Uniprot accession / id : P70268  OR   Uniprot accession / id : Q16512  OR   Uniprot accession / id : K7EN76
 
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Entry Information
Entry status  (1)
REL
(8)
 
Experimental methods  (2)
X-ray diffraction
(6)
Solution NMR
(2)
 
Authors  (38)
Abbasian M
(4)
Abbassian M
(4)
Cathers B
(4)
Chamberlain P
(4)
Chamberlain PP
(4)
Delker S
(4)
Jackson P
(4)
Mahmoudi A
(4)
Muir J
(4)
Pagarigan B
(4)
Raheja N
(4)
Mott HR
(2)
Nietlispach D
(2)
Owen D
(2)
Blundell TL
(1)
Brosnan CE
(1)
Buhecha HR
(1)
Campbell LJ
(1)
Chirgadze DY
(1)
Hakoshima T
(1)
Ihara K
(1)
Kaibuchi K
(1)
Keszei AF
(1)
Keszei AFA
(1)
Kuroda S
(1)
Lowe PN
(1)
Maesaki R
(1)
McCormick C
(1)
Mccormick C
(1)
Modha R
(1)
Parker PJ
(1)
Rohde JR
(1)
Shimizu T
(1)
Sicheri F
(1)
Tang X
(1)
Tyers M
(1)
Xiaojing T
(1)
Zeqiraj E
(1)
 
Homo / hetero assembly  (2)
homo
(5)
hetero
(3)
 
Assembly composition  (2)
protein structure
(5)
protein/protein complex
(3)
 
Assembly polymer count  (2)
monomer
(5)
dimer
(3)
 
Resolution distribution
1.5 - 2
(3)
2.0 - 2.5
(1)
2.5 - 3
(2)
 
Release year distribution
1995 - 2000
(1)
2000 - 2005
(1)
2005 - 2010
(1)
2010 - 2015
(5)
 
Journal  (4)
PLoS One
(4)
J Biol Chem
(2)
Mol Cell
(1)
Mol Cell Biol
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(8)
 
Organism name  (1)
Homo sapiens
(8)
 
Molecule name  (8)
PAK-1
(8)
Protease-activated kinase 1
(8)
Protein kinase C-like 1
(8)
Protein kinase C-like PKN
(8)
Protein kinase PKN-alpha
(8)
Protein-kinase C-related kinase 1
(8)
Serine-threonine protein kinase N
(8)
Serine/threonine-protein kinase N1
(8)
 
Molecule type  (1)
Protein
(8)
 
Gene names  (5)
PAK1
(8)
PKN
(8)
PKN1
(8)
PRK1
(8)
PRKCL1
(8)
 
Interacting Molecules  (3)
E3 ubiquitin-protein ligase SspH1
(1)
Ras-related C3 botulinum toxin substrate 1
(1)
Transforming protein RhoA
(1)
 
Interacting ligands  (4)
2V9 : Lestaurtinib
(1)
DRN : BISINDOLYLMALEIMIDE IX
(1)
HEZ : HEXANE-1,6-DIOL
(1)
MI1 : 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile
(1)
 
Function and Biology
EC number / name  (1)
2.7.11.13 : Protein kinase C
(8)
 
Biological function  (3)
ATP binding
(4)
protein kinase activity
(4)
protein serine/threonine kinase activity
(4)
 
Biological process  (2)
protein phosphorylation
(4)
signal transduction
(4)
 
Representative Structures
Representative Structures
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Entries 1 to 8 of 8
Entries 1 to 8 of 8
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HR1b domain from PRK1
Owen D, Lowe PN, Nietlispach D, Brosnan CE, Chirgadze DY, Parker PJ, Blundell TL, Mott HR
J Biol Chem (2003) [PMID: 14514689  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Serine/threonine-protein kinase N1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172465 (Preferred)   search this ID
PDBe-KB: Q16512   
Solution NMR
Released: 6 Nov 2003
Model geometry
Fit model/data
Data not analysed
1urf
1urf
1urf
CRYSTAL STRUCTURE OF HUMAN RHOA COMPLEXED WITH THE EFFECTOR DOMAIN OF THE PROTEIN KINASE PKN/PRK1
Maesaki R, Ihara K, Shimizu T, Kuroda S, Kaibuchi K, Hakoshima T
Mol Cell (1999) [PMID: 10619026  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    GSP    GSP    MG   
Assembly name: Transforming protein RhoA and Serine/threonine-protein kinase N1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-158280 (Preferred)   search this ID
PDBe-KB: Q16512    P61586   
X-ray diffraction
2.2Å resolution
Released: 8 Oct 1999
Model geometry
Fit model/data
1cxz
1cxz
1cxz
Crystal Structure of PRK1 Catalytic Domain in Complex with Tofacitinib
Chamberlain PP, Delker S, Pagarigan B, Mahmoudi A, Jackson P, Abbassian M, Muir J, Raheja N, Cathers B
PLoS One (2014) [PMID: 25111382  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: MI1    MI1   
Modified residues: SEP    TPO    SEP    TPO   
Assembly name: Serine/threonine-protein kinase N1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172465 (Preferred)   search this ID
PDBe-KB: Q16512   
X-ray diffraction
1.93Å resolution
Released: 27 Aug 2014
Model geometry
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4oti
4oti
4oti
Crystal Structure of PRK1 Catalytic Domain
Chamberlain PP, Delker S, Pagarigan B, Mahmoudi A, Jackson P, Abbassian M, Muir J, Raheja N, Cathers B
PLoS One (2014) [PMID: 25111382  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Modified residues: SEP    TPO    SEP    TPO   
Assembly name: Serine/threonine-protein kinase N1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172465 (Preferred)   search this ID
PDBe-KB: Q16512   
X-ray diffraction
2Å resolution
Released: 27 Aug 2014
Model geometry
Fit model/data
4otd
4otd
4otd
Crystal Structure of PRK1 Catalytic Domain in Complex with Ro-31-8220
Chamberlain PP, Delker S, Pagarigan B, Mahmoudi A, Jackson P, Abbassian M, Muir J, Raheja N, Cathers B
PLoS One (2014) [PMID: 25111382  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: DRN    DRN   
Modified residues: SEP    TPO    SEP    TPO   
Assembly name: Serine/threonine-protein kinase N1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172465 (Preferred)   search this ID
PDBe-KB: Q16512   
X-ray diffraction
1.8Å resolution
Released: 27 Aug 2014
Model geometry
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4oth
4oth
4oth
Crystal Structure of PRK1 Catalytic Domain in Complex with Lestaurtinib
Chamberlain PP, Delker S, Pagarigan B, Mahmoudi A, Jackson P, Abbassian M, Muir J, Raheja N, Cathers B
PLoS One (2014) [PMID: 25111382  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 2V9   
Modified residues: SEP    TPO    SEP    TPO   
Assembly name: Serine/threonine-protein kinase N1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172465 (Preferred)   search this ID
PDBe-KB: Q16512   
X-ray diffraction
2.6Å resolution
Released: 27 Aug 2014
Model geometry
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4otg
4otg
4otg
Rac1/PRK1 Complex
Modha R, Campbell LJ, Nietlispach D, Buhecha HR, Owen D, Mott HR
J Biol Chem (2008) [PMID: 18006505  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GCP    MG    MG    GCP   
Assembly name: Ras-related C3 botulinum toxin substrate 1 and Serine/threonine-protein kinase N1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-158901 (Preferred)   search this ID
PDBe-KB: Q16512    P63000   
Solution NMR
Released: 13 Nov 2007
Model geometry
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Data not analysed
2rmk
2rmk
2rmk
Crystal structure of SspH1 LRR domain in complex PKN1 HR1b domain
Keszei AFA, Xiaojing T, Mccormick C, Zeqiraj E, Rohde JR, Tyers M, Sicheri F
Mol Cell Biol (2014) [PMID: 24248594  ]
Assembly composition: protein/protein complex
Bound ligands: HEZ   
Assembly name: Serine/threonine-protein kinase N1 and E3 ubiquitin-protein ligase SspH1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-112224 (Preferred)   search this ID
PDBe-KB: Q16512    D0ZVG2   
X-ray diffraction
2.9Å resolution
Released: 11 Dec 2013
Model geometry
Fit model/data
4nkg
4nkg
4nkg
Entries 1 to 8 of 8
Entries 1 to 8 of 8