Uniprot accession / id : Q3LS21  OR   Uniprot accession / id : Q9NPC2
 
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Entry Information
Entry status  (1)
REL
(22)
 
Experimental methods  (2)
X-ray diffraction
(16)
Electron Microscopy
(6)
 
Authors  (38)
Higuchi Y
(16)
Kato N
(16)
Ottmann C
(16)
Anders C
(15)
Bartel M
(15)
Daut J
(15)
Koschinsky K
(15)
Nitta H
(15)
Ohkanda J
(15)
Preisig-Muller R
(15)
Preisig-Müller R
(15)
Renigunta V
(15)
Schlichthorl G
(15)
Schlichthörl G
(15)
Schumacher B
(15)
Thiel P
(15)
Chen S
(4)
Li J
(4)
Lin H
(4)
Yang H
(4)
Zhang Q
(4)
Baukrowitz T
(2)
Carpenter EP
(2)
Hall PH
(2)
Hall PR
(2)
Jouen-Tachoire T
(2)
Newstead S
(2)
Proks P
(2)
Rodstrom KEJ
(2)
Rödström KEJ
(2)
Schewe M
(2)
Tucker SJ
(2)
Andrei SA
(1)
Brunsveld L
(1)
Han L
(1)
Sijbesma E
(1)
de Vink P
(1)
de Vink PJ
(1)
 
Homo / hetero assembly  (2)
hetero
(16)
homo
(6)
 
Assembly composition  (2)
protein/protein complex
(16)
protein structure
(6)
 
Assembly polymer count  (2)
tetramer
(15)
dimer
(7)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(14)
2.0 - 2.5
(2)
2.5 - 3
(1)
3.0 - 3.5
(3)
3.5 - 4
(1)
 
Release year distribution
2010 - 2015
(14)
2015 - 2020
(2)
2020 - 2025
(6)
 
Journal  (4)
Chem Biol
(15)
Proc Natl Acad Sci U S A
(4)
Structure
(2)
Angew Chem Int Ed Engl
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(22)
 
Organism name  (1)
Homo sapiens
(22)
 
Molecule name  (5)
Acid-sensitive potassium channel protein TASK-3
(22)
Potassium channel subfamily K member 9
(22)
TWIK-related acid-sensitive K(+) channel 3
(22)
Two pore K(+) channel KT3.2
(22)
Two pore potassium channel KT3.2
(22)
 
Molecule type  (1)
Protein
(22)
 
Gene names  (2)
KCNK9
(22)
TASK3
(22)
 
Interacting Molecules  (1)
14-3-3 protein sigma
(16)
 
Interacting ligands  (11)
K : POTASSIUM ION
(6)
Y01 : CHOLESTEROL HEMISUCCINATE
(6)
FSC : FUSICOCCIN
(3)
FC7 : Fusicoccin A-THF
(2)
FJA : Fusicoccin J aglycone
(2)
0DV : (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(hydroxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrod icyclopenta[a,d][8]annulen-4-yl alpha-D-gulopyranoside
(1)
0V4 : (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-glucopyranoside
(1)
CW7 : Cotylenin A
(1)
CX7 : Cotylenol
(1)
EZ5 : ~{N}-[(2~{S})-2-[(1~{E},3~{R},4~{S},8~{R},9~{R},10~{R},11~{S},14~{S})-14-(methoxymethyl)-3,10-dimethyl-8-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(2-methylbut-3-en-2-yloxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,9-bis(oxidanyl)-6-tricyclo[9.3.0.0^{3,7}]tetradeca-1,6-dienyl]propyl]ethanamide
(1)
FW1 : Fusicoccin A aglycone
(1)
 
Function and Biology
Biological function  (1)
potassium channel activity
(4)
 
Biological process  (1)
potassium ion transmembrane transport
(4)
 
Biological cell component  (1)
membrane
(4)
 
Sequence and Structure classification
Pfam accession / name  (1)
PF07885 : Ion_trans_2
(6)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(16)
 
Diffraction radiation source type  (2)
Rotating anode
(15)
Synchrotron
(1)
 
Diffraction source  (3)
BRUKER AXS MICROSTAR
(14)
RIGAKU MICROMAX-003
(1)
SLS BEAMLINE X10SA
(1)
 
Synchrotron site  (1)
SLS
(1)
 
Diffraction detector type  (3)
Image plate
(14)
CCD
(1)
Pixel
(1)
 
Refinement software  (2)
REFMAC
(15)
PHENIX
(1)
 
EM microscope model  (1)
FEI TITAN KRIOS
(6)
 
EM detector name  (2)
GATAN K3 (6k x 4k)
(4)
GATAN K3 BIOQUANTUM (6k x 4k)
(2)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 22
Entries 1 to 10 of 22
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Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4, 5 mM KCl and 135 mM NaCl
Chen S, Lin H
Proc Natl Acad Sci U S A (2024) [PMID: 38630723  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: K    K    Y01   
Assembly name: Potassium channel subfamily K member 9 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-275432 (Preferred)   search this ID
PDBe-KB: Q9NPC2   
Electron Microscopy
3.48Å resolution
Released: 17 Apr 2024
Model geometry
Fit model/data
Data not analysed
8k1v
8k1v
8k1v
Structure of the human two pore domain potassium ion channel TASK-3 (K2P9.1) G236R mutant
Rodstrom KEJ, Hall PH, Tucker SJ
Structure (2024) [PMID: 39637865  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: K    K    Y01   
Assembly name: Potassium channel subfamily K member 9 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-275432 (Preferred)   search this ID
PDBe-KB: Q9NPC2   
Electron Microscopy
2.48Å resolution
Released: 18 Dec 2024
Model geometry
Fit model/data
Data not analysed
9g9w
9g9w
9g9w
Structure of the human two pore domain potassium ion channel TASK-3 (K2P9.1)
Hall PH, Rodstrom KEJ, Tucker SJ
Structure (2024) [PMID: 39637865  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: K    K    Y01   
Assembly name: Potassium channel subfamily K member 9 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-275432 (Preferred)   search this ID
PDBe-KB: Q9NPC2   
Electron Microscopy
3.32Å resolution
Released: 18 Dec 2024
Model geometry
Fit model/data
Data not analysed
9g9v
9g9v
9g9v
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 200 mM KCl
Chen S, Lin H
Proc Natl Acad Sci U S A (2024) [PMID: 38630723  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: K    K    Y01   
Assembly name: Potassium channel subfamily K member 9 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-275432 (Preferred)   search this ID
PDBe-KB: Q9NPC2   
Electron Microscopy
3.41Å resolution
Released: 17 Apr 2024
Model geometry
Fit model/data
Data not analysed
8k1z
8k1z
8k1z
14-3-3sigma in complex with a TASK3 peptide stabilized by semi-synthetic natural product FC-NAc
Andrei SA, de Vink PJ, Brunsveld L, Ottmann C, Higuchi Y
Angew Chem Int Ed Engl (2018) [PMID: 30025189  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: NA    CL    EZ5    NA   
Modified residues: CSO    SEP    ACE    ACE    CSO    SEP   
Assembly name: Potassium channel subfamily K member 9 and 14-3-3 protein sigma (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152170 (Preferred)   search this ID
PDBe-KB: Q9NPC2    P31947   
X-ray diffraction
1.95Å resolution
Released: 1 Aug 2018
Model geometry
Fit model/data
6ghp
6ghp
6ghp
Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide
Anders C, Higuchi Y, Schumacher B, Thiel P, Kato N, Ottmann C
Chem Biol (2013) [PMID: 23601647  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    CL    MG   
Modified residues: SEP    SEP   
Assembly name: Potassium channel subfamily K member 9 and 14-3-3 protein sigma (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152170 (Preferred)   search this ID
PDBe-KB: Q9NPC2    P31947   
X-ray diffraction
1.95Å resolution
Released: 12 Oct 2011
Model geometry
Fit model/data
3p1p
3p1p
3p1p
Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Cotylenol
Anders C, Schumacher B, Ottmann C
Chem Biol (2013) [PMID: 23601647  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    MG    CX7   
Modified residues: SEP    SEP   
Assembly name: Potassium channel subfamily K member 9 and 14-3-3 protein sigma (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152123 (Preferred)   search this ID
PDBe-KB: Q9NPC2    P31947   
X-ray diffraction
1.8Å resolution
Released: 4 May 2016
Model geometry
Fit model/data
3sp5
3sp5
3sp5
Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Fusicoccin J aglycone
Anders C, Schumacher B, Ottmann C
Chem Biol (2013) [PMID: 23601647  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    MG    FJA   
Modified residues: SEP    SEP   
Assembly name: Potassium channel subfamily K member 9 and 14-3-3 protein sigma (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152170 (Preferred)   search this ID
PDBe-KB: Q9NPC2    P31947   
X-ray diffraction
1.8Å resolution
Released: 11 Jul 2012
Model geometry
Fit model/data
3smo
3smo
3smo
Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer 16-O-Me-FC-H
Ottmann C, Anders C, Schumacher B
Chem Biol (2013) [PMID: 23601647  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    MG    0V4   
Modified residues: CSO    SEP    CSO    SEP   
Assembly name: Potassium channel subfamily K member 9 and 14-3-3 protein sigma (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152170 (Preferred)   search this ID
PDBe-KB: Q9NPC2    P31947   
X-ray diffraction
1.9Å resolution
Released: 8 May 2013
Model geometry
Fit model/data
4fr3
4fr3
4fr3
Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 Peptide and stabilizer fusicoccin A
Anders C, Higuchi Y, Schumacher B, Thiel P, Kato N, Ottmann C
Chem Biol (2013) [PMID: 23601647  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CA    MG    CA    FSC    CL    MG   
Modified residues: SEP    SEP   
Assembly name: Potassium channel subfamily K member 9 and 14-3-3 protein sigma (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152170 (Preferred)   search this ID
PDBe-KB: Q9NPC2    P31947   
X-ray diffraction
1.7Å resolution
Released: 12 Oct 2011
Model geometry
Fit model/data
3p1q
3p1q
3p1q
Entries 1 to 10 of 22
Entries 1 to 10 of 22