Uniprot accession / id : P70426  OR   Uniprot accession / id : Q92963  OR   Uniprot accession / id : V9GYC3
 
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Entry Information
Entry status  (1)
REL
(1)
 
Experimental methods  (1)
X-ray diffraction
(1)
 
Authors  (10)
Ab E
(1)
Andrews M
(1)
Hoedemaeker FJ
(1)
Keizers PH
(1)
Kobayashi M
(1)
Manning L
(1)
Rzepiela AA
(1)
Shah DM
(1)
Siegal G
(1)
Tuin AW
(1)
 
Homo / hetero assembly  (1)
homo
(1)
 
Assembly composition  (1)
protein structure
(1)
 
Assembly polymer count  (1)
monomer
(1)
 
Resolution distribution
2.0 - 2.5
(1)
 
Release year distribution
2010 - 2015
(1)
 
Journal  (1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(1)
 
Organism name  (1)
Homo sapiens
(1)
 
Molecule name  (3)
GTP-binding protein Rit1
(1)
Ras-like protein expressed in many tissues
(1)
Ras-like without CAAX protein 1
(1)
 
Molecule type  (1)
Protein
(1)
 
Gene names  (4)
RIBB
(1)
RIT
(1)
RIT1
(1)
ROC1
(1)
 
Interacting ligands  (2)
GDP : GUANOSINE-5'-DIPHOSPHATE
(1)
MG : MAGNESIUM ION
(1)
 
Function and Biology
EC number / name  (1)
3.6.5.2 : Small monomeric GTPase
(1)
 
Biological function  (2)
GTP binding
(1)
GTPase activity
(1)
 
Biological process  (1)
signal transduction
(1)
 
Biological cell component  (1)
membrane
(1)
 
Sequence and Structure classification
CATH class  (1)
Alpha Beta
(1)
 
CATH topology  (1)
Rossmann fold
(1)
 
Pfam accession / name  (1)
PF00071 : Ras
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(1)
 
Diffraction radiation source type  (1)
Rotating anode
(1)
 
Diffraction source  (1)
OTHER
(1)
 
Diffraction detector type  (1)
CCD
(1)
 
Refinement software  (1)
REFMAC
(1)
 
Representative Structures
Representative Structures
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Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis
Shah DM, Kobayashi M, Keizers PH, Tuin AW, Ab E, Manning L, Rzepiela AA, Andrews M, Hoedemaeker FJ, Siegal G
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GDP    MG    GDP    MG   
Assembly name: GTP-binding protein Rit1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-187822 (Preferred)   search this ID
PDBe-KB: Q92963    Q92963   
X-ray diffraction
2.3Å resolution
Released: 17 Sep 2014
Model geometry
Fit model/data
4klz
4klz
4klz
Entries 1 to 1 of 1
Entries 1 to 1 of 1