec 2024
Model geometry
Fit model/data
Data not analysed
8yjw
8yjw
8yjw
Structure of the human endogenous PCNA-FEN1 complex - State A
Tian Y, Gao N
EMBO J (2024) [PMID: 39578540  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: PCNA homotrimer and Flap endonuclease 1 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-281319 (Preferred)   search this ID
PDBe-KB: P12004    P39748   
Electron Microscopy
3.68Å resolution
Released: 4 Dec 2024
Model geometry
Fit model/data
Data not analysed
8yjh
8yjh
8yjh
Structure of the human endogenous PCNA-FEN1-RNase H2 complex - State D
Tian Y, Gao N
EMBO J (2024) [PMID: 39578540  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: PCNA homotrimer and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-281327 (Preferred)   search this ID
PDBe-KB: P12004    O75792    Q8TDP1    P39748    Q5TBB1   
Electron Microscopy
5.15Å resolution
Released: 4 Dec 2024
Model geometry
Fit model/data
Data not analysed
8yjz
8yjz
8yjz
Structure of the human endogenous PCNA-FEN1 complex - State E
Tian Y, Gao N
EMBO J (2024) [PMID: 39578540  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: PCNA homotrimer and Flap endonuclease 1 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-281323 (Preferred)   search this ID
PDBe-KB: P12004    P39748   
Electron Microscopy
3.55Å resolution
Released: 4 Dec 2024
Model geometry
Fit model/data
Data not analysed
8yjs
8yjs
8yjs
Crystal structure of human PCNA in complex with the PIP box of DVC1
Jiang T, Xu M, Wang Y
Biochem Biophys Res Commun (2016) [PMID: 27084448  ]
Assembly composition: protein/protein complex
Assembly name: PCNA homotrimer and DNA-dependent metalloprotease SPRTN (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146064 (Preferred)   search this ID
PDBe-KB: P12004    Q9H040   
X-ray diffraction
2.945Å resolution
Released: 8 Jun 2016
Model geometry
Fit model/data
5iy4
5iy4
5iy4
Crystal structure of the complex between the C-terminal domain of mouse MUTYH and human PCNA
Nakamura T, Nakabeppu Y, Yamagata Y
Nucleic Acids Res (2021) [PMID: 34142156  ]
Assembly composition: protein/protein complex
Assembly name: PCNA homotrimer and Adenine DNA glycosylase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146063 (Preferred)   search this ID
PDBe-KB: P12004    Q99P21   
X-ray diffraction
2.7Å resolution
Released: 23 Jun 2021
Model geometry
Fit model/data
7efa
7efa
7efa
...
Entries 1 to 10 of 91
Entries 1 to 10 of 91