Uniprot accession / id : (P81605)
 
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Entry Information
Entry status  (1)
REL
(4)
 
Experimental methods  (2)
Solution NMR
(2)
X-ray diffraction
(2)
 
Authors  (19)
Zeth K
(2)
Bechinger B
(1)
Chew FT
(1)
De Groot BL
(1)
Dynowski M
(1)
Forsberg BO
(1)
Jung H
(1)
Kim J
(1)
Mok YK
(1)
Nguyen VS
(1)
Ramesh K
(1)
Salnikov ES
(1)
Song C
(1)
Steinem C
(1)
Tan KW
(1)
Weichbrodt C
(1)
Yang S
(1)
Zachariae U
(1)
de Groot BL
(1)
 
Homo / hetero assembly  (1)
homo
(4)
 
Assembly composition  (1)
protein structure
(4)
 
Assembly polymer count  (2)
hexamer
(2)
monomer
(2)
 
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(1)
 
Release year distribution
2005 - 2010
(1)
2010 - 2015
(2)
2015 - 2020
(2)
 
Journal  (3)
To be published
(2)
Proc Natl Acad Sci U S A
(1)
Sci Rep
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(4)
 
Organism name  (1)
Homo sapiens
(4)
 
Molecule name  (4)
DCD-1
(4)
Dermcidin
(4)
Preproteolysin
(4)
Survival-promoting peptide
(4)
 
Molecule type  (1)
Protein
(4)
 
Gene names  (3)
AIDD
(4)
DCD
(4)
DSEP
(4)
 
Interacting ligands  (1)
ZN : ZINC ION
(2)
 
Function and Biology
Biological function  (1)
peptidase activity
(4)
 
Biological process  (1)
killing of cells of another organism
(4)
 
Biological cell component  (1)
extracellular region
(4)
 
Sequence and Structure classification
CATH class  (2)
Mainly Alpha
(1)
Special
(1)
 
CATH topology  (2)
Helix Hairpins
(1)
Single alpha-helices involved in coiled-coils or other helix-helix interfaces
(1)
 
Pfam accession / name  (1)
PF15291 : Dermcidin
(4)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(2)
 
Diffraction radiation source type  (1)
Synchrotron
(2)
 
Diffraction source  (2)
PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
(1)
SLS BEAMLINE X10SA
(1)
 
Synchrotron site  (2)
PETRA III, EMBL c/o DESY
(1)
SLS
(1)
 
Diffraction detector type  (1)
Pixel
(2)
 
Refinement software  (2)
PHENIX
(1)
REFMAC
(1)
 
NMR
NMR software packages  (2)
CNS
(2)
CYANA
(1)
 
NMR Field Strength
500.0 - 600
(1)
600.0 - 700
(1)
700.0 - 800
(1)
800.0 - 900
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 4 of 4
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20 lowest energy ensemble of dermcidin (DCD1L) NMR structure
Tan KW, Mok YK
Sci Rep (2017) [PMID: 29066724  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: DCD-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-160538 (Preferred)   search this ID
PDBe-KB: P81605   
Solution NMR
Released: 5 Jul 2017
Model geometry
Fit model/data
Data not analysed
2ndk
2ndk
2ndk
Solution structure of dermcidin-1L, a human antibiotic peptide
Jung H, Yang S, Kim J
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: DCD-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-160538 (Preferred)   search this ID
PDBe-KB: P81605   
Solution NMR
Released: 2 Mar 2010
Model geometry
Fit model/data
Data not analysed
2ksg
2ksg
2ksg
High resolution structure of the antimicrobial peptide Dermcidin from human
Zeth K
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: Dermcidin antimicrobial peptide complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-160539 (Preferred)   search this ID
PDBe-KB: P81605   
X-ray diffraction
1.992Å resolution
Released: 25 Sep 2019
Model geometry
Fit model/data
6shk
6shk
6shk
Crystal structure of the hexameric anti-microbial peptide channel dermcidin
Zeth K
Proc Natl Acad Sci U S A (2013) [PMID: 23426625  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: Dermcidin antimicrobial peptide complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-160539 (Preferred)   search this ID
PDBe-KB: P81605   
X-ray diffraction
2.49Å resolution
Released: 17 Oct 2012
Model geometry
Fit model/data
2ymk
2ymk
2ymk
Entries 1 to 4 of 4
Entries 1 to 4 of 4