Uniprot accession / id : P56402  OR   Uniprot accession / id : P41181
 
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Entry Information
Entry status  (1)
REL
(7)
 
Experimental methods  (3)
X-ray diffraction
(5)
Electron Microscopy
(1)
Electron crystallography
(1)
 
Authors  (58)
Tornroth-Horsefield S
(4)
Törnroth-Horsefield S
(4)
Frick A
(3)
Kreida S
(3)
Al-Jubair T
(2)
Engel A
(2)
Gourdon P
(2)
Hagstroemer CJ
(2)
Hagstromer CJ
(2)
Hagströmer CJ
(2)
Horsefield S
(2)
Hyld Steffen J
(2)
Transcontinental EM Initiative for Membrane Protein Structure (TEMIMPS)
(2)
Vahedi-Faridi A
(2)
Barthelmess M
(1)
Bergtholdt J
(1)
Burkhardt A
(1)
Cerv M
(1)
Chapman HN
(1)
Crosas E
(1)
De groot B
(1)
Deen PM
(1)
Deen PMT
(1)
Eriksson U
(1)
Eriksson UK
(1)
Fischer J
(1)
Fischer P
(1)
Fujiyoshi Y
(1)
Grip WD
(1)
Guenther S
(1)
Hedfalk K
(1)
Kamegawa A
(1)
Kaptan S
(1)
Komadina D
(1)
Lane TJ
(1)
Lieske J
(1)
Lodowski D
(1)
Lodowski DT
(1)
Lorbeer O
(1)
Mariani V
(1)
Mattia FD
(1)
Meents A
(1)
Neutze R
(1)
Nishikawa K
(1)
Numoto N
(1)
Oberg F
(1)
Pakendorf T
(1)
Ross BH
(1)
Schenk A
(1)
Schoen S
(1)
Seine T
(1)
Suzuki H
(1)
Suzuki S
(1)
Tornroth-horsefield S
(1)
Walz T
(1)
Yefanov O
(1)
de Grip WJ
(1)
de Mattia F
(1)
 
Homo / hetero assembly  (1)
homo
(7)
 
Assembly composition  (1)
protein structure
(7)
 
Assembly polymer count  (2)
tetramer
(6)
dodecamer
(1)
 
Resolution distribution
2.5 - 3
(3)
3.0 - 3.5
(2)
3.5 - 4
(2)
 
Release year distribution
2010 - 2015
(2)
2015 - 2020
(1)
2020 - 2025
(4)
2025 - 2030
(1)
 
Journal  (5)
Sci Rep
(2)
To be published
(2)
IUCrJ
(1)
J Struct Biol
(1)
Proc Natl Acad Sci U S A
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(7)
 
Organism name  (1)
Homo sapiens
(7)
 
Molecule name  (8)
ADH water channel
(7)
AQP-2
(7)
AQP-CD
(7)
Aquaporin-2
(7)
Aquaporin-CD
(7)
Collecting duct water channel protein
(7)
WCH-CD
(7)
Water channel protein for renal collecting duct
(7)
 
Molecule type  (1)
Protein
(7)
 
Gene names  (1)
AQP2
(7)
 
Interacting ligands  (2)
CD : CADMIUM ION
(4)
ZN : ZINC ION
(1)
 
Function and Biology
Biological function  (5)
channel activity
(6)
glycerol transmembrane transporter activity
(3)
protein binding
(3)
water channel activity
(3)
water transmembrane transporter activity
(3)
 
Biological process  (11)
transmembrane transport
(6)
actin filament organization
(3)
cellular response to copper ion
(3)
cellular response to mercury ion
(3)
cellular response to water deprivation
(3)
glycerol transmembrane transport
(3)
metanephric collecting duct development
(3)
protein homotetramerization
(3)
renal water homeostasis
(3)
renal water transport
(3)
water transport
(3)
 
Biological cell component  (13)
membrane
(7)
Golgi apparatus
(3)
apical plasma membrane
(3)
basolateral plasma membrane
(3)
cytoplasm
(3)
cytoplasmic vesicle
(3)
cytoplasmic vesicle membrane
(3)
extracellular exosome
(3)
lumenal side of membrane
(3)
perinuclear region of cytoplasm
(3)
plasma membrane
(3)
recycling endosome
(3)
transport vesicle membrane
(3)
 
Sequence and Structure classification
CATH class  (1)
Mainly Alpha
(2)
 
CATH topology  (1)
Glycerol uptake facilitator protein
(2)
 
Pfam accession / name  (1)
PF00230 : MIP
(7)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(5)
 
Diffraction radiation source type  (2)
Synchrotron
(4)
Free-electron laser
(1)
 
Diffraction source  (5)
APS BEAMLINE 24-ID-C
(1)
ESRF BEAMLINE ID14-4
(1)
MAX IV BEAMLINE BioMAX
(1)
PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
(1)
SLAC LCLS BEAMLINE MFX
(1)
 
Synchrotron site  (5)
APS
(1)
ESRF
(1)
MAX IV
(1)
PETRA III, EMBL c/o DESY
(1)
SLAC LCLS
(1)
 
Diffraction detector type  (2)
Pixel
(3)
CCD
(2)
 
Refinement software  (4)
PHENIX
(3)
REFMAC
(2)
BUSTER
(1)
BUSTER-TNT
(1)
 
EM microscope model  (2)
FEI TECNAI F20
(1)
JEOL CRYO ARM 300
(1)
 
EM detector name  (2)
GATAN K2 SUMMIT (4k x 4k)
(1)
GATAN ULTRASCAN 1000 (2k x 2k)
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 7 of 7
Entries 1 to 7 of 7
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Cryo-EM structure of hAQP2 in DDM
Kamegawa A, Suzuki S, Nishikawa K, Numoto N, Suzuki H, Fujiyoshi Y
J Struct Biol (2023) [PMID: 37315821  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Aquaporin-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154260 (Preferred)   search this ID
PDBe-KB: P41181   
Electron Microscopy
2.89Å resolution
Released: 21 Jun 2023
Model geometry
Fit model/data
Data not analysed
8gcl
8gcl
8gcl
Crystal structure of human AQP2 T125M mutant
Horsefield S, Hagstroemer CJ
Sci Rep (2023) [PMID: 37674034  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CD    CD   
Assembly name: Aquaporin-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154260 (Preferred)   search this ID
PDBe-KB: P41181   
X-ray diffraction
3.9Å resolution
Released: 20 Sep 2023
Model geometry
Fit model/data
8ghj
8ghj
8ghj
Human Aquaporin 2 from 2D electron diffraction data
Vahedi-Faridi A, Lodowski DT, Engel A, Transcontinental EM Initiative for Membrane Protein Structure (TEMIMPS)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Aquaporin-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-284946 (Preferred)   search this ID
PDBe-KB: P41181   
Electron crystallography
2.6Å resolution
Released: 5 Feb 2025
Model geometry
Fit model/data
8vvx
8vvx
8vvx
Crystal structure of human AQP2 T126M mutant
Horsefield S, Hagstroemer CJ
Sci Rep (2023) [PMID: 37674034  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CD    CD   
Assembly name: Aquaporin-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154260 (Preferred)   search this ID
PDBe-KB: P41181   
X-ray diffraction
3.15Å resolution
Released: 20 Sep 2023
Model geometry
Fit model/data
8oee
8oee
8oee
X-Ray structure of human Aquaporin 2 crystallized on a silicon chip
Lieske J, Cerv M, Kreida S, Barthelmess M, Fischer P, Pakendorf T, Yefanov O, Mariani V, Seine T, Ross BH, Crosas E, Lorbeer O, Burkhardt A, Lane TJ, Guenther S, Bergtholdt J, Schoen S, Tornroth-Horsefield S, Chapman HN, Meents A
IUCrJ (2019) [PMID: 31316815  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CD    CD   
Assembly name: Aquaporin-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154260 (Preferred)   search this ID
PDBe-KB: P41181   
X-ray diffraction
3.7Å resolution
Released: 10 Jul 2019
Model geometry
Fit model/data
6qf5
6qf5
6qf5
X-ray structure of human Aquaporin 2
Frick A, Eriksson U, Mattia FD, Oberg F, Hedfalk K, Neutze R, Grip WD, Deen PMT, Tornroth-horsefield S
Proc Natl Acad Sci U S A (2014) [PMID: 24733887  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN    CD    CD   
Assembly name: Aquaporin-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154260 (Preferred)   search this ID
PDBe-KB: P41181   
X-ray diffraction
2.75Å resolution
Released: 16 Apr 2014
Model geometry
Fit model/data
4nef
4nef
4nef
The structure of aquaporin
Vahedi-Faridi A, Lodowski D, Engel A, Transcontinental EM Initiative for Membrane Protein Structure (TEMIMPS)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Aquaporin-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154260 (Preferred)   search this ID
PDBe-KB: P41181   
X-ray diffraction
3.05Å resolution
Released: 7 May 2014
Model geometry
Fit model/data
4oj2
4oj2
4oj2
Entries 1 to 7 of 7
Entries 1 to 7 of 7