Uniprot accession / id : (P27348)
 
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Entry Information
Entry status  (1)
REL
(9)
 
Experimental methods  (1)
X-ray diffraction
(9)
 
Authors  (26)
Dominguez R
(5)
Kast DJ
(5)
Shao Y
(2)
Wen Y
(2)
Aitken A
(1)
Arrowsmith C
(1)
Dodson GG
(1)
Doyle DA
(1)
Edwards A
(1)
Elkins JM
(1)
Gamblin SJ
(1)
Grossmann JG
(1)
Johansson ACE
(1)
Jones DH
(1)
Lee WH
(1)
Papagrigoriou E
(1)
Robinson CV
(1)
Smee C
(1)
Smerdon SJ
(1)
Sobott F
(1)
Soneji Y
(1)
Structural Genomics Consortium (SGC)
(1)
Sundstrom M
(1)
Sundström M
(1)
Xiao B
(1)
Yang X
(1)
 
Homo / hetero assembly  (2)
hetero
(8)
homo
(1)
 
Assembly composition  (2)
protein/protein complex
(8)
protein structure
(1)
 
Assembly polymer count  (3)
tetramer
(6)
trimer
(2)
dimer
(1)
 
Resolution distribution
1.5 - 2
(2)
2.0 - 2.5
(2)
2.5 - 3
(5)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(1)
2015 - 2020
(8)
2020 - 2025
(2)
 
Journal  (4)
Nat Commun
(5)
To be published
(2)
Nature
(1)
Proc Natl Acad Sci U S A
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(9)
 
Organism name  (1)
Homo sapiens
(9)
 
Molecule name  (18)
14-3-3 protein T-cell
(9)
14-3-3 protein tau
(9)
14-3-3 protein theta
(9)
Protein HS1
(9)
BAI-associated protein 2
(5)
BAI1-associated protein 2
(5)
BAR/IMD domain-containing adapter protein 2
(5)
Brain-specific angiogenesis inhibitor 1-associated protein 2
(5)
FLAF3
(5)
Fas ligand-associated factor 3
(5)
IRS-58
(5)
IRSp53
(5)
IRSp53/58
(5)
Insulin receptor substrate p53
(5)
Insulin receptor substrate p53/p58
(5)
Insulin receptor substrate protein of 53 kDa
(5)
Protein BAP2
(5)
Protein capicua homolog
(2)
 
Molecule type  (1)
Protein
(9)
 
Gene names  (4)
YWHAQ
(9)
BAIAP2
(5)
CIC
(2)
KIAA0306
(2)
 
Interacting Molecules  (4)
14-3-3 protein theta
(7)
BAR/IMD domain-containing adapter protein 2
(5)
Protein capicua homolog
(2)
CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS
(1)
 
Interacting ligands  (10)
1PE : PENTAETHYLENE GLYCOL
(5)
PEG : DI(HYDROXYETHYL)ETHER
(4)
EDO : 1,2-ETHANEDIOL
(3)
MG : MAGNESIUM ION
(3)
PG4 : TETRAETHYLENE GLYCOL
(3)
PE4 : 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL
(2)
PGE : TRIETHYLENE GLYCOL
(2)
ETF : TRIFLUOROETHANOL
(1)
GOL : GLYCEROL
(1)
SO4 : SULFATE ION
(1)
 
Function and Biology
Biological function  (5)
14-3-3 protein binding
(9)
identical protein binding
(9)
protein binding
(9)
protein domain specific binding
(9)
transmembrane transporter binding
(9)
 
Biological process  (7)
negative regulation of DNA-templated transcription
(9)
negative regulation of monoatomic ion transmembrane transport
(9)
protein localization
(9)
protein targeting
(9)
signal transduction
(9)
small GTPase-mediated signal transduction
(9)
substantia nigra development
(9)
 
Biological cell component  (8)
cytoplasm
(9)
cytosol
(9)
extracellular exosome
(9)
focal adhesion
(9)
membrane
(9)
nucleus
(9)
protein-containing complex
(9)
synapse
(9)
 
Sequence and Structure classification
CATH class  (1)
Mainly Alpha
(7)
 
CATH topology  (1)
Delta-Endotoxin; domain 1
(7)
 
Pfam accession / name  (1)
PF00244 : 14-3-3
(9)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(9)
 
Diffraction radiation source type  (3)
Synchrotron
(5)
Sealed tube
(3)
Rotating anode
(1)
 
Diffraction source  (7)
BRUKER AXS MICROSTAR
(2)
SSRF BEAMLINE BL18U1
(2)
BRUKER IMUS MICROFOCUS
(1)
CHESS BEAMLINE A1
(1)
ESRF BEAMLINE ID2
(1)
NSLS BEAMLINE X6A
(1)
RIGAKU FR-E
(1)
 
Synchrotron site  (4)
SSRF
(2)
CHESS
(1)
ESRF
(1)
NSLS
(1)
 
Diffraction detector type  (3)
CCD
(5)
Image plate
(2)
Pixel
(2)
 
Refinement software  (2)
PHENIX
(8)
REFMAC
(1)
 
Representative Structures
Representative Structures
100%
95%
90%
70%
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30%
Entries 1 to 9 of 9
Entries 1 to 9 of 9
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Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and T360
Kast DJ, Dominguez R
Nat Commun (2019) [PMID: 30696821  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: PE4    PEG    PG4    GOL    PE4    PEG    1PE    PG4    1PE    EDO    PGE    PGE   
Modified residues: TPO    TPO   
Assembly name: 14-3-3 protein theta and BAR/IMD domain-containing adapter protein 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150978 (Preferred)   search this ID
PDBe-KB: Q9UQB8    P27348   
X-ray diffraction
2.8Å resolution
Released: 5 Dec 2018
Model geometry
Fit model/data
6bqt
6bqt
6bqt
Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at S366
Kast DJ, Dominguez R
Nat Commun (2019) [PMID: 30696821  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    PEG    PEG    1PE    MG    1PE   
Modified residues: SEP    SEP   
Assembly name: 14-3-3 protein theta and BAR/IMD domain-containing adapter protein 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150979 (Preferred)   search this ID
PDBe-KB: Q9UQB8    P27348   
X-ray diffraction
2.35Å resolution
Released: 24 Oct 2018
Model geometry
Fit model/data
6bd1
6bd1
6bd1
Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T340
Kast DJ, Dominguez R
Nat Commun (2019) [PMID: 30696821  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ETF    MG    PEG    PEG    1PE    MG    1PE    EDO   
Modified residues: TPO    TPO   
Assembly name: 14-3-3 protein theta and BAR/IMD domain-containing adapter protein 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150979 (Preferred)   search this ID
PDBe-KB: Q9UQB8    P27348   
X-ray diffraction
1.986Å resolution
Released: 24 Oct 2018
Model geometry
Fit model/data
6bcr
6bcr
6bcr
Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T360
Kast DJ, Dominguez R
Nat Commun (2019) [PMID: 30696821  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    PE4    PEG    PG4    PE4    PEG    1PE    MG    PG4    1PE   
Modified residues: TPO    TPO   
Assembly name: 14-3-3 protein theta and BAR/IMD domain-containing adapter protein 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150979 (Preferred)   search this ID
PDBe-KB: Q9UQB8    P27348   
X-ray diffraction
2.3Å resolution
Released: 24 Oct 2018
Model geometry
Fit model/data
6bcy
6bcy
6bcy
14-3-3 protein in Complex with CIC S173 phosphorylated peptide
Wen Y, Shao Y
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: SEP    SEP   
Assembly name: 14-3-3 protein theta and Protein capicua homolog (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150977 (Preferred)   search this ID
PDBe-KB: Q96RK0    P27348   
X-ray diffraction
2.645Å resolution
Released: 30 Sep 2020
Model geometry
Fit model/data
6kzh
6kzh
6kzh
14-3-3 protein in Complex with CIC S301 phosphorylated peptide
Wen Y, Shao Y
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: SEP    SEP   
Assembly name: 14-3-3 protein theta and Protein capicua homolog (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150977 (Preferred)   search this ID
PDBe-KB: Q96RK0    P27348   
X-ray diffraction
2Å resolution
Released: 30 Sep 2020
Model geometry
Fit model/data
6kzg
6kzg
6kzg
Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and S366
Kast DJ, Dominguez R
Nat Commun (2019) [PMID: 30696821  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: PEG    PG4    PEG    1PE    PG4    1PE    EDO    PGE    PGE   
Modified residues: SEP    TPO    SEP    TPO   
Assembly name: 14-3-3 protein theta and BAR/IMD domain-containing adapter protein 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150978 (Preferred)   search this ID
PDBe-KB: Q9UQB8    P27348   
X-ray diffraction
2.9Å resolution
Released: 24 Oct 2018
Model geometry
Fit model/data
6bd2
6bd2
6bd2
14-3-3 PROTEIN TAU ISOFORM
Xiao B, Smerdon SJ, Gamblin SJ
Nature (1995) [PMID: 7603573  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SO4   
Assembly name: 14-3-3 protein theta (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150975 (Preferred)   search this ID
PDBe-KB: P27348   
X-ray diffraction
2.602Å resolution
Released: 23 Mar 2016
Model geometry
Fit model/data
5iqp
5iqp
5iqp
14-3-3 Protein Theta (Human) Complexed to Peptide
Elkins JM, Johansson ACE, Smee C, Yang X, Sundstrom M, Edwards A, Arrowsmith C, Doyle DA, Structural Genomics Consortium (SGC)
Proc Natl Acad Sci U S A (2006) [PMID: 17085597  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: SEP    SEP   
Assembly name: 14-3-3 protein theta and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150976 (Preferred)   search this ID
PDBe-KB: P27348   
X-ray diffraction
2.8Å resolution
Released: 28 Jun 2005
Model geometry
Fit model/data
2btp
2btp
2btp
Entries 1 to 9 of 9
Entries 1 to 9 of 9