Uniprot accession / id : P63072  OR   Uniprot accession / id : O15205
 
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Entry Information
Entry status  (1)
REL
(5)
 
Experimental methods  (3)
Solution NMR
(2)
X-ray diffraction
(2)
Electron Microscopy
(1)
 
Authors  (37)
Aichem A
(2)
Anders S
(2)
Berg A
(2)
Bialas J
(2)
Catone N
(2)
Groettrup M
(2)
Peter C
(2)
Roessler P
(2)
Rößler P
(2)
Scheuermann S
(2)
Schmidtke G
(2)
Schutz-Stoffregen MC
(2)
Schwab R
(2)
Schütz-Stoffregen MC
(2)
Stotz S
(2)
Wiesner S
(2)
Arkinson C
(1)
Chan C
(1)
Chong SS
(1)
Dong KC
(1)
Gao Y
(1)
Gee CL
(1)
Kuhn M
(1)
Lee CG
(1)
Li S
(1)
Lim L
(1)
Mah WC
(1)
Martin A
(1)
Misra M
(1)
Qin H
(1)
Schindelin H
(1)
Song J
(1)
Theng SS
(1)
Truongvan N
(1)
Wang W
(1)
Zhang Z
(1)
Zhuo J
(1)
 
Homo / hetero assembly  (2)
homo
(3)
hetero
(2)
 
Assembly composition  (2)
protein structure
(3)
protein/protein complex
(2)
 
Assembly polymer count  (3)
monomer
(3)
34-mer
(1)
dimer
(1)
 
Resolution distribution
1.5 - 2
(1)
3.0 - 3.5
(2)
 
Release year distribution
2010 - 2015
(1)
2015 - 2020
(2)
2020 - 2025
(2)
 
Journal  (3)
Nat Commun
(3)
Proc Natl Acad Sci U S A
(1)
bioRxiv
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(5)
 
Organism name  (2)
Homo sapiens
(5)
Lobophyllia hemprichii
(1)
 
Molecule name  (4)
Diubiquitin
(5)
Ubiquitin D
(5)
Ubiquitin-like protein FAT10
(5)
Green to red photoconvertible GFP-like protein EosFP
(1)
 
Molecule type  (1)
Protein
(5)
 
Gene names  (2)
FAT10
(5)
UBD
(5)
 
Interacting Molecules  (35)
26S proteasome complex subunit SEM1
(1)
26S proteasome non-ATPase regulatory subunit 1
(1)
26S proteasome non-ATPase regulatory subunit 11
(1)
26S proteasome non-ATPase regulatory subunit 12
(1)
26S proteasome non-ATPase regulatory subunit 13
(1)
26S proteasome non-ATPase regulatory subunit 14
(1)
26S proteasome non-ATPase regulatory subunit 2
(1)
26S proteasome non-ATPase regulatory subunit 3
(1)
26S proteasome non-ATPase regulatory subunit 4
(1)
26S proteasome non-ATPase regulatory subunit 6
(1)
26S proteasome non-ATPase regulatory subunit 7
(1)
26S proteasome non-ATPase regulatory subunit 8
(1)
26S proteasome regulatory subunit 10B
(1)
26S proteasome regulatory subunit 4
(1)
26S proteasome regulatory subunit 6A
(1)
26S proteasome regulatory subunit 6B
(1)
26S proteasome regulatory subunit 7
(1)
26S proteasome regulatory subunit 8
(1)
Proteasome subunit alpha type-1
(1)
Proteasome subunit alpha type-2
(1)
Proteasome subunit alpha type-3
(1)
Proteasome subunit alpha type-4
(1)
Proteasome subunit alpha type-5
(1)
Proteasome subunit alpha type-6
(1)
Proteasome subunit alpha type-7
(1)
Proteasome subunit beta type-1
(1)
Proteasome subunit beta type-2
(1)
Proteasome subunit beta type-3
(1)
Proteasome subunit beta type-4
(1)
Proteasome subunit beta type-5
(1)
Proteasome subunit beta type-6
(1)
Proteasome subunit beta type-7
(1)
Thioredoxin-like protein 1
(1)
Ubiquitin-like modifier-activating enzyme 1
(1)
Ubiquitin-like modifier-activating enzyme 6
(1)
 
Interacting ligands  (1)
SO4 : SULFATE ION
(1)
 
Function and Biology
Biological function  (2)
proteasome binding
(5)
protein binding
(2)
 
Biological process  (13)
response to tumor necrosis factor
(5)
aggresome assembly
(2)
myeloid dendritic cell differentiation
(2)
positive regulation of apoptotic process
(2)
positive regulation of canonical NF-kappaB signal transduction
(2)
protein modification by small protein conjugation
(2)
protein ubiquitination
(2)
proteolysis
(2)
regulation of mitotic cell cycle phase transition
(2)
response to type II interferon
(2)
ubiquitin-dependent protein catabolic process
(2)
bioluminescence
(1)
generation of precursor metabolites and energy
(1)
 
Biological cell component  (6)
aggresome
(2)
cytoplasm
(2)
cytosol
(2)
fibrillar center
(2)
nucleoplasm
(2)
nucleus
(2)
 
Sequence and Structure classification
CATH class  (1)
Alpha Beta
(1)
 
CATH topology  (1)
Ubiquitin-like (UB roll)
(1)
 
Pfam accession / name  (2)
PF00240 : ubiquitin
(5)
PF01353 : GFP
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(2)
 
Diffraction radiation source type  (1)
Synchrotron
(2)
 
Diffraction source  (2)
ESRF BEAMLINE ID30B
(1)
SLS BEAMLINE X10SA
(1)
 
Synchrotron site  (2)
ESRF
(1)
SLS
(1)
 
Diffraction detector type  (1)
Pixel
(2)
 
Refinement software  (1)
PHENIX
(2)
 
EM microscope model  (1)
TFS KRIOS
(1)
 
EM detector name  (1)
GATAN K3 (6k x 4k)
(1)
 
NMR
NMR software packages  (8)
ARIA
(1)
Amber
(1)
CYANA
(1)
NMRPipe
(1)
NMRView
(1)
TALOS
(1)
TopSpin
(1)
XEASY
(1)
 
NMR Field Strength
500.0 - 600
(1)
600.0 - 700
(1)
700.0 - 800
(2)
800.0 - 900
(2)
 
Representative Structures
Representative Structures
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Entries 1 to 5 of 5
Entries 1 to 5 of 5
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The structure of the ubiquitin-like modifier FAT10 reveals a novel targeting mechanism for degradation by the 26S proteasome
Aichem A, Anders S, Catone N, Roessler P, Stotz S, Berg A, Schwab R, Scheuermann S, Bialas J, Schmidtke G, Peter C, Groettrup M, Wiesner S
Nat Commun (2018) [PMID: 30127417  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Ubiquitin D (Preferred)   search this complex
PDBe complex ID: PDB-CPX-127352 (Preferred)   search this ID
PDBe-KB: O15205   
Solution NMR
Released: 8 Aug 2018
Model geometry
Fit model/data
Data not analysed
6gf2
6gf2
6gf2
Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt2 at top of spiral staircase and partially unfolded Eos
Arkinson C, Gee CL, Martin A
bioRxiv (2024) [PMID: 39574680  ]
Assembly composition: protein/protein complex
Bound ligands: MG    ZN    ADP    ADP    ZN    ATP    MG    ATP   
Modified residues: CR8    CR8   
PDBe complex ID: PDB-CPX-281387 (Preferred)   search this ID
PDBe-KB: O15205    Q5S6Z9    P43686    P25789    O43242    Q9UNM6    (view 29 more)
Electron Microscopy
3.1Å resolution
Released: 4 Dec 2024
Model geometry
Fit model/data
Data not analysed
9e8o
9e8o
9e8o
The structure of the ubiquitin-like modifier FAT10 reveals a novel targeting mechanism for degradation by the 26S proteasome
Aichem A, Anders S, Catone N, Roessler P, Stotz S, Berg A, Schwab R, Scheuermann S, Bialas J, Schmidtke G, Peter C, Groettrup M, Wiesner S
Nat Commun (2018) [PMID: 30127417  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SO4   
Assembly name: Ubiquitin D (Preferred)   search this complex
PDBe complex ID: PDB-CPX-127352 (Preferred)   search this ID
PDBe-KB: O15205   
X-ray diffraction
1.925Å resolution
Released: 29 Aug 2018
Model geometry
Fit model/data
6gf1
6gf1
6gf1
Crystal structure of human UBA6 in complex with the ubiquitin-like modifier FAT10
Li S, Truongvan N, Schindelin H
Nat Commun (2022) [PMID: 35970836  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Ubiquitin-like modifier-activating enzyme 1, Ubiquitin-like modifier-activating enzyme 6 and Ubiquitin D (Preferred)   search this complex
PDBe complex ID: PDB-CPX-106055 (Preferred)   search this ID
PDBe-KB: O15205    P22314    A0AVT1   
X-ray diffraction
3.27Å resolution
Released: 24 Aug 2022
Model geometry
Fit model/data
7pyv
7pyv
7pyv
Backbone 1H and 15N Chemical Shift Assignments for the first domain of FAT10
Wang W, Lim L, Qin H
Proc Natl Acad Sci U S A (2014) [PMID: 25422469  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Ubiquitin D (Preferred)   search this complex
PDBe complex ID: PDB-CPX-127352 (Preferred)   search this ID
PDBe-KB: O15205   
Solution NMR
Released: 27 Aug 2014
Model geometry
Fit model/data
Data not analysed
2mbe
2mbe
2mbe
Entries 1 to 5 of 5
Entries 1 to 5 of 5