Entry status  (1)

REL

(5)

Experimental methods  (1)

X-ray diffraction

(5)

Authors  (8)

Johnson EF

(5)

Schoch GA

(5)

Stout CD

(5)

Yano JK

(5)

Dansette PM

(4)

Sansen S

(4)

Griffin KJ

(1)

Wester MR

(1)

Homo / hetero assembly  (1)

homo

(5)

Assembly composition  (1)

protein structure

(5)

Assembly polymer count  (1)

monomer

(5)

Resolution distribution

2.0 - 2.5

(1)

2.5 - 3

(4)

Release year distribution

2000 - 2005

(1)

2005 - 2010

(4)

Journal  (1)

J Biol Chem

(5)

Organism superkingdom  (1)

Eukaryota

(5)

Organism name  (1)

Homo sapiens

(5)

Molecule name  (7)

CYPIIC8

(5)

Cytochrome P450 2C8

(5)

Cytochrome P450 IIC2

(5)

Cytochrome P450 MP-12

(5)

Cytochrome P450 MP-20

(5)

Cytochrome P450 form 1

(5)

S-mephenytoin 4-hydroxylase

(5)

Molecule type  (1)

Protein

(5)

Gene names  (1)

CYP2C8

(5)

Interacting ligands  (8)

HEM : PROTOPORPHYRIN IX CONTAINING FE

(5)

PLM : PALMITIC ACID

(5)

SO4 : SULFATE ION

(3)

225 : FELODIPINE

(1)

9CR : (9cis)-retinoic acid

(1)

MTK : MONTELUKAST

(1)

PO4 : PHOSPHATE ION

(1)

TDZ : (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE

(1)

EC number / name  (1)

1.14.14.1 : Unspecific monooxygenase

(5)

Biological function  (12)

arachidonate epoxygenase activity

(5)

caffeine oxidase activity

(5)

estrogen 16-alpha-hydroxylase activity

(5)

heme binding

(5)

iron ion binding

(5)

metal ion binding

(5)

monooxygenase activity

(5)

oxidoreductase activity

(5)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

(5)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

(5)

protein binding

(5)

retinoic acid 4-hydroxylase activity

(5)

Biological process  (15)

arachidonate metabolic process

(5)

epoxygenase P450 pathway

(5)

estrogen metabolic process

(5)

icosanoid biosynthetic process

(5)

lipid hydroxylation

(5)

lipid metabolic process

(5)

long-chain fatty acid biosynthetic process

(5)

omega-hydroxylase P450 pathway

(5)

organic acid metabolic process

(5)

oxidative demethylation

(5)

retinoic acid metabolic process

(5)

retinol metabolic process

(5)

steroid metabolic process

(5)

xenobiotic catabolic process

(5)

xenobiotic metabolic process

(5)

Biological cell component  (6)

cytoplasm

(5)

endoplasmic reticulum

(5)

endoplasmic reticulum membrane

(5)

intracellular membrane-bounded organelle

(5)

membrane

(5)

plasma membrane

(5)

Compound cofactor class  (1)

Heme

(5)

SCOP fold  (1)

Cytochrome P450

(5)

SCOP family  (1)

Cytochrome P450

(5)

CATH class  (1)

Mainly Alpha

(5)

CATH topology  (1)

Cytochrome p450

(5)

Pfam accession / name  (1)

PF00067 : p450

(5)

Diffraction protocol  (1)

Single wavelength

(5)

Diffraction radiation source type  (2)

Synchrotron

(4)

Rotating anode

(1)

Diffraction source  (5)

RIGAKU

(1)

SSRL BEAMLINE BL1-5

(1)

SSRL BEAMLINE BL11-1

(1)

SSRL BEAMLINE BL7-1

(1)

SSRL BEAMLINE BL9-1

(1)

Synchrotron site  (1)

SSRL

(4)

Diffraction detector type  (2)

CCD

(3)

Image plate

(2)

Refinement software  (1)

CNS

(5)

Representative Structures

100%

95%

90%

70%

50%

40%

30%