Uniprot accession / id : P70671  OR   Uniprot accession / id : Q14653  OR   Uniprot accession / id : E2GIM8  OR   Uniprot accession / id : M0R0R8
 
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Entry Information
Entry status  (1)
REL
(19)
 
Experimental methods  (1)
X-ray diffraction
(19)
 
Authors  (65)
Gao X
(8)
Li P
(8)
Sankaran B
(8)
Zhao B
(8)
Du F
(6)
Herr AB
(6)
Ji JY
(6)
Shelton CL
(6)
Shu C
(6)
Harrison SC
(3)
Maniatis T
(3)
Panne D
(3)
Aggarwal AK
(2)
Altschuh D
(2)
Bonhoure A
(2)
Chebaro Y
(2)
Chi L
(2)
Correia JJ
(2)
Cousido-Siah A
(2)
Derynck R
(2)
Escalante CR
(2)
Forster A
(2)
Fujita T
(2)
Han H
(2)
Horiuchi M
(2)
Inagaki F
(2)
Jing T
(2)
Lam SS
(2)
Lin K
(2)
Liu C
(2)
Masson M
(2)
Mitschler A
(2)
Podjarny A
(2)
Poirson J
(2)
Qin BY
(2)
Srinath H
(2)
Straub M
(2)
Suarez IP
(2)
Takahasi K
(2)
Trave G
(2)
Xu P
(2)
Akira S
(1)
De Ioannes P
(1)
De Ioannes PE
(1)
Delston R
(1)
Fujii K
(1)
Fukuhara Y
(1)
Garcia-Sastre A
(1)
García-Sastre A
(1)
Hiscott J
(1)
Leyi S
(1)
Lin R
(1)
Mori M
(1)
Nakamura S
(1)
Nistal-Villan E
(1)
Nistal-Villán E
(1)
Noda N
(1)
Noda NN
(1)
Okabe Y
(1)
Qin B
(1)
Shen L
(1)
Suhara W
(1)
Suzuki NN
(1)
Terasawa H
(1)
Yoneyama M
(1)
 
Homo / hetero assembly  (2)
hetero
(15)
homo
(4)
 
Assembly composition  (3)
protein/protein complex
(11)
DNA/protein complex
(4)
protein structure
(4)
 
Assembly polymer count  (5)
dimer
(8)
tetramer
(4)
hexamer
(3)
monomer
(3)
pentamer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(6)
2.0 - 2.5
(8)
2.5 - 3
(3)
3.0 - 3.5
(1)
 
Release year distribution
2000 - 2005
(3)
2005 - 2010
(5)
2010 - 2015
(2)
2015 - 2020
(10)
2020 - 2025
(2)
 
Journal  (10)
Proc Natl Acad Sci U S A
(6)
Cell
(2)
J Immunol
(2)
Nat Struct Biol
(2)
To be published
(2)
EMBO J
(1)
Genes Cells
(1)
Mol Cell
(1)
Nucleic Acids Res
(1)
Structure
(1)
 
Macromolecules
Organism superkingdom  (2)
Eukaryota
(19)
Bacteria
(2)
 
Organism name  (4)
Homo sapiens
(18)
Escherichia coli
(1)
Escherichia coli K-12
(1)
Mus musculus
(1)
 
Molecule name  (12)
IRF-3
(19)
Interferon regulatory factor 3
(19)
MBP
(2)
MMBP
(2)
Maltodextrin-binding protein
(2)
Maltose-binding protein
(2)
Maltose/maltodextrin-binding periplasmic protein
(2)
IRF-7
(1)
Interferon regulatory factor 7
(1)
Nuclear factor NF-kappa-B p65 subunit
(1)
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
(1)
Transcription factor p65
(1)
 
Molecule type  (1)
Protein
(19)
 
Gene names  (8)
IRF3
(18)
JW3994
(2)
b4034
(2)
malE
(2)
IRF7
(1)
Irf3
(1)
NFKB3
(1)
RELA
(1)
 
Interacting Molecules  (15)
CREB-binding protein
(4)
Non-structural protein 1
(2)
Protein E6
(2)
31-MER
(1)
34-MER
(1)
36-MER
(1)
Cyclic AMP-dependent transcription factor ATF-2
(1)
Mitochondrial antiviral-signaling protein
(1)
Nuclear factor NF-kappa-B p50 subunit
(1)
PRDIII-I region of human interferon-B promoter strand 1
(1)
PRDIII-I region of human interferon-B promoter strand 2
(1)
Stimulator of interferon genes protein
(1)
TIR domain-containing adapter molecule 1
(1)
Transcription factor Jun
(1)
interferon-b enhancer
(1)
 
Interacting ligands  (8)
GLC : alpha-D-glucopyranose
(2)
PO4 : PHOSPHATE ION
(2)
ACY : ACETIC ACID
(1)
CL : CHLORIDE ION
(1)
MPD : (4S)-2-METHYL-2,4-PENTANEDIOL
(1)
NA : SODIUM ION
(1)
PRD_900030 : alpha-maltopentaose
(1)
ZN : ZINC ION
(1)
 
Function and Biology
Biological function  (6)
DNA-binding transcription factor activity
(17)
transcription cis-regulatory region binding
(5)
carbohydrate transmembrane transporter activity
(2)
DNA binding
(1)
maltose binding
(1)
protein binding
(1)
 
Biological process  (9)
regulation of DNA-templated transcription
(17)
carbohydrate transport
(2)
transmembrane transport
(2)
DNA damage response
(1)
carbohydrate transmembrane transport
(1)
cell chemotaxis
(1)
detection of maltose stimulus
(1)
maltodextrin transmembrane transport
(1)
maltose transport
(1)
 
Biological cell component  (7)
ATP-binding cassette (ABC) transporter complex
(1)
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
(1)
cytoplasm
(1)
maltose transport complex
(1)
membrane
(1)
outer membrane-bounded periplasmic space
(1)
periplasmic space
(1)
 
Sequence and Structure classification
SCOP fold  (2)
DNA/RNA-binding 3-helical bundle
(3)
SMAD/FHA domain
(2)
 
SCOP family  (2)
Interferon regulatory factor
(3)
Interferon regulatory factor 3 (IRF3), transactivation domain
(2)
 
CATH class  (2)
Mainly Beta
(11)
Mainly Alpha
(5)
 
CATH topology  (3)
Tumour Suppressor Smad4
(10)
Arc Repressor Mutant, subunit A
(5)
Immunoglobulin-like
(1)
 
Pfam accession / name  (5)
PF10401 : IRF-3
(12)
PF00605 : IRF
(5)
PF01547 : SBP_bac_1
(2)
PF00554 : RHD_DNA_bind
(1)
PF16179 : RHD_dimer
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(19)
 
Diffraction radiation source type  (2)
Synchrotron
(18)
Rotating anode
(1)
 
Diffraction source  (10)
ALS BEAMLINE 5.0.1
(9)
SLS BEAMLINE X06DA
(2)
ALS BEAMLINE 8.2.1
(1)
APS BEAMLINE 14-BM-C
(1)
APS BEAMLINE 17-BM
(1)
APS BEAMLINE 17-ID
(1)
CHESS BEAMLINE F1
(1)
RIGAKU MICROMAX-007
(1)
SPRING-8 BEAMLINE BL41XU
(1)
SPRING-8 BEAMLINE BL44XU
(1)
 
Synchrotron site  (5)
ALS
(10)
APS
(3)
SLS
(2)
SPring-8
(2)
CHESS
(1)
 
Diffraction detector type  (3)
CCD
(14)
Pixel
(2)
Image plate
(1)
 
Refinement software  (3)
PHENIX
(11)
CNS
(7)
REFMAC
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 19
Entries 1 to 10 of 19
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Crystal structure of human phosphorylated IRF-3 bound to CBP
Li P, Jing T, Zhao B
J Immunol (2020) [PMID: 32826280  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: SEP    SEP   
Assembly name: CREB-binding protein and Interferon regulatory factor 3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172057 (Preferred)   search this ID
PDBe-KB: Q14653    Q92793   
X-ray diffraction
1.68Å resolution
Released: 9 Sep 2020
Model geometry
Fit model/data
7jfl
7jfl
7jfl
Phosphorylated MAVS in complex with IRF-3
Zhao B, Li P
Proc Natl Acad Sci U S A (2016) [PMID: 27302953  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: SEP    SEP   
Assembly name: Mitochondrial antiviral-signaling protein and Interferon regulatory factor 3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172050 (Preferred)   search this ID
PDBe-KB: Q14653    Q7Z434   
X-ray diffraction
2.4Å resolution
Released: 15 Jun 2016
Model geometry
Fit model/data
5jek
5jek
5jek
Structure of Rotavirus NSP1 bound to IRF-3
Zhao B, Li P
Proc Natl Acad Sci U S A (2016) [PMID: 27302953  ]
Assembly composition: protein/protein complex
Assembly name: Interferon regulatory factor 3 and Non-structural protein 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172053 (Preferred)   search this ID
PDBe-KB: Q14653    Q99FX5   
X-ray diffraction
2.913Å resolution
Released: 15 Jun 2016
Model geometry
Fit model/data
5jer
5jer
5jer
Phosphorylated TRIF in complex with IRF-3
Zhao B, Li P
Proc Natl Acad Sci U S A (2016) [PMID: 27302953  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: SEP    SEP   
Assembly name: Interferon regulatory factor 3 and TIR domain-containing adapter molecule 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172051 (Preferred)   search this ID
PDBe-KB: Q14653    Q8IUC6   
X-ray diffraction
1.6Å resolution
Released: 15 Jun 2016
Model geometry
Fit model/data
5jel
5jel
5jel
Structure of HPV16 E6 oncoprotein in complex with mutant IRF3 LxxLL motif
Suarez IP, Cousido-Siah A, Bonhoure A, Mitschler A, Podjarny A, Trave G
To be published
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Carbohydrate polymer components:
Molecule 1 - GLC(5)
Assembly name: Interferon regulatory factor 3, Maltose/maltodextrin-binding periplasmic protein and Protein E6 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-136588 (Preferred)   search this ID
PDBe-KB: P0AEX9    Q14653    P03126   
X-ray diffraction
1.752Å resolution
Released: 21 Aug 2019
Model geometry
Fit model/data
6siv
6siv
6siv
Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif
Suarez IP, Cousido-Siah A, Bonhoure A, Mitschler A, Podjarny A, Trave G
To be published
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Carbohydrate polymer components:
Molecule 1 - GLC(5)
Assembly name: Interferon regulatory factor 3, Maltose/maltodextrin-binding periplasmic protein and Protein E6 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-136588 (Preferred)   search this ID
PDBe-KB: P0AEX9    Q14653    P03126   
X-ray diffraction
1.5Å resolution
Released: 4 Sep 2019
Model geometry
Fit model/data
6sja
6sja
6sja
Phosphorylated Rotavirus NSP1 in complex with IRF-3
Zhao B, Li P
Proc Natl Acad Sci U S A (2016) [PMID: 27302953  ]
Assembly composition: protein/protein complex
Bound ligands: PO4   
Modified residues: SEP    SEP   
Assembly name: Interferon regulatory factor 3 and Non-structural protein 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172053 (Preferred)   search this ID
PDBe-KB: Q14653    Q99FX5   
X-ray diffraction
1.719Å resolution
Released: 15 Jun 2016
Model geometry
Fit model/data
5jeo
5jeo
5jeo
Phosphorylated STING in complex with IRF-3 CTD
Li P, Shu C
Proc Natl Acad Sci U S A (2016) [PMID: 27302953  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: SEP    SEP   
Assembly name: Interferon regulatory factor 3 and Stimulator of interferon genes protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172055 (Preferred)   search this ID
PDBe-KB: Q14653    Q86WV6   
X-ray diffraction
2Å resolution
Released: 15 Jun 2016
Model geometry
Fit model/data
5jej
5jej
5jej
Complex of IRF-3 with CBP
Zhao B, Li P
Proc Natl Acad Sci U S A (2016) [PMID: 27302953  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: CREB-binding protein and Interferon regulatory factor 3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172057 (Preferred)   search this ID
PDBe-KB: Q14653    Q92793    Q14653   
X-ray diffraction
2.5Å resolution
Released: 15 Jun 2016
Model geometry
Fit model/data
5jem
5jem
5jem
Crystal structure of mouse phosphorylated IRF-3 bound to CBP
Li P, Jing T, Zhao B
J Immunol (2020) [PMID: 32826280  ]
Assembly composition: protein/protein complex
Modified residues: SEP    SEP   
Assembly name: CREB-binding protein and Interferon regulatory factor 3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-159751 (Preferred)   search this ID
PDBe-KB: P70671    Q92793   
X-ray diffraction
2.23Å resolution
Released: 9 Sep 2020
Model geometry
Fit model/data
7jfm
7jfm
7jfm
Entries 1 to 10 of 19
Entries 1 to 10 of 19