Uniprot accession / id : (Q05315)
 
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new
(3)
 
Entry Information
Entry status  (1)
REL
(39)
 
Experimental methods  (1)
X-ray diffraction
(39)
 
Authors  (57)
Cui L
(17)
Si Y
(17)
Song C
(17)
Su J
(17)
Tai G
(17)
Zhou Y
(17)
Gao J
(11)
Wang Y
(11)
Wu R
(11)
Aegerter H
(7)
Bachert C
(7)
Blanchetot C
(7)
Chanez P
(7)
Dansercoer A
(7)
De Haard H
(7)
Deswarte K
(7)
Gevaert E
(7)
Goncalves A
(7)
Gonçalves A
(7)
Gras D
(7)
Hammad H
(7)
Heyndrickx I
(7)
Itoh A
(7)
Kamitori S
(7)
Lambrecht BN
(7)
Nakakita SI
(7)
Nakamura T
(7)
Nishi N
(7)
Nonaka Y
(7)
Percier JM
(7)
Persson EK
(7)
Saunders M
(7)
Savvides SN
(7)
Van Gorp H
(7)
Verschueren KHG
(7)
Verstraete K
(7)
Yoshida H
(7)
Li Y
(6)
Verschueren K
(6)
Wang H
(6)
Yang T
(6)
Acharya KR
(4)
Ackerman SJ
(4)
Leonidas DD
(4)
Savage MP
(3)
Su JY
(3)
Sun YQ
(3)
Swaminathan GJ
(3)
Kwatia MA
(2)
Liu L
(2)
Abe S
(1)
Elbert BL
(1)
Hirata K
(1)
Kojima M
(1)
Leffler H
(1)
Ueno T
(1)
Zhou Z
(1)
 
Homo / hetero assembly  (2)
homo
(36)
hetero
(2)
 
Assembly composition  (2)
protein structure
(36)
protein/protein complex
(2)
 
Assembly polymer count  (3)
dimer
(32)
monomer
(4)
hexamer
(2)
 
Resolution distribution
1.0 - 1.5
(2)
1.5 - 2
(30)
2.0 - 2.5
(6)
3.0 - 3.5
(1)
 
Release year distribution
1995 - 2000
(2)
2000 - 2005
(3)
2015 - 2020
(31)
2020 - 2025
(11)
2025 - 2030
(3)
 
Journal  (7)
Glycobiology
(17)
Biochem Biophys Res Commun
(7)
Science
(7)
To be published
(4)
J Biol Chem
(2)
Biochemistry
(1)
Structure
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(39)
 
Organism name  (1)
Homo sapiens
(39)
 
Molecule name  (6)
CLC
(39)
Charcot-Leyden crystal protein
(39)
Eosinophil lysophospholipase
(39)
Gal-10
(39)
Galectin-10
(39)
Lysolecithin acylhydrolase
(39)
 
Molecule type  (1)
Protein
(39)
 
Gene names  (3)
CLC
(39)
LGALS10
(39)
LGALS10A
(39)
 
Interacting Molecules  (4)
Fab 4E8 - Heavy chain
(1)
Fab 4E8 - Light chain
(1)
Fab 6F5 - Heavy Chain
(1)
Fab 6F5 - Light chain
(1)
 
Interacting ligands  (19)
GOL : GLYCEROL
(11)
BGC : beta-D-glucopyranose
(2)
GAL : beta-D-galactopyranose
(2)
PG4 : TETRAETHYLENE GLYCOL
(2)
64K : alpha-D-arabinopyranose
(1)
ALL : beta-D-allopyranose
(1)
BMA : beta-D-mannopyranose
(1)
CA : CALCIUM ION
(1)
FRU : beta-D-fructofuranose
(1)
FUL : beta-L-fucopyranose
(1)
GLC : alpha-D-glucopyranose
(1)
MAN : alpha-D-mannopyranose
(1)
NEQ : N-ETHYLMALEIMIDE
(1)
NGA : 2-acetamido-2-deoxy-beta-D-galactopyranose
(1)
P6G : HEXAETHYLENE GLYCOL
(1)
PGE : TRIETHYLENE GLYCOL
(1)
PMB : PARA-MERCURY-BENZENESULFONIC ACID
(1)
PRD_900004 : beta-lactose
(1)
RIP : beta-D-ribopyranose
(1)
 
Function and Biology
EC number / name  (1)
3.1.1.5 : Lysophospholipase
(4)
 
Biological function  (4)
carbohydrate binding
(36)
identical protein binding
(36)
lysophospholipase activity
(36)
protein binding
(36)
 
Biological process  (4)
T cell apoptotic process
(36)
regulation of T cell anergy
(36)
regulation of T cell cytokine production
(36)
regulation of activated T cell proliferation
(36)
 
Biological cell component  (3)
collagen-containing extracellular matrix
(36)
cytoplasm
(36)
cytosol
(36)
 
Sequence and Structure classification
SCOP fold  (1)
Concanavalin A-like lectins/glucanases
(4)
 
SCOP family  (1)
Galectin (animal S-lectin)
(4)
 
CATH class  (1)
Mainly Beta
(21)
 
CATH topology  (1)
Jelly Rolls
(21)
 
Pfam accession / name  (1)
PF00337 : Gal-bind_lectin
(39)
 
Experimental Information
Diffraction protocol  (2)
Single wavelength
(38)
MAD
(1)
 
Diffraction radiation source type  (2)
Synchrotron
(32)
Rotating anode
(8)
 
Diffraction source  (11)
SSRF BEAMLINE BL18U1
(20)
RIGAKU
(5)
PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
(3)
SRS BEAMLINE PX9.6
(3)
ESRF BEAMLINE ID23-2
(2)
RIGAKU MICROMAX-007 HF
(2)
EMBL/DESY, HAMBURG BEAMLINE X31
(1)
RIGAKU RU300
(1)
SLS BEAMLINE X06SA
(1)
SOLEIL BEAMLINE PROXIMA 2
(1)
SPRING-8 BEAMLINE BL32XU
(1)
 
Synchrotron site  (8)
SSRF
(20)
PETRA III, EMBL c/o DESY
(3)
SRS
(3)
ESRF
(2)
EMBL/DESY, Hamburg
(1)
SLS
(1)
SOLEIL
(1)
SPring-8
(1)
 
Diffraction detector type  (2)
Pixel
(28)
Image plate
(11)
 
Refinement software  (5)
PHENIX
(22)
REFMAC
(8)
BUSTER
(5)
X-PLOR
(3)
CNS
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 39
Entries 1 to 10 of 39
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CHARCOT-LEYDEN CRYSTAL PROTEIN
Acharya KR, Leonidas DD
Structure (1995) [PMID: 8747464  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Galectin-10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-170169 (Preferred)   search this ID
PDBe-KB: Q05315   
X-ray diffraction
1.8Å resolution
Released: 11 Jan 1997
Model geometry
Fit model/data
Data not deposited
1lcl
1lcl
1lcl
Galectin-10/Charcot-Leyden crystal protein variant H53A crystal structure
Su J
Glycobiology (2018) [PMID: 29293962  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Galectin-10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-170169 (Preferred)   search this ID
PDBe-KB: Q05315   
X-ray diffraction
1.9Å resolution
Released: 24 Jan 2018
Model geometry
Fit model/data
5xrj
5xrj
5xrj
Charcot-Leyden crystal protein/Galectin-10 variant W127A
Su J
Glycobiology (2019) [PMID: 30239701  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Galectin-10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-170167 (Preferred)   search this ID
PDBe-KB: Q05315   
X-ray diffraction
1.99Å resolution
Released: 26 Dec 2018
Model geometry
Fit model/data
6a1x
6a1x
6a1x
Charcot-Leyden crystal protein/Galectin-10 variant E33D
Su J
Glycobiology (2019) [PMID: 30239701  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Galectin-10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-170169 (Preferred)   search this ID
PDBe-KB: Q05315   
X-ray diffraction
1.62Å resolution
Released: 26 Dec 2018
Model geometry
Fit model/data
6a1u
6a1u
6a1u
Charcot-Leyden crystal protein/Galectin-10 variant E33Q
Su J
Glycobiology (2019) [PMID: 30239701  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Galectin-10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-170169 (Preferred)   search this ID
PDBe-KB: Q05315   
X-ray diffraction
1.984Å resolution
Released: 26 Dec 2018
Model geometry
Fit model/data
6a1v
6a1v
6a1v
CHARCOT-LEYDEN CRYSTAL PROTEIN/N-ETHYLMALEIMIDE COMPLEX
Ackerman SJ, Liu L, Kwatia MA, Savage MP, Leonidas DD, Swaminathan GJ, Acharya KR
J Biol Chem (2002) [PMID: 11834744  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NEQ    NEQ   
Assembly name: Galectin-10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-170167 (Preferred)   search this ID
PDBe-KB: Q05315   
X-ray diffraction
1.8Å resolution
Released: 19 Jun 2002
Model geometry
Fit model/data
Data not deposited
1g86
1g86
1g86
Charcot-Leyden crystal protein/Galectin-10 variant E33A
Su J
Glycobiology (2019) [PMID: 30239701  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Galectin-10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-170169 (Preferred)   search this ID
PDBe-KB: Q05315   
X-ray diffraction
1.63Å resolution
Released: 26 Dec 2018
Model geometry
Fit model/data
6a1s
6a1s
6a1s
CHARCOT-LEYDEN CRYSTAL PROTEIN - MANNOSE COMPLEX
Swaminathan GJ, Leonidas DD, Acharya KR
Biochemistry (1999) [PMID: 10529229  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: MAN    MAN   
Assembly name: Galectin-10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-170167 (Preferred)   search this ID
PDBe-KB: Q05315   
X-ray diffraction
1.8Å resolution
Released: 18 Jan 2000
Model geometry
Fit model/data
Data not deposited
1qkq
1qkq
1qkq
Charcot-Leyden crystal protein/Galectin-10 variant Y35A
Su J
Glycobiology (2019) [PMID: 30239701  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Galectin-10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-170169 (Preferred)   search this ID
PDBe-KB: Q05315   
X-ray diffraction
1.63Å resolution
Released: 26 Dec 2018
Model geometry
Fit model/data
6a1y
6a1y
6a1y
Charcot-Leyden Crystal Protein - pCMBS Complex
Ackerman SJ, Savage MP, Liu L, Leonidas DD, Kwatia MA, Swaminathan GJ, Acharya KR
J Biol Chem (2002) [PMID: 11834744  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PMB   
Assembly name: Galectin-10 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-170167 (Preferred)   search this ID
PDBe-KB: Q05315   
X-ray diffraction
1.8Å resolution
Released: 15 Nov 2001
Model geometry
Fit model/data
Data not deposited
1hdk
1hdk
1hdk
Entries 1 to 10 of 39
Entries 1 to 10 of 39