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Entry Information
Entry status
(1)
Experimental methods
(2)
X-ray diffraction
(6)
Solution NMR
(2)
Authors
(38)
Abbasian M
(4)
Abbassian M
(4)
Cathers B
(4)
Chamberlain P
(4)
Chamberlain PP
(4)
Delker S
(4)
Jackson P
(4)
Mahmoudi A
(4)
Muir J
(4)
Pagarigan B
(4)
Raheja N
(4)
Mott HR
(2)
Nietlispach D
(2)
Owen D
(2)
Blundell TL
(1)
Brosnan CE
(1)
Buhecha HR
(1)
Campbell LJ
(1)
Chirgadze DY
(1)
Hakoshima T
(1)
Ihara K
(1)
Kaibuchi K
(1)
Keszei AF
(1)
Keszei AFA
(1)
Kuroda S
(1)
Lowe PN
(1)
Maesaki R
(1)
McCormick C
(1)
Mccormick C
(1)
Modha R
(1)
Parker PJ
(1)
Rohde JR
(1)
Shimizu T
(1)
Sicheri F
(1)
Tang X
(1)
Tyers M
(1)
Xiaojing T
(1)
Zeqiraj E
(1)
Homo / hetero assembly
(2)
homo
(5)
hetero
(3)
Assembly composition
(2)
protein structure
(5)
protein/protein complex
(3)
Assembly polymer count
(2)
monomer
(5)
dimer
(3)
Resolution distribution
1.5 - 2
(3)
2.0 - 2.5
(1)
2.5 - 3
(2)
Release year distribution
1995 - 2000
(1)
2000 - 2005
(1)
2005 - 2010
(1)
2010 - 2015
(5)
Journal
(4)
PLoS One
(4)
J Biol Chem
(2)
Mol Cell
(1)
Mol Cell Biol
(1)
Macromolecules
Organism superkingdom
(1)
Eukaryota
(8)
Organism name
(1)
Homo sapiens
(8)
Molecule name
(8)
PAK-1
(8)
Protease-activated kinase 1
(8)
Protein kinase C-like 1
(8)
Protein kinase C-like PKN
(8)
Protein kinase PKN-alpha
(8)
Protein-kinase C-related kinase 1
(8)
Serine-threonine protein kinase N
(8)
Serine/threonine-protein kinase N1
(8)
Molecule type
(1)
Protein
(8)
Gene names
(5)
PAK1
(8)
PKN
(8)
PKN1
(8)
PRK1
(8)
PRKCL1
(8)
Interacting Molecules
(3)
E3 ubiquitin-protein ligase SspH1
(1)
Ras-related C3 botulinum toxin substrate 1
(1)
Transforming protein RhoA
(1)
Interacting ligands
(4)
2V9 : Lestaurtinib
(1)
DRN : BISINDOLYLMALEIMIDE IX
(1)
HEZ : HEXANE-1,6-DIOL
(1)
MI1 : 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile
(1)
Function and Biology
EC number / name
(1)
2.7.11.13 : Protein kinase C
(8)
Biological function
(3)
ATP binding
(4)
protein kinase activity
(4)
protein serine/threonine kinase activity
(4)
Biological process
(2)
protein phosphorylation
(4)
signal transduction
(4)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 8 of 8
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HR1b domain from PRK1
Owen D, Lowe PN, Nietlispach D, Brosnan CE, Chirgadze DY, Parker PJ, Blundell TL, Mott HR
J Biol Chem
(2003)
[PMID: 14514689 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Serine/threonine-protein kinase N1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-172465 (Preferred)
search this ID

CRYSTAL STRUCTURE OF HUMAN RHOA COMPLEXED WITH THE EFFECTOR DOMAIN OF THE PROTEIN KINASE PKN/PRK1
Maesaki R, Ihara K, Shimizu T, Kuroda S, Kaibuchi K, Hakoshima T
Mol Cell
(1999)
[PMID: 10619026 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Transforming protein RhoA and Serine/threonine-protein kinase N1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-158280 (Preferred)
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Crystal Structure of PRK1 Catalytic Domain in Complex with Tofacitinib
Chamberlain PP, Delker S, Pagarigan B, Mahmoudi A, Jackson P, Abbassian M, Muir J, Raheja N, Cathers B
PLoS One
(2014)
[PMID: 25111382 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Serine/threonine-protein kinase N1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-172465 (Preferred)
search this ID

Crystal Structure of PRK1 Catalytic Domain
Chamberlain PP, Delker S, Pagarigan B, Mahmoudi A, Jackson P, Abbassian M, Muir J, Raheja N, Cathers B
PLoS One
(2014)
[PMID: 25111382 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Serine/threonine-protein kinase N1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-172465 (Preferred)
search this ID

Crystal Structure of PRK1 Catalytic Domain in Complex with Ro-31-8220
Chamberlain PP, Delker S, Pagarigan B, Mahmoudi A, Jackson P, Abbassian M, Muir J, Raheja N, Cathers B
PLoS One
(2014)
[PMID: 25111382 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Serine/threonine-protein kinase N1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-172465 (Preferred)
search this ID

Crystal Structure of PRK1 Catalytic Domain in Complex with Lestaurtinib
Chamberlain PP, Delker S, Pagarigan B, Mahmoudi A, Jackson P, Abbassian M, Muir J, Raheja N, Cathers B
PLoS One
(2014)
[PMID: 25111382 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Bound ligands:
2V9
Assembly name:
Serine/threonine-protein kinase N1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-172465 (Preferred)
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Rac1/PRK1 Complex
Modha R, Campbell LJ, Nietlispach D, Buhecha HR, Owen D, Mott HR
J Biol Chem
(2008)
[PMID: 18006505 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Ras-related C3 botulinum toxin substrate 1 and Serine/threonine-protein kinase N1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-158901 (Preferred)
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Crystal structure of SspH1 LRR domain in complex PKN1 HR1b domain
Keszei AFA, Xiaojing T, Mccormick C, Zeqiraj E, Rohde JR, Tyers M, Sicheri F
Mol Cell Biol
(2014)
[PMID: 24248594 ]
Source organisms: Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S , Homo sapiens
Assembly composition: protein/protein complex
Bound ligands:
HEZ
Assembly name:
Serine/threonine-protein kinase N1 and E3 ubiquitin-protein ligase SspH1
(Preferred)
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PDBe complex ID:
PDB-CPX-112224 (Preferred)
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Entries 1 to 8 of 8