Uniprot accession / id : (P22061)
 
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Entry Information
Entry status  (1)
REL
(2)
 
Experimental methods  (1)
X-ray diffraction
(2)
 
Authors  (15)
Carson M
(1)
Chantalat L
(1)
Chattopadhyay D
(1)
Clarke S
(1)
Delucas L
(1)
Friedman AM
(1)
Griffith SC
(1)
MacLaren DC
(1)
Ryttersgaard C
(1)
Sawaya MR
(1)
Shirasawa T
(1)
Skinner MM
(1)
Smith CD
(1)
Weise L
(1)
Yeates TO
(1)
 
Homo / hetero assembly  (1)
homo
(2)
 
Assembly composition  (1)
protein structure
(2)
 
Assembly polymer count  (1)
monomer
(2)
 
Resolution distribution
1.0 - 1.5
(1)
2.0 - 2.5
(1)
 
Release year distribution
2000 - 2005
(2)
 
Journal  (2)
J Biol Chem
(1)
Protein Sci
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(2)
 
Organism name  (1)
Homo sapiens
(2)
 
Molecule name  (5)
L-isoaspartyl protein carboxyl methyltransferase
(2)
PIMT
(2)
Protein L-isoaspartyl/D-aspartyl methyltransferase
(2)
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
(2)
Protein-beta-aspartate methyltransferase
(2)
 
Molecule type  (1)
Protein
(2)
 
Gene names  (1)
PCMT1
(2)
 
Interacting ligands  (1)
SAH : S-ADENOSYL-L-HOMOCYSTEINE
(2)
 
Function and Biology
EC number / name  (1)
2.1.1.77 : Protein-L-isoaspartate(D-aspartate) O-methyltransferase
(2)
 
Biological function  (5)
cadherin binding
(2)
methyltransferase activity
(2)
protein binding
(2)
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
(2)
transferase activity
(2)
 
Biological process  (4)
methylation
(2)
protein methylation
(2)
protein modification process
(2)
protein repair
(2)
 
Biological cell component  (4)
cytoplasm
(2)
cytosol
(2)
extracellular exosome
(2)
extracellular vesicle
(2)
 
Compound cofactor class  (1)
S-adenosylmethionine
(2)
 
Sequence and Structure classification
SCOP fold  (1)
S-adenosyl-L-methionine-dependent methyltransferases
(2)
 
SCOP family  (1)
Protein-L-isoaspartyl O-methyltransferase
(2)
 
CATH class  (1)
Alpha Beta
(2)
 
CATH topology  (1)
Rossmann fold
(2)
 
Pfam accession / name  (1)
PF01135 : PCMT
(2)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(2)
 
Diffraction radiation source type  (2)
Rotating anode
(1)
Synchrotron
(1)
 
Diffraction source  (2)
NSLS BEAMLINE X8C
(1)
RIGAKU RU300
(1)
 
Synchrotron site  (1)
NSLS
(1)
 
Diffraction detector type  (2)
CCD
(1)
Image plate
(1)
 
Refinement software  (1)
CNS
(2)
 
Representative Structures
Representative Structures
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Crystal structure of human L-isoaspartyl methyltransferase
Ryttersgaard C, Griffith SC, Sawaya MR, MacLaren DC, Clarke S, Yeates TO
J Biol Chem (2002) [PMID: 11792715  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SAH    SAH   
Assembly name: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149513 (Preferred)   search this ID
PDBe-KB: P22061   
X-ray diffraction
2.1Å resolution
Released: 8 Feb 2002
Model geometry
Fit model/data
1kr5
1kr5
1kr5
HUMAN PROTEIN L-ISOASPARTATE O-METHYLTRANSFERASE WITH S-ADENOSYL HOMOCYSTEINE
Smith CD, Chattopadhyay D, Carson M, Friedman AM, Skinner MM
Protein Sci (2002) [PMID: 11847284  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SAH    SAH   
Assembly name: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149513 (Preferred)   search this ID
PDBe-KB: P22061   
X-ray diffraction
1.5Å resolution
Released: 13 Mar 2002
Model geometry
Fit model/data
1i1n
1i1n
1i1n
Entries 1 to 2 of 2
Entries 1 to 2 of 2