Uniprot accession / id : P70340  OR   Uniprot accession / id : Q15797  OR   Uniprot accession / id : D6RDN7
 
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Entry Information
Entry status  (1)
REL
(11)
 
Experimental methods  (2)
Solution NMR
(6)
X-ray diffraction
(5)
 
Authors  (41)
Aragon E
(6)
Aragón E
(6)
Escobedo A
(6)
Goerner N
(6)
Macias MJ
(6)
Massague J
(6)
Massagué J
(6)
Xi Q
(6)
Zaromytidou A
(6)
Zaromytidou AI
(6)
Chang Z
(2)
Chen L
(2)
Hao R
(2)
Liu YT
(2)
Wang HR
(2)
Wang L
(2)
Wang ZX
(2)
Wu JW
(2)
Asashima M
(1)
BabuRajendran N
(1)
Baburajendran N
(1)
Chacko BM
(1)
Correia JJ
(1)
Fukatsu Y
(1)
Ito T
(1)
Jauch R
(1)
Kolatkar PR
(1)
Kurisaki A
(1)
Lam SS
(1)
Lin K
(1)
Miyazono K
(1)
Miyazono KI
(1)
Narasimhan K
(1)
Ohno Y
(1)
Palasingam P
(1)
Prabhakar S
(1)
Qin BY
(1)
Sun W
(1)
Tanokura M
(1)
Wada H
(1)
de Caestecker MP
(1)
 
Homo / hetero assembly  (2)
hetero
(10)
homo
(1)
 
Assembly composition  (3)
protein/protein complex
(9)
DNA/protein complex
(1)
protein structure
(1)
 
Assembly polymer count  (4)
dimer
(8)
hexamer
(1)
tetramer
(1)
trimer
(1)
 
Resolution distribution
1.5 - 2
(2)
2.0 - 2.5
(1)
2.5 - 3
(2)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(1)
2010 - 2015
(9)
2015 - 2020
(1)
 
Journal  (4)
Genes Dev
(6)
J Biol Chem
(2)
Nucleic Acids Res
(2)
Mol Cell
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(11)
 
Organism name  (2)
Homo sapiens
(10)
Mus musculus
(1)
 
Molecule name  (15)
MAD homolog 1
(11)
Mad-related protein 1
(11)
Mothers against DPP homolog 1
(11)
Mothers against decapentaplegic homolog 1
(11)
SMAD 1
(11)
SMAD family member 1
(11)
Smad1
(11)
BSP-1
(10)
JV4-1
(10)
Transforming growth factor-beta-signaling protein 1
(10)
hSMAD1
(10)
Dwarfin-A
(1)
Dwf-A
(1)
Mothers-against-DPP-related 1
(1)
mMad1
(1)
 
Molecule type  (1)
Protein
(11)
 
Gene names  (7)
BSP1
(10)
MADH1
(10)
MADR1
(10)
SMAD1
(10)
Madh1
(1)
Madr1
(1)
Smad1
(1)
 
Interacting Molecules  (6)
E3 ubiquitin-protein ligase SMURF1
(3)
Transcriptional coactivator YAP1
(3)
E3 ubiquitin-protein ligase CHIP
(2)
5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A)-3'
(1)
5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP*GP*A)-3'
(1)
Inner nuclear membrane protein Man1
(1)
 
Interacting ligands  (2)
GOL : GLYCEROL
(1)
ZN : ZINC ION
(1)
 
Function and Biology
Biological process  (1)
regulation of DNA-templated transcription
(3)
 
Biological cell component  (1)
transcription regulator complex
(1)
 
Sequence and Structure classification
SCOP fold  (1)
SMAD/FHA domain
(1)
 
SCOP family  (1)
SMAD domain
(1)
 
CATH class  (2)
Mainly Beta
(2)
Alpha Beta
(1)
 
CATH topology  (2)
Tumour Suppressor Smad4
(2)
Smad3; Chain A
(1)
 
Pfam accession / name  (2)
PF03166 : MH2
(2)
PF03165 : MH1
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(5)
 
Diffraction radiation source type  (2)
Synchrotron
(3)
Rotating anode
(2)
 
Diffraction source  (4)
SSRF BEAMLINE BL17U
(2)
NSRRC BEAMLINE BL13B1
(1)
RIGAKU
(1)
RIGAKU FR-E SUPERBRIGHT
(1)
 
Synchrotron site  (2)
SSRF
(2)
NSRRC
(1)
 
Diffraction detector type  (2)
CCD
(3)
Image plate
(1)
 
Refinement software  (2)
PHENIX
(4)
CNS
(1)
 
NMR
NMR software packages  (4)
CNS
(6)
NMRPipe
(6)
TopSpin
(6)
XEASY
(6)
 
NMR Field Strength
500.0 - 600
(6)
600.0 - 700
(6)
 
Representative Structures
Representative Structures
100%
95%
90%
70%
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40%
30%
Entries 1 to 10 of 11
Entries 1 to 10 of 11
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Crystal structure of human SMAD1-MAN1 complex.
Miyazono K, Ito T, Tanokura M
Nucleic Acids Res (2018) [PMID: 30321401  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: SMAD1 homotrimer and Inner nuclear membrane protein Man1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172412 (Preferred)   search this ID
PDBe-KB: Q15797    Q9Y2U8   
X-ray diffraction
2.85Å resolution
Released: 17 Oct 2018
Model geometry
Fit model/data
5zok
5zok
5zok
Crystal structure of TPR domain of CHIP complexed with pseudophosphorylated Smad1 peptide
Wang L, Chen L, Wu JW
J Biol Chem (2011) [PMID: 21454478  ]
Assembly composition: protein/protein complex
Assembly name: E3 ubiquitin-protein ligase CHIP and Mothers against decapentaplegic homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172410 (Preferred)   search this ID
PDBe-KB: Q15797    Q9WUD1   
X-ray diffraction
1.705Å resolution
Released: 16 Mar 2011
Model geometry
Fit model/data
3q47
3q47
3q47
Structure of first WW domain of human YAP in complex with a human Smad1 doubly-phosphorilated derived peptide.
Macias MJ, Aragon E, Goerner N, Zaromytidou A, Xi Q, Escobedo A, Massague J
Genes Dev (2011) [PMID: 21685363  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: SEP    TPO    SEP    TPO   
Assembly name: Transcriptional coactivator YAP1 and Mothers against decapentaplegic homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155555 (Preferred)   search this ID
PDBe-KB: Q15797    P46937   
Solution NMR
Released: 6 Jul 2011
Model geometry
Fit model/data
Data not analysed
2lax
2lax
2lax
Structure of the second domain of human Smurf1 in complex with a human Smad1 derived peptide
Macias MJ, Aragon E, Goerner N, Zaromytidou A, Xi Q, Escobedo A, Massague J
Genes Dev (2011) [PMID: 21685363  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: NH2    NH2   
Assembly name: E3 ubiquitin-protein ligase SMURF1 and Mothers against decapentaplegic homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172409 (Preferred)   search this ID
PDBe-KB: Q15797    Q9HCE7   
Solution NMR
Released: 6 Jul 2011
Model geometry
Fit model/data
Data not analysed
2lb1
2lb1
2lb1
Structure of the first WW domain of human Smurf1 in complex with a di-phosphorylated human Smad1 derived peptide
Macias MJ, Aragon E, Goerner N, Zaromytidou A, Xi Q, Escobedo A, Massague J
Genes Dev (2011) [PMID: 21685363  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: SEP    SEP   
Assembly name: E3 ubiquitin-protein ligase SMURF1 and Mothers against decapentaplegic homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172409 (Preferred)   search this ID
PDBe-KB: Q15797    Q9HCE7   
Solution NMR
Released: 6 Jul 2011
Model geometry
Fit model/data
Data not analysed
2lb0
2lb0
2lb0
Structure of the first WW domain of human YAP in complex with a phosphorylated human Smad1 derived peptide
Macias MJ, Aragon E, Goerner N, Zaromytidou A, Xi Q, Escobedo A, Massague J
Genes Dev (2011) [PMID: 21685363  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: SEP    SEP   
Assembly name: Transcriptional coactivator YAP1 and Mothers against decapentaplegic homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155555 (Preferred)   search this ID
PDBe-KB: Q15797    P46937   
Solution NMR
Released: 6 Jul 2011
Model geometry
Fit model/data
Data not analysed
2lay
2lay
2lay
Structure of the first WW domain of human Smurf1 in complex with a mono-phosphorylated human Smad1 derived peptide
Macias MJ, Aragon E, Goerner N, Zaromytidou A, Xi Q, Escobedo A, Massague J
Genes Dev (2011) [PMID: 21685363  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: SEP    SEP   
Assembly name: E3 ubiquitin-protein ligase SMURF1 and Mothers against decapentaplegic homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172409 (Preferred)   search this ID
PDBe-KB: Q15797    Q9HCE7   
Solution NMR
Released: 6 Jul 2011
Model geometry
Fit model/data
Data not analysed
2laz
2laz
2laz
Smad1 crystal structure reveals the details of BMP signaling pathway
Qin BY, Lin K
Mol Cell (2001) [PMID: 11779505  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: SMAD1 homotrimer (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172411 (Preferred)   search this ID
PDBe-KB: Q15797   
X-ray diffraction
2.5Å resolution
Released: 12 Dec 2001
Model geometry
Fit model/data
1khu
1khu
1khu
Crystal structure of the TPR domain of CHIP complexed with phosphorylated Smad1 peptide
Wang L, Chen L, Wu JW
J Biol Chem (2011) [PMID: 21454478  ]
Assembly composition: protein/protein complex
Modified residues: SEP    SEP   
Assembly name: E3 ubiquitin-protein ligase CHIP and Mothers against decapentaplegic homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172410 (Preferred)   search this ID
PDBe-KB: Q15797    Q9WUD1   
X-ray diffraction
1.542Å resolution
Released: 16 Mar 2011
Model geometry
Fit model/data
3q4a
3q4a
3q4a
Crystal Structure of SMAD1-MH1/DNA complex
Baburajendran N, Palasingam P, Narasimhan K, Jauch R, Kolatkar PR
Nucleic Acids Res (2010) [PMID: 20147459  ]
Source organisms: Synthetic construct, Mus musculus  
Assembly composition: DNA/protein complex
Bound ligands: GOL    ZN    ZN   
Assembly name: Mothers against decapentaplegic homolog 1 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-116492 (Preferred)   search this ID
PDBe-KB: P70340   
X-ray diffraction
2.7Å resolution
Released: 23 Feb 2010
Model geometry
Fit model/data
3kmp
3kmp
3kmp
Entries 1 to 10 of 11
Entries 1 to 10 of 11