Uniprot accession / id : P81122  OR   Uniprot accession / id : Q9Y4H2
 
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Entry Information
Entry status  (1)
REL
(5)
 
Experimental methods  (1)
X-ray diffraction
(5)
 
Authors  (17)
Hubbard SR
(3)
Neubert TA
(3)
Tseng YD
(3)
White MF
(3)
Wu J
(3)
Xu CF
(3)
Nair AK
(2)
Nastovska R
(2)
Petersen J
(2)
Purcell AW
(2)
Ramarathinam SH
(2)
Reid HH
(2)
Rossjohn J
(2)
Rudge G
(2)
Williamson NA
(2)
Wurzbacher SJ
(2)
Zhao AY
(2)
 
Homo / hetero assembly  (1)
hetero
(5)
 
Assembly composition  (1)
protein/protein complex
(5)
 
Assembly polymer count  (2)
dimer
(3)
trimer
(2)
 
Resolution distribution
1.5 - 2
(4)
2.0 - 2.5
(1)
 
Release year distribution
2005 - 2010
(5)
 
Journal  (2)
Nat Struct Mol Biol
(3)
Proc Natl Acad Sci U S A
(2)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(5)
 
Organism name  (2)
Mus musculus
(3)
Homo sapiens
(2)
 
Molecule name  (3)
IRS-2
(5)
Insulin receptor substrate 2
(5)
4PS
(3)
 
Molecule type  (1)
Protein
(5)
 
Gene names  (2)
Irs2
(3)
IRS2
(2)
 
Interacting Molecules  (3)
Insulin receptor subunit beta
(3)
Beta-2-microglobulin
(2)
HLA class I histocompatibility antigen, A alpha chain
(2)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(5)
 
Diffraction radiation source type  (2)
Synchrotron
(3)
Rotating anode
(2)
 
Diffraction source  (2)
NSLS BEAMLINE X4A
(3)
RIGAKU RUH3R
(2)
 
Synchrotron site  (1)
NSLS
(3)
 
Diffraction detector type  (2)
CCD
(3)
Image plate
(2)
 
Refinement software  (2)
REFMAC
(3)
PHENIX
(2)
 
Representative Structures
Representative Structures
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Entries 1 to 5 of 5
Entries 1 to 5 of 5
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Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide
Wu J, Hubbard SR
Nat Struct Mol Biol (2008) [PMID: 18278056  ]
Assembly composition: protein/protein complex
Modified residues: PTR    PTR   
Assembly name: Insulin receptor subunit beta and Insulin receptor substrate 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-138935 (Preferred)   search this ID
PDBe-KB: P81122    P06213   
X-ray diffraction
1.65Å resolution
Released: 19 Feb 2008
Model geometry
Fit model/data
3bu3
3bu3
3bu3
Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide and ATP
Wu J, Hubbard SR
Nat Struct Mol Biol (2008) [PMID: 18278056  ]
Assembly composition: protein/protein complex
Bound ligands: MG    ATP    MG    ATP   
Modified residues: PTR    PTR   
Assembly name: Insulin receptor subunit beta and Insulin receptor substrate 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-138935 (Preferred)   search this ID
PDBe-KB: P81122    P06213   
X-ray diffraction
2.1Å resolution
Released: 19 Feb 2008
Model geometry
Fit model/data
3bu5
3bu5
3bu5
Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB phosphopeptide
Wu J, Hubbard SR
Nat Struct Mol Biol (2008) [PMID: 18278056  ]
Assembly composition: protein/protein complex
Modified residues: PTR    PTR   
Assembly name: Insulin receptor subunit beta and Insulin receptor substrate 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-138935 (Preferred)   search this ID
PDBe-KB: P81122    P06213   
X-ray diffraction
1.95Å resolution
Released: 19 Feb 2008
Model geometry
Fit model/data
3bu6
3bu6
3bu6
Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes
Petersen J, Rossjohn J
Proc Natl Acad Sci U S A (2009) [PMID: 19196958  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CO    CO    CD    CD   
PDBe complex ID: PDB-CPX-137834 (Preferred)   search this ID
PDBe-KB: Q9Y4H2    P04439    P61769   
X-ray diffraction
1.927Å resolution
Released: 3 Mar 2009
Model geometry
Fit model/data
3fqw
3fqw
3fqw
Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes
Petersen J, Rossjohn J
Proc Natl Acad Sci U S A (2009) [PMID: 19196958  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    GOL    CD    MG    CD   
Modified residues: SEP    SEP   
PDBe complex ID: PDB-CPX-137834 (Preferred)   search this ID
PDBe-KB: Q9Y4H2    P04439    P61769   
X-ray diffraction
1.7Å resolution
Released: 3 Mar 2009
Model geometry
Fit model/data
3fqx
3fqx
3fqx
Entries 1 to 5 of 5
Entries 1 to 5 of 5