Uniprot accession / id : (P59665)
 
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Entry Information
Entry status  (1)
REL
(18)
 
Experimental methods  (2)
X-ray diffraction
(17)
Solid-state NMR
(1)
 
Authors  (31)
Lu W
(18)
Pazgier M
(17)
Yuan W
(16)
Zou G
(12)
de Leeuw E
(12)
Li J
(11)
Wei G
(11)
Lu WY
(10)
Rajabi M
(10)
Lehrer RI
(9)
Ericksen B
(8)
Jung G
(8)
Li X
(5)
Wu X
(5)
Zhan C
(5)
Zhao L
(5)
Lubkowski J
(4)
Tolbert WD
(4)
Lu W-Y
(3)
Lehrer RL
(2)
Szmacinski H
(2)
Wu Z
(2)
Barinka C
(1)
Doherty T
(1)
Doherty TF
(1)
Hong M
(1)
Li C
(1)
Li S
(1)
Wang J
(1)
Zeng P
(1)
Zhang Y
(1)
 
Homo / hetero assembly  (1)
homo
(18)
 
Assembly composition  (1)
protein structure
(18)
 
Assembly polymer count  (3)
monomer
(11)
tetramer
(4)
dimer
(3)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(16)
 
Release year distribution
2005 - 2010
(13)
2010 - 2015
(14)
 
Journal  (4)
J Biol Chem
(10)
PLoS One
(4)
To be published
(3)
J Mol Biol
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(18)
 
Organism name  (1)
Homo sapiens
(18)
 
Molecule name  (10)
Defensin, alpha 1
(18)
HNP-1
(18)
HNP-2
(18)
HP 1-56
(18)
HP-1
(18)
HP-2
(18)
HP1
(18)
HP2
(18)
Neutrophil defensin 1
(18)
Neutrophil defensin 2
(18)
 
Molecule type  (1)
Protein
(18)
 
Gene names  (5)
DEF1
(18)
DEFA1
(18)
DEFA1B
(18)
DEFA2
(18)
MRS
(18)
 
Interacting ligands  (8)
GOL : GLYCEROL
(5)
CL : CHLORIDE ION
(3)
SO4 : SULFATE ION
(3)
MPD : (4S)-2-METHYL-2,4-PENTANEDIOL
(2)
PEG : DI(HYDROXYETHYL)ETHER
(2)
AZI : AZIDE ION
(1)
PG0 : 2-(2-METHOXYETHOXY)ETHANOL
(1)
TFA : trifluoroacetic acid
(1)
 
Function and Biology
Biological process  (1)
defense response
(18)
 
Biological cell component  (1)
extracellular region
(18)
 
Sequence and Structure classification
Pfam accession / name  (1)
PF00323 : Defensin_1
(18)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(17)
 
Diffraction radiation source type  (2)
Rotating anode
(10)
Synchrotron
(7)
 
Diffraction source  (4)
RIGAKU MICROMAX-007
(10)
SSRL BEAMLINE BL7-1
(4)
APS BEAMLINE 22-ID
(2)
APS BEAMLINE 22-BM
(1)
 
Synchrotron site  (2)
SSRL
(4)
APS
(3)
 
Diffraction detector type  (2)
Image plate
(10)
CCD
(7)
 
Refinement software  (2)
REFMAC
(14)
PHENIX
(3)
 
NMR
NMR software packages  (4)
Sparky
(1)
TopSpin
(1)
UCSF Chimera
(1)
Xplor-NIH
(1)
 
NMR Field Strength
500.0 - 600
(1)
600.0 - 700
(1)
800.0 - 900
(1)
900.0 - 1000
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 18
Entries 1 to 10 of 18
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Crystal structure of covalent dimer of HNP1
Lubkowski J, Pazgier M, Lu W
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Neutrophil defensin 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157837 (Preferred)   search this ID
PDBe-KB: P59665   
X-ray diffraction
1.4Å resolution
Released: 20 Oct 2009
Model geometry
Fit model/data
3hj2
3hj2
3hj2
X-ray structure of monomeric variant of HNP1
Lubkowski J, Pazgier M, Lu W
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Modified residues: IML    IML   
Assembly name: Neutrophil defensin 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157836 (Preferred)   search this ID
PDBe-KB: P59665   
X-ray diffraction
1.65Å resolution
Released: 13 Oct 2009
Model geometry
Fit model/data
3hjd
3hjd
3hjd
Crystal structure of human alpha-defensin 1 (Y16A mutant)
Pazgier M, Lu W
J Biol Chem (2010) [PMID: 20220136  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: AZI    PG0   
Assembly name: Neutrophil defensin 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157836 (Preferred)   search this ID
PDBe-KB: P59665   
X-ray diffraction
1.6Å resolution
Released: 9 Mar 2010
Model geometry
Fit model/data
3lo1
3lo1
3lo1
Crystal structure of human alpha-defensin 1 (HNP1) Y16A/F28A mutant
Tolbert WD, Wu X, Pazgier M
PLoS One (2013) [PMID: 24236072  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Neutrophil defensin 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157838 (Preferred)   search this ID
PDBe-KB: P59665   
X-ray diffraction
2Å resolution
Released: 27 Nov 2013
Model geometry
Fit model/data
4lb1
4lb1
4lb1
Crystal structure of human alpha-defensin 1 (HNP1) Y16A/I20A/L25A/F28A mutant.
Tolbert WD, Wu X, Pazgier M
PLoS One (2013) [PMID: 24236072  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Neutrophil defensin 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157838 (Preferred)   search this ID
PDBe-KB: P59665   
X-ray diffraction
1.902Å resolution
Released: 27 Nov 2013
Model geometry
Fit model/data
4lb7
4lb7
4lb7
Crystal structure of human alpha-defensin 1 (W26Ahp mutant)
Pazgier M, Lu W
J Biol Chem (2010) [PMID: 20220136  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Modified residues: AHP   
Assembly name: Neutrophil defensin 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157836 (Preferred)   search this ID
PDBe-KB: P59665   
X-ray diffraction
1.56Å resolution
Released: 9 Mar 2010
Model geometry
Fit model/data
3lo9
3lo9
3lo9
NMR Structure of human alpha defensin HNP-1
Zhang Y, Li S, Doherty TF, Lubkowski J, Lu W, Li J, Barinka C, Hong M
J Mol Biol (2010) [PMID: 20097206  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Neutrophil defensin 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157836 (Preferred)   search this ID
PDBe-KB: P59665   
Solid-state NMR
Released: 9 Feb 2010
Model geometry
Fit model/data
Data not analysed
2kht
2kht
2kht
Crystal structure of human alpha-defensin 1 (HNP1) I20A mutant
Tolbert WD, Wu X, Pazgier M
PLoS One (2013) [PMID: 24236072  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CL   
Assembly name: Neutrophil defensin 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157836 (Preferred)   search this ID
PDBe-KB: P59665   
X-ray diffraction
1.719Å resolution
Released: 27 Nov 2013
Model geometry
Fit model/data
4lbb
4lbb
4lbb
Derivative of human alpha-defensin 1 (HNP1)
Lubkowski J, Pazgier M, Lu W
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Modified residues: DAB   
Assembly name: Neutrophil defensin 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157836 (Preferred)   search this ID
PDBe-KB: P59665   
X-ray diffraction
1.6Å resolution
Released: 29 May 2007
Model geometry
Fit model/data
2pm1
2pm1
2pm1
Crystal structure of human alpha-defensin 1 (Mutant Gln22Ala)
Pazgier M, Lu W
J Biol Chem (2010) [PMID: 20220136  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PEG    PEG    CL   
Assembly name: Neutrophil defensin 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-157838 (Preferred)   search this ID
PDBe-KB: P59665   
X-ray diffraction
1.63Å resolution
Released: 9 Mar 2010
Model geometry
Fit model/data
3h6c
3h6c
3h6c
Entries 1 to 10 of 18
Entries 1 to 10 of 18