Entries released this week  (1)

new

(1)

New ligands in PDB  (1)

A1IMD : N-[2-(dimethylsulfamoyl)-5-[(1-methylpyrazol-4-yl)methoxy]phenyl]propanamide

(1)

Entry status  (1)

REL

(177)

Experimental methods  (3)

X-ray diffraction

(133)

Electron Microscopy

(42)

Solution NMR

(2)

Authors  (766)

Ciulli A

(72)

Van Molle I

(26)

Gadd MS

(25)

Soares P

(22)

Galdeano C

(21)

Chen X

(15)

Zhang J

(15)

Koren I

(13)

Li S

(13)

Xu C

(13)

Yao X

(13)

Zhang K

(13)

Dias DM

(12)

Elledge SJ

(12)

Lucas X

(12)

Testa A

(12)

Hewitt S

(11)

Makukhin N

(11)

Birced I

(10)

Casement R

(10)

Diers E

(10)

Eisert J

(10)

Farnaby W

(10)

Hartung IV

(10)

Hecht M

(10)

Koegl M

(10)

Krieger J

(10)

Lehmann M

(10)

Leibrock EM

(10)

Leuthner B

(10)

Machrouhi-Porcher F

(10)

Mueller JE

(10)

Muller JE

(10)

Scaffidi S

(10)

Schlesiger S

(10)

Sorell FJ

(10)

Sorrell FJ

(10)

Trainor N

(10)

Wegener AA

(10)

Weinstabl H

(10)

Whitworth C

(10)

van Molle I

(10)

Bruno E

(9)

Crews CM

(9)

Ellis L

(9)

Epemolu O

(9)

Frost J

(9)

Knapp S

(9)

Ramachandran S

(9)

Read KD

(9)

Rocha S

(9)

Wegener A

(9)

Buckley DL

(8)

Kleiger G

(8)

Purser N

(8)

Schulman BA

(8)

Scott DC

(8)

Zhou H

(8)

Arnhof H

(7)

Bader G

(7)

Ettmayer P

(7)

Gerstberger T

(7)

Greb P

(7)

Guo Q

(7)

Karolyi-Oezguer J

(7)

Kofink C

(7)

McLennan R

(7)

Mischerikow N

(7)

Petermann O

(7)

Raiff A

(7)

Timms RT

(7)

Vetma V

(7)

Wurm M

(7)

Zollman D

(7)

Forrester B

(6)

Gitto R

(6)

Haubrich K

(6)

Jin J

(6)

Kraemer A

(6)

Lynch DM

(6)

Nagala M

(6)

Olmayev-Yaakobov D

(6)

Rinnenthal J

(6)

Roy MJ

(6)

Ru W

(6)

Rumpel K

(6)

Structural Genomics Consortium (SGC)

(6)

Wohrle S

(6)

Wöhrle S

(6)

Yu X

(6)

Zhao S

(6)

Cheng Y

(5)

Doelle A

(5)

Gareiss PC

(5)

Jorgensen WL

(5)

King MT

(5)

Kousek R

(5)

Li J

(5)

Liu Y

(5)

Nourse A

(5)

 

More...

Homo / hetero assembly  (1)

hetero

(177)

Assembly composition  (4)

protein/protein complex

(168)

RNA/protein complex

(4)

DNA/RNA/protein complex

(3)

DNA/protein complex

(2)

Assembly polymer count  (15)

trimer

(69)

tetramer

(61)

dodecamer

(12)

pentamer

(7)

decamer

(5)

octamer

(5)

hexamer

(4)

nonamer

(3)

22-mer

(2)

nonadecamer

(2)

tetradecamer

(2)

undecamer

(2)

21-mer

(1)

26-mer

(1)

octadecamer

(1)

Resolution distribution

1.0 - 1.5

(2)

1.5 - 2

(24)

2.0 - 2.5

(50)

2.5 - 3

(49)

3.0 - 3.5

(29)

3.5 - 4

(15)

4.0 - 4.5

(3)

6.0 - 6.5

(1)

8.0 - 8.5

(1)

8.5 - 9

(1)

Release year distribution

1995 - 2000

(1)

2000 - 2005

(2)

2005 - 2010

(5)

2010 - 2015

(28)

2015 - 2020

(39)

2020 - 2025

(106)

2025 - 2030

(3)

Journal  (31)

Nat Commun

(41)

J Med Chem

(30)

To be published

(11)

ChemMedChem

(10)

Nature

(8)

Proc Natl Acad Sci U S A

(7)

Nat Chem Biol

(6)

Nat Struct Mol Biol

(6)

Science

(6)

Angew Chem Int Ed Engl

(5)

J Am Chem Soc

(5)

Cell Chem Biol

(4)

Chem Biol

(4)

EMBO J

(4)

ACS Med Chem Lett

(3)

Bioorg Med Chem

(3)

Mol Cell

(3)

Sci Adv

(3)

Structure

(3)

Bioorg Med Chem Lett

(2)

J Mol Biol

(2)

Sci Transl Med

(2)

ACS Chem Biol

(1)

Acta Crystallogr D Biol Crystallogr

(1)

Biochemistry

(1)

Cell Host Microbe

(1)

Chemrxiv

(1)

J Virol

(1)

JACS Au

(1)

Open Biol

(1)

PLoS One

(1)

Organism superkingdom  (1)

Eukaryota

(177)

Organism name  (2)

Homo sapiens

(174)

Mus musculus

(3)

Molecule name  (7)

EloC

(177)

Elongin 15 kDa subunit

(177)

Elongin-C

(177)

RNA polymerase II transcription factor SIII subunit C

(177)

SIII p15

(177)

Transcription elongation factor B polypeptide 1

(177)

Stromal membrane-associated protein SMAP1B homolog

(3)

Molecule type  (1)

Protein

(177)

Gene names  (4)

ELOC

(174)

TCEB1

(174)

Eloc

(3)

Tceb1

(3)

Interacting Molecules  (125)

Elongin-B

(177)

von Hippel-Lindau disease tumor suppressor

(113)

Cullin-2

(29)

Bromodomain-containing protein 4

(13)

E3 ubiquitin-protein ligase RBX1, N-terminally processed

(13)

Suppressor of cytokine signaling 2

(13)

E3 ubiquitin-protein ligase RBX1

(11)

Protein fem-1 homolog B

(10)

Virion infectivity factor

(9)

Core-binding factor subunit beta

(8)

Probable global transcription activator SNF2L2

(7)

WD repeat-containing protein 5

(7)

Amyloid protein-binding protein 2

(6)

Ubiquitin

(6)

Hypoxia-inducible factor 1-alpha

(5)

Cullin-5

(4)

Ubiquitin-like protein NEDD8

(4)

Ankyrin repeat and SOCS box protein 9

(3)

COP9 signalosome complex subunit 1

(3)

COP9 signalosome complex subunit 2

(3)

COP9 signalosome complex subunit 3

(3)

COP9 signalosome complex subunit 4

(3)

COP9 signalosome complex subunit 7b

(3)

COP9 signalosome complex subunit 8

(3)

Coiled-coil domain-containing protein 89

(3)

DNA dC->dU-editing enzyme APOBEC-3G

(3)

DNA-directed RNA polymerase II subunit E

(3)

DNA-directed RNA polymerase II subunit RPB9

(3)

DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein

(3)

DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein

(3)

DNA-directed RNA polymerase subunit

(3)

DNA-directed RNA polymerase subunit beta

(3)

DNA-directed RNA polymerases I, II, and III subunit RPABC2

(3)

DNA-directed RNA polymerases I, II, and III subunit RPABC3

(3)

DNA-directed RNA polymerases I, II, and III subunit RPABC5

(3)

Elongin-A

(3)

GTPase KRas, N-terminally processed

(3)

Kelch domain-containing protein 3

(3)

RNA

(3)

RNA polymerase II, I and III subunit K

(3)

RNA polymerase Rpb4/RPC9 core domain-containing protein

(3)

Template DNA

(3)

Transcription activator BRG1

(3)

Ubiquitin-conjugating enzyme E2 R2

(3)

Apoptosis regulator Bcl-2

(2)

Bcl-2-like protein 1

(2)

COP9 signalosome complex subunit 5

(2)

COP9 signalosome complex subunit 6

(2)

Cyclic GMP-AMP synthase

(2)

Cysteine dioxygenase type 1

(2)

Endothelial PAS domain-containing protein 1

(2)

Growth hormone receptor peptide

(2)

Kelch domain-containing protein 2

(2)

Non-template DNA

(2)

Nucleotide exchange factor SIL1

(2)

Polyubiquitin-C

(2)

Protein CASP

(2)

Protein fem-1 homolog C

(2)

SPRY domain-containing SOCS box protein 3

(2)

Transcription elongation factor SPT6

(2)

p7

(2)

3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE

(1)

Ankyrin repeat and SOCS box protein 7

(1)

Cell division control protein 45 homolog

(1)

Claspin

(1)

Creatine kinase B-type

(1)

DNA (145-MER)

(1)

DNA dC->dU-editing enzyme APOBEC-3H

(1)

DNA polymerase epsilon catalytic subunit A

(1)

DNA polymerase epsilon subunit 2

(1)

DNA replication complex GINS protein PSF1

(1)

DNA replication complex GINS protein PSF2

(1)

DNA replication complex GINS protein PSF3

(1)

DNA replication complex GINS protein SLD5

(1)

DNA replication licensing factor MCM2

(1)

DNA replication licensing factor MCM3

(1)

DNA replication licensing factor MCM4

(1)

DNA replication licensing factor MCM5

(1)

DNA replication licensing factor MCM6

(1)

DNA replication licensing factor MCM7

(1)

Erythropoietin receptor

(1)

Focal adhesion kinase 1

(1)

Folliculin-interacting protein 1

(1)

GTPase KRas

(1)

H313

(1)

Histone H2A type 1-H

(1)

Histone H2A type 1-J

(1)

Histone H2B type 1-H

(1)

Histone H2B type 1-N

(1)

Histone H3.2

(1)

Histone H4

(1)

Interleukin-6 receptor subunit beta

(1)

Kelch domain-containing protein 10

(1)

LEU-THR-ARG-ASN-LYS-GLY-PRO

(1)

Lagging strand DNA

(1)

Large ribosomal subunit protein bL28m

(1)

Leading strand DNA

(1)

Leucine zipper putative tumor suppressor 1

(1)

Leucine-rich repeat protein 1

(1)

MRPL28 C-degron

(1)

 

More...

Interacting ligands  (21)

EDO : 1,2-ETHANEDIOL

(12)

GOL : GLYCEROL

(5)

ACT : ACETATE ION

(4)

DMS : DIMETHYL SULFOXIDE

(2)

PEG : DI(HYDROXYETHYL)ETHER

(2)

SCN : THIOCYANATE ION

(2)

SO4 : SULFATE ION

(2)

A1L2C : 4-(hydroxymethyl)-7-oxidanyl-chromen-2-one

(1)

A1L2D : ethyl 7-oxidanyl-2-oxidanylidene-chromene-4-carboxylate

(1)

A1L2Z : 7-Hydroxy-4-methoxymethylcoumarin

(1)

CL : CHLORIDE ION

(1)

F4E : methyl 4~{H}-furo[3,2-b]pyrrole-5-carboxylate

(1)

F7B : 6-chloranyl-2,3-dihydrothiochromen-4-one

(1)

IOD : IODIDE ION

(1)

MLI : MALONATE ION

(1)

MPD : (4S)-2-METHYL-2,4-PENTANEDIOL

(1)

NA : SODIUM ION

(1)

P6G : HEXAETHYLENE GLYCOL

(1)

PO4 : PHOSPHATE ION

(1)

TFA : trifluoroacetic acid

(1)

VH3 : (2~{S},4~{R})-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[(1~{S})-1-[5-fluoranyl-2-methoxy-4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide

(1)

Biological function  (3)

protein binding

(22)

protein-macromolecule adaptor activity

(22)

transcription corepressor binding

(22)

Biological process  (5)

ubiquitin-dependent protein catabolic process

(172)

protein ubiquitination

(22)

regulation of transcription by RNA polymerase II

(22)

target-directed miRNA degradation

(22)

transcription initiation at RNA polymerase II promoter

(22)

Biological cell component  (6)

Cul2-RING ubiquitin ligase complex

(22)

Cul5-RING ubiquitin ligase complex

(22)

cytosol

(22)

elongin complex

(22)

nucleoplasm

(22)

nucleus

(22)

SCOP fold  (1)

POZ domain

(8)

SCOP family  (1)

BTB/POZ domain

(8)

CATH class  (1)

Alpha Beta

(62)

CATH topology  (1)

Potassium Channel Kv1.1; Chain A

(62)

Pfam accession / name  (1)

PF03931 : Skp1_POZ

(177)

Diffraction protocol  (1)

Single wavelength

(133)

Diffraction radiation source type  (1)

Synchrotron

(133)

Diffraction source  (37)

SLS BEAMLINE X10SA

(18)

DIAMOND BEAMLINE I04-1

(16)

DIAMOND BEAMLINE I04

(13)

DIAMOND BEAMLINE I24

(12)

DIAMOND BEAMLINE I03

(9)

SOLEIL BEAMLINE PROXIMA 1

(6)

ALS BEAMLINE 5.0.2

(4)

APS BEAMLINE 24-ID-E

(4)

SLS BEAMLINE X06DA

(4)

SLS BEAMLINE X06SA

(4)

DIAMOND BEAMLINE I02

(3)

ESRF BEAMLINE BM14

(3)

NSLS-II BEAMLINE 17-ID-2

(3)

ALS BEAMLINE 5.0.1

(2)

APS BEAMLINE 24-ID-C

(2)

AUSTRALIAN SYNCHROTRON BEAMLINE MX2

(2)

CHESS BEAMLINE F1

(2)

CLSI BEAMLINE 08ID-1

(2)

ESRF BEAMLINE ID14-4

(2)

ESRF BEAMLINE ID23-2

(2)

PAL/PLS BEAMLINE 5C (4A)

(2)

PHOTON FACTORY BEAMLINE BL-17A

(2)

SSRF BEAMLINE BL17U1

(2)

SSRF BEAMLINE BL19U1

(2)

ALS BEAMLINE 8.3.1

(1)

APS BEAMLINE 17-ID

(1)

APS BEAMLINE 19-ID

(1)

APS BEAMLINE 21-ID-D

(1)

BESSY BEAMLINE 14.1

(1)

ESRF BEAMLINE ID14-2

(1)

ESRF BEAMLINE MASSIF-1

(1)

NSLS BEAMLINE X29A

(1)

PAL/PLS BEAMLINE 4A

(1)

PAL/PLS BEAMLINE 6B

(1)

SPRING-8 BEAMLINE BL45XU

(1)

SSRF BEAMLINE BL10U2

(1)

SSRF BEAMLINE BL17U

(1)

Synchrotron site  (16)

Diamond

(53)

SLS

(26)

APS

(9)

ESRF

(9)

ALS

(7)

SOLEIL

(6)

SSRF

(6)

NSLS-II

(3)

PAL/PLS

(3)

Australian Synchrotron

(2)

CHESS

(2)

CLSI

(2)

Photon Factory

(2)

BESSY

(1)

NSLS

(1)

SPring-8

(1)

Diffraction detector type  (2)

Pixel

(104)

CCD

(28)

Refinement software  (5)

PHENIX

(66)

REFMAC

(59)

BUSTER

(17)

CNS

(5)

phenix.real_space_refine

(2)

EM microscope model  (3)

FEI TITAN KRIOS

(40)

FEI TALOS ARCTICA

(1)

TFS GLACIOS

(1)

EM detector name  (6)

GATAN K3 BIOQUANTUM (6k x 4k)

(22)

GATAN K3 (6k x 4k)

(11)

FEI FALCON IV (4k x 4k)

(4)

GATAN K2 QUANTUM (4k x 4k)

(2)

GATAN K2 SUMMIT (4k x 4k)

(2)

TFS FALCON 4i (4k x 4k)

(1)

NMR software packages  (6)

TopSpin

(2)

CS-ROSETTA

(1)

CcpNmr Analysis

(1)

HADDOCK

(1)

NMRPipe

(1)

TALOS

(1)

NMR Field Strength

400.0 - 500

(1)

500.0 - 600

(1)

600.0 - 700

(2)

700.0 - 800

(2)

800.0 - 900

(2)

Representative Structures

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95%

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