Entry status  (1)

REL

(67)

Experimental methods  (3)

X-ray diffraction

(45)

Electron Microscopy

(21)

Solution NMR

(1)

Authors  (207)

Hunt JF

(27)

Chen J

(19)

Wang C

(17)

Riordan JR

(16)

Conners K

(15)

Emtage S

(15)

Guggino WB

(15)

Lewis HA

(15)

Sauder JM

(15)

Zhao X

(15)

Brouillette CG

(14)

Fiedorczuk K

(13)

Yang Z

(13)

Khazanov N

(12)

Senderowitz H

(12)

Aleksandrov AA

(11)

An J

(11)

Boel G

(11)

Dokholyan NV

(11)

Forouhar F

(11)

Kaplan A

(11)

Kearins MC

(11)

Kota P

(11)

Maloney PC

(11)

Proctor E

(11)

Stockwell BR

(11)

Thomas PJ

(9)

Gao X

(8)

Lorimer D

(8)

Thibodeau PH

(8)

Lu F

(7)

Weber PC

(7)

Buchanan SG

(6)

Burley SK

(6)

Csanady L

(6)

Csanády L

(6)

Dickey M

(6)

Dorwart M

(6)

Fowler R

(6)

Garcia-Pino A

(6)

Govaerts C

(6)

Hendrickson WA

(6)

Laeremans T

(6)

Overtus M

(6)

Pardon E

(6)

Post KW

(6)

Rajashankar KR

(6)

Rutter ME

(6)

Scholl D

(6)

Shriver S

(6)

Sigoillot M

(6)

Steyaert J

(6)

Zhang M

(6)

Brunsveld L

(5)

Grodecka M

(5)

He L

(5)

Hildebrandt E

(5)

Iordanov I

(5)

Levring J

(5)

Liu F

(5)

Mihalyi C

(5)

Mihályi C

(5)

Ottmann C

(5)

Stevers LM

(5)

Szollosi A

(5)

Urbatsch I

(5)

Atwell S

(4)

Carlile GW

(4)

Gheyi T

(4)

Thomas DY

(4)

Wasserman SR

(4)

Wetmore D

(4)

Zhang Z

(4)

Brautigam CA

(3)

Coales SJ

(3)

Glenn NR

(3)

Hamuro Y

(3)

Hendle J

(3)

Lam CV

(3)

Leysen SF

(3)

Leysen SFR

(3)

Meijer FA

(3)

Milroy LG

(3)

Molnar KS

(3)

Protasevich II

(3)

Rodgers LA

(3)

Romero R

(3)

Shoichet BK

(3)

Smith D

(3)

Tien H

(3)

Wetmore DR

(3)

Zhang FF

(3)

de Vries RM

(3)

van Scheppingen DS

(3)

Blanchard SC

(2)

Condon B

(2)

Fan C

(2)

Forman-Kay JD

(2)

Howard RJ

(2)

Hwang T

(2)

 

More...

Homo / hetero assembly  (2)

homo

(39)

hetero

(28)

Assembly composition  (2)

protein structure

(39)

protein/protein complex

(28)

Assembly polymer count  (7)

monomer

(37)

dimer

(16)

trimer

(9)

tetramer

(2)

hexamer

(1)

octadecamer

(1)

pentamer

(1)

Resolution distribution

1.5 - 2

(18)

2.0 - 2.5

(13)

2.5 - 3

(18)

3.0 - 3.5

(6)

3.5 - 4

(7)

4.0 - 4.5

(1)

5.5 - 6

(1)

6.5 - 7

(1)

8.5 - 9

(1)

Release year distribution

2000 - 2005

(13)

2005 - 2010

(8)

2010 - 2015

(5)

2015 - 2020

(27)

2020 - 2025

(22)

Journal  (15)

To be published

(13)

Proc Natl Acad Sci U S A

(10)

Nat Commun

(8)

Cell

(6)

EMBO J

(6)

Science

(6)

J Biol Chem

(5)

J Mol Biol

(3)

Protein Eng Des Sel

(3)

Nat Struct Mol Biol

(2)

Biochemistry

(1)

J Am Chem Soc

(1)

Nat Chem Biol

(1)

Nature

(1)

Protein Sci

(1)

Organism superkingdom  (2)

Eukaryota

(67)

Bacteria

(1)

Organism name  (3)

Homo sapiens

(58)

Mus musculus

(9)

Escherichia coli K-12

(1)

Molecule name  (13)

ATP-binding cassette sub-family C member 7

(67)

CFTR

(67)

Channel conductance-controlling ATPase

(67)

Cystic fibrosis transmembrane conductance regulator

(67)

cAMP-dependent chloride channel

(67)

EBP50

(1)

Ezrin-radixin-moesin-binding phosphoprotein 50

(1)

Maltose/maltodextrin import ATP-binding protein MalK

(1)

NHERF-1

(1)

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

(1)

Regulatory cofactor of Na(+)/H(+) exchanger

(1)

Sodium-hydrogen exchanger regulatory factor 1

(1)

Solute carrier family 9 isoform A3 regulatory factor 1

(1)

Molecule type  (1)

Protein

(67)

Gene names  (10)

ABCC7

(58)

CFTR

(58)

Abcc7

(9)

Cftr

(9)

JW3995

(1)

NHERF

(1)

NHERF1

(1)

SLC9A3R1

(1)

b4035

(1)

malK

(1)

Interacting Molecules  (19)

Cystic fibrosis transmembrane conductance regulator

(7)

cAMP-dependent protein kinase catalytic subunit alpha

(5)

Nanobody D12

(3)

14-3-3 protein zeta/delta

(2)

Nanobody T4

(2)

Unknown Peptide

(2)

14-3-3 domain-containing protein

(1)

14-3-3 protein beta/alpha

(1)

14-3-3 protein gamma

(1)

Filamin-A

(1)

G11a nanobody

(1)

Golgi-associated PDZ and coiled-coil motif-containing protein

(1)

Nanobody G3a

(1)

Nanobody T27

(1)

Nanobody T2a

(1)

Nanobody T8

(1)

Piece of Molecule-1

(1)

cystic fibrosis transmembrane conductance regulator

(1)

human cystic fibrosis transmembrane conductance regulator

(1)

Interacting ligands  (45)

MG : MAGNESIUM ION

(47)

ATP : ADENOSINE-5'-TRIPHOSPHATE

(37)

CLR : CHOLESTEROL

(11)

ACY : ACETIC ACID

(8)

POV : (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate

(6)

GOL : GLYCEROL

(5)

D12 : DODECANE

(4)

VX8 : Lumacaftor

(3)

WJX : (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide

(3)

B44 : N-(2-phenylethyl)adenosine 5'-(tetrahydrogen triphosphate)

(2)

CL : CHLORIDE ION

(2)

CV6 : Tezacaftor

(2)

D10 : DECANE

(2)

VX7 : N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

(2)

WG5 : 4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid

(2)

ACT : ACETATE ION

(1)

ADP : ADENOSINE-5'-DIPHOSPHATE

(1)

AJP : Digitonin

(1)

ANP : PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

(1)

ARG : ARGININE

(1)

C14 : TETRADECANE

(1)

CTP : CYTIDINE-5'-TRIPHOSPHATE

(1)

DCP : 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

(1)

DD9 : nonane

(1)

DGT : 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE

(1)

DTP : 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

(1)

DUT : DEOXYURIDINE-5'-TRIPHOSPHATE

(1)

EDO : 1,2-ETHANEDIOL

(1)

GLC : alpha-D-glucopyranose

(1)

GLN : GLUTAMINE

(1)

GTP : GUANOSINE-5'-TRIPHOSPHATE

(1)

LBN : 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine

(1)

LJP : N-(3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-1H-pyrazole-3-carboxamide

(1)

M5T : 5-Methyluridine triphosphate

(1)

MGP : 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE

(1)

PEG : DI(HYDROXYETHYL)ETHER

(1)

PJ8 : heptadecane

(1)

PRD_900032 : surcrose isoform

(1)

Q95 : [2-(2-methylphenyl)sulfanylphenyl]methanamine

(1)

TTP : THYMIDINE-5'-TRIPHOSPHATE

(1)

TYR : TYROSINE

(1)

UND : UNDECANE

(1)

UTP : URIDINE 5'-TRIPHOSPHATE

(1)

Z9N : alpha-D-fructofuranose

(1)

ZRH : (2S)-1-(3-amino-6-fluoro-1H-indazol-1-yl)-2-methyl-3-phenoxypropan-1-one

(1)

EC number / name  (2)

5.6.1.6 : Channel-conductance-controlling ATPase

(67)

7.5.2.1 : ABC-type maltose transporter

(1)

Biological function  (20)

ATP binding

(59)

ATP hydrolysis activity

(59)

14-3-3 protein binding

(21)

ABC-type transporter activity

(21)

ATPase-coupled inorganic anion transmembrane transporter activity

(21)

ATPase-coupled transmembrane transporter activity

(21)

PDZ domain binding

(21)

Sec61 translocon complex binding

(21)

bicarbonate transmembrane transporter activity

(21)

chloride channel activity

(21)

chloride channel inhibitor activity

(21)

chloride channel regulator activity

(21)

chloride transmembrane transporter activity

(21)

enzyme binding

(21)

intracellularly ATP-gated chloride channel activity

(21)

isomerase activity

(21)

nucleotide binding

(21)

protein binding

(21)

protein-folding chaperone binding

(21)

transmembrane transporter activity

(1)

Biological process  (24)

transmembrane transport

(22)

amelogenesis

(21)

bicarbonate transport

(21)

cellular response to cAMP

(21)

cellular response to forskolin

(21)

chloride transmembrane transport

(21)

chloride transport

(21)

cholesterol biosynthetic process

(21)

cholesterol transport

(21)

establishment of localization in cell

(21)

intracellular pH elevation

(21)

membrane hyperpolarization

(21)

monoatomic ion transmembrane transport

(21)

monoatomic ion transport

(21)

multicellular organismal-level water homeostasis

(21)

positive regulation of cyclic nucleotide-gated ion channel activity

(21)

positive regulation of enamel mineralization

(21)

positive regulation of exocytosis

(21)

positive regulation of insulin secretion involved in cellular response to glucose stimulus

(21)

positive regulation of voltage-gated chloride channel activity

(21)

response to endoplasmic reticulum stress

(21)

sperm capacitation

(21)

transepithelial water transport

(21)

vesicle docking involved in exocytosis

(21)

Biological cell component  (21)

Golgi-associated vesicle membrane

(21)

apical plasma membrane

(21)

cell surface

(21)

chloride channel complex

(21)

clathrin-coated endocytic vesicle membrane

(21)

cytoplasm

(21)

cytosol

(21)

early endosome

(21)

early endosome membrane

(21)

endoplasmic reticulum

(21)

endoplasmic reticulum membrane

(21)

endosome

(21)

endosome membrane

(21)

lysosomal membrane

(21)

membrane

(21)

nucleus

(21)

plasma membrane

(21)

protein-containing complex

(21)

recycling endosome

(21)

recycling endosome membrane

(21)

ATP-binding cassette (ABC) transporter complex

(1)

SCOP fold  (1)

P-loop containing nucleoside triphosphate hydrolases

(10)

SCOP family  (1)

ABC transporter ATPase domain-like

(10)

CATH class  (2)

Alpha Beta

(30)

Mainly Beta

(1)

CATH topology  (2)

Rossmann fold

(30)

OB fold (Dihydrolipoamide Acetyltransferase, E2P)

(1)

Pfam accession / name  (5)

PF00005 : ABC_tran

(59)

PF00664 : ABC_membrane

(21)

PF14396 : CFTR_R

(21)

PF00595 : PDZ

(1)

PF08402 : TOBE_2

(1)

Diffraction protocol  (1)

Single wavelength

(45)

Diffraction radiation source type  (1)

Synchrotron

(45)

Diffraction source  (19)

APS BEAMLINE 31-ID

(11)

SSRL BEAMLINE BL14-1

(8)

ALS BEAMLINE 5.0.1

(3)

NSLS BEAMLINE X4C

(3)

SLS BEAMLINE X10SA

(3)

APS BEAMLINE 19-BM

(2)

APS BEAMLINE 19-ID

(2)

DIAMOND BEAMLINE I04

(2)

ALS BEAMLINE 4.2.2

(1)

ALS BEAMLINE 8.3.1

(1)

APS BEAMLINE 17-ID

(1)

APS BEAMLINE 21-ID-F

(1)

AUSTRALIAN SYNCHROTRON BEAMLINE MX2

(1)

DIAMOND BEAMLINE I02

(1)

DIAMOND BEAMLINE I24

(1)

PETRA III, DESY BEAMLINE P11

(1)

SLS BEAMLINE X06SA

(1)

SOLEIL BEAMLINE PROXIMA 1

(1)

SOLEIL BEAMLINE PROXIMA 2

(1)

Synchrotron site  (9)

APS

(17)

SSRL

(8)

ALS

(5)

Diamond

(4)

SLS

(4)

NSLS

(3)

SOLEIL

(2)

Australian Synchrotron

(1)

PETRA III, DESY

(1)

Diffraction detector type  (2)

CCD

(30)

Pixel

(12)

Refinement software  (5)

PHENIX

(29)

REFMAC

(13)

BUSTER

(6)

CNS

(6)

phenix.real_space_refine

(1)

EM microscope model  (2)

FEI TITAN KRIOS

(14)

TFS KRIOS

(7)

EM detector name  (2)

GATAN K3 (6k x 4k)

(13)

GATAN K2 SUMMIT (4k x 4k)

(8)

NMR software packages  (1)

Sparky

(1)

NMR Field Strength

500.0 - 600

(1)

600.0 - 700

(1)

Representative Structures

100%

95%

90%

70%

50%

40%

30%