Uniprot accession / id : P70315  OR   Uniprot accession / id : P42768  OR   Uniprot accession / id : A0A024QYX8
 
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Entry Information
Entry status  (1)
REL
(6)
 
Experimental methods  (2)
Solution NMR
(4)
X-ray diffraction
(2)
 
Authors  (27)
Rosen MK
(4)
Abdul-Manan N
(2)
Kim AS
(2)
Liu GA
(2)
Ouerfelli O
(2)
Aghazadeh B
(1)
Bickford LC
(1)
Campellone KG
(1)
Cheng H-C
(1)
Cheng HC
(1)
Chereau D
(1)
Dominguez R
(1)
Grabarek Z
(1)
Graceffa P
(1)
Izard T
(1)
Kakalis LT
(1)
Kerff F
(1)
Kirschner MW
(1)
Langsetmo K
(1)
Leong JM
(1)
Majumdar A
(1)
Morgan D
(1)
Peterson JR
(1)
Siminovitch KA
(1)
Skehan BM
(1)
St-Jean M
(1)
Sygusch J
(1)
 
Homo / hetero assembly  (2)
hetero
(4)
homo
(2)
 
Assembly composition  (2)
protein/protein complex
(4)
protein structure
(2)
 
Assembly polymer count  (4)
dimer
(2)
monomer
(2)
octamer
(1)
trimer
(1)
 
Resolution distribution
2.0 - 2.5
(2)
 
Release year distribution
1995 - 2000
(2)
2000 - 2005
(3)
2005 - 2010
(3)
 
Journal  (4)
Nature
(3)
J Biol Chem
(1)
Nat Struct Mol Biol
(1)
Proc Natl Acad Sci U S A
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(6)
 
Organism name  (1)
Homo sapiens
(6)
 
Molecule name  (3)
Actin nucleation-promoting factor WAS
(6)
WASp
(6)
Wiskott-Aldrich syndrome protein
(6)
 
Molecule type  (1)
Protein
(6)
 
Gene names  (2)
IMD2
(6)
WAS
(6)
 
Interacting Molecules  (5)
Actin, alpha skeletal muscle
(1)
Cell division control protein 42 homolog
(1)
Deoxyribonuclease-1
(1)
ESPFU
(1)
Fructose-bisphosphate aldolase A
(1)
 
Interacting ligands  (1)
WSK : (2S)-1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL
(1)
 
Function and Biology
Biological function  (1)
actin binding
(1)
 
Biological process  (1)
actin filament organization
(4)
 
Sequence and Structure classification
SCOP fold  (1)
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
(2)
 
SCOP family  (1)
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
(2)
 
CATH class  (1)
Alpha Beta
(4)
 
CATH topology  (1)
SerineThreonine-protein kinase PAK-alpha; Chain A
(4)
 
Pfam accession / name  (2)
PF00786 : PBD
(4)
PF02205 : WH2
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(3)
 
Diffraction radiation source type  (1)
Synchrotron
(2)
 
Diffraction source  (2)
APS BEAMLINE 17-ID
(1)
APS BEAMLINE 22-BM
(1)
 
Synchrotron site  (1)
APS
(2)
 
Diffraction detector type  (1)
CCD
(1)
 
Refinement software  (2)
CNS
(1)
REFMAC
(1)
 
NMR
NMR software packages  (6)
ARIA
(4)
NMRPipe
(4)
NMRView
(4)
CNS
(3)
X-PLOR
(3)
VNMR
(2)
 
NMR Field Strength
400.0 - 500
(2)
500.0 - 600
(4)
600.0 - 700
(4)
 
Representative Structures
Representative Structures
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Entries 1 to 6 of 6
Entries 1 to 6 of 6
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Solution Structure of the GTPase Binding Domain of WASP in Complex with EspFU, an EHEC Effector
Cheng H-C, Skehan BM, Campellone KG, Leong JM, Rosen MK
Nature (2008) [PMID: 18650809  ]
Assembly composition: protein/protein complex
Assembly name: Actin nucleation-promoting factor WAS (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154864 (Preferred)   search this ID
PDBe-KB: P42768   
Solution NMR
Released: 22 Jul 2008
Model geometry
Fit model/data
Data not analysed
2k42
2k42
2k42
SOLUTION STRUCTURE OF THE AUTOINHIBITED CONFORMATION OF WASP
Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK
Nature (2000) [PMID: 10724160  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Actin nucleation-promoting factor WAS (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154862 (Preferred)   search this ID
PDBe-KB: P42768   
Solution NMR
Released: 5 Apr 2000
Model geometry
Fit model/data
Data not deposited
1ej5
1ej5
1ej5
SOLUTION STRUCTURE OF CDC42 IN COMPLEX WITH THE GTPASE BINDING DOMAIN OF WASP
Abdul-Manan N, Aghazadeh B, Liu GA, Majumdar A, Ouerfelli O, Rosen MK
Nature (1999) [PMID: 10360578  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GCP    MG    MG    GCP   
Assembly name: Actin nucleation-promoting factor WAS and Cell division control protein 42 homolog (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154863 (Preferred)   search this ID
PDBe-KB: P42768    P60953   
Solution NMR
Released: 30 Jun 1999
Model geometry
Fit model/data
Data not deposited
1cee
1cee
1cee
Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with a C-terminal peptide of Wiskott-Aldrich syndrome protein
St-Jean M, Izard T, Sygusch J
J Biol Chem (2007) [PMID: 17329259  ]
Assembly composition: protein/protein complex
Assembly name: Actin nucleation-promoting factor WAS and Fructose-bisphosphate aldolase A (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133667 (Preferred)   search this ID
PDBe-KB: P42768    P00883   
X-ray diffraction
2.05Å resolution
Released: 27 Feb 2007
Model geometry
Fit model/data
2ot0
2ot0
2ot0
Ternary complex of the WH2 domain of WASP with Actin-DNAse I
Chereau D, Kerff F, Dominguez R
Proc Natl Acad Sci U S A (2005) [PMID: 16275905  ]
Assembly composition: protein/protein complex
Bound ligands: FMT    CA    MG    FMT    GOL    CA    ATP    MG    ATP   
Modified residues: HIC    HIC   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
PDBe complex ID: PDB-CPX-132781 (Preferred)   search this ID
PDBe-KB: P42768    P00639    P68135   
X-ray diffraction
2.078Å resolution
Released: 1 Nov 2005
Model geometry
Fit model/data
2a3z
2a3z
2a3z
Solution structure of the Wiskott-Aldrich Syndrome Protein (WASP) autoinhibited core domain complexed with (S)-wiskostatin, a small molecule inhibitor
Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK
Nat Struct Mol Biol (2004) [PMID: 15235593  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: WSK    WSK   
Assembly name: Actin nucleation-promoting factor WAS (Preferred)   search this complex
PDBe complex ID: PDB-CPX-154862 (Preferred)   search this ID
PDBe-KB: P42768   
Solution NMR
Released: 13 Jul 2004
Model geometry
Fit model/data
Data not deposited
1t84
1t84
1t84
Entries 1 to 6 of 6
Entries 1 to 6 of 6