Uniprot accession / id : P83887  OR   Uniprot accession / id : P23258
 
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Entry Information
Entry status  (1)
REL
(30)
 
Experimental methods  (2)
Electron Microscopy
(27)
X-ray diffraction
(3)
 
Authors  (53)
Neuner A
(18)
Pfeffer S
(18)
Schiebel E
(18)
Vermeulen BJA
(18)
Wurtz M
(18)
Würtz M
(18)
Atorino ES
(15)
Bohler A
(15)
Böhler A
(15)
Eustermann S
(15)
Rahadian AS
(15)
Tonon G
(15)
Zupa E
(15)
Kapoor TM
(6)
Urnavicius L
(6)
Aher A
(4)
Neselu K
(4)
Xue A
(4)
Agard DA
(3)
Llorca O
(3)
Rice LM
(3)
Serna M
(3)
Aldaz H
(2)
Aldaz HA
(2)
Chait BT
(2)
Fernandez-Leiro R
(2)
Filbeck S
(2)
Gao Q
(2)
Gruss OJ
(2)
Hofer FW
(2)
Kaplan C
(2)
Luders J
(2)
Molloy KR
(2)
Sala C
(2)
Shin H
(2)
Stearns T
(2)
Ti S
(2)
Ti SC
(2)
Wieczorek M
(2)
Zezlina M
(2)
Zimmermann F
(2)
Brito C
(1)
Ezquerra A
(1)
Gonzalez-Rodriguez N
(1)
Guerra P
(1)
Lubbehusen N
(1)
Lübbehusen N
(1)
Lüders J
(1)
Mayer MP
(1)
Montabana EA
(1)
Surrey T
(1)
Vineethakumari C
(1)
Zheng A
(1)
 
Homo / hetero assembly  (2)
hetero
(26)
homo
(4)
 
Assembly composition  (2)
protein/protein complex
(26)
protein structure
(4)
 
Assembly polymer count  (18)
33-mer
(3)
monomer
(3)
22-mer
(2)
28-mer
(2)
31-mer
(2)
35-mer
(2)
37-mer
(2)
41-mer
(2)
60-mer
(2)
hexadecamer
(2)
34-mer
(1)
38-mer
(1)
42-mer
(1)
45-mer
(1)
dimer
(1)
heptamer
(1)
octamer
(1)
tetramer
(1)
 
Resolution distribution
2.0 - 2.5
(1)
2.5 - 3
(2)
3.5 - 4
(3)
4.0 - 4.5
(4)
5.0 - 5.5
(1)
6.5 - 7
(2)
7.0 - 7.5
(1)
7.5 - 8
(4)
8.0 - 8.5
(2)
8.5 - 9
(5)
9.0 - 9.5
(2)
16.0 - 16.5
(1)
22.0 - 22.5
(1)
23.0 - 23.5
(1)
 
Release year distribution
2000 - 2005
(2)
2005 - 2010
(3)
2015 - 2020
(2)
2020 - 2025
(27)
2025 - 2030
(3)
 
Journal  (8)
Nat Commun
(18)
Nat Struct Mol Biol
(4)
Cell
(2)
Nature
(2)
Dev Cell
(1)
Proc Natl Acad Sci U S A
(1)
Sci Adv
(1)
Science
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(30)
 
Organism name  (1)
Homo sapiens
(30)
 
Molecule name  (4)
GCP-1
(30)
Gamma-1-tubulin
(30)
Gamma-tubulin complex component 1
(30)
Tubulin gamma-1 chain
(30)
 
Molecule type  (1)
Protein
(30)
 
Gene names  (2)
TUBG
(30)
TUBG1
(30)
 
Interacting Molecules  (16)
Gamma-tubulin complex component 6
(25)
Gamma-tubulin complex component 2
(24)
Gamma-tubulin complex component 4
(24)
Gamma-tubulin complex component 5
(24)
Gamma-tubulin complex component 3
(23)
Mitotic-spindle organizing protein 1
(21)
Actin, cytoplasmic 1
(15)
Tubulin alpha-1B chain
(3)
CDK5 regulatory subunit-associated protein 2
(2)
Mitotic-spindle organizing protein 2A
(2)
Tubulin beta-3 chain
(2)
Unassigned poly-alanine chain ("staple")
(1)
Unassigned poly-alanine model ("CC")
(1)
Unassigned poly-alanine model ("HB")
(1)
Unassigned poly-alanine model ("Lumenal bridge helical bundles")
(1)
beta actin
(1)
 
Interacting ligands  (4)
GDP : GUANOSINE-5'-DIPHOSPHATE
(8)
MG : MAGNESIUM ION
(2)
GSP : 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
(1)
GTP : GUANOSINE-5'-TRIPHOSPHATE
(1)
 
Function and Biology
EC number / name  (1)
3.6.5.6 : Tubulin GTPase
(1)
 
Biological function  (6)
GTP binding
(28)
identical protein binding
(28)
microtubule nucleator activity
(28)
nucleotide binding
(28)
protein binding
(28)
structural constituent of cytoskeleton
(28)
 
Biological process  (8)
meiotic spindle organization
(28)
microtubule cytoskeleton organization
(28)
microtubule nucleation
(28)
mitotic cell cycle
(28)
mitotic sister chromatid segregation
(28)
mitotic spindle organization
(28)
cytoplasmic microtubule organization
(27)
microtubule-based process
(27)
 
Biological cell component  (24)
apical part of cell
(28)
cell leading edge
(28)
centriole
(28)
centrosome
(28)
ciliary basal body
(28)
cilium
(28)
condensed nuclear chromosome
(28)
cytoplasm
(28)
cytoplasmic microtubule
(28)
cytoskeleton
(28)
cytosol
(28)
gamma-tubulin complex
(28)
gamma-tubulin ring complex
(28)
microtubule
(28)
microtubule cytoskeleton
(28)
mitotic spindle microtubule
(28)
neuron projection
(28)
non-motile cilium
(28)
nucleus
(28)
pericentriolar material
(28)
polar microtubule
(28)
recycling endosome
(28)
spindle
(28)
spindle microtubule
(28)
 
Sequence and Structure classification
CATH class  (2)
Alpha Beta
(3)
Mainly Alpha
(3)
 
CATH topology  (3)
60s Ribosomal Protein L30; Chain: A;
(3)
Helix Hairpins
(3)
Rossmann fold
(3)
 
Pfam accession / name  (2)
PF00091 : Tubulin
(30)
PF03953 : Tubulin_C
(30)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(3)
 
Diffraction radiation source type  (1)
Synchrotron
(3)
 
Diffraction source  (1)
ALS BEAMLINE 8.2.1
(3)
 
Synchrotron site  (1)
ALS
(3)
 
Diffraction detector type  (1)
CCD
(3)
 
Refinement software  (3)
PHENIX
(6)
CNS
(2)
REFMAC
(1)
 
EM microscope model  (2)
FEI TITAN KRIOS
(25)
TFS KRIOS
(2)
 
EM detector name  (3)
GATAN K3 (6k x 4k)
(23)
GATAN K2 SUMMIT (4k x 4k)
(2)
GATAN K3 BIOQUANTUM (6k x 4k)
(2)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 30
Entries 1 to 10 of 30
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Recombinant human gTuRC
Serna M, Fernandez-Leiro R, Llorca O
Sci Adv (2020) [PMID: 33355144  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GDP    GDP   
PDBe complex ID: PDB-CPX-149912 (Preferred)   search this ID
PDBe-KB: P23258    Q96RT8    Q9BSJ2    Q9UGJ1    Q96CW5    Q96RT7    (view 2 more)
Electron Microscopy
4.13Å resolution
Released: 20 Jan 2021
Model geometry
Fit model/data
Data not analysed
7as4
7as4
7as4
CryoEM structure of the gTuRC-CM1dim complex
Llorca O, Serna M, Gonzalez-Rodriguez N
Dev Cell (2024) [PMID: 39321809  ]
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-286571 (Preferred)   search this ID
PDBe-KB: P23258    Q6P582    Q96RT8    Q9BSJ2    Q9UGJ1    Q96SN8    (view 4 more)
Electron Microscopy
3.57Å resolution
Released: 25 Sep 2024
Model geometry
Fit model/data
Data not analysed
8rx1
8rx1
8rx1
Structure of gamma-tubulin in the native human gamma-tubulin ring complex
Wieczorek M, Urnavicius L, Ti S, Molloy KR, Chait BT, Kapoor TM
Cell (2020) [PMID: 31862189  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GDP    GDP   
Assembly name: Tubulin gamma-1 chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149909 (Preferred)   search this ID
PDBe-KB: P23258   
Electron Microscopy
3.8Å resolution
Released: 1 Jan 2020
Model geometry
Fit model/data
Data not analysed
6v5v
6v5v
6v5v
Structure of the native human gamma-tubulin ring complex
Wieczorek M, Urnavicius L, Ti S, Molloy KR, Chait BT, Kapoor TM
Cell (2020) [PMID: 31862189  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GDP    ADP    ADP    GDP   
PDBe complex ID: PDB-CPX-149913 (Preferred)   search this ID
PDBe-KB: P23258    Q96RT8    Q9BSJ2    Q9UGJ1    Q96CW5    Q96RT7   
Electron Microscopy
4.3Å resolution
Released: 1 Jan 2020
Model geometry
Fit model/data
Data not analysed
6v6s
6v6s
6v6s
Structure of recombinant human gamma-Tubulin Ring Complex (spokes 1-14)
Zupa E, Pfeffer S
Nat Commun (2022) [PMID: 35078983  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-105655 (Preferred)   search this ID
PDBe-KB: P23258    Q96RT8    Q9BSJ2    Q9UGJ1    Q96CW5    Q96RT7    (view 2 more)
Electron Microscopy
8.7Å resolution
Released: 26 Jan 2022
Model geometry
Fit model/data
Data not analysed
7qj5
7qj5
7qj5
Early closed conformation of the g-tubulin ring complex
Llorca O, Serna M, Fernandez-Leiro R
Science (2024) [PMID: 38305685  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-273394 (Preferred)   search this ID
PDBe-KB: P23258    Q96RT8    Q9BSJ2    Q9UGJ1    Q96CW5    Q96RT7   
Electron Microscopy
3.72Å resolution
Released: 7 Feb 2024
Model geometry
Fit model/data
Data not analysed
8q62
8q62
8q62
Structure of recombinant human gamma-Tubulin Ring Complex 6-spoked assembly intermediate (spokes 7-12)
Zupa E, Pfeffer S
Nat Commun (2022) [PMID: 35078983  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-149917 (Preferred)   search this ID
PDBe-KB: P23258    Q96RT8    Q9BSJ2    Q9UGJ1    Q96CW5    Q96RT7    (view 1 more)
Electron Microscopy
5.32Å resolution
Released: 26 Jan 2022
Model geometry
Fit model/data
Data not analysed
7qj0
7qj0
7qj0
Structure of recombinant human gamma-Tubulin Ring Complex without actin
Zupa E, Pfeffer S
Nat Commun (2022) [PMID: 35078983  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-149914 (Preferred)   search this ID
PDBe-KB: P23258    Q96RT8    Q9BSJ2    Q9UGJ1    Q96CW5    Q96RT7    (view 1 more)
Electron Microscopy
7.1Å resolution
Released: 26 Jan 2022
Model geometry
Fit model/data
Data not analysed
7qjd
7qjd
7qjd
Structure of recombinant human gamma-Tubulin Ring Complex 8-spoked assembly intermediate (spokes 5-12)
Zupa E, Pfeffer S
Nat Commun (2022) [PMID: 35078983  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-149918 (Preferred)   search this ID
PDBe-KB: P23258    Q96RT8    Q9BSJ2    Q9UGJ1    Q96CW5    Q96RT7    (view 1 more)
Electron Microscopy
8.6Å resolution
Released: 26 Jan 2022
Model geometry
Fit model/data
Data not analysed
7qj2
7qj2
7qj2
Structure of recombinant human gamma-Tubulin Ring Complex 12-spoked assembly intermediate (spokes 3-14, substoichiometric spokes 1-2)
Zupa E, Pfeffer S
Nat Commun (2022) [PMID: 35078983  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-105653 (Preferred)   search this ID
PDBe-KB: P23258    Q96RT8    Q9BSJ2    Q9UGJ1    Q96CW5    Q96RT7    (view 2 more)
Electron Microscopy
8.7Å resolution
Released: 26 Jan 2022
Model geometry
Fit model/data
Data not analysed
7qj8
7qj8
7qj8
Entries 1 to 10 of 30
Entries 1 to 10 of 30