Uniprot accession / id : (P25815)
 
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Entry Information
Entry status  (1)
REL
(4)
 
Experimental methods  (2)
Solution NMR
(2)
X-ray diffraction
(2)
 
Authors  (24)
Barraclough R
(1)
Chou RH
(1)
Ding Y
(1)
Ecsedi P
(1)
Fernig DG
(1)
Gorenstein DG
(1)
Gribenko AV
(1)
Kleerekoper Q
(1)
Lee Y-C
(1)
Lee YC
(1)
Luxon BA
(1)
Makhatadze GI
(1)
Nyitray L
(1)
Penumutchu SR
(1)
Rao PS
(1)
Rao Z
(1)
Rudland PS
(1)
Thiviyanathan V
(1)
Volk DE
(1)
Wang G
(1)
Wang Z
(1)
Yu C
(1)
Zhang H
(1)
Zhang S
(1)
 
Homo / hetero assembly  (2)
hetero
(2)
homo
(2)
 
Assembly composition  (2)
protein structure
(2)
protein/protein complex
(2)
 
Assembly polymer count  (2)
dimer
(3)
tetramer
(1)
 
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(1)
 
Release year distribution
2000 - 2005
(2)
2010 - 2015
(1)
2020 - 2025
(1)
 
Journal  (4)
J Biomol NMR
(1)
J Mol Biol
(1)
PLoS One
(1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(4)
 
Organism name  (1)
Homo sapiens
(4)
 
Molecule name  (22)
MIG9
(4)
Migration-inducing gene 9 protein
(4)
Protein S100-E
(4)
Protein S100-P
(4)
S100 calcium-binding protein P
(4)
Advanced glycosylation end product-specific receptor
(1)
Annexin A2
(1)
Annexin II
(1)
Annexin-2
(1)
Antigen NY-CO-13
(1)
Calpactin I heavy chain
(1)
Calpactin-1 heavy chain
(1)
Cellular tumor antigen p53
(1)
Chromobindin-8
(1)
Lipocortin II
(1)
PAP-IV
(1)
Phosphoprotein p53
(1)
Placental anticoagulant protein IV
(1)
Protein I
(1)
Receptor for advanced glycosylation end products
(1)
Tumor suppressor p53
(1)
p36
(1)
 
Molecule type  (1)
Protein
(4)
 
Gene names  (11)
S100E
(4)
S100P
(4)
AGER
(1)
ANX2
(1)
ANX2L4
(1)
ANXA2
(1)
CAL1H
(1)
LPC2D
(1)
P53
(1)
RAGE
(1)
TP53
(1)
 
Interacting Molecules  (4)
Protein S100-P
(2)
Advanced glycosylation end product-specific receptor
(1)
Annexin A2
(1)
Cellular tumor antigen p53
(1)
 
Interacting ligands  (2)
CA : CALCIUM ION
(2)
GOL : GLYCEROL
(1)
 
Function and Biology
Biological function  (18)
cadherin binding
(4)
calcium ion binding
(4)
calcium-dependent protein binding
(4)
magnesium ion binding
(4)
metal ion binding
(4)
protein binding
(4)
protein homodimerization activity
(4)
transition metal ion binding
(4)
RNA binding
(1)
S100 protein binding
(1)
cadherin binding involved in cell-cell adhesion
(1)
calcium-dependent phospholipid binding
(1)
identical protein binding
(1)
phosphatidylinositol-4,5-bisphosphate binding
(1)
phosphatidylserine binding
(1)
phospholipase A2 inhibitor activity
(1)
protease binding
(1)
serine-type endopeptidase inhibitor activity
(1)
 
Biological process  (27)
endothelial cell migration
(4)
angiogenesis
(1)
cell adhesion
(1)
cell-cell adhesion
(1)
cell-matrix adhesion
(1)
collagen fibril organization
(1)
epithelial cell apoptotic process
(1)
fibrinolysis
(1)
lung development
(1)
mRNA transcription by RNA polymerase II
(1)
membrane raft assembly
(1)
negative regulation of coagulation
(1)
negative regulation of low-density lipoprotein particle receptor catabolic process
(1)
negative regulation of receptor internalization
(1)
osteoclast development
(1)
positive regulation of exocytosis
(1)
positive regulation of low-density lipoprotein particle clearance
(1)
positive regulation of plasma membrane repair
(1)
positive regulation of plasminogen activation
(1)
positive regulation of receptor recycling
(1)
positive regulation of receptor-mediated endocytosis involved in cholesterol transport
(1)
positive regulation of transcription by RNA polymerase II
(1)
positive regulation of vacuole organization
(1)
positive regulation of vesicle fusion
(1)
regulation of neurogenesis
(1)
response to activity
(1)
vesicle budding from membrane
(1)
 
Biological cell component  (37)
cell projection
(4)
cytoplasm
(4)
extracellular exosome
(4)
extracellular region
(4)
membrane
(4)
microvillus membrane
(4)
nucleoplasm
(4)
nucleus
(4)
plasma membrane
(4)
secretory granule lumen
(4)
AnxA2-p11 complex
(1)
PCSK9-AnxA2 complex
(1)
RNA polymerase II transcription regulator complex
(1)
Schmidt-Lanterman incisure
(1)
adherens junction
(1)
azurophil granule lumen
(1)
basement membrane
(1)
basolateral plasma membrane
(1)
cell surface
(1)
collagen-containing extracellular matrix
(1)
cornified envelope
(1)
cytosol
(1)
early endosome
(1)
endosome
(1)
extracellular space
(1)
late endosome membrane
(1)
lipid droplet
(1)
lysosomal membrane
(1)
melanosome
(1)
membrane raft
(1)
midbody
(1)
myelin sheath adaxonal region
(1)
nuclear matrix
(1)
plasma membrane protein complex
(1)
sarcolemma
(1)
vesicle
(1)
vesicle membrane
(1)
 
Sequence and Structure classification
SCOP fold  (1)
EF Hand-like
(2)
 
SCOP family  (1)
S100 proteins
(2)
 
CATH class  (2)
Mainly Alpha
(3)
Mainly Beta
(1)
 
CATH topology  (2)
Recoverin; domain 1
(3)
Immunoglobulin-like
(1)
 
Pfam accession / name  (4)
PF01023 : S_100
(4)
PF00191 : Annexin
(1)
PF08563 : P53_TAD
(1)
PF18521 : TAD2
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(3)
 
Diffraction radiation source type  (2)
Rotating anode
(1)
Synchrotron
(1)
 
Diffraction source  (2)
RIGAKU RU200
(1)
SLS BEAMLINE X06SA
(1)
 
Synchrotron site  (1)
SLS
(1)
 
Diffraction detector type  (2)
Image plate
(1)
Pixel
(1)
 
Refinement software  (2)
CNS
(1)
PHENIX
(1)
 
NMR
NMR software packages  (5)
Amber
(1)
DIAMOD
(1)
Felix
(1)
HADDOCK
(1)
Sparky
(1)
 
NMR Field Strength
500.0 - 600
(1)
600.0 - 700
(2)
700.0 - 800
(2)
 
Representative Structures
Representative Structures
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Entries 1 to 4 of 4
Entries 1 to 4 of 4
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Structural Insights into Calcium Bound S100P - V Domain of the receptor for advanced glycation end products (RAGE) Complex
Rao PS
PLoS One (2014) [PMID: 25084534  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Advanced glycosylation end product-specific receptor and Protein S100-P (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150595 (Preferred)   search this ID
PDBe-KB: Q15109    P25815   
Solution NMR
Released: 5 Nov 2014
Model geometry
Fit model/data
Data not analysed
2mjw
2mjw
2mjw
Transactivation domain of p53 in complex with S100P, using annexin A2 as crystallization chaperone
Ecsedi P, Nyitray L
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CA    GOL    CA   
Assembly name: Annexin A2, Protein S100-P and Cellular tumor antigen p53 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-138106 (Preferred)   search this ID
PDBe-KB: P04637    P25815    P07355   
X-ray diffraction
2.1Å resolution
Released: 2 Mar 2022
Model geometry
Fit model/data
7nmi
7nmi
7nmi
Three-dimensional solution structure of apo-S100P protein determined by NMR spectroscopy
Lee Y-C, Volk DE, Thiviyanathan V, Kleerekoper Q, Gribenko AV, Zhang S, Gorenstein DG, Makhatadze GI, Luxon BA
J Biomol NMR (2004) [PMID: 15213440  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Protein S100-P (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150594 (Preferred)   search this ID
PDBe-KB: P25815   
Solution NMR
Released: 20 Apr 2004
Model geometry
Fit model/data
Data not analysed
1ozo
1ozo
1ozo
The Crystal Structure of Ca+-bound Human S100P Determined at 2.0A Resolution by X-ray
Zhang H, Wang G, Ding Y, Wang Z, Barraclough R, Rudland PS, Fernig DG, Rao Z
J Mol Biol (2003) [PMID: 12507480  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CA    CA   
Assembly name: Protein S100-P (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150594 (Preferred)   search this ID
PDBe-KB: P25815   
X-ray diffraction
2Å resolution
Released: 7 Jan 2003
Model geometry
Fit model/data
Data not deposited
1j55
1j55
1j55
Entries 1 to 4 of 4
Entries 1 to 4 of 4