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Deubiquitinating enzyme otulin
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OTU domain-containing deubiquitinase with linear linkage specificity
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Ubiquitin thioesterase Gumby
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FAM105B
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OTULIN
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3.4.19.12 : Ubiquitinyl hydrolase 1
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Representative Structures
Representative Structures
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Entries 1 to 10 of 11
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Structure of OTULIN bound to the Met1-linked diubiquitin activity probe
Elliott PR, Komander D
Cell Chem Biol
(2017)
[PMID: 28919039 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Modified residues:
DHA
Assembly name:
Ubiquitin thioesterase otulin and Ubiquitin
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-143393 (Preferred)
search this ID
Structure of the OTULINcat C129A - SNX27 PDZ domain complex.
Elliott PR, Komander D
Nat Commun
(2019)
[PMID: 31541095 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Ubiquitin thioesterase otulin and Sorting nexin-27
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-188380 (Preferred)
search this ID
Crystal structure of HOIP PUB domain in complex with OTULIN PIM
Akutsu M, Schaeffer V, Olma MH, Gomes LC, Kawasaki M, Dikic I
Mol Cell
(2014)
[PMID: 24726327 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
E3 ubiquitin-protein ligase RNF31 and Ubiquitin thioesterase otulin
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-188379 (Preferred)
search this ID
Crystal structure of OTULIN OTU domain (C129A) in complex with Met1- di ubiquitin
Keusekotten K, Elliott PR, Glockner L, Kulathu Y, Wauer T, Krappmann D, Hofmann K, Komander D
Cell
(2013)
[PMID: 23746843 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Bound ligands:
SO4
Assembly name:
Ubiquitin thioesterase otulin and Ubiquitin
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-143393 (Preferred)
search this ID
Structure of the OTU domain of OTULIN G281R mutant
Damgaard RB, Elliott PR, Swatek KN, Maher ER, Stepensky P, Elpeleg O, Komander D, Berkun Y
EMBO Mol Med
(2019)
[PMID: 30804083 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Ubiquitin thioesterase otulin
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-188378 (Preferred)
search this ID

Crystal structure of the OTU domain of OTULIN at 1.3 Angstroms.
Keusekotten K, Elliott PR, Glockner L, Kulathu Y, Wauer T, Krappmann D, Hofmann K, Komander D
Cell
(2013)
[PMID: 23746843 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Ubiquitin thioesterase otulin
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-188378 (Preferred)
search this ID

Structure of HOIP PUB domain bound to OTULIN PIM
Elliott PR, Komander D
Mol Cell
(2014)
[PMID: 24726323 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Bound ligands:
CL
Assembly name:
E3 ubiquitin-protein ligase RNF31 and Ubiquitin thioesterase otulin
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-188379 (Preferred)
search this ID
Crystal structure of the OTU domain of Gumby/Fam105B at 1.6 angstrom
Ceccarelli DF, Juang Y-C, Sicheri F
Nature
(2013)
[PMID: 23708998 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Ubiquitin thioesterase otulin
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-188378 (Preferred)
search this ID

Gumby/Fam105B in complex with ubiquitin
Ceccarelli DF, Juang Y-C, Sicheri F
Nature
(2013)
[PMID: 23708998 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Bound ligands:
SO4
Assembly name:
Ubiquitin thioesterase otulin and Ubiquitin
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-143393 (Preferred)
search this ID
Gumby/Fam105B in complex with linear di-ubiquitin
Juang Y-C, Ceccarelli DF, Sicheri F
Nature
(2013)
[PMID: 23708998 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Ubiquitin thioesterase otulin and Ubiquitin
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-143393 (Preferred)
search this ID
Entries 1 to 10 of 11