Uniprot accession / id : P48346  OR   Uniprot accession / id : P40933
 
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revised
(1)
 
Entry Information
Entry status  (1)
REL
(5)
 
Experimental methods  (1)
X-ray diffraction
(5)
 
Authors  (53)
Chirifu M
(2)
Davis SJ
(2)
Hayashi C
(2)
Ikemizu S
(2)
Kai H
(2)
Nakamura T
(2)
Shuto T
(2)
Toma S
(2)
Yamagata Y
(2)
Anderson M
(1)
Bowman GR
(1)
Buchanan C
(1)
Cochrane D
(1)
Cruwys S
(1)
Feng D
(1)
Ferraro F
(1)
Finch DK
(1)
Garcia KC
(1)
Gerhardt S
(1)
Hargreaves D
(1)
Kanagawa O
(1)
Kishishita S
(1)
Kukimoto-Niino M
(1)
Leonard WJ
(1)
Li P
(1)
Lin JX
(1)
Lowe DC
(1)
Mallinder PR
(1)
Mitra S
(1)
Moraga I
(1)
Murayama K
(1)
Olsen SK
(1)
Ota N
(1)
Ozkan E
(1)
Pande VS
(1)
Pattison DV
(1)
Pauptit RA
(1)
Popovic B
(1)
RIKEN Structural Genomics/Proteomics Initiative (RSGI)
(1)
Rickert M
(1)
Ring AM
(1)
Shirouzu M
(1)
Sleeman M
(1)
Spolski R
(1)
StGallay S
(1)
Terada T
(1)
Toyama M
(1)
Uchiyama H
(1)
Vaughan TJ
(1)
Vousden K
(1)
Ward A
(1)
Wilkinson T
(1)
Yokoyama S
(1)
 
Homo / hetero assembly  (1)
hetero
(5)
 
Assembly composition  (1)
protein/protein complex
(5)
 
Assembly polymer count  (3)
dimer
(3)
tetramer
(1)
trimer
(1)
 
Resolution distribution
1.5 - 2
(2)
2.0 - 2.5
(2)
2.5 - 3
(1)
 
Release year distribution
2005 - 2010
(4)
2010 - 2015
(2)
 
Journal  (3)
Nat Immunol
(3)
J Biol Chem
(1)
J Mol Biol
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(5)
 
Organism name  (2)
Homo sapiens
(4)
Mus musculus
(1)
 
Molecule name  (2)
IL-15
(5)
Interleukin-15
(5)
 
Molecule type  (1)
Protein
(5)
 
Gene names  (2)
IL15
(4)
Il15
(1)
 
Interacting Molecules  (4)
Soluble interleukin-15 receptor subunit alpha
(4)
ANTI-IL-15 ANTIBODY
(1)
Cytokine receptor common subunit gamma
(1)
Interleukin-2 receptor subunit beta
(1)
 
Interacting ligands  (3)
BEN : BENZAMIDINE
(1)
GOL : GLYCEROL
(1)
SO4 : SULFATE ION
(1)
 
Function and Biology
Biological function  (1)
cytokine receptor binding
(5)
 
Biological process  (1)
immune response
(5)
 
Biological cell component  (1)
extracellular region
(5)
 
Sequence and Structure classification
SCOP fold  (1)
4-helical cytokines
(3)
 
SCOP family  (1)
Short-chain cytokines
(3)
 
CATH class  (1)
Mainly Alpha
(5)
 
CATH topology  (1)
Growth Hormone; Chain: A;
(5)
 
Pfam accession / name  (1)
PF02372 : IL15
(5)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(5)
 
Diffraction radiation source type  (2)
Synchrotron
(4)
Rotating anode
(1)
 
Diffraction source  (3)
PHOTON FACTORY BEAMLINE AR-NW12A
(3)
ALS BEAMLINE 8.2.1
(1)
RIGAKU FR-E
(1)
 
Synchrotron site  (2)
Photon Factory
(3)
ALS
(1)
 
Diffraction detector type  (1)
CCD
(5)
 
Refinement software  (3)
REFMAC
(3)
CNS
(1)
PHENIX
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 5 of 5
Entries 1 to 5 of 5
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Crystal Structure of anti-IL-15 Antibody in Complex with human IL-15
Lowe DC, Gerhardt S, Ward A, Hargreaves D, Anderson M, StGallay S, Vousden K, Ferraro F, Pauptit RA, Cochrane D, Pattison DV, Buchanan C, Popovic B, Finch DK, Wilkinson T, Sleeman M, Vaughan TJ, Cruwys S, Mallinder PR
J Mol Biol (2011) [PMID: 21167836  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Interleukin-15 and IG-heavy chain and IG-light lambda chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-211192 (Preferred)   search this ID
PDBe-KB: P40933   
X-ray diffraction
2.6Å resolution
Released: 29 Dec 2010
Model geometry
Fit model/data
Data not analysed
2xqb
2xqb
2xqb
Crystal structure of Interleukin 15 in complex with Interleukin 15 receptor alpha
Olsen SK, Murayama K, Kishishita S, Kukimoto-Niino M, Terada T, Shirouzu M, Ota N, Kanagawa O, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
J Biol Chem (2007) [PMID: 17947230  ]
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Bound ligands: BEN   
Assembly name: Soluble interleukin-15 receptor subunit alpha and Interleukin-15 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155718 (Preferred)   search this ID
PDBe-KB: P48346    Q60819   
X-ray diffraction
2.19Å resolution
Released: 6 Nov 2007
Model geometry
Fit model/data
2psm
2psm
2psm
Crystal structure of the IL-15/IL-15Ra complex
Chirifu M, Yamagata Y, Davis SJ, Ikemizu S
Nat Immunol (2007) [PMID: 17643103  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Soluble interleukin-15 receptor subunit alpha and Interleukin-15 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154210 (Preferred)   search this ID
PDBe-KB: P40933    Q13261   
X-ray diffraction
1.85Å resolution
Released: 4 Sep 2007
Model geometry
Fit model/data
Data not deposited
2z3q
2z3q
2z3q
Crystal structure of the IL-15/IL-15Ra complex
Chirifu M, Yamagata Y, Davis SJ, Ikemizu S
Nat Immunol (2007) [PMID: 17643103  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GOL   
Assembly name: Soluble interleukin-15 receptor subunit alpha and Interleukin-15 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154210 (Preferred)   search this ID
PDBe-KB: P40933    Q13261   
X-ray diffraction
2Å resolution
Released: 4 Sep 2007
Model geometry
Fit model/data
Data not deposited
2z3r
2z3r
2z3r
Structure of the Interleukin-15 quaternary complex
Ring AM, Ozkan E, Feng D, Garcia KC
Nat Immunol (2012) [PMID: 23104097  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ACT    NAG    NAG    EDO    ACT   
Modified residues: MLY    MLY   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Assembly name: Interleukin-15 receptor-ligand complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-147093 (Preferred)   search this ID
PDBe-KB: P40933    Q13261    P14784    P31785   
X-ray diffraction
2.35Å resolution
Released: 7 Nov 2012
Model geometry
Fit model/data
4gs7
4gs7
4gs7
Entries 1 to 5 of 5
Entries 1 to 5 of 5