Uniprot accession / id : P19838  OR   Uniprot accession / id : D6RDI9
 
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Entry Information
Entry status  (1)
REL
(15)
 
Experimental methods  (2)
X-ray diffraction
(11)
Solution NMR
(4)
 
Authors  (121)
Cingolani G
(4)
Florio TJ
(4)
Gillilan RE
(4)
Lokareddy RK
(4)
Ott CA
(4)
Sankhala RS
(4)
Yeggoni DP
(4)
Clore GM
(3)
Gronenborn AM
(3)
Harrison SC
(3)
Huth JR
(3)
Kennedy WM
(3)
Qin J
(3)
Aragao D
(2)
Aragão D
(2)
Basler CF
(2)
Bosence LA
(2)
Edwards MR
(2)
Forwood JK
(2)
Foster JK
(2)
Munasinghe TS
(2)
Roby JA
(2)
Smith KM
(2)
Stewart M
(2)
Tsimbalyuk S
(2)
Vogel OA
(2)
Acker A
(1)
Alghali ASO
(1)
Assaad J
(1)
Bar-Peled L
(1)
Bardeesy NM
(1)
Bates DL
(1)
Boland GM
(1)
Brooijmans N
(1)
Bussema L
(1)
Chen L
(1)
Chen N
(1)
Chong HB
(1)
Clark SE
(1)
Domingues AC
(1)
Dong R
(1)
Dubash T
(1)
Durr BR
(1)
Dürr BR
(1)
Fang J
(1)
Fisher DE
(1)
Ge M
(1)
Gohar M
(1)
Griesshaber H
(1)
Haber DA
(1)
Han A
(1)
Hara T
(1)
Harrison D
(1)
Harry S
(1)
Hata AN
(1)
Healy A
(1)
Hilbert B
(1)
Hilbert BJ
(1)
Hosp T
(1)
Inoue M
(1)
Jacobs MD
(1)
Jenkins RW
(1)
Karakyriakou B
(1)
Kastanos J
(1)
Khandelwal N
(1)
Kigawa T
(1)
Koglin AS
(1)
Koshiba S
(1)
Kryukov G
(1)
Lawless A
(1)
Lawrence MS
(1)
Lazarov MJ
(1)
Liau BB
(1)
Maheswaran S
(1)
Makram F
(1)
Maniatis T
(1)
Martin BR
(1)
Maynard M
(1)
Mueller CW
(1)
Muller CW
(1)
Murrey HE
(1)
Müller CW
(1)
Neil JR
(1)
Nguyen LP
(1)
Oh E
(1)
Ojeda S
(1)
Oltman A
(1)
Oltman AJ
(1)
Ott CJ
(1)
Panne D
(1)
Patel H
(1)
Popoola G
(1)
RIKEN Structural Genomics/Proteomics Initiative (RSGI)
(1)
Rachmin I
(1)
Rasmussen MQ
(1)
Reeves SM
(1)
Rey FA
(1)
Richter M
(1)
Rivera MN
(1)
Rubio K
(1)
 
More...
 
Homo / hetero assembly  (2)
hetero
(13)
homo
(2)
 
Assembly composition  (3)
protein/protein complex
(10)
DNA/protein complex
(3)
protein structure
(2)
 
Assembly polymer count  (5)
dimer
(7)
trimer
(3)
monomer
(2)
tetramer
(2)
hexamer
(1)
 
Resolution distribution
2.0 - 2.5
(5)
2.5 - 3
(5)
3.5 - 4
(1)
 
Release year distribution
1990 - 1995
(3)
1995 - 2000
(5)
2005 - 2010
(3)
2020 - 2025
(7)
 
Journal  (6)
Nat Commun
(6)
Cell
(3)
Structure
(3)
J Mol Biol
(1)
Nature
(1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(15)
 
Organism name  (1)
Homo sapiens
(15)
 
Molecule name  (5)
DNA-binding factor KBF1
(15)
EBP-1
(15)
Nuclear factor NF-kappa-B p105 subunit
(15)
Nuclear factor NF-kappa-B p50 subunit
(15)
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
(15)
 
Molecule type  (1)
Protein
(15)
 
Gene names  (1)
NFKB1
(15)
 
Interacting Molecules  (12)
Transcription factor p65
(5)
Importin subunit alpha-1
(3)
Importin subunit alpha-3
(3)
Thioredoxin
(3)
34-MER
(1)
36-MER
(1)
DNA (5'-D(*AP*GP*AP*TP*GP*GP*GP*GP*AP*AP*TP*CP*CP*CP*CP*TP*A P*GP*A)-3')
(1)
HIV-LTR Core Forward Strand
(1)
HIV-LTR Core Reverse Strand
(1)
Interferon regulatory factor 3
(1)
Interferon regulatory factor 7
(1)
NF-kappa-B inhibitor alpha
(1)
 
Interacting ligands  (1)
JMR : 1-(2-bromo-4-chlorophenyl)-N-{(3S)-1-[(E)-iminomethyl]pyrrolidin-3-yl}methanesulfonamide
(1)
 
Function and Biology
Biological function  (2)
DNA-binding transcription factor activity
(7)
DNA binding
(4)
 
Biological process  (2)
regulation of DNA-templated transcription
(7)
signal transduction
(1)
 
Biological cell component  (1)
cytoplasm
(7)
 
Sequence and Structure classification
SCOP fold  (2)
Immunoglobulin-like beta-sandwich
(3)
Common fold of diphtheria toxin/transcription factors/cytochrome f
(2)
 
SCOP family  (2)
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
(3)
Rel/Dorsal transcription factors, DNA-binding domain
(2)
 
CATH class  (2)
Mainly Beta
(4)
Mainly Alpha
(1)
 
CATH topology  (2)
Immunoglobulin-like
(4)
Death Domain, Fas
(1)
 
Pfam accession / name  (3)
PF00554 : RHD_DNA_bind
(4)
PF16179 : RHD_dimer
(4)
PF00531 : Death
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(10)
 
Diffraction radiation source type  (1)
Synchrotron
(10)
 
Diffraction source  (6)
SSRL BEAMLINE BL12-1
(4)
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
(2)
ALS BEAMLINE 8.2.1
(1)
ALS BEAMLINE 8.2.2
(1)
NSLS BEAMLINE X25
(1)
SPRING-8 BEAMLINE BL45XU
(1)
 
Synchrotron site  (5)
SSRL
(4)
ALS
(2)
Australian Synchrotron
(2)
NSLS
(1)
SPring-8
(1)
 
Diffraction detector type  (3)
Pixel
(7)
CCD
(3)
Area detector
(1)
 
Refinement software  (4)
PHENIX
(6)
CNS
(3)
REFMAC
(1)
X-PLOR
(1)
 
NMR
NMR software packages  (4)
CNS
(1)
NMRPipe
(1)
NMRView
(1)
XwinNMR
(1)
 
NMR Field Strength
700.0 - 800
(1)
800.0 - 900
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 15
Entries 1 to 10 of 15
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Structure of importin a2 bound to the p50- and p65-NLSs
Florio TJ, Lokareddy RK, Cingolani G
Nat Commun (2022) [PMID: 35260573  ]
Assembly composition: protein/protein complex
Assembly name: NF-kappaB DNA-binding transcription factor complex, p50/p65 and Importin subunit alpha-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-148767 (Preferred)   search this ID
PDBe-KB: P19838    P52293    Q04206   
X-ray diffraction
2.4Å resolution
Released: 19 Jan 2022
Model geometry
Fit model/data
7let
7let
7let
Structure of importin a3 bound to p50 NLS
Florio TJ, Lokareddy RK, Cingolani G
Nat Commun (2022) [PMID: 35260573  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Nuclear factor NF-kappa-B p50 subunit and Importin subunit alpha-3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-126372 (Preferred)   search this ID
PDBe-KB: P19838    O00629   
X-ray diffraction
2.1Å resolution
Released: 19 Jan 2022
Model geometry
Fit model/data
7lfc
7lfc
7lfc
Structure of importin a3 bound to the p50- and p65-NLSs
Florio TJ, Lokareddy RK, Cingolani G
Nat Commun (2022) [PMID: 35260573  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: NF-kappaB DNA-binding transcription factor complex, p50/p65 and Importin subunit alpha-3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-126373 (Preferred)   search this ID
PDBe-KB: P19838    O00629    Q04206   
X-ray diffraction
2.85Å resolution
Released: 19 Jan 2022
Model geometry
Fit model/data
7lf4
7lf4
7lf4
Structure of importin a2 bound to p50 NLS
Florio TJ, Lokareddy RK, Cingolani G
Nat Commun (2022) [PMID: 35260573  ]
Assembly composition: protein/protein complex
Assembly name: Importin subunit alpha-1 and Nuclear factor NF-kappa-B p50 subunit (Preferred)   search this complex
PDBe complex ID: PDB-CPX-148766 (Preferred)   search this ID
PDBe-KB: P19838    P52293   
X-ray diffraction
2.24Å resolution
Released: 19 Jan 2022
Model geometry
Fit model/data
7leq
7leq
7leq
NF-Kappa-B1 Bound with a Covalent Inhibitor
Hilbert BJ
Cell (2024) [PMID: 38653237  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: JMR    JMR   
Assembly name: Nuclear factor NF-kappa-B p50 subunit (Preferred)   search this complex
PDBe complex ID: PDB-CPX-148764 (Preferred)   search this ID
PDBe-KB: P19838   
X-ray diffraction
2.02Å resolution
Released: 24 Apr 2024
Model geometry
Fit model/data
8tqd
8tqd
8tqd
HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN NFKB (RESIDUES 56-68 OF THE P50 SUBUNIT OF NFKB)
Clore GM, Qin J, Gronenborn AM
Structure (1995) [PMID: 7788295  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Thioredoxin and Nuclear factor NF-kappa-B p50 subunit (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145349 (Preferred)   search this ID
PDBe-KB: P19838    P10599   
Solution NMR
Released: 3 Jun 1995
Model geometry
Fit model/data
Data not deposited
1mdj
1mdj
1mdj
HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN NFKB (RESIDUES 56-68 OF THE P50 SUBUNIT OF NFKB)
Clore GM, Qin J, Gronenborn AM
Structure (1995) [PMID: 7788295  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Thioredoxin and Nuclear factor NF-kappa-B p50 subunit (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145349 (Preferred)   search this ID
PDBe-KB: P19838    P10599   
Solution NMR
Released: 3 Jun 1995
Model geometry
Fit model/data
Data not deposited
1mdk
1mdk
1mdk
NFKB P50 HOMODIMER BOUND TO DNA
Mueller CW, Harrison SC
Nature (1995) [PMID: 7830764  ]
Source organisms: Synthetic construct, Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: NF-kappaB transcription regulation complex, p50/p50 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-114617 (Preferred)   search this ID
PDBe-KB: P19838    P19838   
X-ray diffraction
2.6Å resolution
Released: 10 Jun 1996
Model geometry
Fit model/data
Data not deposited
1svc
1svc
1svc
Solution structure of the Death domain in human Nuclear factor NF-kappa-B p105 subunit
Saito K, Inoue M, Koshiba S, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Nuclear factor NF-kappa-B p50 subunit (Preferred)   search this complex
PDBe complex ID: PDB-CPX-148764 (Preferred)   search this ID
PDBe-KB: P19838   
Solution NMR
Released: 19 Dec 2006
Model geometry
Fit model/data
Data not deposited
2dbf
2dbf
2dbf
I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX
Jacobs MD, Harrison SC
Cell (1998) [PMID: 9865693  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: NF-kappaB DNA-binding transcription factor complex, p50/p65 and NF-kappa-B inhibitor alpha (Preferred)   search this complex
PDBe complex ID: PDB-CPX-148765 (Preferred)   search this ID
PDBe-KB: P19838    P25963    Q04206   
X-ray diffraction
2.7Å resolution
Released: 18 Nov 1998
Model geometry
Fit model/data
Data not deposited
1nfi
1nfi
1nfi
Entries 1 to 10 of 15
Entries 1 to 10 of 15