Entry status  (1)

REL

(16)

Experimental methods  (1)

X-ray diffraction

(16)

Authors  (150)

Bong SM

(4)

Cho N

(4)

Hara H

(4)

Hoffman I

(4)

Hoffman ID

(4)

Homma M

(4)

Iwai K

(4)

Kurasawa O

(4)

Lee BI

(4)

Lee SJ

(4)

Miyazaki T

(4)

Oguro Y

(4)

Ohashi A

(4)

Park TH

(4)

Skene R

(4)

Adam LP

(3)

Hu Z

(3)

Muckelbauer JK

(3)

Quan ML

(3)

Sitkoff D

(3)

Skene RJ

(3)

Wang C

(3)

Wexler RR

(3)

Cheadle NL

(2)

Glunz PW

(2)

Imada T

(2)

Ishikawa T

(2)

Iwata K

(2)

Mori K

(2)

Nomura T

(2)

Ohori M

(2)

Sugimoto H

(2)

Uchiyama N

(2)

Xu S

(2)

Yamamoto Y

(2)

Yoshida S

(2)

Accetta A

(1)

Aguirre AL

(1)

Akama T

(1)

Alen J

(1)

Augustin M

(1)

Barnes M

(1)

Beaumont V

(1)

Boland S

(1)

Boumans N

(1)

Bourin A

(1)

Brown BS

(1)

Bu W

(1)

Cachope R

(1)

Castermans K

(1)

Chauhan A

(1)

Chen AY

(1)

Chen XQ

(1)

Clark D

(1)

Cui Y

(1)

Defert O

(1)

DiGiammarino E

(1)

Ding P

(1)

Dominguez C

(1)

Dominguez E

(1)

Dong C

(1)

Edwards C

(1)

Egan DA

(1)

Facchinetti F

(1)

Fan XQ

(1)

Fransen S

(1)

Freiberg GM

(1)

Freund Y

(1)

Gallati C

(1)

Geraets J

(1)

Gopalakrishnan SM

(1)

Guarino VR

(1)

Harris CM

(1)

Haughan AF

(1)

Hennan J

(1)

Hobson AD

(1)

Honore MP

(1)

Jarnagin K

(1)

Judge RA

(1)

Kage KL

(1)

Kapecki NJ

(1)

Kempf G

(1)

Kindt N

(1)

Krapp S

(1)

Ladduwahetty T

(1)

Lee MR

(1)

Leysen D

(1)

Li J

(1)

Ling C

(1)

Liu L

(1)

Luckhurst CA

(1)

Ma J

(1)

Mack H

(1)

Maillard MC

(1)

Malysa P

(1)

Mamo M

(1)

Matthews K

(1)

Maurus S

(1)

McAllister G

(1)

McRae B

(1)

 

More...

Homo / hetero assembly  (1)

homo

(16)

Assembly composition  (1)

protein structure

(16)

Assembly polymer count  (2)

monomer

(9)

dimer

(7)

Resolution distribution

2.0 - 2.5

(2)

2.5 - 3

(10)

3.0 - 3.5

(4)

Release year distribution

2010 - 2015

(2)

2015 - 2020

(8)

2020 - 2025

(11)

Journal  (6)

J Med Chem

(5)

To be published

(4)

Bioorg Med Chem Lett

(3)

Bioorg Med Chem

(2)

J Pharmacol Exp Ther

(1)

RSC Med Chem

(1)

Organism superkingdom  (1)

Eukaryota

(16)

Organism name  (1)

Homo sapiens

(16)

Molecule name  (6)

ROCK-II

(16)

Rho kinase 2

(16)

Rho-associated protein kinase 2

(16)

Rho-associated, coiled-coil-containing protein kinase 2

(16)

Rho-associated, coiled-coil-containing protein kinase II

(16)

p164 ROCK-2

(16)

Molecule type  (1)

Protein

(16)

Gene names  (2)

KIAA0619

(16)

ROCK2

(16)

Interacting ligands  (18)

SO4 : SULFATE ION

(4)

MES : 2-(N-MORPHOLINO)-ETHANESULFONIC ACID

(2)

1WU : 6-[4-(aminomethyl)-2-fluorophenoxy]-2,1-benzoxaborol-1(3H)-ol

(1)

3SG : methyl 3-[({2'-(aminomethyl)-5'-[(3-fluoropyridin-4-yl)carbamoyl]biphenyl-3-yl}carbonyl)amino]-4-fluorobenzoate

(1)

5YS : ~{N}-[(1~{R})-1-(3-methoxyphenyl)ethyl]-4-pyridin-4-yl-piperidine-1-carboxamide

(1)

81G : (1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1H-pyrazol-4-yl)-1'H-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'H)-one

(1)

A1H6L : 8-(azaindolyl)-benzoazepinone

(1)

EDO : 1,2-ETHANEDIOL

(1)

J0P : N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide

(1)

O1S : 6-(5-methyl-1H-pyrazol-4-yl)-2-[(pyrrolidin-1-yl)methyl]thieno[3,2-d]pyrimidin-4(3H)-one

(1)

O1V : 2-[(2S)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one

(1)

VFA : N-[(3-methoxyphenyl)methyl]-5H-[1]benzopyrano[3,4-c]pyridine-8-carboxamide

(1)

VFS : N-[(1S)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1H-pyrazol-4-yl)benzamide

(1)

YDW : ~{N}-methyl-3-[[1-oxidanylidene-6-[5-(trifluoromethyl)-1~{H}-pyrazol-4-yl]isoquinolin-2-yl]methyl]benzamide

(1)

YEA : 3-fluoranyl-~{N}-methyl-5-[[1-oxidanylidene-6-[5-(trifluoromethyl)-1~{H}-pyrazol-4-yl]isoquinolin-2-yl]methyl]benzamide

(1)

YEI : ~{N}-methyl-3-[[6-(3-methyl-1,2-oxazol-4-yl)-1-oxidanylidene-isoquinolin-2-yl]methyl]benzamide

(1)

YEW : ~{N}-methyl-3-[[6-(2-methylpyrazol-3-yl)-1-oxidanylidene-isoquinolin-2-yl]methyl]benzamide

(1)

Z8O : 4-{4-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]phenyl}phthalazin-1(2H)-one

(1)

EC number / name  (1)

2.7.11.1 : Non-specific serine/threonine protein kinase

(16)

Biological function  (3)

ATP binding

(16)

protein kinase activity

(16)

protein serine/threonine kinase activity

(16)

Biological process  (1)

protein phosphorylation

(16)

CATH class  (2)

Alpha Beta

(4)

Mainly Alpha

(4)

CATH topology  (2)

Phosphorylase Kinase; domain 1

(4)

Transferase(Phosphotransferase); domain 1

(4)

Pfam accession / name  (1)

PF00069 : Pkinase

(16)

Diffraction protocol  (1)

Single wavelength

(16)

Diffraction radiation source type  (1)

Synchrotron

(16)

Diffraction source  (8)

ALS BEAMLINE 5.0.3

(3)

PAL/PLS BEAMLINE 11C

(3)

SLS BEAMLINE X06SA

(3)

SLS BEAMLINE X10SA

(3)

ALS BEAMLINE 5.0.2

(1)

APS BEAMLINE 21-ID-G

(1)

SLS BEAMLINE X06DA

(1)

SPRING-8 BEAMLINE BL44XU

(1)

Synchrotron site  (5)

SLS

(7)

ALS

(4)

PAL/PLS

(3)

APS

(1)

SPring-8

(1)

Diffraction detector type  (2)

Pixel

(11)

CCD

(5)

Refinement software  (3)

REFMAC

(8)

BUSTER

(4)

PHENIX

(4)

Representative Structures

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