Entry status  (1)

REL

(7)

Experimental methods  (1)

X-ray diffraction

(7)

Authors  (88)

Am Ende CW

(3)

Humphrey JM

(3)

Liras S

(3)

Menniti FS

(3)

Pandit J

(3)

Aertgeerts K

(2)

Allerston CK

(2)

Andersen CB

(2)

Arnold EP

(2)

Augustin M

(2)

Barido R

(2)

Barker R

(2)

Botrous I

(2)

Branstetter B

(2)

Breitenbucher JG

(2)

Cedervall EP

(2)

Chun LE

(2)

Dyck B

(2)

Edwards TE

(2)

Evdokimova A

(2)

Evdomikov A

(2)

Gharbaoui T

(2)

Gomez L

(2)

Head JL

(2)

Hudson AR

(2)

Jenkinsonb S

(2)

Lebel LA

(2)

Lee D

(2)

Limberis J

(2)

Mansour M

(2)

Marrone T

(2)

Massari ME

(2)

Neul D

(2)

Peters M

(2)

Petroski R

(2)

Samas B

(2)

Schmelzer K

(2)

Sebring K

(2)

Simons S

(2)

Simons SP

(2)

Sridhar V

(2)

Tabatabaei A

(2)

Vajdos F

(2)

Xu R

(2)

Yang EX

(2)

Zhou X

(2)

Artis DR

(1)

Beard JD

(1)

Becker SL

(1)

Bollag G

(1)

Card GL

(1)

Chappie TA

(1)

Davis RE

(1)

Fong D

(1)

Gillette S

(1)

Hendrick JP

(1)

Heyser CJ

(1)

Hsieh D

(1)

Ida K

(1)

Jenkinson S

(1)

Kim S-H

(1)

Kim SH

(1)

Lane W

(1)

Li P

(1)

Liras JL

(1)

Milburn MV

(1)

Movsesian M

(1)

Neiman J

(1)

Orozco C

(1)

Schlessinger J

(1)

Snell G

(1)

Snyder GL

(1)

Sogabe S

(1)

Suzuki Y

(1)

Vajdos FF

(1)

Vandeput F

(1)

Vanover KE

(1)

Wennogle LP

(1)

West BL

(1)

Yang E

(1)

Yao W

(1)

Zhang C

(1)

Zhang KY

(1)

Zhang KYJ

(1)

Zhang L

(1)

Zhao J

(1)

Zheng H

(1)

Zhu H

(1)

Homo / hetero assembly  (1)

homo

(7)

Assembly composition  (1)

protein structure

(7)

Assembly polymer count  (1)

monomer

(7)

Resolution distribution

1.5 - 2

(5)

2.0 - 2.5

(2)

Release year distribution

2000 - 2005

(1)

2010 - 2015

(2)

2015 - 2020

(4)

Journal  (3)

J Med Chem

(4)

MEDCHEMCOMM

(2)

Mol Cell

(1)

Organism superkingdom  (1)

Eukaryota

(7)

Organism name  (1)

Homo sapiens

(7)

Molecule name  (3)

63 kDa Cam-PDE

(7)

Cam-PDE 1B

(7)

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

(7)

Molecule type  (1)

Protein

(7)

Gene names  (2)

PDE1B

(7)

PDES1B

(7)

Interacting ligands  (9)

MG : MAGNESIUM ION

(7)

ZN : ZINC ION

(7)

0NY : 7,8-dimethoxy-N-[(2S)-1-(3-methyl-1H-pyrazol-5-yl)propan-2-yl]quinazolin-4-amine

(2)

0NK : 6,7,8-trimethoxy-N-(pentan-3-yl)quinazolin-4-amine

(1)

4QJ : (11R,15S)-4-{[4-(6-fluoropyridin-2-yl)phenyl]methyl}-8-methyl-5-(phenylamino)-1,3,4,8,10-pentaazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one

(1)

8HM : 6-[(4-methoxyphenyl)methyl]-9-[(oxan-4-yl)methyl]-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one

(1)

8HP : 6-[(4-chlorophenyl)methyl]-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one

(1)

GOL : GLYCEROL

(1)

SO4 : SULFATE ION

(1)

EC number / name  (1)

3.1.4.17 : 3',5'-cyclic-nucleotide phosphodiesterase

(7)

Biological function  (2)

3',5'-cyclic-nucleotide phosphodiesterase activity

(7)

phosphoric diester hydrolase activity

(7)

Biological process  (1)

signal transduction

(7)

SCOP fold  (1)

HD-domain/PDEase-like

(1)

SCOP family  (1)

PDEase

(1)

CATH class  (1)

Mainly Alpha

(7)

CATH topology  (1)

Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b

(7)

Pfam accession / name  (1)

PF00233 : PDEase_I

(7)

Diffraction protocol  (1)

Single wavelength

(7)

Diffraction radiation source type  (1)

Synchrotron

(7)

Diffraction source  (4)

APS BEAMLINE 21-ID-D

(3)

ALS BEAMLINE 5.0.2

(2)

ALS BEAMLINE 5.0.3

(1)

ALS BEAMLINE 8.3.1

(1)

Synchrotron site  (2)

ALS

(4)

APS

(3)

Diffraction detector type  (2)

CCD

(5)

Pixel

(2)

Refinement software  (3)

REFMAC

(3)

BUSTER

(2)

PHENIX

(2)

Representative Structures

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