Entry status  (1)

REL

(38)

Experimental methods  (1)

X-ray diffraction

(38)

Authors  (227)

Knapp S

(26)

Structural Genomics Consortium (SGC)

(25)

Chaikuad A

(19)

Schroder M

(13)

Schroeder M

(13)

Schröder M

(13)

Arrowsmith CH

(11)

Bountra C

(11)

Bracher F

(10)

Edwards AM

(10)

Bullock AN

(8)

Fedorov O

(8)

Domovich Y

(7)

Livnah O

(7)

Meijer L

(6)

von Delft F

(6)

Anizon F

(4)

Berger BT

(4)

Drapela S

(4)

Drápela S

(4)

Esvan YJ

(4)

Flegel J

(4)

Giraud F

(4)

Hylsova M

(4)

Hylsová M

(4)

Loaec N

(4)

Loaëc N

(4)

Maier L

(4)

Moreau P

(4)

Nemec V

(4)

Němec V

(4)

Paruch K

(4)

Sievers S

(4)

Soucek K

(4)

Souček K

(4)

Uldrijan S

(4)

Valcikova B

(4)

Valčíková B

(4)

Waldmann H

(4)

Zeinyeh W

(4)

Ziegler S

(4)

Edwards A

(3)

Aiger C

(2)

Arrowsmith C

(2)

Bach S

(2)

Baratte B

(2)

Benderitter P

(2)

Boibessot T

(2)

Chatterjee D

(2)

Cho S

(2)

Deau E

(2)

Denis A

(2)

Filippakopoulos P

(2)

George N

(2)

George P

(2)

Helmer R

(2)

Hoflack J

(2)

Huber K

(2)

Joerger AC

(2)

Josselin B

(2)

Khiari J

(2)

Kraemer A

(2)

Kramer A

(2)

Krämer A

(2)

Kunick C

(2)

Lindberg MF

(2)

Miege F

(2)

Nauton L

(2)

Ott I

(2)

Preu L

(2)

Roche D

(2)

Ruchaud S

(2)

Sundstrom M

(2)

Tazarki H

(2)

Thery V

(2)

Théry V

(2)

Walter A

(2)

Albayya F

(1)

Amos A

(1)

Amos AL

(1)

Aret E

(1)

Arnaud B

(1)

Ball L

(1)

Bergsdorf C

(1)

Bernhard M

(1)

Bonnet P

(1)

Bouchard K

(1)

Brennan P

(1)

Brichet M

(1)

Brooijmans N

(1)

Brubaker JD

(1)

Brugman SJT

(1)

Bullock A

(1)

Chang JH

(1)

Chen C

(1)

Chen K

(1)

Chun HS

(1)

Cobos-Correa A

(1)

Dairou J

(1)

Danieli T

(1)

 

More...

Homo / hetero assembly  (1)

homo

(38)

Assembly composition  (1)

protein structure

(38)

Assembly polymer count  (1)

monomer

(38)

Resolution distribution

1.0 - 1.5

(2)

1.5 - 2

(17)

2.0 - 2.5

(14)

2.5 - 3

(5)

Release year distribution

2000 - 2005

(1)

2005 - 2010

(2)

2015 - 2020

(30)

2020 - 2025

(21)

Journal  (13)

To be published

(10)

J Med Chem

(9)

Angew Chem Int Ed Engl

(5)

Eur J Med Chem

(4)

PLoS One

(2)

Biomed Res Int

(1)

Chem Biol

(1)

ChemMedChem

(1)

Int J Mol Sci

(1)

Mol Cell

(1)

Protein Expr Purif

(1)

Sci Transl Med

(1)

Structure

(1)

Organism superkingdom  (1)

Eukaryota

(38)

Organism name  (1)

Homo sapiens

(38)

Molecule name  (2)

CDC-like kinase 1

(38)

Dual specificity protein kinase CLK1

(38)

Molecule type  (1)

Protein

(38)

Gene names  (2)

CLK

(38)

CLK1

(38)

Interacting ligands  (43)

EDO : 1,2-ETHANEDIOL

(9)

GOL : GLYCEROL

(9)

PO4 : PHOSPHATE ION

(7)

V25 : ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate

(3)

EAE : (1~{Z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one

(2)

JTQ : 5-[6,7-bis(chloranyl)-1-methyl-indol-3-yl]pyrimidin-4-amine

(2)

NA : SODIUM ION

(2)

SO4 : SULFATE ION

(2)

06N : 4-[2-(propylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenol

(1)

3NG : 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid

(1)

5ID : (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL

(1)

6FB : pyrido[3,4-g]quinazolin-2-amine

(1)

6FD : pyrido[3,4-g]quinazoline-2,10-diamine

(1)

7A7 : methyl 9-[(2-fluoranyl-4-methoxy-phenyl)amino]-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate

(1)

BR : BROMIDE ION

(1)

CL : CHLORIDE ION

(1)

DBQ : DEBROMOHYMENIALDISINE

(1)

E6T : 3-(3-hydroxyphenyl)-1~{H}-pyrrolo[3,4-g]indol-8-one

(1)

E6W : 2-bromanyl-3-phenyl-1~{H}-pyrrolo[3,4-g]indol-8-one

(1)

EAQ : 6-~{tert}-butyl-~{N}-[6-(1~{H}-pyrazol-4-yl)-1~{H}-imidazo[1,2-a]pyridin-2-yl]pyridine-3-carboxamide

(1)

FG9 : ~{N}2-(3-morpholin-4-ylpropyl)pyrido[3,4-g]quinazoline-2,10-diamine

(1)

H3E : 5-(1-methylpyrazol-4-yl)-3-[1-(phenylmethyl)pyrazol-4-yl]furo[3,2-b]pyridine

(1)

H3H : 5-(1-methylpyrazol-4-yl)-3-(3-propan-2-yloxyphenyl)furo[3,2-b]pyridine

(1)

H3N : 5-(1-methylpyrazol-4-yl)-3-(3-phenoxyphenyl)furo[3,2-b]pyridine

(1)

H3Q : 3-(3-cyclobutylphenyl)-5-(1-methylpyrazol-4-yl)furo[3,2-b]pyridine

(1)

HQB : ~{N}-methyl-10-nitro-pyrido[3,4-g]quinazolin-2-amine

(1)

IOD : IODIDE ION

(1)

IYZ : 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE

(1)

JQW : 4-[6,7-bis(chloranyl)-1~{H}-indol-3-yl]pyrimidin-2-amine

(1)

JU8 : 5-(1-methylindol-3-yl)pyrimidin-4-amine

(1)

JUW : 4-(1-methylindol-3-yl)pyrimidin-2-amine

(1)

JWN : 4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{N}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide

(1)

K : POTASSIUM ION

(1)

KHC : (4~{S})-7,8-bis(chloranyl)-9-methyl-1-oxidanylidene-spiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrile

(1)

PKB : 4-(6-ethoxypyrazolo[1,5-b]pyridazin-3-yl)-~{N}-[3-methoxy-5-(trifluoromethyl)phenyl]pyrimidin-2-amine

(1)

PQ5 : 7,10-Dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxylic acid

(1)

Q7K : 11,15-dimethyl-6-(oxan-4-yloxy)-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one

(1)

RH8 : ~{N}-[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine

(1)

SQZ : 5-[1-[(1S)-1-(4-fluorophenyl)ethyl]-[1,2,3]triazolo[4,5-c]quinolin-8-yl]-1,3-benzoxazole

(1)

V5T : 4-(1~{H}-indol-3-yl)pyrimidin-2-amine

(1)

WAK : (4~{Z})-2-(1-adamantylamino)-4-(1,3-benzothiazol-6-ylmethylidene)-1~{H}-imidazol-5-one

(1)

WAZ : (4~{Z})-4-(1,3-benzothiazol-6-ylmethylidene)-2-[[(2~{R})-1-methoxy-4-methyl-pentan-2-yl]amino]-1~{H}-imidazol-5-one

(1)

XQX : cyclopropyl(4-{(8R)-6-[4-(piperazin-1-yl)phenyl]pyrrolo[1,2-b]pyridazin-4-yl}piperazin-1-yl)methanone

(1)

EC number / name  (1)

2.7.12.1 : Dual-specificity kinase

(38)

Biological function  (11)

ATP binding

(38)

protein kinase activity

(38)

kinase activity

(1)

non-membrane spanning protein tyrosine kinase activity

(1)

nucleotide binding

(1)

protein binding

(1)

protein serine kinase activity

(1)

protein serine/threonine kinase activity

(1)

protein serine/threonine/tyrosine kinase activity

(1)

protein tyrosine kinase activity

(1)

transferase activity

(1)

Biological process  (2)

protein phosphorylation

(38)

regulation of RNA splicing

(1)

Biological cell component  (1)

nucleus

(1)

CATH class  (2)

Alpha Beta

(4)

Mainly Alpha

(4)

CATH topology  (2)

Phosphorylase Kinase; domain 1

(4)

Transferase(Phosphotransferase); domain 1

(4)

Pfam accession / name  (1)

PF00069 : Pkinase

(38)

Diffraction protocol  (1)

Single wavelength

(38)

Diffraction radiation source type  (1)

Synchrotron

(38)

Diffraction source  (13)

DIAMOND BEAMLINE I03

(5)

BESSY BEAMLINE 14.2

(4)

DIAMOND BEAMLINE I04

(4)

ESRF BEAMLINE ID29

(4)

SLS BEAMLINE X06SA

(4)

SLS BEAMLINE X10SA

(4)

ESRF BEAMLINE ID23-1

(3)

SLS BEAMLINE X06DA

(3)

DIAMOND BEAMLINE I02

(2)

DIAMOND BEAMLINE I04-1

(2)

ESRF BEAMLINE BM30A

(1)

PAL/PLS BEAMLINE 7A (6B, 6C1)

(1)

SSRF BEAMLINE BL17U

(1)

Synchrotron site  (6)

Diamond

(13)

SLS

(11)

ESRF

(8)

BESSY

(4)

PAL/PLS

(1)

SSRF

(1)

Diffraction detector type  (2)

Pixel

(33)

CCD

(5)

Refinement software  (2)

REFMAC

(32)

PHENIX

(6)

Representative Structures

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