Uniprot accession / id : P22907  OR   Uniprot accession / id : P08397
 
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Entry Information
Entry status  (1)
REL
(11)
 
Experimental methods  (1)
X-ray diffraction
(11)
 
Authors  (47)
Hirabayashi K
(4)
Hisaeda Y
(4)
Iijima M
(4)
Masuko T
(4)
Omata Y
(4)
Sato H
(4)
Sugishima M
(4)
Takano M
(4)
Tsukaguchi M
(4)
Wada K
(4)
Yamamoto K
(4)
Bustad HJ
(3)
Cooper JB
(3)
Janis J
(3)
Jänis J
(3)
Kallio JP
(3)
Laitaoja M
(3)
Martinez A
(3)
Bernardo-Seisdedos G
(2)
Gu S
(2)
Kursula I
(2)
Millet O
(2)
Pickersgill RW
(2)
Pluta P
(2)
Rojas AL
(2)
Roversi P
(2)
Toska K
(2)
Aarsand AK
(1)
Al D-Bass A
(1)
Cheng C
(1)
Christie MS
(1)
Gao A
(1)
Gill R
(1)
Joachimiak A
(1)
Kolstoe SE
(1)
Li Y
(1)
Liu ZJ
(1)
Mohammed F
(1)
Mosely JE
(1)
Saeter MC
(1)
Sarwar M
(1)
Shaw N
(1)
Shoolingin-Jordan PM
(1)
Song G
(1)
Wood SP
(1)
Zhang R
(1)
Zhao Y
(1)
 
Homo / hetero assembly  (1)
homo
(11)
 
Assembly composition  (1)
protein structure
(11)
 
Assembly polymer count  (1)
monomer
(11)
 
Resolution distribution
1.5 - 2
(5)
2.0 - 2.5
(3)
2.5 - 3
(3)
 
Release year distribution
2005 - 2010
(2)
2015 - 2020
(2)
2020 - 2025
(7)
 
Journal  (5)
Biochem J
(5)
Biochim Biophys Acta Gen Subj
(2)
iScience
(2)
FASEB J
(1)
FEBS J
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(11)
 
Representative Structures
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Entries 1 to 10 of 11
Entries 1 to 10 of 11
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Crystal structure of the 2-iodoporphobilinogen-bound holo form of human hydroxymethylbilane synthase
Sato H, Sugishima M, Wada K, Hirabayashi K, Tsukaguchi M
Biochem J (2021) [PMID: 33600566  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: DPM    DPM    FWL   
Assembly name: Porphobilinogen deaminase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-140114 (Preferred)   search this ID
PDBe-KB: P08397   
X-ray diffraction
2.4Å resolution
Released: 17 Mar 2021
Model geometry
Fit model/data
7ccy
7ccy
7ccy
Human porphobilinogen deaminase in complex with cofactor
Kallio JP, Bustad HJ, Martinez A
iScience (2021) [PMID: 33665570  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    DPM    DPM   
Assembly name: Porphobilinogen deaminase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-140114 (Preferred)   search this ID
PDBe-KB: P08397   
X-ray diffraction
1.8Å resolution
Released: 17 Feb 2021
Model geometry
Fit model/data
7aaj
7aaj
7aaj
Human porphobilinogen deaminase in complex with DPM cofactor
Pluta P, Millet O, Roversi P, Rojas AL, Gu S
Biochim Biophys Acta Gen Subj (2018) [PMID: 29908816  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SO4    DPM    DPM   
Assembly name: Porphobilinogen deaminase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-140114 (Preferred)   search this ID
PDBe-KB: P08397   
X-ray diffraction
2.78Å resolution
Released: 15 Nov 2017
Model geometry
Fit model/data
5m7f
5m7f
5m7f
Human porphobilinogen deaminase in complex with reaction intermediate
Pluta P, Millet O, Roversi P, Rojas AL, Gu S
Biochim Biophys Acta Gen Subj (2018) [PMID: 29908816  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 7J8    EPE    PO4   
Assembly name: Porphobilinogen deaminase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-140114 (Preferred)   search this ID
PDBe-KB: P08397   
X-ray diffraction
2.73Å resolution
Released: 15 Nov 2017
Model geometry
Fit model/data
5m6r
5m6r
5m6r
Crystal structure of the 2-iodoporphobilinogen-bound ES2 intermediate form of human hydroxymethylbilane synthase
Sato H, Sugishima M, Wada K, Hirabayashi K, Tsukaguchi M
Biochem J (2021) [PMID: 33600566  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 7J8    FWL   
Assembly name: Porphobilinogen deaminase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-140114 (Preferred)   search this ID
PDBe-KB: P08397   
X-ray diffraction
2.31Å resolution
Released: 17 Mar 2021
Model geometry
Fit model/data
7cd0
7cd0
7cd0
Crystal structure of the ES2 intermediate form of human hydroxymethylbilane synthase
Sato H, Sugishima M, Wada K, Hirabayashi K, Tsukaguchi M
Biochem J (2021) [PMID: 33600566  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 7J8   
Assembly name: Porphobilinogen deaminase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-140114 (Preferred)   search this ID
PDBe-KB: P08397   
X-ray diffraction
1.79Å resolution
Released: 17 Mar 2021
Model geometry
Fit model/data
7ccz
7ccz
7ccz
The ES3 intermediate of hydroxymethylbilane synthase R167Q variant
Saeter MC, Bustad HJ, Laitaoja M, Janis J, Martinez A, Aarsand AK, Kallio JP
FEBS J (2023) [PMID: 37863644  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZWW    GOL    EDO   
Assembly name: Porphobilinogen deaminase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-140114 (Preferred)   search this ID
PDBe-KB: P08397   
X-ray diffraction
1.9Å resolution
Released: 1 Nov 2023
Model geometry
Fit model/data
8pnd
8pnd
8pnd
Crystal structure of the holo form of human hydroxymethylbilane synthase
Sato H, Sugishima M, Wada K, Hirabayashi K, Tsukaguchi M
Biochem J (2021) [PMID: 33600566  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: DPM    DPM   
Assembly name: Porphobilinogen deaminase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-140114 (Preferred)   search this ID
PDBe-KB: P08397   
X-ray diffraction
1.84Å resolution
Released: 17 Mar 2021
Model geometry
Fit model/data
7ccx
7ccx
7ccx
Human porphobilinogen deaminase R173W mutant crystallized in the ES2 intermediate state
Kallio JP, Bustad HJ, Martinez A
iScience (2021) [PMID: 33665570  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    7J8   
Assembly name: Porphobilinogen deaminase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-140114 (Preferred)   search this ID
PDBe-KB: P08397   
X-ray diffraction
1.7Å resolution
Released: 17 Feb 2021
Model geometry
Fit model/data
7aak
7aak
7aak
Structure of human porphobilinogen deaminase
Song G, Li Y, Cheng C, Zhao Y, Gao A, Zhang R, Joachimiak A, Shaw N, Liu ZJ
FASEB J (2009) [PMID: 18936296  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: DPM    DPM   
Assembly name: Porphobilinogen deaminase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-140114 (Preferred)   search this ID
PDBe-KB: P08397   
X-ray diffraction
2.182Å resolution
Released: 30 Sep 2008
Model geometry
Fit model/data
3ecr
3ecr
3ecr
Entries 1 to 10 of 11
Entries 1 to 10 of 11