Uniprot accession / id : P63028  OR   Uniprot accession / id : P13693  OR   Uniprot accession / id : H0YCX0
 
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Entry Information
Entry status  (1)
REL
(9)
 
Experimental methods  (2)
X-ray diffraction
(8)
Solution NMR
(1)
 
Authors  (57)
Davies AM
(3)
Dore KA
(3)
Doré KA
(3)
Gould HJ
(3)
Kashiwakura J
(3)
Kashiwakura JI
(3)
Kawakami T
(3)
McDonnell JM
(3)
Sutton BJ
(3)
Amson R
(2)
Cavarelli J
(2)
Kim MS
(2)
Martinou JC
(2)
Shin DH
(2)
Telerman A
(2)
Agez M
(1)
Andrews DW
(1)
Atkinson AR
(1)
Beekman C
(1)
Besse S
(1)
Billas-Massobrio I
(1)
Birck C
(1)
Busso D
(1)
Chi X
(1)
Cianferani S
(1)
Cianférani S
(1)
Cura V
(1)
Ding J
(1)
Dong X
(1)
Duflaut D
(1)
Feng Y
(1)
Fiucci G
(1)
Gautier F
(1)
Honore J
(1)
Honoré J
(1)
Johnson CM
(1)
Juin P
(1)
Karafin T
(1)
Lespagnol A
(1)
Li Y
(1)
Liu D
(1)
Maillet L
(1)
Marine JC
(1)
Montessuit S
(1)
Moras D
(1)
Poussin P
(1)
Senff-Ribeiro A
(1)
Stojko J
(1)
Susini L
(1)
Telerman SB
(1)
Thebault S
(1)
Thébault S
(1)
Troffer-Charlier N
(1)
Wang J
(1)
Yang B
(1)
Yao H
(1)
Zhong C
(1)
 
Homo / hetero assembly  (2)
homo
(8)
hetero
(1)
 
Assembly composition  (2)
protein structure
(8)
protein/protein complex
(1)
 
Assembly polymer count  (3)
monomer
(5)
dimer
(3)
octamer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(3)
2.0 - 2.5
(2)
2.5 - 3
(1)
4.0 - 4.5
(1)
 
Release year distribution
2005 - 2010
(3)
2015 - 2020
(6)
 
Journal  (6)
Mol Immunol
(3)
To be published
(2)
Arch Biochem Biophys
(1)
Cell Death Differ
(1)
J Biol Chem
(1)
Sci Rep
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(9)
 
Organism name  (2)
Homo sapiens
(8)
Mus musculus
(1)
 
Molecule name  (8)
TCTP
(9)
Translationally-controlled tumor protein
(9)
p23
(9)
Fortilin
(8)
HRF
(8)
Histamine-releasing factor
(8)
21 kDa polypeptide
(1)
p21
(1)
 
Molecule type  (1)
Protein
(9)
 
Gene names  (3)
TPT1
(8)
Tpt1
(1)
Trt
(1)
 
Interacting Molecules  (1)
Bcl-2-like protein 1
(1)
 
Interacting ligands  (3)
GOL : GLYCEROL
(1)
NA : SODIUM ION
(1)
PEG : DI(HYDROXYETHYL)ETHER
(1)
 
Function and Biology
Biological function  (4)
DNA-binding transcription factor binding
(7)
calcium ion binding
(7)
protein binding
(7)
RNA binding
(6)
 
Biological process  (9)
negative regulation of ectoderm development
(7)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
(7)
response to virus
(7)
stem cell population maintenance
(7)
calcium ion transport
(6)
intracellular calcium ion homeostasis
(6)
negative regulation of apoptotic process
(6)
regulation of apoptotic process
(6)
spermatogenesis
(1)
 
Biological cell component  (9)
cytoplasm
(7)
cytoplasmic microtubule
(7)
cytosol
(7)
extracellular space
(7)
multivesicular body
(7)
nucleoplasm
(7)
nucleus
(7)
spindle pole
(7)
extracellular exosome
(6)
 
Sequence and Structure classification
SCOP fold  (1)
Mss4-like
(2)
 
SCOP family  (1)
Translationally controlled tumor protein TCTP (histamine-releasing factor)
(2)
 
CATH class  (1)
Mainly Beta
(5)
 
CATH topology  (1)
Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A
(5)
 
Pfam accession / name  (1)
PF00838 : TCTP
(8)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(8)
 
Diffraction radiation source type  (2)
Synchrotron
(7)
Free-electron laser
(1)
 
Diffraction source  (8)
DIAMOND BEAMLINE I03
(1)
DIAMOND BEAMLINE I04
(1)
DIAMOND BEAMLINE I04-1
(1)
ESRF BEAMLINE ID14-1
(1)
ESRF BEAMLINE ID29
(1)
PAL/PLS BEAMLINE 7A (6B, 6C1)
(1)
PHOTON FACTORY BEAMLINE AR-NW12A
(1)
SwissFEL ARAMIS BEAMLINE ESA
(1)
 
Synchrotron site  (5)
Diamond
(3)
ESRF
(2)
PAL/PLS
(1)
Photon Factory
(1)
SwissFEL ARAMIS
(1)
 
Diffraction detector type  (2)
Pixel
(5)
CCD
(3)
 
Refinement software  (3)
PHENIX
(6)
CNS
(1)
REFMAC
(1)
 
NMR
NMR software packages  (3)
CNS
(1)
Felix
(1)
XwinNMR
(1)
 
NMR Field Strength
500.0 - 600
(1)
600.0 - 700
(1)
 
Representative Structures
Representative Structures
100%
95%
90%
70%
50%
40%
30%
Entries 1 to 9 of 9
Entries 1 to 9 of 9
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TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL
Cura V, Agez M, Thebault S, Cavarelli J
Sci Rep (2016) [PMID: 26813996  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: BCT    NA    NA   
Assembly name: Bcl-2-like protein 1 and Translationally-controlled tumor protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146707 (Preferred)   search this ID
PDBe-KB: P13693    Q07817   
X-ray diffraction
2.099Å resolution
Released: 10 Feb 2016
Model geometry
Fit model/data
4z9v
4z9v
4z9v
Crystal structure of human Histamine-Releasing Factor (HRF/TCTP)containing a disulphide-linked dimer
Dore KA, Kashiwakura J, McDonnell JM, Gould HJ, Kawakami T, Sutton BJ, Davies AM
Mol Immunol (2018) [PMID: 29216544  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PEG    PEG   
Assembly name: Translationally-controlled tumor protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146706 (Preferred)   search this ID
PDBe-KB: P13693   
X-ray diffraction
1.4Å resolution
Released: 20 Dec 2017
Model geometry
Fit model/data
5o9m
5o9m
5o9m
Crystal structure of human Histamine-Releasing Factor (HRF/TCTP)
Dore KA, Kashiwakura J, McDonnell JM, Gould HJ, Kawakami T, Sutton BJ, Davies AM
Mol Immunol (2018) [PMID: 29216544  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Translationally-controlled tumor protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146705 (Preferred)   search this ID
PDBe-KB: P13693   
X-ray diffraction
1.75Å resolution
Released: 20 Dec 2017
Model geometry
Fit model/data
5o9l
5o9l
5o9l
Dimeric human TCTP
Shin DH, Kim MS
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Translationally-controlled tumor protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146706 (Preferred)   search this ID
PDBe-KB: P13693   
X-ray diffraction
2.29Å resolution
Released: 25 Dec 2019
Model geometry
Fit model/data
6ize
6ize
6ize
Flexible loop truncated human TCTP
Shin DH, Kim MS
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Translationally-controlled tumor protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146706 (Preferred)   search this ID
PDBe-KB: P13693    P13693   
X-ray diffraction
1.899Å resolution
Released: 25 Dec 2019
Model geometry
Fit model/data
6izb
6izb
6izb
Crystal structure of Murine Histmaine-Releasing Factor (HRF/TCTP)
Dore KA, Kashiwakura J, McDonnell JM, Gould HJ, Kawakami T, Sutton BJ, Davies AM
Mol Immunol (2018) [PMID: 29216544  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Bound ligands: GOL   
Assembly name: Translationally-controlled tumor protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-158928 (Preferred)   search this ID
PDBe-KB: P63028   
X-ray diffraction
4.014Å resolution
Released: 20 Dec 2017
Model geometry
Fit model/data
5o9k
5o9k
5o9k
Crystal structure of human translationally controlled tumour associated protein (hTCTP) mutant E12V
Yang B, Dong X, Zhong C, Ding J
J Biol Chem (2009) [PMID: 19570981  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Translationally-controlled tumor protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146705 (Preferred)   search this ID
PDBe-KB: P13693    P13693   
X-ray diffraction
2.6Å resolution
Released: 30 Jun 2009
Model geometry
Fit model/data
3ebm
3ebm
3ebm
Crystal structure of human translationally controlled tumour associated protein
Cavarelli J, Moras D, Amson R, Telerman A
Cell Death Differ (2008) [PMID: 18274553  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Translationally-controlled tumor protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146705 (Preferred)   search this ID
PDBe-KB: P13693   
X-ray diffraction
2Å resolution
Released: 16 May 2006
Model geometry
Fit model/data
1yz1
1yz1
1yz1
Solution structure of human translationally controlled tumor protein
Feng Y, Liu D, Yao H, Wang J
Arch Biochem Biophys (2007) [PMID: 17897616  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Translationally-controlled tumor protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-146705 (Preferred)   search this ID
PDBe-KB: P13693   
Solution NMR
Released: 8 Aug 2006
Model geometry
Fit model/data
Data not analysed
2hr9
2hr9
2hr9
Entries 1 to 9 of 9
Entries 1 to 9 of 9