Uniprot accession / id : (P62841)
 
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Latest PDB release
Entries released this week  (1)
revised
(3)
 
Entry Information
Entry status  (1)
REL
(122)
 
Experimental methods  (2)
Electron Microscopy
(121)
X-ray diffraction
(1)
 
Authors  (388)
Beckmann R
(46)
Cheng J
(45)
Berninghausen O
(35)
Ameismeier M
(30)
Thoms M
(22)
Buschauer R
(18)
Denk T
(16)
Kratzat H
(15)
Becker T
(14)
Li Y
(14)
Mackens-Kiani T
(14)
Wang M
(12)
Natchiar SK
(11)
Frohlich T
(9)
Fröhlich T
(9)
Hayn M
(9)
Hirschenberger M
(9)
Kirchhoff F
(9)
Koepke L
(9)
Sparrer KMJ
(9)
Straub JH
(9)
Sturzel CM
(9)
Stürzel CM
(9)
Yokoyama T
(9)
Cate JHD
(8)
Chang ST
(8)
Fischer N
(8)
Huang Z
(8)
Li W
(8)
Li X
(8)
Montabana E
(8)
Myasnikov AG
(8)
Petrychenko V
(8)
Rodnina MV
(8)
Ward FR
(8)
Yi S-H
(8)
Yi SH
(8)
Dullea RG
(7)
Hurt E
(7)
Klaholz BP
(7)
Kutay U
(7)
Lau B
(7)
Liras S
(7)
McClure KF
(7)
Shirouzu M
(7)
Ban N
(6)
Fraser CS
(6)
Green R
(6)
Leibundgut M
(6)
Liedtke D
(6)
Peng BZ
(6)
Sokabe M
(6)
van den Heuvel J
(6)
Altman RB
(5)
Blanchard SC
(5)
Brito Querido J
(5)
Gordiyenko Y
(5)
Holm M
(5)
Natchiar KS
(5)
Ramakrishnan V
(5)
Rundlet EJ
(5)
Taunton J
(5)
Wang HY
(5)
Watson ZL
(5)
Ye X
(5)
Zemp I
(5)
Akichika S
(4)
Best K
(4)
Irie T
(4)
Ishibashi K
(4)
Ishiguro K
(4)
Iwasaki S
(4)
Karousis ED
(4)
Ma D
(4)
Matsuzawa I
(4)
Mishima Y
(4)
Mito M
(4)
Muehlemann O
(4)
Muhlemann O
(4)
Mühlemann O
(4)
Saito H
(4)
Sakaguchi Y
(4)
Scaiola A
(4)
Schubert K
(4)
Suzuki T
(4)
Wakabayashi K
(4)
Zhao X
(4)
von Loeffelholz O
(4)
Artus-Revel CG
(3)
Bhaskar V
(3)
Bretones G
(3)
Cavadini S
(3)
Chao JA
(3)
Chen FX
(3)
Diaz-Lopez I
(3)
Diehl FF
(3)
Díaz-López I
(3)
Fernandez IS
(3)
Fernández IS
(3)
Fraser C
(3)
 
More...
 
Homo / hetero assembly  (1)
hetero
(122)
 
Assembly composition  (1)
RNA/protein complex
(122)
 
Assembly polymer count  (29)
37-mer
(12)
83-mer
(11)
36-mer
(10)
86-mer
(10)
35-mer
(9)
80-mer
(8)
81-mer
(7)
38-mer
(6)
84-mer
(6)
50-mer
(4)
51-mer
(4)
54-mer
(4)
82-mer
(4)
34-mer
(3)
79-mer
(3)
85-mer
(3)
33-mer
(2)
53-mer
(2)
57-mer
(2)
78-mer
(2)
88-mer
(2)
31-mer
(1)
48-mer
(1)
49-mer
(1)
52-mer
(1)
89-mer
(1)
92-mer
(1)
hexadecamer
(1)
octadecamer
(1)
 
Resolution distribution
1.5 - 2
(4)
2.0 - 2.5
(9)
2.5 - 3
(38)
3.0 - 3.5
(38)
3.5 - 4
(24)
4.0 - 4.5
(5)
4.5 - 5
(2)
5.5 - 6
(1)
6.0 - 6.5
(1)
 
Release year distribution
2010 - 2015
(7)
2015 - 2020
(56)
2020 - 2025
(92)
2025 - 2030
(3)
 
Journal  (17)
Nature
(25)
Nat Struct Mol Biol
(17)
Nat Commun
(14)
Science
(12)
Nucleic Acids Res
(11)
Mol Cell
(9)
Cell
(7)
Cell Rep
(5)
EMBO J
(5)
Cell Res
(3)
Elife
(3)
PLoS Biol
(3)
Cancer Discov
(2)
Front Mol Biosci
(2)
J Biochem
(2)
To be published
(1)
bioRxiv
(1)
 
Macromolecules
Organism superkingdom  (2)
Eukaryota
(122)
Viruses
(14)
 
Organism name  (7)
Homo sapiens
(115)
Severe acute respiratory syndrome coronavirus 2
(11)
Mus musculus
(4)
Middle East respiratory syndrome-related coronavirus
(2)
Sus scrofa
(2)
Bat Hp-betacoronavirus/Zhejiang2013
(1)
Oryctolagus cuniculus
(1)
 
Molecule name  (595)
40S ribosomal protein S15
(122)
RIG protein
(122)
Small ribosomal subunit protein uS19
(122)
40S ribosomal protein S16
(116)
40S ribosomal protein S17
(116)
40S ribosomal protein S18
(116)
40S ribosomal protein S25
(116)
40S ribosomal protein S28
(116)
40S ribosomal protein S5
(116)
40S ribosomal protein S5, N-terminally processed
(116)
Ke-3
(116)
Ke3
(116)
Small ribosomal subunit protein eS17
(116)
Small ribosomal subunit protein eS25
(116)
Small ribosomal subunit protein eS28
(116)
Small ribosomal subunit protein uS13
(116)
Small ribosomal subunit protein uS7
(116)
Small ribosomal subunit protein uS7, N-terminally processed
(116)
Small ribosomal subunit protein uS9
(116)
40S ribosomal protein S19
(115)
Small ribosomal subunit protein eS19
(115)
40S ribosomal protein S11
(114)
40S ribosomal protein S13
(114)
40S ribosomal protein S15a
(114)
40S ribosomal protein S24
(114)
40S ribosomal protein S27
(114)
40S ribosomal protein S3a
(114)
40S ribosomal protein S4
(114)
40S ribosomal protein S6
(114)
40S ribosomal protein S7
(114)
40S ribosomal protein S8
(114)
40S ribosomal protein S9
(114)
Fte-1
(114)
MPS-1
(114)
Metallopan-stimulin 1
(114)
Phosphoprotein NP33
(114)
Small ribosomal subunit protein eS1
(114)
Small ribosomal subunit protein eS27
(114)
Small ribosomal subunit protein eS6
(114)
Small ribosomal subunit protein eS7
(114)
Small ribosomal subunit protein eS8
(114)
Small ribosomal subunit protein uS15
(114)
Small ribosomal subunit protein uS17
(114)
Small ribosomal subunit protein uS4
(114)
Small ribosomal subunit protein uS8
(114)
v-fos transformation effector protein
(114)
40S ribosomal protein S14
(113)
Small ribosomal subunit protein uS11
(113)
Small ribosomal subunit protein eS24
(112)
Ubiquitin
(112)
37 kDa laminin receptor precursor
(111)
37/67 kDa laminin receptor
(111)
37LRP
(111)
40S ribosomal protein SA
(111)
67 kDa laminin receptor
(111)
67LR
(111)
Colon carcinoma laminin-binding protein
(111)
FAU ubiquitin like and ribosomal protein S30 fusion
(111)
LBP/p40
(111)
LRP/LR
(111)
LamR
(111)
Laminin receptor 1
(111)
Laminin-binding protein precursor p40
(111)
Multidrug resistance-associated protein MGr1-Ag
(111)
NEM/1CHD4
(111)
Small ribosomal subunit protein uS2
(111)
40S ribosomal protein S2
(110)
40S ribosomal protein S21
(110)
Protein LLRep3
(110)
SCR10
(110)
Single copy abundant mRNA protein
(110)
Small ribosomal subunit protein eS21
(110)
Small ribosomal subunit protein eS4, X isoform
(110)
Small ribosomal subunit protein uS5
(110)
40S ribosomal protein S23
(109)
40S ribosomal protein S30
(109)
Small ribosomal subunit protein eS30
(109)
Small ribosomal subunit protein uS12
(109)
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
(109)
Ubiquitin-like protein FUBI
(109)
Cell proliferation-inducing gene 21 protein
(107)
Guanine nucleotide-binding protein subunit beta-2-like 1
(107)
Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed
(107)
Guanine nucleotide-binding protein subunit beta-like protein 12.3
(107)
HLC-7
(107)
Human lung cancer oncogene 7 protein
(107)
Receptor for activated C kinase
(107)
Receptor of activated protein C kinase 1
(107)
Receptor of activated protein C kinase 1, N-terminally processed
(107)
Small ribosomal subunit protein RACK1
(107)
Small ribosomal subunit protein RACK1, N-terminally processed
(107)
40S ribosomal protein S10
(106)
40S ribosomal protein S12
(106)
40S ribosomal protein S20
(106)
40S ribosomal protein S29
(106)
40S ribosomal protein S3
(106)
Small ribosomal subunit protein eS10
(106)
Small ribosomal subunit protein eS12
(106)
Small ribosomal subunit protein uS10
(106)
Small ribosomal subunit protein uS14
(106)
 
More...
 
Molecule type  (1)
Protein
(122)
 
Gene names  (326)
RIG
(118)
RPS15
(118)
D6S218E
(116)
RPS16
(116)
RPS17
(116)
RPS17L
(116)
RPS18
(116)
RPS25
(116)
RPS28
(116)
RPS5
(116)
RPS19
(115)
FTE1
(114)
MFTL
(114)
MPS1
(114)
OK/SW-cl.2
(114)
OK/SW-cl.82
(114)
OK/SW-cl.83
(114)
RPS11
(114)
RPS13
(114)
RPS14
(114)
RPS15A
(114)
RPS24
(114)
RPS27
(114)
RPS3A
(114)
RPS4
(114)
RPS6
(114)
RPS7
(114)
RPS8
(114)
RPS9
(114)
PRO2640
(113)
FAU
(111)
LAMBR
(111)
LAMR1
(111)
RPSA
(111)
CCG2
(110)
RPS2
(110)
RPS21
(110)
RPS4X
(110)
SCAR
(110)
RPS23
(109)
GNB2L1
(107)
HLC7
(107)
PIG21
(107)
RACK1
(107)
OK/SW-cl.26
(106)
RPS10
(106)
RPS12
(106)
RPS20
(106)
RPS27A
(106)
RPS29
(106)
RPS3
(106)
UBA80
(104)
UBCEP1
(104)
RPS26
(93)
RPL41
(86)
RPL19
(53)
RPL24
(53)
EC45
(52)
GIG33
(52)
MSTP030
(52)
OK/SW-cl.103
(52)
OK/SW-cl.32
(52)
PP9932
(52)
RPL1
(52)
RPL11
(52)
RPL13A
(52)
RPL14
(52)
RPL15
(52)
RPL17
(52)
RPL18
(52)
RPL18A
(52)
RPL21
(52)
RPL23
(52)
RPL23A
(52)
RPL26
(52)
RPL28
(52)
RPL3
(52)
RPL30
(52)
RPL31
(52)
RPL32
(52)
RPL34
(52)
RPL35
(52)
RPL35A
(52)
RPL36
(52)
RPL36A
(52)
RPL37
(52)
RPL37A
(52)
RPL38
(52)
RPL39
(52)
RPL4
(52)
RPL5
(52)
RPL6
(52)
RPL7
(52)
RPL7A
(52)
RPL9
(52)
RPL9P7
(52)
RPL9P8
(52)
RPL9P9
(52)
SURF-3
(52)
SURF3
(52)
 
More...
 
Interacting Molecules  (305)
Small ribosomal subunit protein eS17
(122)
Small ribosomal subunit protein eS28
(122)
Small ribosomal subunit protein uS13
(122)
Small ribosomal subunit protein uS7
(122)
Small ribosomal subunit protein uS9
(122)
Small ribosomal subunit protein eS19
(121)
Small ribosomal subunit protein eS1
(120)
Small ribosomal subunit protein eS25
(120)
Small ribosomal subunit protein uS15
(119)
Small ribosomal subunit protein uS17
(119)
Small ribosomal subunit protein eS6
(118)
Small ribosomal subunit protein eS7
(118)
Small ribosomal subunit protein eS8
(118)
Small ribosomal subunit protein uS4
(118)
Small ribosomal subunit protein uS8
(118)
Small ribosomal subunit protein uS11
(117)
Small ribosomal subunit protein uS2
(117)
Small ribosomal subunit protein eS21
(116)
Small ribosomal subunit protein eS24
(116)
Small ribosomal subunit protein eS27
(116)
Small ribosomal subunit protein uS19
(116)
Small ribosomal subunit protein uS12
(115)
Small ribosomal subunit protein uS5
(115)
Small ribosomal subunit protein RACK1
(113)
Small ribosomal subunit protein uS10
(112)
Small ribosomal subunit protein uS14
(112)
Small ribosomal subunit protein uS3
(112)
Small ribosomal subunit protein eS10
(111)
Small ribosomal subunit protein eS4, X isoform
(110)
Small ribosomal subunit protein eS12
(109)
18S Ribosomal RNA
(107)
Small ribosomal subunit protein eS26
(99)
Small ribosomal subunit protein eS30
(97)
Small ribosomal subunit protein eS32
(90)
Ubiquitin-ribosomal protein eS31 fusion protein
(89)
Large ribosomal subunit protein eL14
(58)
Large ribosomal subunit protein eL19
(58)
Large ribosomal subunit protein eL20
(58)
Large ribosomal subunit protein eL21
(58)
Large ribosomal subunit protein eL22
(58)
Large ribosomal subunit protein eL24
(58)
Large ribosomal subunit protein eL30
(58)
Large ribosomal subunit protein eL31
(58)
Large ribosomal subunit protein eL32
(58)
Large ribosomal subunit protein eL34
(58)
Large ribosomal subunit protein eL38
(58)
Large ribosomal subunit protein uL18
(58)
Large ribosomal subunit protein uL29
(58)
Large ribosomal subunit protein uL5
(58)
Large ribosomal subunit protein uL6
(58)
Large ribosomal subunit protein eL18
(57)
Large ribosomal subunit protein eL29
(57)
Large ribosomal subunit protein eL39
(57)
Large ribosomal subunit protein eL6
(57)
Large ribosomal subunit protein uL14
(57)
Large ribosomal subunit protein uL15
(57)
Large ribosomal subunit protein uL22
(57)
Large ribosomal subunit protein uL4
(57)
Large ribosomal subunit protein eL15
(56)
Large ribosomal subunit protein eL27
(56)
Large ribosomal subunit protein eL28
(56)
Large ribosomal subunit protein eL33
(56)
Large ribosomal subunit protein eL36
(56)
Large ribosomal subunit protein eL37
(56)
Large ribosomal subunit protein eL43
(56)
Large ribosomal subunit protein eL8
(56)
Large ribosomal subunit protein uL13
(56)
Large ribosomal subunit protein uL23
(56)
Large ribosomal subunit protein uL24
(56)
Large ribosomal subunit protein uL3
(56)
Large ribosomal subunit protein uL30
(56)
Large ribosomal subunit protein eL13
(55)
28S ribosomal RNA
(54)
5.8S ribosomal RNA
(53)
5S ribosomal RNA
(53)
Large ribosomal subunit protein uL2
(52)
Large ribosomal subunit protein eL42
(49)
Ubiquitin-ribosomal protein eL40 fusion protein
(41)
Messenger RNA
(37)
Ribosomal protein uL16-like
(31)
Large ribosomal subunit protein uL1
(29)
tRNA
(22)
Large ribosomal subunit protein uL16
(21)
Large ribosomal subunit protein uL11
(19)
Small ribosomal subunit protein eS31
(19)
Eukaryotic translation initiation factor 3 subunit A
(18)
Eukaryotic translation initiation factor 3 subunit C
(18)
Eukaryotic translation initiation factor 3 subunit D
(18)
Eukaryotic translation initiation factor 3 subunit E
(18)
Eukaryotic translation initiation factor 3 subunit L
(18)
Eukaryotic translation initiation factor 3 subunit M
(18)
Large ribosomal subunit protein uL10
(18)
RNA-binding protein PNO1
(18)
Eukaryotic translation initiation factor 3 subunit B
(17)
Eukaryotic translation initiation factor 3 subunit F
(17)
Eukaryotic translation initiation factor 3 subunit H
(17)
Eukaryotic translation initiation factor 3 subunit K
(17)
Pre-rRNA-processing protein TSR1 homolog
(16)
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
(16)
Eukaryotic translation initiation factor 3 subunit G
(15)
 
More...
 
Interacting ligands  (26)
ZN : ZINC ION
(105)
MG : MAGNESIUM ION
(75)
K : POTASSIUM ION
(11)
SPD : SPERMIDINE
(8)
GTP : GUANOSINE-5'-TRIPHOSPHATE
(7)
MVM : N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide
(7)
ADP : ADENOSINE-5'-DIPHOSPHATE
(5)
ATP : ADENOSINE-5'-TRIPHOSPHATE
(5)
PUT : 1,4-DIAMINOBUTANE
(5)
3H3 : 4-{(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4E,6Z,10E)-3-methyl-12-oxooxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-en-1-yl}piperidine-2,6-dione
(4)
3HE : 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione
(4)
MET : METHIONINE
(3)
SAH : S-ADENOSYL-L-HOMOCYSTEINE
(3)
SF4 : IRON/SULFUR CLUSTER
(3)
T1C : TIGECYCLINE
(3)
ASP : ASPARTIC ACID
(2)
GSP : 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
(2)
NA : SODIUM ION
(2)
PHE : PHENYLALANINE
(2)
84D : Dibekacin
(1)
84G : Arbekacin
(1)
GNP : PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
(1)
TRS : 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
(1)
WV3 : 4-{(2R)-2-[(1R,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione
(1)
YRB : (3R,6R,9S,12S,15S,18S,20R,24aR)-6-[(2S)-butan-2-yl]-3,12-bis[(1R)-1-hydroxy-2-methylpropyl]-8,9,11,17,18-pentamethyl-15-[(2S)-2-methylbutyl]hexadecahydropyrido[1,2-a][1,4,7,10,13,16,19]heptaazacyclohenicosine-1,4,7,10,13,16,19(21H)-heptone
(1)
ZIY : plitidepsin
(1)
 
Function and Biology
EC number / name  (12)
4.2.99.18 : DNA-(apurinic or apyrimidinic site) lyase
(106)
3.4.19.12 : Ubiquitinyl hydrolase 1
(27)
3.6.4.13 : RNA helicase
(20)
2.1.1.57 : Methyltransferase cap1
(14)
2.7.11.1 : Non-specific serine/threonine protein kinase
(14)
3.6.4.12 : DNA helicase
(14)
3.6.5.3 : Protein-synthesizing GTPase
(14)
2.1.1.56 : mRNA (guanine-N(7))-methyltransferase
(13)
2.7.7.48 : RNA-directed RNA polymerase
(13)
2.7.7.50 : mRNA guanylyltransferase
(13)
3.4.22.69 : SARS coronavirus main proteinase
(11)
3.1.13.1 : Exoribonuclease II
(2)
 
Biological function  (164)
RNA binding
(119)
structural constituent of ribosome
(119)
protein binding
(117)
ubiquitin ligase inhibitor activity
(117)
DNA binding
(113)
identical protein binding
(113)
mRNA binding
(113)
protein kinase binding
(113)
rRNA binding
(113)
small ribosomal subunit rRNA binding
(113)
translation regulator activity
(113)
zinc ion binding
(113)
fibroblast growth factor binding
(112)
mRNA 3'-UTR binding
(111)
mRNA 5'-UTR binding
(111)
translation initiation factor binding
(111)
cadherin binding
(110)
enzyme binding
(110)
ribosome binding
(110)
nucleic acid binding
(106)
metal ion binding
(105)
BH3 domain binding
(104)
SH2 domain binding
(104)
cyclin binding
(104)
cysteine-type endopeptidase activator activity involved in apoptotic process
(104)
enzyme activator activity
(104)
ion channel inhibitor activity
(104)
molecular adaptor activity
(104)
protein homodimerization activity
(104)
protein kinase C binding
(104)
protein phosphatase binding
(104)
protein serine/threonine kinase inhibitor activity
(104)
protein tyrosine kinase inhibitor activity
(104)
receptor tyrosine kinase binding
(104)
signaling adaptor activity
(104)
signaling receptor binding
(104)
DNA N-glycosylase activity
(103)
DNA endonuclease activity
(103)
DNA-(apurinic or apyrimidinic site) endonuclease activity
(103)
DNA-binding transcription factor binding
(103)
Hsp70 protein binding
(103)
Hsp90 protein binding
(103)
MDM2/MDM4 family protein binding
(103)
RNA polymerase II transcription regulatory region sequence-specific DNA binding
(103)
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
(103)
damaged DNA binding
(103)
iron-sulfur cluster binding
(103)
kinase binding
(103)
lyase activity
(103)
microtubule binding
(103)
oxidized purine DNA binding
(103)
oxidized pyrimidine DNA binding
(103)
protein kinase A binding
(103)
protein-containing complex binding
(103)
supercoiled DNA binding
(103)
tubulin binding
(103)
ubiquitin-like protein conjugating enzyme binding
(103)
ubiquitin protein ligase binding
(100)
laminin binding
(93)
laminin receptor activity
(93)
virus receptor activity
(93)
protein tag activity
(89)
tRNA binding
(66)
5S rRNA binding
(52)
large ribosomal subunit rRNA binding
(52)
transcription coactivator binding
(52)
TORC2 complex binding
(42)
heparin binding
(42)
GTPase activity
(40)
GTP binding
(38)
hydrolase activity
(35)
translation initiation factor activity
(27)
ATP binding
(20)
mRNA cap binding
(18)
metal-dependent deubiquitinase activity
(16)
metallopeptidase activity
(16)
peptidase activity
(16)
translation factor activity, RNA binding
(16)
cysteine-type deubiquitinase activity
(15)
cysteine-type peptidase activity
(15)
ribosomal small subunit binding
(15)
structural molecule activity
(15)
U3 snoRNA binding
(14)
RNA endonuclease activity
(13)
endonuclease activity
(13)
3-phosphoinositide-dependent protein kinase activity
(11)
AMP-activated protein kinase activity
(11)
DNA-dependent protein kinase activity
(11)
Rho-dependent protein serine/threonine kinase activity
(11)
eukaryotic translation initiation factor 2alpha kinase activity
(11)
histone H2AS1 kinase activity
(11)
histone H2AS121 kinase activity
(11)
histone H2AT120 kinase activity
(11)
histone H2AXS139 kinase activity
(11)
histone H2BS14 kinase activity
(11)
histone H2BS36 kinase activity
(11)
histone H3S10 kinase activity
(11)
histone H3S28 kinase activity
(11)
histone H3S57 kinase activity
(11)
histone H3T11 kinase activity
(11)
 
More...
 
Biological process  (316)
translation
(119)
cytoplasmic translation
(117)
rRNA processing
(117)
ribosomal small subunit biogenesis
(117)
cellular response to leukemia inhibitory factor
(113)
erythrocyte differentiation
(113)
erythrocyte homeostasis
(113)
gastrulation
(113)
maintenance of translational fidelity
(113)
maturation of SSU-rRNA
(113)
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
(113)
positive regulation of apoptotic process
(113)
positive regulation of gene expression
(113)
regulation of translation
(113)
regulation of translational fidelity
(113)
ribosomal small subunit assembly
(113)
translational initiation
(113)
antimicrobial humoral immune response mediated by antimicrobial peptide
(112)
defense response to Gram-negative bacterium
(112)
killing of cells of another organism
(112)
monocyte chemotaxis
(112)
negative regulation of respiratory burst involved in inflammatory response
(112)
nucleolus organization
(112)
positive regulation of respiratory burst involved in inflammatory response
(112)
positive regulation of signal transduction by p53 class mediator
(112)
negative regulation of RNA splicing
(111)
negative regulation of ubiquitin protein ligase activity
(111)
negative regulation of ubiquitin-dependent protein catabolic process
(111)
neural crest cell differentiation
(111)
neural tube closure
(111)
positive regulation of cell cycle
(111)
positive regulation of cell population proliferation
(111)
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
(111)
positive regulation of translation
(111)
protein stabilization
(111)
protein ubiquitination
(111)
response to virus
(111)
translation at postsynapse
(111)
translation at presynapse
(111)
G1/S transition of mitotic cell cycle
(110)
T cell differentiation in thymus
(110)
T cell proliferation involved in immune response
(110)
TOR signaling
(110)
activation-induced cell death of T cells
(110)
erythrocyte development
(110)
glucose homeostasis
(110)
mammalian oogenesis stage
(110)
mitotic cell cycle
(110)
negative regulation of apoptotic process
(110)
placenta development
(110)
negative regulation of transcription by RNA polymerase II
(108)
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
(107)
endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
(107)
ribosome biogenesis
(107)
stress granule assembly
(106)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(105)
apoptotic process
(104)
cell division
(104)
cellular response to glucose stimulus
(104)
cellular response to growth factor stimulus
(104)
negative regulation of Wnt signaling pathway
(104)
negative regulation of cell growth
(104)
negative regulation of endoplasmic reticulum unfolded protein response
(104)
negative regulation of gene expression
(104)
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
(104)
negative regulation of phagocytosis
(104)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
(104)
negative regulation of protein binding
(104)
negative regulation of smoothened signaling pathway
(104)
negative regulation of translation
(104)
negative regulation of translational frameshifting
(104)
pigmentation
(104)
positive regulation of GTPase activity
(104)
positive regulation of Golgi to plasma membrane protein transport
(104)
positive regulation of cell migration
(104)
positive regulation of gastrulation
(104)
positive regulation of intrinsic apoptotic signaling pathway
(104)
positive regulation of mitochondrial depolarization
(104)
positive regulation of protein phosphorylation
(104)
positive regulation of protein-containing complex assembly
(104)
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
(104)
regulation of cell cycle
(104)
regulation of cell division
(104)
regulation of establishment of cell polarity
(104)
regulation of protein localization
(104)
rescue of stalled ribosome
(104)
rhythmic process
(104)
DNA damage response
(103)
DNA repair
(103)
base-excision repair
(103)
cellular response to hydrogen peroxide
(103)
cellular response to reactive oxygen species
(103)
cellular response to tumor necrosis factor
(103)
chromosome segregation
(103)
negative regulation of DNA repair
(103)
negative regulation of protein ubiquitination
(103)
positive regulation of DNA repair
(103)
positive regulation of NF-kappaB transcription factor activity
(103)
positive regulation of T cell receptor signaling pathway
(103)
positive regulation of activated T cell proliferation
(103)
 
More...
 
Biological cell component  (114)
cytoplasm
(119)
cytosolic small ribosomal subunit
(119)
ribonucleoprotein complex
(119)
ribosome
(119)
small ribosomal subunit
(119)
cytosol
(117)
cytosolic ribosome
(117)
cytoplasmic side of rough endoplasmic reticulum membrane
(115)
cell body
(113)
cytoskeleton
(113)
dendrite
(113)
endoplasmic reticulum
(113)
extracellular exosome
(113)
focal adhesion
(113)
membrane
(113)
nucleolus
(113)
nucleoplasm
(113)
nucleus
(113)
perinuclear region of cytoplasm
(113)
postsynaptic density
(113)
rough endoplasmic reticulum
(113)
small-subunit processome
(113)
synapse
(113)
plasma membrane
(112)
centrosome
(111)
cytoplasmic ribonucleoprotein granule
(111)
postsynapse
(111)
presynapse
(111)
protein-containing complex
(111)
ribosomal subunit
(111)
cell projection
(105)
IRE1-RACK1-PP2A complex
(104)
midbody
(104)
mitochondrion
(104)
neuron projection
(104)
neuronal cell body
(104)
perikaryon
(104)
phagocytic cup
(104)
spindle
(104)
NF-kappaB complex
(103)
mitochondrial inner membrane
(103)
mitochondrial matrix
(103)
mitotic spindle
(103)
ruffle membrane
(103)
extracellular space
(100)
intracellular membrane-bounded organelle
(99)
Golgi apparatus
(97)
endocytic vesicle membrane
(89)
endoplasmic reticulum membrane
(89)
endosome membrane
(89)
mitochondrial outer membrane
(89)
vesicle
(89)
cytosolic large ribosomal subunit
(85)
A band
(52)
GAIT complex
(52)
eukaryotic 80S initiation complex
(52)
intracellular membraneless organelle
(52)
large ribosomal subunit
(52)
glutamatergic synapse
(42)
nuclear body
(42)
lysosomal membrane
(35)
eukaryotic 43S preinitiation complex
(21)
eukaryotic 48S preinitiation complex
(21)
eukaryotic translation initiation factor 3 complex
(20)
preribosome, small subunit precursor
(20)
eukaryotic translation initiation factor 3 complex, eIF3m
(19)
fibrillar center
(19)
smooth endoplasmic reticulum
(19)
PML body
(18)
chromatin
(18)
cytoplasmic stress granule
(18)
eukaryotic translation initiation factor 3 complex, eIF3e
(18)
extracellular region
(17)
multi-eIF complex
(16)
chromosome
(12)
azurophil granule lumen
(11)
eukaryotic translation initiation factor 2 complex
(11)
glial limiting end-foot
(11)
translation initiation ternary complex
(11)
apical part of cell
(10)
ficolin-1-rich granule lumen
(10)
secretory granule lumen
(10)
aggresome
(7)
methyltransferase complex
(7)
nuclear membrane
(7)
eukaryotic translation initiation factor 4F complex
(5)
tRNA (m2G10) methyltransferase complex
(5)
90S preribosome
(4)
nuclear stress granule
(4)
ciliary basal body
(3)
cortical actin cytoskeleton
(3)
cytoplasmic side of lysosomal membrane
(3)
eukaryotic translation elongation factor 1 complex
(3)
translation release factor complex
(3)
Ski complex
(2)
TORC1 complex
(2)
cytoplasmic exosome (RNase complex)
(2)
euchromatin
(2)
exosome (RNase complex)
(2)
nuclear chromosome
(2)
 
More...
 
Sequence and Structure classification
CATH class  (5)
Alpha Beta
(6)
Mainly Alpha
(6)
Mainly Beta
(6)
Few Secondary Structures
(4)
Special
(2)
 
CATH topology  (25)
Alpha-Beta Plaits
(6)
Arc Repressor Mutant, subunit A
(6)
Dna Ligase; domain 1
(6)
Double Stranded RNA Binding Domain
(6)
Helix Hairpins
(6)
Hypothetical Cytosolic Protein; Chain: A;
(6)
N-terminal domain of TfIIb
(6)
Nucleotidyltransferase; domain 5
(6)
OB fold (Dihydrolipoamide Acetyltransferase, E2P)
(6)
Phosducin; domain 2
(6)
Ribosomal Protein S5; domain 2
(6)
Ribosomal Protein S7
(6)
Ribosomal Protein S8; Chain: A, domain 1
(6)
Rossmann fold
(6)
SH3 type barrels.
(6)
Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region; Chain A
(6)
60s Ribosomal Protein L30; Chain: A;
(5)
Methylamine Dehydrogenase; Chain H
(5)
30s Ribosomal Protein S14; Chain N
(4)
first zn-finger domain of poly(adp-ribose) polymerase-1
(3)
Diphtheria Toxin Repressor; domain 2
(2)
GMP Synthetase; Chain A, domain 3
(2)
Helicase, Ruva Protein; domain 3
(2)
Ribosomal protein S3 C-terminal domain
(2)
Single alpha-helices involved in coiled-coils or other helix-helix interfaces
(2)
 
Pfam accession / name  (193)
PF00203 : Ribosomal_S19
(122)
PF00177 : Ribosomal_S7
(116)
PF00380 : Ribosomal_S9
(116)
PF00416 : Ribosomal_S13
(116)
PF00833 : Ribosomal_S17e
(116)
PF01200 : Ribosomal_S28e
(116)
PF03297 : Ribosomal_S25
(116)
PF01090 : Ribosomal_S19e
(115)
PF00163 : Ribosomal_S4
(114)
PF00312 : Ribosomal_S15
(114)
PF00366 : Ribosomal_S17
(114)
PF00410 : Ribosomal_S8
(114)
PF00411 : Ribosomal_S11
(114)
PF00467 : KOW
(114)
PF00900 : Ribosomal_S4e
(114)
PF01015 : Ribosomal_S3Ae
(114)
PF01092 : Ribosomal_S6e
(114)
PF01201 : Ribosomal_S8e
(114)
PF01248 : Ribosomal_L7Ae
(114)
PF01251 : Ribosomal_S7e
(114)
PF01282 : Ribosomal_S24e
(114)
PF01479 : S4
(114)
PF01667 : Ribosomal_S27e
(114)
PF08069 : Ribosomal_S13_N
(114)
PF08071 : RS4NT
(114)
PF16121 : 40S_S4_C
(114)
PF16205 : Ribosomal_S17_N
(114)
PF00318 : Ribosomal_S2
(111)
PF04758 : Ribosomal_S30
(111)
PF00333 : Ribosomal_S5
(110)
PF01249 : Ribosomal_S21e
(110)
PF03719 : Ribosomal_S5_C
(110)
PF00164 : Ribosom_S12_S23
(109)
PF00400 : WD40
(107)
PF00189 : Ribosomal_S3_C
(106)
PF00253 : Ribosomal_S14
(106)
PF00338 : Ribosomal_S10
(106)
PF03501 : S10_plectin
(106)
PF07650 : KH_2
(106)
PF01599 : Ribosomal_S27
(104)
PF16122 : 40S_SA_C
(96)
PF00240 : ubiquitin
(94)
PF01283 : Ribosomal_S26e
(93)
PF05162 : Ribosomal_L41
(86)
PF00237 : Ribosomal_L22
(52)
PF00238 : Ribosomal_L14
(52)
PF00252 : Ribosomal_L16
(52)
PF00276 : Ribosomal_L23
(52)
PF00281 : Ribosomal_L5
(52)
PF00297 : Ribosomal_L3
(52)
PF00327 : Ribosomal_L30
(52)
PF00347 : Ribosomal_L6
(52)
PF00572 : Ribosomal_L13
(52)
PF00573 : Ribosomal_L4
(52)
PF00673 : Ribosomal_L5_C
(52)
PF00827 : Ribosomal_L15e
(52)
PF00831 : Ribosomal_L29
(52)
PF00832 : Ribosomal_L39
(52)
PF00935 : Ribosomal_L44
(52)
PF01157 : Ribosomal_L21e
(52)
PF01158 : Ribosomal_L36e
(52)
PF01159 : Ribosomal_L6e
(52)
PF01198 : Ribosomal_L31e
(52)
PF01199 : Ribosomal_L34e
(52)
PF01246 : Ribosomal_L24e
(52)
PF01247 : Ribosomal_L35Ae
(52)
PF01280 : Ribosomal_L19e
(52)
PF01655 : Ribosomal_L32e
(52)
PF01775 : Ribosomal_L18A
(52)
PF01776 : Ribosomal_L22e
(52)
PF01778 : Ribosomal_L28e
(52)
PF01780 : Ribosomal_L37ae
(52)
PF01781 : Ribosomal_L38e
(52)
PF01907 : Ribosomal_L37e
(52)
PF01929 : Ribosomal_L14e
(52)
PF03939 : Ribosomal_L23eN
(52)
PF08079 : Ribosomal_L30_N
(52)
PF14204 : Ribosomal_L18_c
(52)
PF14374 : Ribos_L4_asso_C
(52)
PF16906 : Ribosomal_L26
(52)
PF17135 : Ribosomal_L18
(52)
PF17144 : Ribosomal_L5e
(52)
PF00828 : Ribosomal_L27A
(51)
PF01294 : Ribosomal_L13e
(51)
PF01779 : Ribosomal_L29e
(51)
PF03868 : Ribosomal_L6e_N
(51)
PF01777 : Ribosomal_L27e
(50)
PF00181 : Ribosomal_L2
(47)
PF01020 : Ribosomal_L40e
(47)
PF03947 : Ribosomal_L2_C
(47)
PF00687 : Ribosomal_L1
(27)
PF00009 : GTP_EFTU
(24)
PF03144 : GTP_EFTU_D2
(22)
PF00076 : RRM_1
(20)
PF01399 : PCI
(18)
PF05091 : eIF-3_zeta
(18)
PF09440 : eIF3_N
(18)
PF10255 : Paf67
(18)
PF18005 : eIF3m_C_helix
(18)
PF21357 : EIF3E_C
(18)
 
More...
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(4)
 
Diffraction radiation source type  (1)
Synchrotron
(1)
 
Diffraction source  (1)
APS BEAMLINE 24-ID-C
(1)
 
Synchrotron site  (1)
APS
(1)
 
Diffraction detector type  (1)
Pixel
(1)
 
Refinement software  (3)
PHENIX
(25)
phenix.real_space_refine
(14)
REFMAC
(2)
 
EM microscope model  (4)
FEI TITAN KRIOS
(114)
FEI TECNAI ARCTICA
(3)
JEOL CRYO ARM 300
(3)
TFS KRIOS
(2)
 
EM detector name  (10)
GATAN K2 SUMMIT (4k x 4k)
(45)
GATAN K3 (6k x 4k)
(30)
FEI FALCON II (4k x 4k)
(17)
FEI FALCON III (4k x 4k)
(13)
FEI FALCON IV (4k x 4k)
(8)
GATAN K3 BIOQUANTUM (6k x 4k)
(4)
GATAN K2 QUANTUM (4k x 4k)
(2)
FEI EAGLE (4k x 4k)
(1)
GATAN K3 BIOCONTINUUM (6k x 4k)
(1)
TVIPS TEMCAM-F416 (4k x 4k)
(1)
 
Representative Structures
Representative Structures
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50%
40%
30%
...
Entries 1 to 10 of 122
Entries 1 to 10 of 122
 Select all entries on this page
Crystal structure of the human 40S ribosomal subunit in complex with DENR-MCT-1.
Lomakin IB, Stolboushkina EA, Vaidya AT, Garber MB, Dmitriev SE, Steitz TA
Cell Rep (2017) [PMID: 28723557  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-123203 (Preferred)   search this ID
PDBe-KB: E9PR30    P62753    P62081    P60866    P46781    Q9ULC4    (view 30 more)
X-ray diffraction
6Å resolution
Released: 19 Jul 2017
Model geometry
Fit model/data
5vyc
5vyc
5vyc
SARS-CoV-2-Nsp1-40S complex, focused on head
Schubert K, Karousis ED, Jomaa A, Scaiola A, Echeverria B, Gurzeler L-A, Leibundgut ML, Thiel V, Muehlemann O, Ban N
Nat Struct Mol Biol (2020) [PMID: 32908316  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
PDBe complex ID: PDB-CPX-140349 (Preferred)   search this ID
PDBe-KB: P62979    P60866    P62851    P63244    P46782    P39019    (view 9 more)
Electron Microscopy
2.8Å resolution
Released: 22 Jul 2020
Model geometry
Fit model/data
Data not analysed
6zol
6zol
6zol
Cryo-EM structure of a late human pre-40S ribosomal subunit - State A
Ameismeier M, Cheng J, Berninghausen O, Beckmann R
Nature (2018) [PMID: 29875412  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Assembly name: BUD23-TRM112 methyltransferase complex and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-129073 (Preferred)   search this ID
PDBe-KB: Q96GA3    P62753    P62081    Q13895    P46781    P62241    (view 22 more)
Electron Microscopy
4.5Å resolution
Released: 6 Jun 2018
Model geometry
Fit model/data
Data not analysed
6g4w
6g4w
6g4w
Cryo-EM structure of a late human pre-40S ribosomal subunit - State B
Ameismeier M, Cheng J, Berninghausen O, Beckmann R
Nature (2018) [PMID: 29875412  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
PDBe complex ID: PDB-CPX-140347 (Preferred)   search this ID
PDBe-KB: P62861    P62753    P62081    Q13895    P46781    Q9ULX3    (view 24 more)
Electron Microscopy
4Å resolution
Released: 6 Jun 2018
Model geometry
Fit model/data
Data not analysed
6g4s
6g4s
6g4s
Cryo-EM structure of the human ubiquitylated pre-40S ribosome with RIOK3 (without NOB1)
Huang Z, Wang M, Li Y, Beckmann R, Cheng J
Mol Cell (2025) [PMID: 39947183  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-285154 (Preferred)   search this ID
PDBe-KB: P62244    P62753    P62081    P60866    P62979    P46781    (view 29 more)
Electron Microscopy
3.7Å resolution
Released: 12 Feb 2025
Model geometry
Fit model/data
Data not analysed
8zdd
8zdd
8zdd
Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B2
Cheng J, Lau B, Thoms M, Ameismeier M, Berninghausen O, Hurt E, Beckmann R
Nucleic Acids Res (2022) [PMID: 36321656  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-140346 (Preferred)   search this ID
PDBe-KB: P62861    P62753    P62081    Q5JTH9    P62979    Q13895    (view 27 more)
Electron Microscopy
3Å resolution
Released: 19 Oct 2022
Model geometry
Fit model/data
Data not analysed
7wtz
7wtz
7wtz
Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B1
Cheng J, Lau B, Thoms M, Ameismeier M, Berninghausen O, Hurt E, Beckmann R
Nucleic Acids Res (2022) [PMID: 36321656  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-140345 (Preferred)   search this ID
PDBe-KB: P62861    P62753    P62081    Q5JTH9    P62979    Q13895    (view 27 more)
Electron Microscopy
3.1Å resolution
Released: 19 Oct 2022
Model geometry
Fit model/data
Data not analysed
7wtx
7wtx
7wtx
Cryo-EM structure of the human 40S ribosome with LARP1 and LRRC47
Huang Z, Ye X, Li Y, Cheng J
EMBO J (2024) [PMID: 39533057  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-281481 (Preferred)   search this ID
PDBe-KB: P62861    P62753    P62081    P60866    P62979    P46781    (view 30 more)
Electron Microscopy
3.4Å resolution
Released: 20 Nov 2024
Model geometry
Fit model/data
Data not analysed
8xp3
8xp3
8xp3
Cryo-EM structure of the human 40S ribosome with LARP1
Huang Z, Ye X, Li Y, Cheng J
EMBO J (2024) [PMID: 39533057  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-281482 (Preferred)   search this ID
PDBe-KB: P62861    P62753    P62081    P60866    P62979    P46781    (view 29 more)
Electron Microscopy
3.2Å resolution
Released: 20 Nov 2024
Model geometry
Fit model/data
Data not analysed
8xp2
8xp2
8xp2
Cryo-EM structure of the human ubiquitylated 40S ribosome with RIOK3
Huang Z, Wang M, Li Y, Beckmann R, Cheng J
Mol Cell (2025) [PMID: 39947183  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-285152 (Preferred)   search this ID
PDBe-KB: P62280    P62753    P62081    P60866    P62979    P46781    (view 29 more)
Electron Microscopy
3.6Å resolution
Released: 12 Feb 2025
Model geometry
Fit model/data
Data not analysed
8zdb
8zdb
8zdb
...
Entries 1 to 10 of 122
Entries 1 to 10 of 122