Entry status  (1)

REL

(32)

Experimental methods  (1)

X-ray diffraction

(32)

Authors  (192)

Baxter JD

(13)

Li Y

(12)

Yao B

(12)

Yao BQ

(12)

Fletterick RJ

(10)

Webb P

(8)

Li J

(7)

Li Q

(7)

Lu Z

(7)

Wu D

(7)

Wu X

(7)

Xiang Q

(7)

Xu Y

(7)

Yu H

(7)

Zhang C

(7)

Zhang Y

(7)

Zhao S

(7)

Zhuang X

(7)

Apriletti JW

(6)

Huber BR

(6)

Togashi M

(6)

Cunha-Lima ST

(5)

Tian S

(5)

Wang R

(5)

Wei Y

(5)

Xu S

(5)

Zhang S

(5)

Zheng W

(5)

Cunha Lima ST

(4)

Nguyen HT

(4)

Sandler B

(4)

West BL

(4)

Aparicio R

(3)

Figueira AC

(3)

Koehler K

(3)

Malm J

(3)

Nunes FM

(3)

Polikarpov I

(3)

Bleicher L

(2)

Desclozeaux M

(2)

Dias SM

(2)

Farnegardh M

(2)

Figueira ACM

(2)

Färnegårdh M

(2)

Grynfarb M

(2)

Husman B

(2)

Ingraham HA

(2)

Jouravel N

(2)

Juric S

(2)

Ljunggren J

(2)

Martinez L

(2)

Mellstrom K

(2)

Mellström K

(2)

Nascimento AS

(2)

Neves FA

(2)

Nguyen P

(2)

Nilsson S

(2)

Santos MA

(2)

Santos MAM

(2)

Skaf MS

(2)

Wagner R

(2)

Agback P

(1)

Ambrosio AL

(1)

Ambrosio ALB

(1)

Ammirati MJ

(1)

Aparício R

(1)

Apelqvist T

(1)

Arnold LA

(1)

Backsbro-Saedi A

(1)

Beigelman LN

(1)

Bladh LG

(1)

Blatt LM

(1)

Blethrow J

(1)

Borngraeber S

(1)

Brandt P

(1)

Bruning JB

(1)

Budny MJ

(1)

Bäcksbro-Saeidi A

(1)

Carlsson B

(1)

Cavett V

(1)

Chalmers MJ

(1)

Chanda S

(1)

Chiang P

(1)

Chiellini G

(1)

Chrunyk BA

(1)

Cornelius P

(1)

Craievich AF

(1)

DaSilva-Jardine P

(1)

Danley DE

(1)

Darimont BD

(1)

Dejneka T

(1)

Deval J

(1)

Devasthale P

(1)

Dias SGM

(1)

Dias SMG

(1)

Donate PM

(1)

Dow RL

(1)

Doweyko AM

(1)

Einspahr H

(1)

Estebanez-Perpina E

(1)

 

More...

Homo / hetero assembly  (2)

homo

(17)

hetero

(15)

Assembly composition  (3)

protein structure

(17)

protein/protein complex

(14)

DNA/protein complex

(1)

Assembly polymer count  (4)

dimer

(16)

monomer

(14)

tetramer

(1)

trimer

(1)

Resolution distribution

1.5 - 2

(3)

2.0 - 2.5

(10)

2.5 - 3

(15)

3.0 - 3.5

(3)

3.5 - 4

(1)

Release year distribution

1995 - 2000

(2)

2000 - 2005

(10)

2005 - 2010

(7)

2010 - 2015

(1)

2015 - 2020

(6)

2020 - 2025

(8)

Journal  (12)

J Med Chem

(10)

Mol Endocrinol

(5)

iScience

(5)

Bioorg Med Chem Lett

(2)

J Biol Chem

(2)

Proc Natl Acad Sci U S A

(2)

BMC Struct Biol

(1)

Genes Dev

(1)

J Mol Biol

(1)

Nat Commun

(1)

Nature

(1)

Proteins

(1)

Organism superkingdom  (1)

Eukaryota

(32)

Organism name  (1)

Homo sapiens

(32)

Molecule name  (4)

Nuclear receptor subfamily 1 group A member 2

(32)

Thyroid hormone receptor beta

(32)

c-erbA-2

(32)

c-erbA-beta

(32)

Molecule type  (1)

Protein

(32)

Gene names  (4)

ERBA2

(32)

NR1A2

(32)

THR1

(32)

THRB

(32)

Interacting Molecules  (5)

Nuclear receptor coactivator 2

(13)

Retinoic acid receptor RXR-alpha

(2)

DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3')

(1)

DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3')

(1)

PROTEIN (GRIP1)

(1)

Interacting ligands  (24)

4HY : [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID

(7)

8HO : 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid

(5)

T3 : 3,5,3'TRIIODOTHYRONINE

(4)

ARS : ARSENIC

(2)

CAC : CACODYLATE ION

(2)

SO4 : SULFATE ION

(2)

442 : 2-[3,5-DIBROMO-4-(4-HYDROXY-3-{HYDROXY[(2-PHENYLETHYL)AMINO]METHYL}PHENOXY)PHENYL]ETHANE-1,1-DIOL

(1)

9GC : 2-[[1-methoxy-4-oxidanyl-7-[4-(phenylmethyl)phenoxy]isoquinolin-3-yl]carbonylamino]ethanoic acid

(1)

9IF : 2-[[1-methoxy-4-oxidanyl-7-(4-phenoxyphenoxy)isoquinolin-3-yl]carbonylamino]ethanoic acid

(1)

9II : 2-[[1-methoxy-4-oxidanyl-7-(4-phenylphenoxy)isoquinolin-3-yl]carbonylamino]ethanoic acid

(1)

9IL : 2-[[7-[2,6-dimethyl-4-(phenylcarbonyl)phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid

(1)

9IQ : 2-[[7-[4-(3,5-dimethylphenyl)carbonyl-2,6-dimethyl-phenoxy]-1-ethoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid

(1)

9IT : 2-[[7-[2,6-dimethyl-4-(3-methylphenyl)carbonyl-phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid

(1)

9IW : 2-[[1-ethoxy-7-[4-(3-fluoranyl-5-methoxy-phenyl)carbonyl-2,6-dimethyl-phenoxy]-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid

(1)

A1H2J : 6-azanyl-2-[3,5-bis(chloranyl)-4-[(6-oxidanylidene-5-propan-2-yl-1~{H}-pyridazin-3-yl)oxy]phenyl]-1,2,4-triazine-3,5-dione

(1)

B72 : {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid

(1)

G24 : [4-(3-BENZYL-4-HYDROXYBENZYL)-3,5-DIMETHYLPHENOXY]ACETIC ACID

(1)

IH5 : {3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC ACID

(1)

LEG : 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE

(1)

NA : SODIUM ION

(1)

OEF : 3,5-DIBROMO-4-(3-ISOPROPYL-PHENOXY)BENZOIC ACID

(1)

PFA : [4-(4-HYDROXY-3-ISOPROPYL-PHENOXY)-3,5-DIMETHYL-PHENYL]-6-AZAURACIL

(1)

T44 : 3,5,3',5'-TETRAIODO-L-THYRONINE

(1)

ZN : ZINC ION

(1)

Biological function  (5)

DNA binding

(32)

nuclear receptor activity

(32)

DNA-binding transcription factor activity

(1)

sequence-specific DNA binding

(1)

zinc ion binding

(1)

Biological process  (1)

regulation of DNA-templated transcription

(32)

SCOP fold  (2)

Nuclear receptor ligand-binding domain

(10)

Glucocorticoid receptor-like (DNA-binding domain)

(1)

SCOP family  (2)

Nuclear receptor ligand-binding domain

(10)

Nuclear receptor

(1)

CATH class  (2)

Mainly Alpha

(18)

Alpha Beta

(1)

CATH topology  (2)

Retinoid X Receptor

(18)

Erythroid Transcription Factor GATA-1; Chain A

(1)

Pfam accession / name  (2)

PF00104 : Hormone_recep

(31)

PF00105 : zf-C4

(1)

Diffraction protocol  (1)

Single wavelength

(32)

Diffraction radiation source type  (2)

Synchrotron

(26)

Rotating anode

(6)

Diffraction source  (15)

SSRF BEAMLINE BL19U1

(7)

SSRF BEAMLINE BL18U1

(4)

ALS BEAMLINE 5.0.2

(3)

ALS BEAMLINE 8.3.1

(3)

RIGAKU ULTRAX 18

(3)

RIGAKU RU200

(2)

SSRL BEAMLINE BL9-1

(2)

CHESS BEAMLINE A1

(1)

EMBL/DESY, HAMBURG BEAMLINE BW7A

(1)

EMBL/DESY, HAMBURG BEAMLINE BW7B

(1)

RIGAKU RU300

(1)

SLS BEAMLINE X10SA

(1)

SSRF BEAMLINE BL17U1

(1)

SSRL BEAMLINE BL11-1

(1)

SSRL BEAMLINE BL7-1

(1)

Synchrotron site  (6)

SSRF

(12)

ALS

(6)

SSRL

(4)

EMBL/DESY, Hamburg

(2)

CHESS

(1)

SLS

(1)

Diffraction detector type  (4)

Pixel

(14)

CCD

(9)

Image plate

(7)

Area detector

(1)

Refinement software  (6)

REFMAC

(16)

CNS

(9)

PHENIX

(8)

CNX

(1)

ELVES

(1)

X-PLOR

(1)

Representative Structures

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