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Entry Information
Entry status
(1)
Experimental methods
(2)
X-ray diffraction
(17)
Solid-state NMR
(1)
Authors
(31)
Lu W
(18)
Pazgier M
(17)
Yuan W
(16)
Zou G
(12)
de Leeuw E
(12)
Li J
(11)
Wei G
(11)
Lu WY
(10)
Rajabi M
(10)
Lehrer RI
(9)
Ericksen B
(8)
Jung G
(8)
Li X
(5)
Wu X
(5)
Zhan C
(5)
Zhao L
(5)
Lubkowski J
(4)
Tolbert WD
(4)
Lu W-Y
(3)
Lehrer RL
(2)
Szmacinski H
(2)
Wu Z
(2)
Barinka C
(1)
Doherty T
(1)
Doherty TF
(1)
Hong M
(1)
Li C
(1)
Li S
(1)
Wang J
(1)
Zeng P
(1)
Zhang Y
(1)
Homo / hetero assembly
(1)
homo
(18)
Assembly composition
(1)
protein structure
(18)
Assembly polymer count
(3)
monomer
(11)
tetramer
(4)
dimer
(3)
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(16)
Release year distribution
2005 - 2010
(13)
2010 - 2015
(14)
Journal
(4)
J Biol Chem
(10)
PLoS One
(4)
To be published
(3)
J Mol Biol
(1)
Macromolecules
Organism superkingdom
(1)
Eukaryota
(18)
Organism name
(1)
Homo sapiens
(18)
Molecule name
(10)
Defensin, alpha 1
(18)
HNP-1
(18)
HNP-2
(18)
HP 1-56
(18)
HP-1
(18)
HP-2
(18)
HP1
(18)
HP2
(18)
Neutrophil defensin 1
(18)
Neutrophil defensin 2
(18)
Molecule type
(1)
Protein
(18)
Gene names
(5)
DEF1
(18)
DEFA1
(18)
DEFA1B
(18)
DEFA2
(18)
MRS
(18)
Interacting ligands
(8)
GOL : GLYCEROL
(5)
CL : CHLORIDE ION
(3)
SO4 : SULFATE ION
(3)
MPD : (4S)-2-METHYL-2,4-PENTANEDIOL
(2)
PEG : DI(HYDROXYETHYL)ETHER
(2)
AZI : AZIDE ION
(1)
PG0 : 2-(2-METHOXYETHOXY)ETHANOL
(1)
TFA : trifluoroacetic acid
(1)
Function and Biology
Biological process
(1)
defense response
(18)
Biological cell component
(1)
extracellular region
(18)
Sequence and Structure classification
Pfam accession / name
(1)
PF00323 : Defensin_1
(18)
Experimental Information
Diffraction protocol
(1)
Single wavelength
(17)
Diffraction radiation source type
(2)
Rotating anode
(10)
Synchrotron
(7)
Diffraction source
(4)
RIGAKU MICROMAX-007
(10)
SSRL BEAMLINE BL7-1
(4)
APS BEAMLINE 22-ID
(2)
APS BEAMLINE 22-BM
(1)
Synchrotron site
(2)
SSRL
(4)
APS
(3)
Diffraction detector type
(2)
Image plate
(10)
CCD
(7)
Refinement software
(2)
REFMAC
(14)
PHENIX
(3)
NMR
NMR software packages
(4)
Sparky
(1)
TopSpin
(1)
UCSF Chimera
(1)
Xplor-NIH
(1)
NMR Field Strength
500.0 - 600
(1)
600.0 - 700
(1)
800.0 - 900
(1)
900.0 - 1000
(1)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 10 of 18
Select all entries on this page
Crystal structure of covalent dimer of HNP1
Lubkowski J, Pazgier M, Lu W
To be published
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Neutrophil defensin 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-157837 (Preferred)
search this ID

X-ray structure of monomeric variant of HNP1
Lubkowski J, Pazgier M, Lu W
To be published
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Neutrophil defensin 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-157836 (Preferred)
search this ID

Crystal structure of human alpha-defensin 1 (Y16A mutant)
Pazgier M, Lu W
J Biol Chem
(2010)
[PMID: 20220136 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Neutrophil defensin 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-157836 (Preferred)
search this ID

Crystal structure of human alpha-defensin 1 (HNP1) Y16A/F28A mutant
Tolbert WD, Wu X, Pazgier M
PLoS One
(2013)
[PMID: 24236072 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Neutrophil defensin 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-157838 (Preferred)
search this ID

Crystal structure of human alpha-defensin 1 (HNP1) Y16A/I20A/L25A/F28A mutant.
Tolbert WD, Wu X, Pazgier M
PLoS One
(2013)
[PMID: 24236072 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Neutrophil defensin 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-157838 (Preferred)
search this ID

Crystal structure of human alpha-defensin 1 (W26Ahp mutant)
Pazgier M, Lu W
J Biol Chem
(2010)
[PMID: 20220136 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Modified residues:
AHP
Assembly name:
Neutrophil defensin 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-157836 (Preferred)
search this ID

NMR Structure of human alpha defensin HNP-1
Zhang Y, Li S, Doherty TF, Lubkowski J, Lu W, Li J, Barinka C, Hong M
J Mol Biol
(2010)
[PMID: 20097206 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Neutrophil defensin 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-157836 (Preferred)
search this ID

Crystal structure of human alpha-defensin 1 (HNP1) I20A mutant
Tolbert WD, Wu X, Pazgier M
PLoS One
(2013)
[PMID: 24236072 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Bound ligands:
CL
Assembly name:
Neutrophil defensin 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-157836 (Preferred)
search this ID

Derivative of human alpha-defensin 1 (HNP1)
Lubkowski J, Pazgier M, Lu W
To be published
Source organism: Homo sapiens
Assembly composition: protein only structure
Modified residues:
DAB
Assembly name:
Neutrophil defensin 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-157836 (Preferred)
search this ID

Crystal structure of human alpha-defensin 1 (Mutant Gln22Ala)
Pazgier M, Lu W
J Biol Chem
(2010)
[PMID: 20220136 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Neutrophil defensin 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-157838 (Preferred)
search this ID

Entries 1 to 10 of 18