Uniprot accession / id : P52633  OR   Uniprot accession / id : P42226  OR   Uniprot accession / id : G3V370
 
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revised
(1)
 
Entry Information
Entry status  (1)
REL
(7)
 
Experimental methods  (2)
X-ray diffraction
(6)
Solution NMR
(1)
 
Authors  (49)
Becker S
(3)
Cheng G
(3)
Da Y
(3)
Ding W
(3)
Giller K
(3)
Griesinger C
(3)
Hung LW
(3)
Li J
(3)
Liu Y
(3)
Liu Z
(3)
Liu ZJ
(3)
Niu F
(3)
Ouyang S
(3)
Pfitzner E
(3)
Pu M
(3)
Rodriguez JP
(3)
Shao Q
(3)
Wang J
(3)
Wei GH
(3)
Yang J
(3)
Yao Z
(3)
Zhao Y
(3)
Zhu Y
(3)
Russo L
(2)
Bai L
(1)
Carlomagno T
(1)
Chinnaswamy K
(1)
Heimburg T
(1)
Kaneshige A
(1)
Kirchhoff PD
(1)
Lakomek N
(1)
Litterst CM
(1)
Lodrini M
(1)
Mallik L
(1)
McEachern D
(1)
Meagher JL
(1)
Metwally H
(1)
Pftizner E
(1)
Ramakrishnan V
(1)
Razeto A
(1)
Stuckey JA
(1)
Tosovic J
(1)
Tošović J
(1)
Wang M
(1)
Wang S
(1)
Wang Y
(1)
Xu R
(1)
Yang CY
(1)
Yang Y
(1)
 
Homo / hetero assembly  (2)
hetero
(5)
homo
(2)
 
Assembly composition  (3)
protein/protein complex
(3)
DNA/protein complex
(2)
protein structure
(2)
 
Assembly polymer count  (3)
dimer
(4)
tetramer
(2)
monomer
(1)
 
Resolution distribution
2.0 - 2.5
(1)
2.5 - 3
(2)
3.0 - 3.5
(3)
 
Release year distribution
2000 - 2005
(1)
2015 - 2020
(5)
2020 - 2025
(1)
 
Journal  (4)
Proc Natl Acad Sci U S A
(3)
Sci Rep
(2)
J Med Chem
(1)
J Mol Biol
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(7)
 
Organism name  (1)
Homo sapiens
(7)
 
Molecule name  (2)
IL-4 Stat
(7)
Signal transducer and activator of transcription 6
(7)
 
Molecule type  (1)
Protein
(7)
 
Gene names  (1)
STAT6
(7)
 
Interacting Molecules  (5)
Nuclear receptor coactivator 1
(3)
DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*GP*AP*CP*AP*A)-3')
(1)
DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*GP*GP*AP*AP*GP*AP*CP*AP*GP*A)-3')
(1)
DNA (5'-D(P*TP*CP*TP*GP*TP*CP*TP*TP*CP*CP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3')
(1)
DNA (5'-D(P*TP*TP*GP*TP*CP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3')
(1)
 
Interacting ligands  (2)
A1AQQ : [(2-{[(2S)-1-{(2S,4S)-4-[(7-{2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}hept-6-yn-1-yl)oxy]-2-[(2R)-2-phenylmorpholine-4-carbonyl]pyrrolidin-1-yl}-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-1-benzothiophen-5-yl)di(fluoro)methyl]phosphonic acid
(1)
NI : NICKEL (II) ION
(1)
 
Function and Biology
Biological function  (2)
DNA binding
(4)
DNA-binding transcription factor activity
(4)
 
Biological process  (2)
regulation of DNA-templated transcription
(4)
signal transduction
(4)
 
Sequence and Structure classification
Pfam accession / name  (4)
PF00017 : SH2
(4)
PF01017 : STAT_alpha
(4)
PF02864 : STAT_bind
(4)
PF21354 : STAT_linker
(4)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(6)
 
Diffraction radiation source type  (2)
Synchrotron
(5)
Rotating anode
(1)
 
Diffraction source  (5)
APS BEAMLINE 21-ID-D
(2)
SIEMENS M18X
(1)
SLS BEAMLINE X10SA
(1)
SSRF BEAMLINE BL17U
(1)
SSRF BEAMLINE BL19U1
(1)
 
Synchrotron site  (3)
APS
(2)
SSRF
(2)
SLS
(1)
 
Diffraction detector type  (3)
CCD
(2)
Image plate
(2)
Pixel
(2)
 
Refinement software  (3)
PHENIX
(3)
REFMAC
(3)
BUSTER
(1)
 
NMR
NMR software packages  (6)
CARA
(1)
CYANA
(1)
NMRPipe
(1)
Sparky
(1)
TALOS
(1)
TopSpin
(1)
 
NMR Field Strength
500.0 - 600
(1)
600.0 - 700
(1)
700.0 - 800
(1)
800.0 - 900
(1)
900.0 - 1000
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 7 of 7
Entries 1 to 7 of 7
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Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6
Russo L, Giller K, Pfitzner E, Griesinger C, Becker S
Sci Rep (2017) [PMID: 29203888  ]
Assembly composition: protein/protein complex
Assembly name: Signal transducer and activator of transcription 6 and Nuclear receptor coactivator 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154571 (Preferred)   search this ID
PDBe-KB: P42226    P70365   
X-ray diffraction
2.51Å resolution
Released: 13 Dec 2017
Model geometry
Fit model/data
5nwx
5nwx
5nwx
Transcription factor-DNA complex
Li J, Niu F, Ouyang S, Liu Z
Proc Natl Acad Sci U S A (2016) [PMID: 27803324  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Modified residues: PTR    PTR   
Assembly name: STAT6 homodimer and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-118526 (Preferred)   search this ID
PDBe-KB: P42226   
X-ray diffraction
3.2Å resolution
Released: 10 Aug 2016
Model geometry
Fit model/data
5d39
5d39
5d39
Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6
Russo L, Becker S, Griesinger C
Sci Rep (2017) [PMID: 29203888  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Signal transducer and activator of transcription 6 and Nuclear receptor coactivator 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154572 (Preferred)   search this ID
PDBe-KB: P42226    Q15788   
Solution NMR
Released: 6 Dec 2017
Model geometry
Fit model/data
Data not analysed
5nwm
5nwm
5nwm
Stat6 bound to degrader AK-1690
Mallik L, Stuckey JA
J Med Chem (2024) [PMID: 39311434  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: A1AQQ    A1AQQ   
Assembly name: Signal transducer and activator of transcription 6 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-273735 (Preferred)   search this ID
PDBe-KB: P42226   
X-ray diffraction
3.304Å resolution
Released: 2 Oct 2024
Model geometry
Fit model/data
9big
9big
9big
Transcription factor
Li J, Niu F, Ouyang S, Liu Z
Proc Natl Acad Sci U S A (2016) [PMID: 27803324  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NI    NI   
Modified residues: PTR    PTR   
Assembly name: STAT6 homodimer (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154573 (Preferred)   search this ID
PDBe-KB: P42226    P42226   
X-ray diffraction
2.708Å resolution
Released: 17 Feb 2016
Model geometry
Fit model/data
4y5u
4y5u
4y5u
Crystal structure of the Nco-A1 PAS-B domain bound to the STAT6 transactivation domain LXXLL motif
Razeto A, Ramakrishnan V, Giller K, Lakomek N, Carlomagno T, Griesinger C, Lodrini M, Litterst CM, Pftizner E, Becker S
J Mol Biol (2004) [PMID: 14757047  ]
Assembly composition: protein/protein complex
Bound ligands: IOD   
Assembly name: Signal transducer and activator of transcription 6 and Nuclear receptor coactivator 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154571 (Preferred)   search this ID
PDBe-KB: P42226    P70365   
X-ray diffraction
2.21Å resolution
Released: 12 Feb 2004
Model geometry
Fit model/data
1oj5
1oj5
1oj5
Transcription factor-DNA complex
Li J, Niu F, Ouyang S, Liu Z
Proc Natl Acad Sci U S A (2016) [PMID: 27803324  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Modified residues: PTR    PTR   
Assembly name: STAT6 homodimer and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-118302 (Preferred)   search this ID
PDBe-KB: P42226    P42226   
X-ray diffraction
3.104Å resolution
Released: 17 Feb 2016
Model geometry
Fit model/data
4y5w
4y5w
4y5w
Entries 1 to 7 of 7
Entries 1 to 7 of 7