Uniprot accession / id : Q08423  OR   Uniprot accession / id : P04155
 
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Entry Information
Entry status  (1)
REL
(3)
 
Experimental methods  (2)
Solution NMR
(2)
X-ray diffraction
(1)
 
Authors  (15)
Feeney J
(2)
May FE
(2)
Westley BR
(2)
Williams MA
(2)
Chadwick MP
(1)
Frenkiel TA
(1)
Gargaro AR
(1)
Goddard-Borger ED
(1)
Jarva MA
(1)
John A
(1)
Järvå MA
(1)
Lingford JP
(1)
Polshakov VI
(1)
Scott NE
(1)
Soler NM
(1)
 
Homo / hetero assembly  (1)
homo
(3)
 
Assembly composition  (1)
protein structure
(3)
 
Assembly polymer count  (2)
monomer
(2)
dimer
(1)
 
Resolution distribution
2.0 - 2.5
(1)
 
Release year distribution
1995 - 2000
(1)
2000 - 2005
(1)
2015 - 2020
(1)
 
Journal  (3)
FEBS Lett
(1)
J Mol Biol
(1)
Nat Commun
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(3)
 
Organism name  (1)
Homo sapiens
(3)
 
Molecule name  (6)
Breast cancer estrogen-inducible protein
(3)
PNR-2
(3)
Polypeptide P1.A
(3)
Protein pS2
(3)
Trefoil factor 1
(3)
hP1.A
(3)
 
Molecule type  (1)
Protein
(3)
 
Gene names  (3)
BCEI
(3)
PS2
(3)
TFF1
(3)
 
Function and Biology
Biological function  (2)
growth factor activity
(2)
protein binding
(2)
 
Biological process  (9)
carbohydrate metabolic process
(2)
cell differentiation
(2)
cell population proliferation
(2)
maintenance of gastrointestinal epithelium
(2)
negative regulation of cell population proliferation
(2)
response to immobilization stress
(2)
response to iron ion
(2)
response to peptide hormone
(2)
signal transduction
(2)
 
Biological cell component  (2)
extracellular region
(2)
extracellular space
(2)
 
Sequence and Structure classification
SCOP fold  (1)
Trefoil/Plexin domain-like
(2)
 
SCOP family  (1)
Trefoil
(2)
 
CATH class  (1)
Few Secondary Structures
(2)
 
CATH topology  (1)
Spasmolytic Protein; domain 1
(2)
 
Pfam accession / name  (1)
PF00088 : Trefoil
(3)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(1)
 
Diffraction radiation source type  (1)
Synchrotron
(1)
 
Diffraction source  (1)
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
(1)
 
Synchrotron site  (1)
Australian Synchrotron
(1)
 
Diffraction detector type  (1)
Pixel
(1)
 
Refinement software  (2)
PHENIX
(1)
X-PLOR
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 3 of 3
Entries 1 to 3 of 3
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Crystal structure of human trefoil factor 1
Jarva MA, Lingford JP, John A, Scott NE, Goddard-Borger ED
Nat Commun (2020) [PMID: 32404934  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Modified residues: PCA    PCA   
Assembly name: Trefoil factor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-137453 (Preferred)   search this ID
PDBe-KB: P04155   
X-ray diffraction
2.4Å resolution
Released: 11 Dec 2019
Model geometry
Fit model/data
6v1d
6v1d
6v1d
HIGH RESOLUTION NMR SOLUTION STRUCTURE OF HUMAN PS2, 19 STRUCTURES
Williams MA, Polshakov VI, Gargaro AR, Feeney J
J Mol Biol (1997) [PMID: 9096235  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Trefoil factor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-137453 (Preferred)   search this ID
PDBe-KB: P04155   
Solution NMR
Released: 7 Jul 1997
Model geometry
Fit model/data
Data not analysed
1ps2
1ps2
1ps2
NMR SOLUTION STRUCTURE OF THE DISULPHIDE-LINKED HOMODIMER OF HUMAN TFF1, 10 STRUCTURES
Williams MA, Feeney J
FEBS Lett (2001) [PMID: 11286998  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Trefoil factor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-137454 (Preferred)   search this ID
PDBe-KB: P04155   
Solution NMR
Released: 3 Jan 2001
Model geometry
Fit model/data
Data not analysed
1hi7
1hi7
1hi7
Entries 1 to 3 of 3
Entries 1 to 3 of 3