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IL-4 Stat
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Signal transducer and activator of transcription 6
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STAT6
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Nuclear receptor coactivator 1
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DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*GP*AP*CP*AP*A)-3')
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DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*GP*GP*AP*AP*GP*AP*CP*AP*GP*A)-3')
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DNA (5'-D(P*TP*TP*GP*TP*CP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3')
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Interacting ligands
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A1AQQ : [(2-{[(2S)-1-{(2S,4S)-4-[(7-{2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}hept-6-yn-1-yl)oxy]-2-[(2R)-2-phenylmorpholine-4-carbonyl]pyrrolidin-1-yl}-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-1-benzothiophen-5-yl)di(fluoro)methyl]phosphonic acid
(1)
NI : NICKEL (II) ION
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regulation of DNA-templated transcription
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signal transduction
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PF00017 : SH2
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PF01017 : STAT_alpha
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PF02864 : STAT_bind
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PF21354 : STAT_linker
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APS BEAMLINE 21-ID-D
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700.0 - 800
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900.0 - 1000
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Representative Structures
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Entries 1 to 7 of 7
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Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6
Russo L, Giller K, Pfitzner E, Griesinger C, Becker S
Sci Rep
(2017)
[PMID: 29203888 ]
Source organisms: Mus musculus , Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Signal transducer and activator of transcription 6 and Nuclear receptor coactivator 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-154571 (Preferred)
search this ID
Transcription factor-DNA complex
Li J, Niu F, Ouyang S, Liu Z
Proc Natl Acad Sci U S A
(2016)
[PMID: 27803324 ]
Source organism: Homo sapiens
Assembly composition: DNA/protein complex
Assembly name:
STAT6 homodimer and DNA
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-118526 (Preferred)
search this ID

Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6
Russo L, Becker S, Griesinger C
Sci Rep
(2017)
[PMID: 29203888 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Signal transducer and activator of transcription 6 and Nuclear receptor coactivator 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-154572 (Preferred)
search this ID
Stat6 bound to degrader AK-1690
Mallik L, Stuckey JA
J Med Chem
(2024)
[PMID: 39311434 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Signal transducer and activator of transcription 6
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-273735 (Preferred)
search this ID

Transcription factor
Li J, Niu F, Ouyang S, Liu Z
Proc Natl Acad Sci U S A
(2016)
[PMID: 27803324 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
STAT6 homodimer
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-154573 (Preferred)
search this ID
Crystal structure of the Nco-A1 PAS-B domain bound to the STAT6 transactivation domain LXXLL motif
Razeto A, Ramakrishnan V, Giller K, Lakomek N, Carlomagno T, Griesinger C, Lodrini M, Litterst CM, Pftizner E, Becker S
J Mol Biol
(2004)
[PMID: 14757047 ]
Source organisms: Mus musculus , Homo sapiens
Assembly composition: protein/protein complex
Bound ligands:
IOD
Assembly name:
Signal transducer and activator of transcription 6 and Nuclear receptor coactivator 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-154571 (Preferred)
search this ID
Transcription factor-DNA complex
Li J, Niu F, Ouyang S, Liu Z
Proc Natl Acad Sci U S A
(2016)
[PMID: 27803324 ]
Source organism: Homo sapiens
Assembly composition: DNA/protein complex
Assembly name:
STAT6 homodimer and DNA
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-118302 (Preferred)
search this ID
Entries 1 to 7 of 7