Entry status  (1)

REL

(30)

Experimental methods  (1)

X-ray diffraction

(30)

Authors  (130)

Declerck PJ

(10)

Strelkov SV

(8)

Sillen M

(6)

Andreasen PA

(5)

Jensen JK

(4)

Weeks SD

(4)

Florova G

(3)

Gettins PG

(3)

Huang M

(3)

Idell S

(3)

Komissarov AA

(3)

Lawrence DA

(3)

Zhou X

(3)

Bucci JC

(2)

Buckley DI

(2)

Carrell RW

(2)

Deinum J

(2)

Dewilde M

(2)

Emal CD

(2)

Gils A

(2)

Graham H

(2)

Hong ZB

(2)

Huang MD

(2)

Huntington JA

(2)

Li S-H

(2)

Li SH

(2)

Lin ZH

(2)

Matthews DJ

(2)

Miyata T

(2)

Morth JP

(2)

Nissen P

(2)

Pannu NS

(2)

Peterson CB

(2)

Read RJ

(2)

Reinke AA

(2)

Sanders KL

(2)

Stein PE

(2)

Stout TJ

(2)

Stuckey JA

(2)

Thompson LC

(2)

Vaughan DE

(2)

Whisstock JC

(2)

Yuan C

(2)

Aertgeerts K

(1)

Al-Senaidy A

(1)

Baek K

(1)

Bauer M

(1)

Berkenpas MB

(1)

Bjorquist P

(1)

Björquist P

(1)

Bodin C

(1)

Carruthers AM

(1)

Compernolle G

(1)

Connor J

(1)

De Bondt HL

(1)

De Ranter CJ

(1)

Declerck P

(1)

Dufner P

(1)

Fjellstrom O

(1)

Fjellström O

(1)

Furie B

(1)

Furie BC

(1)

Gerard RD

(1)

Geschwindner S

(1)

Gettins PGW

(1)

Ginsburg D

(1)

Goldsmith EJ

(1)

Gong L

(1)

Gong LH

(1)

Gustafsson D

(1)

Han FQ

(1)

Han Q

(1)

Hu LH

(1)

Inghardt T

(1)

Jankun J

(1)

Jiang L

(1)

Johansson C

(1)

Johnson DJD

(1)

Lang D

(1)

Legnehed A

(1)

Lin Z

(1)

Linschoten M

(1)

Liu M

(1)

Lowe DC

(1)

Lundqvist T

(1)

Luo Z

(1)

Madsen JB

(1)

Mallinder PR

(1)

McPheat J

(1)

Mcpheat J

(1)

Min L

(1)

Mottonen J

(1)

Murray C

(1)

Murray LA

(1)

Musil D

(1)

Naiman B

(1)

Nar H

(1)

Nerme V

(1)

Newton P

(1)

Olsson K

(1)

 

More...

Homo / hetero assembly  (2)

homo

(18)

hetero

(12)

Assembly composition  (2)

protein structure

(18)

protein/protein complex

(12)

Assembly polymer count  (3)

monomer

(17)

dimer

(8)

trimer

(5)

Resolution distribution

1.5 - 2

(5)

2.0 - 2.5

(14)

2.5 - 3

(9)

3.0 - 3.5

(1)

3.5 - 4

(1)

Release year distribution

1995 - 2000

(7)

2000 - 2005

(4)

2005 - 2010

(4)

2010 - 2015

(11)

2015 - 2020

(7)

2020 - 2025

(6)

Journal  (13)

J Biol Chem

(5)

Int J Mol Sci

(3)

J Thromb Haemost

(3)

Nat Struct Biol

(3)

To be published

(3)

Biochemistry

(2)

J Struct Biol

(2)

Proc Natl Acad Sci U S A

(2)

Structure

(2)

Int J Mol Med

(1)

J Mol Biol

(1)

Protein Sci

(1)

Sci Rep

(1)

Organism superkingdom  (1)

Eukaryota

(30)

Organism name  (2)

Homo sapiens

(29)

Mus musculus

(1)

Molecule name  (5)

Endothelial plasminogen activator inhibitor

(30)

PAI

(30)

PAI-1

(30)

Plasminogen activator inhibitor 1

(30)

Serpin E1

(30)

Molecule type  (1)

Protein

(30)

Gene names  (7)

PAI1

(29)

PLANH1

(29)

SERPINE1

(29)

Mr1

(1)

Pai1

(1)

Planh1

(1)

Serpine1

(1)

Interacting Molecules  (12)

VHH-2g-42

(3)

Tissue-type plasminogen activator chain B

(2)

VHH-2w-64

(2)

HEAVY CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY

(1)

LIGHT CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY

(1)

PENTAPEPTIDE

(1)

Plasminogen activator inhibitor 1

(1)

Somatomedin-B

(1)

Urokinase-type plasminogen activator chain B

(1)

VHH-2g-42 (Nb42)

(1)

VHH-2w-64 (Nb64)

(1)

VHH-s-a93 (Nb93)

(1)

Interacting ligands  (16)

CL : CHLORIDE ION

(3)

96P : (2S)-3-({[3-(trifluoromethyl)phenoxy]carbonyl}amino)propane-1,2-diyl bis(3,4,5-trihydroxybenzoate)

(2)

EDO : 1,2-ETHANEDIOL

(2)

NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose

(2)

RV2 : 5-Chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acid

(2)

SO4 : SULFATE ION

(2)

ZN : ZINC ION

(2)

ACY : ACETIC ACID

(1)

BMA : beta-D-mannopyranose

(1)

DMS : DIMETHYL SULFOXIDE

(1)

EMJ : 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione

(1)

FUC : alpha-L-fucopyranose

(1)

GDE : 3,4,5-trihydroxybenzoic acid

(1)

GOL : GLYCEROL

(1)

RIP : beta-D-ribopyranose

(1)

TB7 : TERT-BUTYL 3-[(4-OXO-3H-PYRIDO[2,3-D]PYRIMIDIN-2-YL)AMINO]AZETIDINE-1-CARBOXYLATE

(1)

Biological function  (6)

serine-type endopeptidase inhibitor activity

(30)

peptidase inhibitor activity

(28)

protein binding

(28)

endopeptidase inhibitor activity

(27)

protease binding

(27)

signaling receptor binding

(27)

Biological process  (33)

angiogenesis

(28)

defense response to Gram-negative bacterium

(28)

negative regulation of fibrinolysis

(28)

negative regulation of plasminogen activation

(28)

negative regulation of vascular wound healing

(28)

positive regulation of angiogenesis

(28)

cellular response to lipopolysaccharide

(27)

dentinogenesis

(27)

fibrinolysis

(27)

negative regulation of blood coagulation

(27)

negative regulation of cell adhesion mediated by integrin

(27)

negative regulation of cell migration

(27)

negative regulation of endothelial cell apoptotic process

(27)

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

(27)

negative regulation of integrin-mediated signaling pathway

(27)

negative regulation of proteolysis

(27)

negative regulation of smooth muscle cell migration

(27)

negative regulation of smooth muscle cell-matrix adhesion

(27)

negative regulation of thrombin-activated receptor signaling pathway

(27)

negative regulation of wound healing

(27)

positive regulation of blood coagulation

(27)

positive regulation of coagulation

(27)

positive regulation of inflammatory response

(27)

positive regulation of interleukin-8 production

(27)

positive regulation of leukotriene production involved in inflammatory response

(27)

positive regulation of monocyte chemotaxis

(27)

positive regulation of odontoblast differentiation

(27)

positive regulation of receptor-mediated endocytosis

(27)

replicative senescence

(27)

cellular response to transforming growth factor beta stimulus

(1)

placenta development

(1)

regulation of angiogenesis

(1)

regulation of cell population proliferation

(1)

Biological cell component  (8)

extracellular space

(30)

extracellular region

(28)

peptidase inhibitor complex

(28)

serine protease inhibitor complex

(28)

collagen-containing extracellular matrix

(27)

extracellular exosome

(27)

plasma membrane

(27)

platelet alpha granule lumen

(27)

SCOP fold  (1)

Serpins

(9)

SCOP family  (1)

Serpins

(9)

CATH class  (2)

Alpha Beta

(24)

Mainly Beta

(24)

CATH topology  (2)

Alpha-1-antitrypsin; domain 1

(24)

Antithrombin; Chain I, domain 2

(24)

Pfam accession / name  (1)

PF00079 : Serpin

(30)

Diffraction protocol  (1)

Single wavelength

(29)

Diffraction radiation source type  (2)

Synchrotron

(25)

Rotating anode

(5)

Diffraction source  (22)

SSRF BEAMLINE BL17U

(4)

APS BEAMLINE 21-ID-D

(2)

RIGAKU RUH3R

(2)

SIEMENS

(2)

SLS BEAMLINE X06SA

(2)

SOLEIL BEAMLINE PROXIMA 1

(2)

ALS BEAMLINE 5.0.3

(1)

APS BEAMLINE 19-ID

(1)

APS BEAMLINE 22-ID

(1)

EMBL/DESY, HAMBURG BEAMLINE BW7B

(1)

EMBL/DESY, HAMBURG BEAMLINE X13

(1)

ESRF BEAMLINE ID23-1

(1)

ESRF BEAMLINE ID23-2

(1)

ESRF BEAMLINE ID29

(1)

ESRF BEAMLINE ID30B

(1)

ESRF BEAMLINE MASSIF-3

(1)

NSLS BEAMLINE X12C

(1)

RIGAKU RUH2R

(1)

SLS BEAMLINE X10SA

(1)

SOLEIL BEAMLINE PROXIMA 2

(1)

SRS BEAMLINE PX14.1

(1)

SSRF BEAMLINE BL17U1

(1)

Synchrotron site  (9)

ESRF

(5)

SSRF

(5)

APS

(4)

SLS

(3)

SOLEIL

(3)

EMBL/DESY, Hamburg

(2)

ALS

(1)

NSLS

(1)

SRS

(1)

Diffraction detector type  (5)

CCD

(13)

Pixel

(9)

Image plate

(4)

Area detector

(3)

Diffractometer

(1)

Refinement software  (6)

PHENIX

(10)

REFMAC

(10)

X-PLOR

(5)

BUSTER

(3)

BUSTER-TNT

(2)

CNS

(2)

Representative Structures

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