Entry status  (1)

REL

(14)

Experimental methods  (2)

X-ray diffraction

(11)

Solution NMR

(3)

Authors  (40)

Alicea-Velazquez NL

(5)

Boggon TJ

(5)

Zhou GW

(4)

Alicea-Velázquez NL

(3)

Inoue M

(3)

Jakoncic J

(3)

Kigawa T

(3)

Koshiba S

(3)

Liang X

(3)

RIKEN Structural Genomics/Proteomics Initiative (RSGI)

(3)

Yang J

(3)

Yokoyama S

(3)

Zhao ZJ

(3)

Kasai T

(2)

Liu L

(2)

Niu T

(2)

Sato M

(2)

Song X

(2)

Bellamy HD

(1)

Cheng W

(1)

Cheng Z

(1)

Hantschel O

(1)

Harada T

(1)

He D

(1)

Kobayashi N

(1)

Komma C

(1)

Mann G

(1)

Meng W

(1)

Mo Y

(1)

Motoda Y

(1)

Niu Z

(1)

Qi J

(1)

Shen Z

(1)

Tanaka A

(1)

Tochio N

(1)

Tomizawa T

(1)

Wang F

(1)

Wang W

(1)

Yuan Z

(1)

Zhao Z

(1)

Homo / hetero assembly  (2)

homo

(9)

hetero

(5)

Assembly composition  (2)

protein structure

(9)

protein/protein complex

(5)

Assembly polymer count  (2)

monomer

(9)

dimer

(5)

Resolution distribution

1.0 - 1.5

(2)

1.5 - 2

(4)

2.0 - 2.5

(2)

2.5 - 3

(2)

3.0 - 3.5

(1)

Release year distribution

1995 - 2000

(1)

2000 - 2005

(3)

2005 - 2010

(4)

2010 - 2015

(6)

2020 - 2025

(2)

Journal  (5)

To be published

(5)

J Biol Chem

(3)

J Struct Biol

(3)

Protein Pept Lett

(2)

J Cell Biochem

(1)

Organism superkingdom  (1)

Eukaryota

(14)

Organism name  (1)

Homo sapiens

(14)

Molecule name  (6)

Hematopoietic cell protein-tyrosine phosphatase

(14)

PTP-1C

(14)

Protein-tyrosine phosphatase 1C

(14)

Protein-tyrosine phosphatase SHP-1

(14)

SH-PTP1

(14)

Tyrosine-protein phosphatase non-receptor type 6

(14)

Molecule type  (1)

Protein

(14)

Gene names  (3)

HCP

(14)

PTP1C

(14)

PTPN6

(14)

Interacting Molecules  (4)

NKG2-A/NKG2-B type II integral membrane protein

(2)

MbC (monobody targeting SHP1-C-SH2)

(1)

PEPTIDE PY469

(1)

Tyrosine-protein kinase JAK1

(1)

Interacting ligands  (3)

SO4 : SULFATE ION

(3)

PO4 : PHOSPHATE ION

(2)

EDO : 1,2-ETHANEDIOL

(1)

EC number / name  (1)

3.1.3.48 : Protein-tyrosine-phosphatase

(14)

Biological function  (12)

protein tyrosine phosphatase activity

(10)

SH2 domain binding

(1)

SH3 domain binding

(1)

cell adhesion molecule binding

(1)

hydrolase activity

(1)

non-membrane spanning protein tyrosine phosphatase activity

(1)

phosphoprotein phosphatase activity

(1)

phosphorylation-dependent protein binding

(1)

phosphotyrosine residue binding

(1)

protein binding

(1)

protein kinase binding

(1)

transmembrane receptor protein tyrosine phosphatase activity

(1)

Biological process  (45)

dephosphorylation

(10)

protein dephosphorylation

(10)

B cell receptor signaling pathway

(1)

CD27 signaling pathway

(1)

G protein-coupled receptor signaling pathway

(1)

MAPK cascade

(1)

T cell activation

(1)

T cell costimulation

(1)

T cell proliferation

(1)

T cell receptor signaling pathway

(1)

cell differentiation

(1)

cytokine-mediated signaling pathway

(1)

epididymis development

(1)

hematopoietic progenitor cell differentiation

(1)

intracellular signal transduction

(1)

megakaryocyte development

(1)

mitotic cell cycle

(1)

natural killer cell mediated cytotoxicity

(1)

negative regulation of B cell receptor signaling pathway

(1)

negative regulation of MAPK cascade

(1)

negative regulation of T cell proliferation

(1)

negative regulation of T cell receptor signaling pathway

(1)

negative regulation of angiogenesis

(1)

negative regulation of cell population proliferation

(1)

negative regulation of humoral immune response mediated by circulating immunoglobulin

(1)

negative regulation of inflammatory response to wounding

(1)

negative regulation of innate immune response

(1)

negative regulation of interleukin-6 production

(1)

negative regulation of lipopolysaccharide-mediated signaling pathway

(1)

negative regulation of mast cell activation involved in immune response

(1)

negative regulation of neutrophil activation

(1)

negative regulation of tumor necrosis factor production

(1)

peptidyl-tyrosine dephosphorylation

(1)

peptidyl-tyrosine phosphorylation

(1)

platelet aggregation

(1)

platelet formation

(1)

positive regulation of cell adhesion mediated by integrin

(1)

positive regulation of cell population proliferation

(1)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

(1)

regulation of B cell differentiation

(1)

regulation of ERK1 and ERK2 cascade

(1)

regulation of G1/S transition of mitotic cell cycle

(1)

regulation of apoptotic process

(1)

regulation of release of sequestered calcium ion into cytosol

(1)

regulation of type I interferon-mediated signaling pathway

(1)

Biological cell component  (14)

alpha-beta T cell receptor complex

(1)

cell-cell junction

(1)

cytoplasm

(1)

cytosol

(1)

extracellular exosome

(1)

extracellular region

(1)

membrane

(1)

nucleolus

(1)

nucleoplasm

(1)

nucleus

(1)

plasma membrane

(1)

protein-containing complex

(1)

specific granule lumen

(1)

tertiary granule lumen

(1)

SCOP fold  (1)

(Phosphotyrosine protein) phosphatases II

(2)

SCOP family  (1)

Higher-molecular-weight phosphotyrosine protein phosphatases

(2)

CATH class  (1)

Alpha Beta

(12)

CATH topology  (2)

Protein-Tyrosine Phosphatase; Chain A

(9)

SHC Adaptor Protein

(5)

Pfam accession / name  (2)

PF00102 : Y_phosphatase

(10)

PF00017 : SH2

(6)

Diffraction protocol  (1)

Single wavelength

(10)

Diffraction radiation source type  (2)

Synchrotron

(9)

Rotating anode

(2)

Diffraction source  (9)

NSLS BEAMLINE X6A

(3)

APS BEAMLINE 24-ID-C

(1)

CAMD BEAMLINE GCPCC

(1)

CHESS BEAMLINE F1

(1)

CLSI BEAMLINE 08ID-1

(1)

NSLS BEAMLINE X25

(1)

RIGAKU RU300

(1)

RIGAKU RUH3R

(1)

SLS BEAMLINE X06DA

(1)

Synchrotron site  (6)

NSLS

(4)

APS

(1)

CAMD

(1)

CHESS

(1)

CLSI

(1)

SLS

(1)

Diffraction detector type  (3)

CCD

(4)

Pixel

(4)

Image plate

(2)

Refinement software  (4)

PHENIX

(6)

REFMAC

(2)

X-PLOR

(2)

CNS

(1)

NMR software packages  (5)

CYANA

(3)

KUJIRA

(3)

NMRPipe

(3)

NMRView

(3)

XwinNMR

(3)

NMR Field Strength

600.0 - 700

(1)

700.0 - 800

(3)

800.0 - 900

(3)

Representative Structures

100%

95%

90%

70%

50%

40%

30%