Uniprot accession / id : (P62899)
 
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Entry Information
Entry status  (1)
REL
(171)
 
Experimental methods  (1)
Electron Microscopy
(171)
 
Authors  (523)
Beckmann R
(29)
Hegde RS
(27)
Cheng J
(20)
Shao S
(18)
Klinge S
(17)
Li Y
(17)
Ramakrishnan V
(17)
Vanden Broeck A
(17)
Berninghausen O
(16)
Brown A
(16)
Murray J
(16)
Gao N
(15)
Li N
(15)
Liang X
(15)
Ma C
(15)
Zhang Y
(15)
Becker T
(14)
Buschauer R
(14)
Taunton J
(14)
Ban N
(12)
Natchiar SK
(12)
Chen Y
(11)
Denk T
(11)
Luo S
(11)
Chandrasekaran V
(10)
Fernandez IS
(10)
Fernández IS
(10)
Myasnikov AG
(9)
Yokoyama T
(9)
Cate JHD
(8)
Chang ST
(8)
Kratzat H
(8)
Li W
(8)
Li X
(8)
Scaiola A
(8)
Ward FR
(8)
Blanchard SC
(7)
Braunger K
(7)
Dullea RG
(7)
Holm M
(7)
Jomaa A
(7)
Klaholz BP
(7)
Liras S
(7)
Mackens-Kiani T
(7)
McClure KF
(7)
Montabana E
(7)
Rundlet EJ
(7)
Shirouzu M
(7)
Altman RB
(6)
Burger J
(6)
Bürger J
(6)
Mielke T
(6)
Natchiar KS
(6)
Spahn CMT
(6)
Wang HY
(6)
Wang M
(6)
Watson ZL
(6)
Deuerling E
(5)
Gamerdinger M
(5)
Iwasaki S
(5)
Juszkiewicz S
(5)
Kulathu Y
(5)
Leibundgut M
(5)
Lin Z
(5)
Loerke J
(5)
Peter JJ
(5)
Shan SO
(5)
Suzuki T
(5)
Thoms M
(5)
Acosta-Reyes F
(4)
Acosta-Reyes FJ
(4)
Akichika S
(4)
Ameismeier M
(4)
Atkins JF
(4)
Baird MR
(4)
Beatrix B
(4)
Bhaskar V
(4)
Bhatt PR
(4)
Bode JW
(4)
Cavadini S
(4)
Chao JA
(4)
Cymer F
(4)
DaRosa PA
(4)
Dong M
(4)
Dong MQ
(4)
Dreos R
(4)
Frank J
(4)
Frohlich T
(4)
Fröhlich T
(4)
Gatfield D
(4)
Graff-Meyer A
(4)
Gumbin SC
(4)
Harper JW
(4)
Hayn M
(4)
Heijne GV
(4)
Hirschenberger M
(4)
Hsieh HH
(4)
Irie T
(4)
Ishibashi K
(4)
Ishiguro K
(4)
 
More...
 
Homo / hetero assembly  (1)
hetero
(171)
 
Assembly composition  (1)
RNA/protein complex
(171)
 
Assembly polymer count  (34)
86-mer
(20)
83-mer
(15)
85-mer
(12)
87-mer
(12)
81-mer
(11)
84-mer
(9)
80-mer
(8)
48-mer
(7)
53-mer
(7)
82-mer
(6)
45-mer
(5)
50-mer
(5)
54-mer
(5)
79-mer
(5)
88-mer
(5)
51-mer
(4)
52-mer
(4)
56-mer
(4)
58-mer
(4)
46-mer
(3)
59-mer
(3)
92-mer
(3)
49-mer
(2)
78-mer
(2)
43-mer
(1)
44-mer
(1)
47-mer
(1)
55-mer
(1)
60-mer
(1)
61-mer
(1)
62-mer
(1)
63-mer
(1)
65-mer
(1)
89-mer
(1)
 
Resolution distribution
1.5 - 2
(6)
2.0 - 2.5
(16)
2.5 - 3
(52)
3.0 - 3.5
(64)
3.5 - 4
(25)
4.0 - 4.5
(3)
4.5 - 5
(2)
6.0 - 6.5
(1)
6.5 - 7
(1)
9.0 - 9.5
(1)
 
Release year distribution
2010 - 2015
(10)
2015 - 2020
(69)
2020 - 2025
(116)
2025 - 2030
(1)
 
Journal  (21)
Science
(36)
Nature
(23)
Cell
(17)
Nat Commun
(17)
Cell Res
(11)
Elife
(11)
Mol Cell
(11)
Nat Struct Mol Biol
(11)
Cell Rep
(7)
EMBO J
(4)
Nucleic Acids Res
(3)
PLoS Biol
(3)
Sci Adv
(3)
To be published
(3)
Cancer Discov
(2)
Front Mol Biosci
(2)
J Biochem
(2)
bioRxiv
(2)
J Am Chem Soc
(1)
Nat Chem Biol
(1)
RNA
(1)
 
Macromolecules
Organism superkingdom  (2)
Eukaryota
(171)
Viruses
(4)
 
Organism name  (6)
Homo sapiens
(98)
Oryctolagus cuniculus
(64)
Mus musculus
(5)
Severe acute respiratory syndrome coronavirus 2
(4)
Sus scrofa
(4)
Homo sapiens environmental sample
(1)
 
Molecule name  (555)
60S ribosomal protein L31
(171)
Large ribosomal subunit protein eL31
(171)
23 kDa highly basic protein
(98)
60S ribosomal protein L1
(98)
60S ribosomal protein L13a
(98)
60S ribosomal protein L14
(98)
60S ribosomal protein L15
(98)
60S ribosomal protein L17
(98)
60S ribosomal protein L18
(98)
60S ribosomal protein L18a
(98)
60S ribosomal protein L21
(98)
60S ribosomal protein L23
(98)
60S ribosomal protein L26
(98)
60S ribosomal protein L32
(98)
60S ribosomal protein L35
(98)
60S ribosomal protein L35a
(98)
60S ribosomal protein L36
(98)
60S ribosomal protein L37
(98)
60S ribosomal protein L4
(98)
60S ribosomal protein L7
(98)
60S ribosomal protein L7a
(98)
60S ribosomal protein L9
(98)
Cell growth-inhibiting gene 33 protein
(98)
G1.16
(98)
Large ribosomal subunit protein eL14
(98)
Large ribosomal subunit protein eL15
(98)
Large ribosomal subunit protein eL18
(98)
Large ribosomal subunit protein eL20
(98)
Large ribosomal subunit protein eL21
(98)
Large ribosomal subunit protein eL32
(98)
Large ribosomal subunit protein eL33
(98)
Large ribosomal subunit protein eL36
(98)
Large ribosomal subunit protein eL37
(98)
Large ribosomal subunit protein eL8
(98)
Large ribosomal subunit protein uL13
(98)
Large ribosomal subunit protein uL22
(98)
Large ribosomal subunit protein uL24
(98)
Large ribosomal subunit protein uL29
(98)
Large ribosomal subunit protein uL30
(98)
Large ribosomal subunit protein uL4
(98)
Large ribosomal subunit protein uL6
(98)
PD-1
(98)
PLA-X polypeptide
(98)
Surfeit locus protein 3
(98)
60S ribosomal protein L13
(97)
60S ribosomal protein L23a
(97)
60S ribosomal protein L27a
(97)
60S ribosomal protein L28
(97)
60S ribosomal protein L3
(97)
60S ribosomal protein L6
(97)
Breast basic conserved protein 1
(97)
CAG-ISL 7
(97)
HIV-1 TAR RNA-binding protein B
(97)
Large ribosomal subunit protein eL13
(97)
Large ribosomal subunit protein eL28
(97)
Large ribosomal subunit protein eL6
(97)
Large ribosomal subunit protein uL14
(97)
Large ribosomal subunit protein uL15
(97)
Large ribosomal subunit protein uL23
(97)
Large ribosomal subunit protein uL3
(97)
Neoplasm-related protein C140
(97)
TARBP-B
(97)
Tax-responsive enhancer element-binding protein 107
(97)
TaxREB107
(97)
60S ribosomal protein L19
(95)
60S ribosomal protein L30
(95)
60S ribosomal protein L34
(95)
Large ribosomal subunit protein eL19
(95)
Large ribosomal subunit protein eL30
(95)
Large ribosomal subunit protein eL34
(95)
60S ribosomal protein L37a
(94)
60S ribosomal protein L38
(94)
Large ribosomal subunit protein eL38
(94)
Large ribosomal subunit protein eL43
(94)
60S ribosomal protein L11
(93)
60S ribosomal protein L22
(93)
60S ribosomal protein L27
(93)
60S ribosomal protein L39
(93)
60S ribosomal protein L5
(93)
CLL-associated antigen KW-12
(93)
Heparin-binding protein HBp15
(93)
Large ribosomal subunit protein eL22
(93)
Large ribosomal subunit protein eL27
(93)
Large ribosomal subunit protein eL39
(93)
Large ribosomal subunit protein uL18
(93)
Large ribosomal subunit protein uL5
(93)
EAP
(92)
EBER-associated protein
(92)
Epstein-Barr virus small RNA-associated protein
(92)
60S ribosomal protein L8
(88)
Large ribosomal subunit protein uL2
(88)
60S ribosomal protein L29
(85)
Cell surface heparin-binding protein HIP
(85)
Large ribosomal subunit protein eL29
(85)
60S ribosomal protein L36a
(73)
60S ribosomal protein L44
(73)
Cell growth-inhibiting gene 15 protein
(73)
Cell migration-inducing gene 6 protein
(73)
Large ribosomal subunit protein eL42
(73)
60S ribosomal protein L24
(66)
 
More...
 
Molecule type  (1)
Protein
(171)
 
Gene names  (339)
RPL31
(166)
EC45
(98)
GIG33
(98)
OK/SW-cl.103
(98)
PP9932
(98)
RPL1
(98)
RPL13A
(98)
RPL14
(98)
RPL15
(98)
RPL17
(98)
RPL18
(98)
RPL18A
(98)
RPL21
(98)
RPL26
(98)
RPL32
(98)
RPL35
(98)
RPL35A
(98)
RPL36
(98)
RPL37
(98)
RPL4
(98)
RPL7
(98)
RPL7A
(98)
RPL9
(98)
RPL9P7
(98)
RPL9P8
(98)
RPL9P9
(98)
SURF-3
(98)
SURF3
(98)
TCBAP0781
(98)
BBC1
(97)
OK/SW-cl.32
(97)
OK/SW-cl.46
(97)
RPL13
(97)
RPL23
(97)
RPL23A
(97)
RPL27A
(97)
RPL28
(97)
RPL3
(97)
RPL6
(97)
TXREB1
(97)
RPL19
(95)
RPL30
(95)
RPL34
(95)
RPL37A
(94)
RPL38
(94)
MSTP030
(93)
RPL11
(93)
RPL27
(93)
RPL39
(93)
RPL5
(93)
RPL22
(92)
RPL8
(88)
RPL29
(85)
RPL36A
(82)
GIG15
(73)
MIG6
(73)
RPL44
(73)
RPL24
(66)
UBA52
(59)
UBCEP2
(59)
RPL41
(54)
FTE1
(53)
GNB2L1
(53)
HLC7
(53)
LAMBR
(53)
LAMR1
(53)
MFTL
(53)
OK/SW-cl.2
(53)
OK/SW-cl.26
(53)
OK/SW-cl.82
(53)
OK/SW-cl.83
(53)
PIG21
(53)
RACK1
(53)
RPS13
(53)
RPS15A
(53)
RPS17
(53)
RPS17L
(53)
RPS19
(53)
RPS2
(53)
RPS21
(53)
RPS24
(53)
RPS26
(53)
RPS28
(53)
RPS29
(53)
RPS3
(53)
RPS3A
(53)
RPS4
(53)
RPS5
(53)
RPS6
(53)
RPS7
(53)
RPS8
(53)
RPS9
(53)
RPSA
(53)
D6S218E
(52)
FAU
(52)
MPS1
(52)
PRO2640
(52)
RIG
(52)
RPS10
(52)
RPS11
(52)
 
More...
 
Interacting Molecules  (576)
Large ribosomal subunit protein eL21
(171)
Large ribosomal subunit protein eL32
(171)
Large ribosomal subunit protein eL14
(170)
Large ribosomal subunit protein uL29
(170)
Large ribosomal subunit protein uL6
(170)
Large ribosomal subunit protein uL14
(167)
Large ribosomal subunit protein eL15
(166)
Large ribosomal subunit protein eL33
(166)
Large ribosomal subunit protein eL37
(166)
Large ribosomal subunit protein uL18
(165)
Large ribosomal subunit protein uL5
(165)
28S ribosomal RNA
(164)
5.8S ribosomal RNA
(164)
Large ribosomal subunit protein eL39
(164)
Large ribosomal subunit protein uL15
(164)
Large ribosomal subunit protein uL24
(164)
Large ribosomal subunit protein uL3
(164)
Large ribosomal subunit protein eL27
(162)
Large ribosomal subunit protein eL43
(162)
Large ribosomal subunit protein eL28
(161)
5S ribosomal RNA
(160)
Large ribosomal subunit protein eL36
(160)
Large ribosomal subunit protein eL6
(160)
Large ribosomal subunit protein uL22
(159)
Large ribosomal subunit protein eL30
(158)
Large ribosomal subunit protein eL34
(158)
Large ribosomal subunit protein uL23
(158)
Large ribosomal subunit protein uL4
(158)
Large ribosomal subunit protein uL30
(156)
Large ribosomal subunit protein eL29
(148)
Large ribosomal subunit protein uL2
(148)
Large ribosomal subunit protein eL8
(147)
Large ribosomal subunit protein eL24
(131)
Large ribosomal subunit protein eL38
(128)
Large ribosomal subunit protein eL42
(128)
Large ribosomal subunit protein eL19
(127)
Large ribosomal subunit protein eL22
(123)
Large ribosomal subunit protein eL20
(121)
Large ribosomal subunit protein eL13
(115)
Large ribosomal subunit protein uL13
(111)
Large ribosomal subunit protein eL18
(110)
Small ribosomal subunit protein RACK1
(109)
Small ribosomal subunit protein eS1
(109)
Small ribosomal subunit protein eS17
(109)
Small ribosomal subunit protein eS28
(109)
Small ribosomal subunit protein uS7
(109)
Small ribosomal subunit protein uS13
(108)
Small ribosomal subunit protein uS14
(108)
Small ribosomal subunit protein uS15
(108)
Small ribosomal subunit protein uS17
(107)
Small ribosomal subunit protein uS19
(107)
Small ribosomal subunit protein uS4
(107)
Small ribosomal subunit protein eS10
(106)
Small ribosomal subunit protein eS6
(106)
Small ribosomal subunit protein uS3
(106)
Small ribosomal subunit protein uS8
(105)
Small ribosomal subunit protein eS32
(104)
18S Ribosomal RNA
(103)
Small ribosomal subunit protein eS25
(103)
Small ribosomal subunit protein eS7
(102)
Small ribosomal subunit protein uS9
(101)
Small ribosomal subunit protein eS27
(99)
Small ribosomal subunit protein uS10
(99)
Large ribosomal subunit protein eL31
(98)
Large ribosomal subunit protein uL16
(95)
Small ribosomal subunit protein eS12
(94)
Small ribosomal subunit protein eS8
(94)
Small ribosomal subunit protein eS19
(91)
Small ribosomal subunit protein uS11
(91)
Small ribosomal subunit protein uS12
(88)
Large ribosomal subunit protein uL11
(87)
Small ribosomal subunit protein eS21
(81)
Large ribosomal subunit protein uL1
(73)
Small ribosomal subunit protein eS26
(73)
Small ribosomal subunit protein uS2
(72)
Small ribosomal subunit protein uS5
(66)
Ubiquitin-ribosomal protein eS31 fusion protein
(66)
Small ribosomal subunit protein eS30
(61)
Small ribosomal subunit protein eS24
(60)
Ubiquitin-ribosomal protein eL40 fusion protein
(59)
Messenger RNA
(51)
Small ribosomal subunit protein eS4, X isoform
(49)
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
(42)
Ribosomal protein uL16-like
(40)
eL40
(40)
Eukaryotic translation initiation factor 6
(39)
uL13
(37)
Large ribosomal subunit protein uL10
(34)
eL20
(34)
40S ribosomal protein S24
(32)
GTP-binding protein 4
(31)
Probable ribosome biogenesis protein RLP24
(31)
Protein LLP homolog
(31)
eL13
(30)
Small ribosomal subunit protein eS4
(29)
eL38
(29)
mRNA turnover protein 4 homolog
(29)
Small ribosomal subunit protein eS31
(28)
eL18
(28)
uS2
(27)
 
More...
 
Interacting ligands  (26)
MG : MAGNESIUM ION
(91)
ZN : ZINC ION
(78)
K : POTASSIUM ION
(31)
GDP : GUANOSINE-5'-DIPHOSPHATE
(19)
GTP : GUANOSINE-5'-TRIPHOSPHATE
(12)
SPD : SPERMIDINE
(8)
MVM : N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide
(7)
PUT : 1,4-DIAMINOBUTANE
(7)
ADP : ADENOSINE-5'-DIPHOSPHATE
(6)
3H3 : 4-{(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4E,6Z,10E)-3-methyl-12-oxooxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-en-1-yl}piperidine-2,6-dione
(5)
3HE : 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione
(4)
GSP : 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
(3)
PHE : PHENYLALANINE
(3)
T1C : TIGECYCLINE
(3)
EPE : 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
(2)
SF4 : IRON/SULFUR CLUSTER
(2)
SPM : SPERMINE
(2)
ZIY : plitidepsin
(2)
84D : Dibekacin
(1)
84G : Arbekacin
(1)
ATP : ADENOSINE-5'-TRIPHOSPHATE
(1)
BR : BROMIDE ION
(1)
NA : SODIUM ION
(1)
TRS : 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
(1)
WV3 : 4-{(2R)-2-[(1R,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione
(1)
YRB : (3R,6R,9S,12S,15S,18S,20R,24aR)-6-[(2S)-butan-2-yl]-3,12-bis[(1R)-1-hydroxy-2-methylpropyl]-8,9,11,17,18-pentamethyl-15-[(2S)-2-methylbutyl]hexadecahydropyrido[1,2-a][1,4,7,10,13,16,19]heptaazacyclohenicosine-1,4,7,10,13,16,19(21H)-heptone
(1)
 
Function and Biology
EC number / name  (10)
4.2.99.18 : DNA-(apurinic or apyrimidinic site) lyase
(53)
3.6.4.13 : RNA helicase
(9)
2.1.1.56 : mRNA (guanine-N(7))-methyltransferase
(4)
2.1.1.57 : Methyltransferase cap1
(4)
2.7.7.48 : RNA-directed RNA polymerase
(4)
2.7.7.50 : mRNA guanylyltransferase
(4)
3.4.19.12 : Ubiquitinyl hydrolase 1
(4)
3.4.22.69 : SARS coronavirus main proteinase
(4)
3.6.4.12 : DNA helicase
(4)
3.1.13.1 : Exoribonuclease II
(1)
 
Biological function  (141)
structural constituent of ribosome
(169)
protein binding
(101)
5S rRNA binding
(97)
DNA binding
(97)
RNA binding
(97)
cadherin binding
(97)
identical protein binding
(97)
mRNA 3'-UTR binding
(97)
mRNA 5'-UTR binding
(97)
mRNA binding
(97)
rRNA binding
(97)
tRNA binding
(97)
ubiquitin ligase inhibitor activity
(97)
ubiquitin protein ligase binding
(97)
zinc ion binding
(97)
large ribosomal subunit rRNA binding
(96)
transcription coactivator binding
(96)
ribosome binding
(91)
MDM2/MDM4 family protein binding
(86)
TORC2 complex binding
(85)
heparin binding
(81)
nucleic acid binding
(80)
translation regulator activity
(60)
protein kinase binding
(58)
DNA-binding transcription factor binding
(57)
signaling receptor binding
(57)
cyclin binding
(56)
BH3 domain binding
(53)
DNA N-glycosylase activity
(53)
DNA endonuclease activity
(53)
DNA-(apurinic or apyrimidinic site) endonuclease activity
(53)
Hsp70 protein binding
(53)
Hsp90 protein binding
(53)
RNA polymerase II transcription regulatory region sequence-specific DNA binding
(53)
SH2 domain binding
(53)
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
(53)
cysteine-type endopeptidase activator activity involved in apoptotic process
(53)
damaged DNA binding
(53)
enzyme activator activity
(53)
enzyme binding
(53)
fibroblast growth factor binding
(53)
ion channel inhibitor activity
(53)
iron-sulfur cluster binding
(53)
kinase binding
(53)
lyase activity
(53)
metal ion binding
(53)
microtubule binding
(53)
molecular adaptor activity
(53)
oxidized purine DNA binding
(53)
oxidized pyrimidine DNA binding
(53)
protein homodimerization activity
(53)
protein kinase A binding
(53)
protein kinase C binding
(53)
protein phosphatase binding
(53)
protein serine/threonine kinase inhibitor activity
(53)
protein tyrosine kinase inhibitor activity
(53)
protein-containing complex binding
(53)
receptor tyrosine kinase binding
(53)
signaling adaptor activity
(53)
small ribosomal subunit rRNA binding
(53)
supercoiled DNA binding
(53)
translation initiation factor binding
(53)
tubulin binding
(53)
ubiquitin-like protein conjugating enzyme binding
(53)
protein tag activity
(51)
GTPase activity
(43)
GTP binding
(42)
laminin binding
(42)
laminin receptor activity
(42)
virus receptor activity
(42)
ribosomal large subunit binding
(38)
translation initiation factor activity
(38)
preribosome binding
(33)
basal RNA polymerase II transcription machinery binding
(30)
hydrolase activity
(21)
ribonucleoprotein complex binding
(20)
transcription corepressor activity
(17)
p53 binding
(15)
SUMO binding
(12)
translation elongation factor activity
(11)
translation elongation factor binding
(9)
translation repressor activity
(9)
chromatin binding
(7)
lncRNA binding
(7)
ATP binding
(6)
ATP hydrolysis activity
(6)
RNA 2'-O-methyltransferase activity
(5)
RNA helicase activity
(5)
UFM1 ligase activity
(5)
UFM1 transferase activity
(5)
helicase activity
(5)
methyltransferase activity
(5)
rRNA (guanine) methyltransferase activity
(5)
rRNA (uridine-2'-O-)-methyltransferase activity
(5)
rRNA methyltransferase activity
(5)
transcription coactivator activity
(5)
transferase activity
(5)
RNA methyltransferase activity
(4)
S-adenosylmethionine-dependent methyltransferase activity
(4)
histone binding
(4)
 
More...
 
Biological process  (365)
translation
(163)
cytoplasmic translation
(143)
cellular response to type II interferon
(97)
homeostatic process
(97)
lung morphogenesis
(97)
macrophage chemotaxis
(97)
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
(97)
negative regulation of formation of translation preinitiation complex
(97)
negative regulation of translation
(97)
negative regulation of ubiquitin protein ligase activity
(97)
negative regulation of ubiquitin-dependent protein catabolic process
(97)
positive regulation of gene expression
(97)
positive regulation of signal transduction by p53 class mediator
(97)
positive regulation of translation
(97)
protein stabilization
(97)
rRNA processing
(97)
regulation of signal transduction by p53 class mediator
(97)
regulation of translation
(97)
response to ethanol
(97)
response to lipopolysaccharide
(97)
ribosomal large subunit assembly
(97)
ribosomal large subunit biogenesis
(97)
G1 to G0 transition
(96)
blastocyst development
(96)
bone development
(96)
cellular response to actinomycin D
(96)
cellular response to interleukin-4
(96)
negative regulation of transcription by RNA polymerase II
(96)
positive regulation of cell population proliferation
(96)
protein-DNA complex disassembly
(96)
regulation of G1 to G0 transition
(96)
ribosomal protein import into nucleus
(96)
ribosome biogenesis
(96)
DNA damage response, signal transduction by p53 class mediator
(95)
cellular response to UV
(95)
cellular response to gamma radiation
(95)
cellular response to ionizing radiation
(95)
obsolete DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
(95)
positive regulation of DNA damage response, signal transduction by p53 class mediator
(95)
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
(95)
regulation of translation involved in cellular response to UV
(95)
antimicrobial humoral immune response mediated by antimicrobial peptide
(94)
90S preribosome assembly
(93)
axial mesoderm development
(93)
defense response to Gram-negative bacterium
(93)
killing of cells of another organism
(93)
middle ear morphogenesis
(93)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
(93)
ossification
(93)
protein-RNA complex assembly
(93)
sensory perception of sound
(93)
skeletal system development
(93)
antibacterial humoral response
(92)
defense response to Gram-positive bacterium
(92)
innate immune response in mucosa
(92)
negative regulation of protein neddylation
(92)
positive regulation of protein binding
(92)
protein localization to nucleus
(92)
protein targeting
(92)
response to aldosterone
(92)
translational initiation
(91)
maturation of LSU-rRNA
(90)
translation at presynapse
(90)
negative regulation of protein ubiquitination
(88)
regulation of DNA-templated transcription
(84)
alpha-beta T cell differentiation
(80)
osteoblast differentiation
(78)
embryo implantation
(74)
DNA damage response
(73)
DNA repair
(73)
regulation of apoptotic process
(72)
regulation of cell cycle
(72)
regulation of protein localization
(72)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(71)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
(68)
negative regulation of apoptotic process
(66)
protein ubiquitination
(63)
mitotic cell cycle
(62)
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
(59)
erythrocyte differentiation
(58)
rescue of stalled ribosome
(58)
apoptotic process
(57)
negative regulation of gene expression
(56)
positive regulation of NF-kappaB transcription factor activity
(56)
positive regulation of apoptotic process
(56)
positive regulation of cell migration
(56)
exit from mitosis
(55)
optic nerve development
(55)
retina development in camera-type eye
(55)
retinal ganglion cell axon guidance
(55)
cell differentiation
(54)
G1/S transition of mitotic cell cycle
(53)
T cell differentiation in thymus
(53)
T cell proliferation involved in immune response
(53)
TOR signaling
(53)
activation-induced cell death of T cells
(53)
base-excision repair
(53)
cell division
(53)
cellular response to glucose stimulus
(53)
cellular response to growth factor stimulus
(53)
 
More...
 
Biological cell component  (110)
ribosome
(169)
cytoplasm
(143)
cytosolic large ribosomal subunit
(143)
ribonucleoprotein complex
(143)
cytosol
(101)
large ribosomal subunit
(101)
synapse
(101)
cytoplasmic side of rough endoplasmic reticulum membrane
(98)
A band
(97)
GAIT complex
(97)
cytoplasmic ribonucleoprotein granule
(97)
cytosolic ribosome
(97)
endoplasmic reticulum
(97)
extracellular exosome
(97)
focal adhesion
(97)
intracellular membraneless organelle
(97)
membrane
(97)
nucleolus
(97)
nucleoplasm
(97)
nucleus
(97)
postsynaptic density
(97)
protein-containing complex
(97)
ribosomal subunit
(97)
rough endoplasmic reticulum
(97)
cell body
(96)
dendrite
(96)
extracellular space
(96)
postsynapse
(96)
eukaryotic 80S initiation complex
(93)
presynapse
(90)
nuclear body
(84)
perinuclear region of cytoplasm
(83)
plasma membrane
(82)
glutamatergic synapse
(80)
mitochondrion
(72)
midbody
(67)
intracellular membrane-bounded organelle
(61)
neuron projection
(58)
centrosome
(56)
cytoskeleton
(56)
IRE1-RACK1-PP2A complex
(53)
NF-kappaB complex
(53)
cell projection
(53)
cytosolic small ribosomal subunit
(53)
mitochondrial inner membrane
(53)
mitochondrial matrix
(53)
mitotic spindle
(53)
neuronal cell body
(53)
perikaryon
(53)
phagocytic cup
(53)
ruffle membrane
(53)
small ribosomal subunit
(53)
small-subunit processome
(53)
spindle
(53)
endocytic vesicle membrane
(51)
endoplasmic reticulum membrane
(51)
endosome membrane
(51)
mitochondrial outer membrane
(51)
vesicle
(51)
Golgi apparatus
(46)
lysosomal membrane
(45)
intermediate filament
(38)
lamin filament
(38)
chromosome
(36)
preribosome, large subunit precursor
(31)
nuclear membrane
(30)
smooth endoplasmic reticulum
(27)
PeBoW complex
(19)
condensed nuclear chromosome
(19)
extracellular region
(19)
fibrillar center
(16)
rDNA heterochromatin
(15)
cilium
(14)
azurophil granule lumen
(13)
ficolin-1-rich granule lumen
(10)
secretory granule lumen
(10)
aggresome
(7)
preribosome, small subunit precursor
(5)
site of double-strand break
(5)
Noc1p-Noc2p complex
(4)
Noc2p-Noc3p complex
(4)
cortical actin cytoskeleton
(4)
euchromatin
(4)
nuclear periphery
(4)
nuclear speck
(4)
Las1 complex
(3)
MLL1 complex
(3)
cytoplasmic side of lysosomal membrane
(3)
dynein axonemal particle
(3)
endomembrane system
(3)
eukaryotic translation elongation factor 1 complex
(3)
microtubule
(3)
nuclear pre-replicative complex
(3)
rixosome complex
(3)
translation release factor complex
(3)
Sec61 translocon complex
(2)
Ssh1 translocon complex
(2)
endoplasmic reticulum Sec complex
(2)
endoplasmic reticulum quality control compartment
(2)
nuclear exosome (RNase complex)
(2)
 
More...
 
Sequence and Structure classification
Pfam accession / name  (196)
PF01198 : Ribosomal_L31e
(171)
PF00237 : Ribosomal_L22
(98)
PF00327 : Ribosomal_L30
(98)
PF00347 : Ribosomal_L6
(98)
PF00467 : KOW
(98)
PF00572 : Ribosomal_L13
(98)
PF00573 : Ribosomal_L4
(98)
PF00827 : Ribosomal_L15e
(98)
PF00831 : Ribosomal_L29
(98)
PF01157 : Ribosomal_L21e
(98)
PF01158 : Ribosomal_L36e
(98)
PF01247 : Ribosomal_L35Ae
(98)
PF01248 : Ribosomal_L7Ae
(98)
PF01655 : Ribosomal_L32e
(98)
PF01775 : Ribosomal_L18A
(98)
PF01778 : Ribosomal_L28e
(98)
PF01907 : Ribosomal_L37e
(98)
PF01929 : Ribosomal_L14e
(98)
PF08079 : Ribosomal_L30_N
(98)
PF14374 : Ribos_L4_asso_C
(98)
PF16906 : Ribosomal_L26
(98)
PF17135 : Ribosomal_L18
(98)
PF00238 : Ribosomal_L14
(97)
PF00276 : Ribosomal_L23
(97)
PF00297 : Ribosomal_L3
(97)
PF00828 : Ribosomal_L27A
(97)
PF01159 : Ribosomal_L6e
(97)
PF01246 : Ribosomal_L24e
(97)
PF01294 : Ribosomal_L13e
(97)
PF03939 : Ribosomal_L23eN
(97)
PF03868 : Ribosomal_L6e_N
(96)
PF01199 : Ribosomal_L34e
(95)
PF01280 : Ribosomal_L19e
(95)
PF01780 : Ribosomal_L37ae
(94)
PF01781 : Ribosomal_L38e
(94)
PF00281 : Ribosomal_L5
(93)
PF00673 : Ribosomal_L5_C
(93)
PF00832 : Ribosomal_L39
(93)
PF01776 : Ribosomal_L22e
(93)
PF01777 : Ribosomal_L27e
(93)
PF14204 : Ribosomal_L18_c
(93)
PF17144 : Ribosomal_L5e
(93)
PF00181 : Ribosomal_L2
(88)
PF03947 : Ribosomal_L2_C
(88)
PF01779 : Ribosomal_L29e
(85)
PF00935 : Ribosomal_L44
(82)
PF01201 : Ribosomal_S8e
(75)
PF00252 : Ribosomal_L16
(69)
PF00400 : WD40
(67)
PF01020 : Ribosomal_L40e
(59)
PF05162 : Ribosomal_L41
(54)
PF00163 : Ribosomal_S4
(53)
PF00177 : Ribosomal_S7
(53)
PF00189 : Ribosomal_S3_C
(53)
PF00253 : Ribosomal_S14
(53)
PF00312 : Ribosomal_S15
(53)
PF00318 : Ribosomal_S2
(53)
PF00333 : Ribosomal_S5
(53)
PF00410 : Ribosomal_S8
(53)
PF00833 : Ribosomal_S17e
(53)
PF01015 : Ribosomal_S3Ae
(53)
PF01090 : Ribosomal_S19e
(53)
PF01092 : Ribosomal_S6e
(53)
PF01200 : Ribosomal_S28e
(53)
PF01249 : Ribosomal_S21e
(53)
PF01251 : Ribosomal_S7e
(53)
PF01282 : Ribosomal_S24e
(53)
PF01283 : Ribosomal_S26e
(53)
PF01479 : S4
(53)
PF03719 : Ribosomal_S5_C
(53)
PF07650 : KH_2
(53)
PF08069 : Ribosomal_S13_N
(53)
PF00203 : Ribosomal_S19
(52)
PF00240 : ubiquitin
(52)
PF00338 : Ribosomal_S10
(52)
PF00366 : Ribosomal_S17
(52)
PF00380 : Ribosomal_S9
(52)
PF00411 : Ribosomal_S11
(52)
PF00416 : Ribosomal_S13
(52)
PF00687 : Ribosomal_L1
(52)
PF00900 : Ribosomal_S4e
(52)
PF01667 : Ribosomal_S27e
(52)
PF03297 : Ribosomal_S25
(52)
PF03501 : S10_plectin
(52)
PF04758 : Ribosomal_S30
(52)
PF08071 : RS4NT
(52)
PF16121 : 40S_S4_C
(52)
PF16205 : Ribosomal_S17_N
(52)
PF00164 : Ribosom_S12_S23
(47)
PF00466 : Ribosomal_L10
(46)
PF17777 : RL10P_insert
(45)
PF01599 : Ribosomal_S27
(44)
PF00298 : Ribosomal_L11
(42)
PF03946 : Ribosomal_L11_N
(42)
PF16122 : 40S_SA_C
(42)
PF01912 : eIF-6
(39)
PF06858 : NOG1
(31)
PF08155 : NOGCT
(31)
PF10169 : LLPH
(31)
PF17835 : NOG1_N
(31)
 
More...
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(5)
 
Refinement software  (3)
PHENIX
(21)
phenix.real_space_refine
(20)
REFMAC
(10)
 
EM microscope model  (8)
FEI TITAN KRIOS
(150)
FEI TECNAI ARCTICA
(5)
TFS KRIOS
(4)
FEI POLARA 300
(3)
FEI TECNAI F30
(3)
JEOL CRYO ARM 300
(3)
FEI TALOS ARCTICA
(2)
TFS GLACIOS
(2)
 
EM detector name  (9)
GATAN K3 (6k x 4k)
(49)
GATAN K2 SUMMIT (4k x 4k)
(47)
FEI FALCON II (4k x 4k)
(29)
FEI FALCON III (4k x 4k)
(14)
GATAN K2 QUANTUM (4k x 4k)
(11)
FEI FALCON IV (4k x 4k)
(10)
GATAN K3 BIOQUANTUM (6k x 4k)
(10)
FEI EAGLE (4k x 4k)
(1)
TVIPS TEMCAM-F416 (4k x 4k)
(1)
 
Representative Structures
Representative Structures
100%
95%
90%
70%
50%
40%
30%
...
Entries 1 to 10 of 171
Entries 1 to 10 of 171
 Select all entries on this page
UFL1 E3 ligase bound 60S ribosome
Makhlouf L, Kulathu Y, Zeqiraj E
Nature (2024) [PMID: 38383789  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
PDBe complex ID: PDB-CPX-279391 (Preferred)   search this ID
PDBe-KB: P62917    P32969    P40429    P46779    P26373    P18621    (view 36 more)
Electron Microscopy
2.2Å resolution
Released: 21 Feb 2024
Model geometry
Fit model/data
Data not analysed
8qfd
8qfd
8qfd
60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (in-vitro reconstitution)
Penchev I, DaRosa PA, Peter JJ, Kulathu Y, Becker T, Beckmann R, Kopito R
Nature (2024) [PMID: 38383785  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
PDBe complex ID: PDB-CPX-271902 (Preferred)   search this ID
PDBe-KB: Q9Y3U8    P32969    P40429    P46779    P26373    P18621    (view 40 more)
Electron Microscopy
2.9Å resolution
Released: 21 Feb 2024
Model geometry
Fit model/data
Data not analysed
8oj5
8oj5
8oj5
60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native)
Penchev I, DaRosa PA, Becker T, Beckmann R, Kopito R
Nature (2024) [PMID: 38383785  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
PDBe complex ID: PDB-CPX-271900 (Preferred)   search this ID
PDBe-KB: P38377    P32969    P40429    P46779    P26373    P18621    (view 41 more)
Electron Microscopy
3.3Å resolution
Released: 21 Feb 2024
Model geometry
Fit model/data
Data not analysed
8oj8
8oj8
8oj8
Cryo-EM structure of the human Ebp1 - 80S ribosome
Desogus J, Bhaskar V, Chao JA
RNA (2021) [PMID: 33479117  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
PDBe complex ID: PDB-CPX-148288 (Preferred)   search this ID
PDBe-KB: P50914    P32969    P40429    P46779    Q9UQ80    P26373    (view 35 more)
Electron Microscopy
3.3Å resolution
Released: 3 Feb 2021
Model geometry
Fit model/data
Data not analysed
7bhp
7bhp
7bhp
Tetracenomycin X bound to the human ribosome
Buschauer R, Cheng J, Berninghausen O, Beckmann R, Wilson DN
Nat Chem Biol (2020) [PMID: 32601485  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: MG    ZN    OCW    ZN    MG   
PDBe complex ID: PDB-CPX-148287 (Preferred)   search this ID
PDBe-KB: P50914    P32969    P40429    P46779    P26373    P18621    (view 37 more)
Electron Microscopy
2.8Å resolution
Released: 8 Jul 2020
Model geometry
Fit model/data
Data not analysed
6y6x
6y6x
6y6x
60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (native)
Penchev I, DaRosa PA, Becker T, Beckmann R, Kopito R
Nature (2024) [PMID: 38383785  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
PDBe complex ID: PDB-CPX-271901 (Preferred)   search this ID
PDBe-KB: P84098    P32969    P40429    P46779    P26373    P18621    (view 41 more)
Electron Microscopy
3.1Å resolution
Released: 21 Feb 2024
Model geometry
Fit model/data
Data not analysed
8ohd
8ohd
8ohd
60S ribosomal subunit bound to the E3-UFM1 complex - state 2 (native)
Penchev I, DaRosa PA, Becker T, Beckmann R, Kopito R
Nature (2024) [PMID: 38383785  ]
Assembly composition: RNA/protein complex
Bound ligands: MG    ZN    ZN    MG   
PDBe complex ID: PDB-CPX-279392 (Preferred)   search this ID
PDBe-KB: P32969    P40429    P46779    P61619    P26373    P18621    (view 44 more)
Electron Microscopy
3.3Å resolution
Released: 21 Feb 2024
Model geometry
Fit model/data
Data not analysed
8oj0
8oj0
8oj0
Human pre-60S - State 5
Thoms M, Denk T, Beckmann R
To be published
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: GDP    MG    ZN    GTP    ZN    MG    GDP    GTP   
PDBe complex ID: PDB-CPX-283817 (Preferred)   search this ID
PDBe-KB: P46777    Q15050    P32969    P40429    P46779    Q13823    (view 43 more)
Electron Microscopy
2.84Å resolution
Released: 15 Jan 2025
Model geometry
Fit model/data
Data not analysed
8rl2
8rl2
8rl2
Human nucleolar pre-60S ribosomal subunit (State G)
Vanden Broeck A, Klinge S
Science (2023) [PMID: 37410842  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: K    GDP    MG    K    ZN    ZN    MG    GDP   
Modified residues: HIC    HIC   
PDBe complex ID: PDB-CPX-221155 (Preferred)   search this ID
PDBe-KB: P50914    P40429    P46779    P32969    Q9BYG3    P26373    (view 42 more)
Electron Microscopy
3.04Å resolution
Released: 12 Jul 2023
Model geometry
Fit model/data
Data not analysed
8fkz
8fkz
8fkz
Human nucleolar pre-60S ribosomal subunit (State D2)
Vanden Broeck A, Klinge S
Science (2023) [PMID: 37410842  ]
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: K    GDP    MG    K    ZN    ADP    ADP    ZN    MG    GDP   
Modified residues: SEP    HIC    HIC    SEP   
PDBe complex ID: PDB-CPX-221157 (Preferred)   search this ID
PDBe-KB: P50914    P40429    P46779    P32969    Q9BYG3    Q15050    (view 44 more)
Electron Microscopy
2.5Å resolution
Released: 12 Jul 2023
Model geometry
Fit model/data
Data not analysed
8fkw
8fkw
8fkw
...
Entries 1 to 10 of 171
Entries 1 to 10 of 171