Uniprot accession / id : P20591  OR   Uniprot accession / id : H9KVD0
 
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Entry Information
Entry status  (1)
REL
(7)
 
Experimental methods  (2)
X-ray diffraction
(6)
Electron Microscopy
(1)
 
Authors  (29)
Bulloch EM
(3)
Gao S
(3)
Kingston RL
(3)
Kochs G
(3)
McKelvie SA
(3)
Rennie ML
(3)
Daumke O
(2)
Haller O
(2)
von der Malsburg A
(2)
Behlke J
(1)
Chappie JS
(1)
Chen Y
(1)
Dick A
(1)
Dyda F
(1)
Faelber K
(1)
Fang S
(1)
Graf L
(1)
Hinshaw JE
(1)
Leonard M
(1)
Liu Y
(1)
Mears JA
(1)
Milligan RA
(1)
Paeschke S
(1)
Schmid SL
(1)
Schroder GF
(1)
Schröder GF
(1)
Yu B
(1)
Zhang L
(1)
Zhao Y
(1)
 
Homo / hetero assembly  (2)
homo
(5)
hetero
(2)
 
Assembly composition  (2)
protein structure
(5)
protein/protein complex
(2)
 
Assembly polymer count  (3)
dimer
(5)
72-mer
(1)
monomer
(1)
 
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(2)
2.5 - 3
(1)
3.0 - 3.5
(2)
12.0 - 12.5
(1)
 
Release year distribution
2005 - 2010
(1)
2010 - 2015
(6)
2015 - 2020
(1)
 
Journal  (5)
Structure
(3)
Cell
(1)
Immunity
(1)
Nat Commun
(1)
Nature
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(7)
 
Organism name  (1)
Homo sapiens
(7)
 
Molecule name  (7)
IFI-78K
(7)
Interferon-induced GTP-binding protein Mx1
(7)
Interferon-induced GTP-binding protein Mx1, N-terminally processed
(7)
Interferon-induced protein p78
(7)
Interferon-regulated resistance GTP-binding protein MxA
(7)
Myxoma resistance protein 1
(7)
Myxovirus resistance protein 1
(7)
 
Molecule type  (1)
Protein
(7)
 
Gene names  (1)
MX1
(7)
 
Interacting Molecules  (2)
Dynamin-1
(1)
Interferon-induced GTP-binding protein Mx1, N-terminally processed
(1)
 
Interacting ligands  (4)
SO4 : SULFATE ION
(2)
GCP : PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
(1)
GDP : GUANOSINE-5'-DIPHOSPHATE
(1)
MG : MAGNESIUM ION
(1)
 
Function and Biology
Biological function  (6)
GTP binding
(7)
GTPase activity
(7)
identical protein binding
(3)
microtubule binding
(3)
nucleotide binding
(3)
protein binding
(3)
 
Biological process  (13)
antiviral innate immune response
(3)
apoptotic process
(3)
defense response
(3)
defense response to virus
(3)
immune system process
(3)
innate immune response
(3)
interleukin-27-mediated signaling pathway
(3)
negative regulation of viral genome replication
(3)
receptor internalization
(3)
response to type I interferon
(3)
response to virus
(3)
signal transduction
(3)
synaptic vesicle budding from presynaptic endocytic zone membrane
(3)
 
Biological cell component  (12)
cytoplasm
(3)
cytosol
(3)
endoplasmic reticulum
(3)
endoplasmic reticulum membrane
(3)
membrane
(3)
microtubule
(3)
nuclear membrane
(3)
nucleus
(3)
perinuclear region of cytoplasm
(3)
plasma membrane
(3)
presynapse
(3)
synapse
(3)
 
Sequence and Structure classification
CATH class  (2)
Alpha Beta
(4)
Mainly Alpha
(2)
 
CATH topology  (2)
Rossmann fold
(4)
Four Helix Bundle (Hemerythrin (Met), subunit A)
(2)
 
Pfam accession / name  (3)
PF01031 : Dynamin_M
(7)
PF00350 : Dynamin_N
(6)
PF02212 : GED
(5)
 
Experimental Information
Diffraction protocol  (2)
Single wavelength
(5)
MAD
(1)
 
Diffraction radiation source type  (1)
Synchrotron
(6)
 
Diffraction source  (3)
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
(3)
BESSY BEAMLINE 14.1
(2)
SSRF BEAMLINE BL17U
(1)
 
Synchrotron site  (3)
Australian Synchrotron
(3)
BESSY
(2)
SSRF
(1)
 
Diffraction detector type  (1)
CCD
(6)
 
Refinement software  (3)
REFMAC
(5)
CNS
(1)
PHENIX
(1)
 
EM microscope model  (1)
FEI TECNAI F20
(1)
 
EM detector name  (1)
GATAN ULTRASCAN 4000 (4k x 4k)
(1)
 
Representative Structures
Representative Structures
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30%
Entries 1 to 7 of 7
Entries 1 to 7 of 7
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Nucleotide-free stalkless-MxA
Rennie ML, McKelvie SA, Bulloch EM, Kingston RL
Structure (2014) [PMID: 25295396  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SO4   
Assembly name: Interferon-induced GTP-binding protein Mx1, N-terminally processed (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149011 (Preferred)   search this ID
PDBe-KB: P20591   
X-ray diffraction
1.9Å resolution
Released: 5 Nov 2014
Model geometry
Fit model/data
4p4u
4p4u
4p4u
Human dynamin 1 deltaPRD polymer stabilized with GMPPCP
Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F
Cell (2011) [PMID: 21962517  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Dynamin-1 and Interferon-induced GTP-binding protein Mx1, N-terminally processed (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149012 (Preferred)   search this ID
PDBe-KB: P20591    Q05193   
Electron Microscopy
12.2Å resolution
Released: 12 Oct 2011
Model geometry
Fit model/data
Data not analysed
3zys
3zys
3zys
GDP-bound stalkless-MxA
Rennie ML, McKelvie SA, Bulloch EM, Kingston RL
Structure (2014) [PMID: 25295396  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GDP    SO4    GDP   
Assembly name: Interferon-induced GTP-binding protein Mx1, N-terminally processed (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149011 (Preferred)   search this ID
PDBe-KB: P20591   
X-ray diffraction
2.3Å resolution
Released: 22 Oct 2014
Model geometry
Fit model/data
4p4t
4p4t
4p4t
GMPPCP-bound stalkless-MxA
Rennie ML, McKelvie SA, Bulloch EM, Kingston RL
Structure (2014) [PMID: 25295396  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GCP    MG    MG    GCP   
Assembly name: Interferon-induced GTP-binding protein Mx1, N-terminally processed (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149010 (Preferred)   search this ID
PDBe-KB: P20591   
X-ray diffraction
3.3Å resolution
Released: 22 Oct 2014
Model geometry
Fit model/data
4p4s
4p4s
4p4s
Crystal structure of modified nucleotide-free human MxA
Gao S, Daumke O
Immunity (2011) [PMID: 21962493  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Interferon-induced GTP-binding protein Mx1, N-terminally processed (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149011 (Preferred)   search this ID
PDBe-KB: P20591    P20591   
X-ray diffraction
3.5Å resolution
Released: 12 Oct 2011
Model geometry
Fit model/data
3szr
3szr
3szr
Modified human MxA, nucleotide-free form
Chen Y, Gao S
Nat Commun (2017) [PMID: 28548099  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Interferon-induced GTP-binding protein Mx1, N-terminally processed (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149009 (Preferred)   search this ID
PDBe-KB: P20591    P20591   
X-ray diffraction
2.896Å resolution
Released: 31 May 2017
Model geometry
Fit model/data
5gtm
5gtm
5gtm
Structural basis of oligomerisation in the MxA stalk
Gao S, Daumke O
Nature (2010) [PMID: 20428112  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Interferon-induced GTP-binding protein Mx1, N-terminally processed (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149011 (Preferred)   search this ID
PDBe-KB: P20591   
X-ray diffraction
2.4Å resolution
Released: 5 May 2010
Model geometry
Fit model/data
3ljb
3ljb
3ljb
Entries 1 to 7 of 7
Entries 1 to 7 of 7