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Entry status
(1)
Experimental methods
(1)
X-ray diffraction
(12)
Authors
(36)
Bewley MC
(6)
Burley SK
(6)
Coleman CS
(6)
Flanagan JM
(6)
Graziano V
(6)
Jiang J
(6)
Jiang JS
(6)
Matz E
(6)
New York SGX Research Center for Structural Genomics (NYSGXRC)
(6)
Pegg AE
(6)
Pegg AP
(6)
Studier FW
(6)
Hoffman DW
(2)
Montemayor EJ
(2)
Vonrhein C
(2)
Wang DC
(2)
Yin L
(2)
Zhang Y
(2)
Zhu DY
(2)
Zhu YQ
(2)
Arrowsmith CH
(1)
Blanchard JS
(1)
Bochkarev A
(1)
Chandler J
(1)
Edwards AM
(1)
Hegde SS
(1)
Loppnau P
(1)
Min JR
(1)
Plotnikov AN
(1)
Structural Genomics Consortium (SGC)
(1)
Sundstrom M
(1)
Vetting MW
(1)
Wu H
(1)
Yang N
(1)
Yu M
(1)
Zeng H
(1)
Homo / hetero assembly
(2)
homo
(10)
hetero
(2)
Assembly composition
(2)
protein structure
(10)
protein/protein complex
(2)
Assembly polymer count
(1)
dimer
(12)
Resolution distribution
1.5 - 2
(8)
2.0 - 2.5
(4)
Release year distribution
2000 - 2005
(1)
2005 - 2010
(12)
Journal
(4)
Proc Natl Acad Sci U S A
(6)
Biochemistry
(3)
Proteins
(2)
To be published
(1)
Macromolecules
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(1)
Eukaryota
(12)
Organism name
(2)
Homo sapiens
(10)
Mus musculus
(2)
Molecule name
(6)
Diamine acetyltransferase 1
(12)
Polyamine N-acetyltransferase 1
(12)
Putrescine acetyltransferase
(12)
SSAT
(12)
SSAT-1
(12)
Spermidine/spermine N(1)-acetyltransferase 1
(12)
Molecule type
(1)
Protein
(12)
Gene names
(4)
SAT
(10)
SAT1
(10)
Sat
(2)
Sat1
(2)
Interacting Molecules
(1)
Diamine acetyltransferase 1
(2)
Interacting ligands
(8)
COA : COENZYME A
(5)
ACO : ACETYL COENZYME *A
(2)
SO4 : SULFATE ION
(2)
ACT : ACETATE ION
(1)
B33 : N-ETHYL-N-[3-(PROPYLAMINO)PROPYL]PROPANE-1,3-DIAMINE
(1)
CA : CALCIUM ION
(1)
NHQ : (3R)-27-AMINO-3-HYDROXY-2,2-DIMETHYL-4,8,14-TRIOXO-12-THIA-5,9,15,19,24-PENTAAZAHEPTACOS-1-YL
[(2S,3R,4S,5S)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE
(1)
SPM : SPERMINE
(1)
Function and Biology
EC number / name
(1)
2.3.1.57 : Diamine N-acetyltransferase
(12)
Biological function
(7)
N-acetyltransferase activity
(12)
acyltransferase activity
(12)
acyltransferase activity, transferring groups other than amino-acyl groups
(12)
diamine N-acetyltransferase activity
(12)
identical protein binding
(10)
protein binding
(10)
spermidine binding
(10)
Biological process
(6)
polyamine biosynthetic process
(12)
putrescine catabolic process
(12)
spermidine acetylation
(12)
angiogenesis
(10)
regulation of cell population proliferation
(2)
spermine catabolic process
(2)
Biological cell component
(2)
cytoplasm
(12)
cytosol
(12)
Compound cofactor class
(1)
Coenzyme A
(8)
Sequence and Structure classification
SCOP fold
(1)
Acyl-CoA N-acyltransferases (Nat)
(10)
SCOP family
(1)
N-acetyl transferase, NAT
(10)
CATH class
(1)
Alpha Beta
(12)
CATH topology
(1)
Aminopeptidase
(12)
Pfam accession / name
(1)
PF00583 : Acetyltransf_1
(12)
Experimental Information
Diffraction protocol
(1)
Single wavelength
(12)
Diffraction radiation source type
(2)
Rotating anode
(5)
Synchrotron
(4)
Diffraction source
(7)
NSLS BEAMLINE X26C
(2)
RIGAKU
(2)
CAMD BEAMLINE GCPCC
(1)
PHOTON FACTORY BEAMLINE BL-6A
(1)
RIGAKU MICROMAX-007
(1)
RIGAKU RU200
(1)
RIGAKU RUH3R
(1)
Synchrotron site
(3)
NSLS
(2)
CAMD
(1)
Photon Factory
(1)
Diffraction detector type
(2)
Image plate
(5)
CCD
(2)
Refinement software
(2)
CNS
(10)
REFMAC
(2)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 10 of 12
Select all entries on this page
Wild Type SSAT- 1.7A structure
Bewley MC, Graziano V, Jiang JS, Matz E, Studier FW, Pegg AP, Coleman CS, Flanagan JM, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)
Proc Natl Acad Sci U S A
(2006)
[PMID: 16455797 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Bound ligands:
SO4
Assembly name:
Diamine acetyltransferase 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-149348 (Preferred)
search this ID

SSAT+COA+SP- SP disordered
Bewley MC, Graziano V, Jiang JS, Matz E, Studier FW, Pegg AP, Coleman CS, Flanagan JM, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)
Proc Natl Acad Sci U S A
(2006)
[PMID: 16455797 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Diamine acetyltransferase 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-149348 (Preferred)
search this ID

Crystal structure of human spermidine/spermine N1-acetyltransferase (hSSAT)
Zhu YQ, Yang N, Wang DC
Proteins
(2006)
[PMID: 16544326 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Diamine acetyltransferase 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-149349 (Preferred)
search this ID

X-ray structure of spermidine/spermine N1-acetyltransferase (SAT) from Homo sapiens
Zhu YQ, Zhu DY, Vonrhein C, Wang DC
Proteins
(2006)
[PMID: 16544326 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Diamine acetyltransferase 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-149349 (Preferred)
search this ID

Human spermidine/spermine N1-acetyltransferase
Min JR, Wu H, Zeng H, Loppnau P, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)
To be published
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Diamine acetyltransferase 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-149349 (Preferred)
search this ID

Spermine spermidine acetyltransferase in complex with acetylcoa, K26R mutant
Bewley MC, Graziano V, Jiang JS, Matz E, Studier FW, Pegg AP, Coleman CS, Flanagan JM, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)
Proc Natl Acad Sci U S A
(2006)
[PMID: 16455797 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Diamine acetyltransferase 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-149349 (Preferred)
search this ID

SSAT with coa_sp, spermine disordered, K26R mutant
Bewley MC, Graziano V, Jiang JS, Matz E, Studier FW, Pegg AP, Coleman CS, Flanagan JM, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)
Proc Natl Acad Sci U S A
(2006)
[PMID: 16455797 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Diamine acetyltransferase 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-149349 (Preferred)
search this ID

Human Spermine spermidine acetyltransferase K26R mutant
Bewley MC, Graziano V, Jiang JS, Matz E, Studier FW, Pegg AP, Coleman CS, Flanagan JM, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)
Proc Natl Acad Sci U S A
(2006)
[PMID: 16455797 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Bound ligands:
SO4
Assembly name:
Diamine acetyltransferase 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-149349 (Preferred)
search this ID

Crystal structure of human spermine,spermidine acetyltransferase in complex with a bisubstrate analog (N1-acetylspermine-S-CoA).
Hegde SS, Chandler J, Vetting MW, Yu M, Blanchard JS
Biochemistry
(2007)
[PMID: 17516632 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Diamine acetyltransferase 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-149349 (Preferred)
search this ID

SSAT+COA+BE-3-3-3, K26R mutant
Bewley MC, Graziano V, Jiang JS, Matz E, Studier FW, Pegg AP, Coleman CS, Flanagan JM, Burley SK, New York SGX Research Center for Structural Genomics (NYSGXRC)
Proc Natl Acad Sci U S A
(2006)
[PMID: 16455797 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Diamine acetyltransferase 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-149349 (Preferred)
search this ID

Entries 1 to 10 of 12