Uniprot accession / id : (P21673)
 
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Entry Information
Entry status  (1)
REL
(12)
 
Experimental methods  (1)
X-ray diffraction
(12)
 
Authors  (36)
Bewley MC
(6)
Burley SK
(6)
Coleman CS
(6)
Flanagan JM
(6)
Graziano V
(6)
Jiang J
(6)
Jiang JS
(6)
Matz E
(6)
New York SGX Research Center for Structural Genomics (NYSGXRC)
(6)
Pegg AE
(6)
Pegg AP
(6)
Studier FW
(6)
Hoffman DW
(2)
Montemayor EJ
(2)
Vonrhein C
(2)
Wang DC
(2)
Yin L
(2)
Zhang Y
(2)
Zhu DY
(2)
Zhu YQ
(2)
Arrowsmith CH
(1)
Blanchard JS
(1)
Bochkarev A
(1)
Chandler J
(1)
Edwards AM
(1)
Hegde SS
(1)
Loppnau P
(1)
Min JR
(1)
Plotnikov AN
(1)
Structural Genomics Consortium (SGC)
(1)
Sundstrom M
(1)
Vetting MW
(1)
Wu H
(1)
Yang N
(1)
Yu M
(1)
Zeng H
(1)
 
Homo / hetero assembly  (2)
homo
(10)
hetero
(2)
 
Assembly composition  (2)
protein structure
(10)
protein/protein complex
(2)
 
Assembly polymer count  (1)
dimer
(12)
 
Resolution distribution
1.5 - 2
(8)
2.0 - 2.5
(4)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(12)
 
Journal  (4)
Proc Natl Acad Sci U S A
(6)
Biochemistry
(3)
Proteins
(2)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(12)
 
Organism name  (2)
Homo sapiens
(10)
Mus musculus
(2)
 
Molecule name  (6)
Diamine acetyltransferase 1
(12)
Polyamine N-acetyltransferase 1
(12)
Putrescine acetyltransferase
(12)
SSAT
(12)
SSAT-1
(12)
Spermidine/spermine N(1)-acetyltransferase 1
(12)
 
Molecule type  (1)
Protein
(12)
 
Gene names  (4)
SAT
(10)
SAT1
(10)
Sat
(2)
Sat1
(2)
 
Interacting Molecules  (1)
Diamine acetyltransferase 1
(2)
 
Interacting ligands  (8)
COA : COENZYME A
(5)
ACO : ACETYL COENZYME *A
(2)
SO4 : SULFATE ION
(2)
ACT : ACETATE ION
(1)
B33 : N-ETHYL-N-[3-(PROPYLAMINO)PROPYL]PROPANE-1,3-DIAMINE
(1)
CA : CALCIUM ION
(1)
NHQ : (3R)-27-AMINO-3-HYDROXY-2,2-DIMETHYL-4,8,14-TRIOXO-12-THIA-5,9,15,19,24-PENTAAZAHEPTACOS-1-YL [(2S,3R,4S,5S)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE
(1)
SPM : SPERMINE
(1)
 
Function and Biology
EC number / name  (1)
2.3.1.57 : Diamine N-acetyltransferase
(12)
 
Biological function  (7)
N-acetyltransferase activity
(12)
acyltransferase activity
(12)
acyltransferase activity, transferring groups other than amino-acyl groups
(12)
diamine N-acetyltransferase activity
(12)
identical protein binding
(10)
protein binding
(10)
spermidine binding
(10)
 
Biological process  (6)
polyamine biosynthetic process
(12)
putrescine catabolic process
(12)
spermidine acetylation
(12)
angiogenesis
(10)
regulation of cell population proliferation
(2)
spermine catabolic process
(2)
 
Biological cell component  (2)
cytoplasm
(12)
cytosol
(12)
 
Compound cofactor class  (1)
Coenzyme A
(8)
 
Sequence and Structure classification
SCOP fold  (1)
Acyl-CoA N-acyltransferases (Nat)
(10)
 
SCOP family  (1)
N-acetyl transferase, NAT
(10)
 
CATH class  (1)
Alpha Beta
(12)
 
CATH topology  (1)
Aminopeptidase
(12)
 
Pfam accession / name  (1)
PF00583 : Acetyltransf_1
(12)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(12)
 
Diffraction radiation source type  (2)
Rotating anode
(5)
Synchrotron
(4)
 
Diffraction source  (7)
NSLS BEAMLINE X26C
(2)
RIGAKU
(2)
CAMD BEAMLINE GCPCC
(1)
PHOTON FACTORY BEAMLINE BL-6A
(1)
RIGAKU MICROMAX-007
(1)
RIGAKU RU200
(1)
RIGAKU RUH3R
(1)
 
Synchrotron site  (3)
NSLS
(2)
CAMD
(1)
Photon Factory
(1)
 
Diffraction detector type  (2)
Image plate
(5)
CCD
(2)
 
Refinement software  (2)
CNS
(10)
REFMAC
(2)
 
Representative Structures
Representative Structures
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90%
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40%
30%
Entries 1 to 10 of 12
Entries 1 to 10 of 12
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Wild Type SSAT- 1.7A structure
Bewley MC, Graziano V, Jiang JS, Matz E, Studier FW, Pegg AP, Coleman CS, Flanagan JM, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)
Proc Natl Acad Sci U S A (2006) [PMID: 16455797  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: SO4   
Modified residues: ALY    MSE    MSE    ALY   
Assembly name: Diamine acetyltransferase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149348 (Preferred)   search this ID
PDBe-KB: P21673   
X-ray diffraction
1.7Å resolution
Released: 17 Jan 2006
Model geometry
Fit model/data
2b5g
2b5g
2b5g
SSAT+COA+SP- SP disordered
Bewley MC, Graziano V, Jiang JS, Matz E, Studier FW, Pegg AP, Coleman CS, Flanagan JM, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)
Proc Natl Acad Sci U S A (2006) [PMID: 16455797  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: COA    COA   
Modified residues: ALY    MSE    MSE    ALY   
Assembly name: Diamine acetyltransferase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149348 (Preferred)   search this ID
PDBe-KB: P21673   
X-ray diffraction
2Å resolution
Released: 17 Jan 2006
Model geometry
Fit model/data
2b4d
2b4d
2b4d
Crystal structure of human spermidine/spermine N1-acetyltransferase (hSSAT)
Zhu YQ, Yang N, Wang DC
Proteins (2006) [PMID: 16544326  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Diamine acetyltransferase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149349 (Preferred)   search this ID
PDBe-KB: P21673   
X-ray diffraction
1.8Å resolution
Released: 7 Mar 2006
Model geometry
Fit model/data
2g3t
2g3t
2g3t
X-ray structure of spermidine/spermine N1-acetyltransferase (SAT) from Homo sapiens
Zhu YQ, Zhu DY, Vonrhein C, Wang DC
Proteins (2006) [PMID: 16544326  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Diamine acetyltransferase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149349 (Preferred)   search this ID
PDBe-KB: P21673   
X-ray diffraction
2.3Å resolution
Released: 6 Dec 2005
Model geometry
Fit model/data
2f5i
2f5i
2f5i
Human spermidine/spermine N1-acetyltransferase
Min JR, Wu H, Zeng H, Loppnau P, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ACO    ACT    CA    CA    ACO    ACT   
Assembly name: Diamine acetyltransferase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149349 (Preferred)   search this ID
PDBe-KB: P21673   
X-ray diffraction
2Å resolution
Released: 14 Feb 2006
Model geometry
Fit model/data
2fxf
2fxf
2fxf
Spermine spermidine acetyltransferase in complex with acetylcoa, K26R mutant
Bewley MC, Graziano V, Jiang JS, Matz E, Studier FW, Pegg AP, Coleman CS, Flanagan JM, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)
Proc Natl Acad Sci U S A (2006) [PMID: 16455797  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ACO    ACO   
Modified residues: MSE    MSE   
Assembly name: Diamine acetyltransferase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149349 (Preferred)   search this ID
PDBe-KB: P21673   
X-ray diffraction
1.95Å resolution
Released: 17 Jan 2006
Model geometry
Fit model/data
2b3v
2b3v
2b3v
SSAT with coa_sp, spermine disordered, K26R mutant
Bewley MC, Graziano V, Jiang JS, Matz E, Studier FW, Pegg AP, Coleman CS, Flanagan JM, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)
Proc Natl Acad Sci U S A (2006) [PMID: 16455797  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: COA    COA   
Modified residues: MSE    MSE   
Assembly name: Diamine acetyltransferase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149349 (Preferred)   search this ID
PDBe-KB: P21673   
X-ray diffraction
1.95Å resolution
Released: 24 Jan 2006
Model geometry
Fit model/data
2b58
2b58
2b58
Human Spermine spermidine acetyltransferase K26R mutant
Bewley MC, Graziano V, Jiang JS, Matz E, Studier FW, Pegg AP, Coleman CS, Flanagan JM, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)
Proc Natl Acad Sci U S A (2006) [PMID: 16455797  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SO4   
Modified residues: MSE    MSE   
Assembly name: Diamine acetyltransferase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149349 (Preferred)   search this ID
PDBe-KB: P21673   
X-ray diffraction
1.85Å resolution
Released: 17 Jan 2006
Model geometry
Fit model/data
2b3u
2b3u
2b3u
Crystal structure of human spermine,spermidine acetyltransferase in complex with a bisubstrate analog (N1-acetylspermine-S-CoA).
Hegde SS, Chandler J, Vetting MW, Yu M, Blanchard JS
Biochemistry (2007) [PMID: 17516632  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NHQ    NHQ   
Assembly name: Diamine acetyltransferase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149349 (Preferred)   search this ID
PDBe-KB: P21673   
X-ray diffraction
2.3Å resolution
Released: 5 Jun 2007
Model geometry
Fit model/data
2jev
2jev
2jev
SSAT+COA+BE-3-3-3, K26R mutant
Bewley MC, Graziano V, Jiang JS, Matz E, Studier FW, Pegg AP, Coleman CS, Flanagan JM, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)
Proc Natl Acad Sci U S A (2006) [PMID: 16455797  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: COA    B33    B33    COA   
Modified residues: MSE    MSE   
Assembly name: Diamine acetyltransferase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149349 (Preferred)   search this ID
PDBe-KB: P21673   
X-ray diffraction
2Å resolution
Released: 17 Jan 2006
Model geometry
Fit model/data
2b4b
2b4b
2b4b
Entries 1 to 10 of 12
Entries 1 to 10 of 12