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Entry Information
Entry status
(1)
Experimental methods
(2)
Electron Microscopy
(43)
Solution NMR
(1)
Authors
(74)
Shi Y
(20)
Urlaub H
(18)
Zhan X
(18)
Dybkov O
(16)
Luehrmann R
(16)
Luhrmann R
(16)
Lührmann R
(16)
Stark H
(16)
Kastner B
(15)
Will CL
(14)
Zhang X
(12)
Zhang Z
(11)
Lei J
(10)
Yan C
(9)
Agafonov DE
(8)
Kumar V
(8)
Lu Y
(8)
Ludwig S
(7)
Ludwig SEJ
(7)
Zhong J
(7)
Bai R
(6)
Bertram K
(6)
Hartmuth K
(5)
Zhang W
(4)
Bian T
(3)
Cretu C
(3)
Galej WP
(3)
Hofele R
(3)
Leelaram MN
(3)
Li L
(3)
Pena V
(3)
Razew M
(3)
Tholen J
(3)
Townsend C
(3)
Weis F
(3)
Xing Z
(3)
Yang F
(3)
Agafonov D
(2)
Dienemann C
(2)
Fan R
(2)
Graf B
(2)
Haselbach D
(2)
Komarov I
(2)
Larsen NA
(2)
Li P
(2)
Schmitzova J
(2)
Schmitzová J
(2)
Wan R
(2)
Zhang QC
(2)
Agrawal A
(1)
Charenton C
(1)
Chen Z
(1)
Cook A
(1)
Gee P
(1)
Ghosh AK
(1)
Inoue M
(1)
Jurica M
(1)
Kigawa T
(1)
Liu X
(1)
Luo T
(1)
Muto Y
(1)
Nagai K
(1)
Nguyen TV
(1)
RIKEN Structural Genomics/Proteomics Initiative (RSGI)
(1)
Shirouzu M
(1)
Suzuki S
(1)
Terada T
(1)
Wang L
(1)
Wilkinson ME
(1)
Xu K
(1)
Yokoyama S
(1)
Yuan M
(1)
Zhang P
(1)
Zhang Q
(1)
Homo / hetero assembly
(2)
hetero
(43)
homo
(1)
Assembly composition
(2)
RNA/protein complex
(43)
protein structure
(1)
Assembly polymer count
(29)
61-mer
(4)
59-mer
(3)
60-mer
(3)
71-mer
(3)
21-mer
(2)
51-mer
(2)
56-mer
(2)
57-mer
(2)
63-mer
(2)
nonamer
(2)
22-mer
(1)
28-mer
(1)
35-mer
(1)
37-mer
(1)
46-mer
(1)
49-mer
(1)
50-mer
(1)
53-mer
(1)
55-mer
(1)
58-mer
(1)
62-mer
(1)
68-mer
(1)
decamer
(1)
heptadecamer
(1)
hexadecamer
(1)
monomer
(1)
nonadecamer
(1)
octamer
(1)
undecamer
(1)
Resolution distribution
2.0 - 2.5
(4)
2.5 - 3
(8)
3.0 - 3.5
(8)
3.5 - 4
(1)
4.0 - 4.5
(7)
4.5 - 5
(2)
5.0 - 5.5
(2)
5.5 - 6
(3)
6.0 - 6.5
(2)
6.5 - 7
(1)
7.0 - 7.5
(2)
7.5 - 8
(2)
9.5 - 10
(1)
Release year distribution
2005 - 2010
(1)
2015 - 2020
(13)
2020 - 2025
(35)
Journal
(8)
Nature
(12)
Cell Res
(9)
Science
(9)
Nat Commun
(8)
Cell
(2)
Nat Struct Mol Biol
(2)
EMBO J
(1)
To be published
(1)
Macromolecules
Organism superkingdom
(1)
Eukaryota
(44)
Organism name
(1)
Homo sapiens
(44)
Molecule name
(5)
Pre-mRNA-splicing factor SF3b 145 kDa subunit
(44)
SAP 145
(44)
SF3b145
(44)
Spliceosome-associated protein 145
(44)
Splicing factor 3B subunit 2
(44)
Molecule type
(1)
Protein
(44)
Gene names
(2)
SAP145
(44)
SF3B2
(44)
Interacting Molecules
(132)
Splicing factor 3B subunit 1
(43)
PHD finger-like domain-containing protein 5A
(42)
Splicing factor 3B subunit 3
(42)
Splicing factor 3B subunit 5
(42)
Splicing factor 3A subunit 3
(39)
Splicing factor 3A subunit 2
(37)
Splicing factor 3B subunit 4
(37)
Small nuclear ribonucleoprotein G
(36)
Small nuclear ribonucleoprotein Sm D1
(36)
Small nuclear ribonucleoprotein Sm D2
(36)
Small nuclear ribonucleoprotein Sm D3
(36)
Small nuclear ribonucleoprotein E
(35)
Small nuclear ribonucleoprotein F
(35)
Small nuclear ribonucleoprotein-associated proteins B and B'
(35)
U2 snRNA
(35)
U2 small nuclear ribonucleoprotein A'
(33)
U2 small nuclear ribonucleoprotein B''
(33)
116 kDa U5 small nuclear ribonucleoprotein component
(31)
Pre-mRNA-processing-splicing factor 8
(31)
Splicing factor 3A subunit 1
(31)
Splicing factor 3B subunit 6
(29)
U5 small nuclear ribonucleoprotein 40 kDa protein
(29)
U5 snRNA
(28)
U5 small nuclear ribonucleoprotein 200 kDa helicase
(27)
U6 snRNA
(26)
pre-mRNA
(22)
Cell division cycle 5-like protein
(17)
Pleiotropic regulator 1
(16)
Spliceosome-associated protein CWC15 homolog
(16)
U6 snRNA-associated Sm-like protein LSm2
(16)
U6 snRNA-associated Sm-like protein LSm3
(16)
U6 snRNA-associated Sm-like protein LSm4
(16)
U6 snRNA-associated Sm-like protein LSm5
(16)
U6 snRNA-associated Sm-like protein LSm6
(16)
U6 snRNA-associated Sm-like protein LSm7
(16)
U6 snRNA-associated Sm-like protein LSm8
(16)
Crooked neck-like protein 1
(15)
NHP2-like protein 1
(15)
Pre-mRNA-processing factor 6
(15)
Protein BUD31 homolog
(15)
Thioredoxin-like protein 4A
(15)
U4/U6 small nuclear ribonucleoprotein Prp3
(15)
U4/U6 small nuclear ribonucleoprotein Prp31
(15)
U4/U6 small nuclear ribonucleoprotein Prp4
(15)
Pre-mRNA-splicing factor RBM22
(14)
SNW domain-containing protein 1
(14)
U4/U6.U5 tri-snRNP-associated protein 1
(14)
U4 snRNA
(13)
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
(12)
Pre-mRNA-splicing factor CWC22 homolog
(12)
Serine/arginine repetitive matrix protein 2
(12)
BUD13 homolog
(11)
E3 ubiquitin-protein ligase RNF113A
(11)
Peptidyl-prolyl cis-trans isomerase E
(11)
Pre-mRNA-splicing factor SYF1
(11)
RNA helicase aquarius
(11)
Ubiquitin carboxyl-terminal hydrolase 39
(11)
Peptidyl-prolyl cis-trans isomerase-like 1
(10)
Probable ATP-dependent RNA helicase DDX23
(10)
RNA-binding motif protein, X-linked 2
(10)
Smad nuclear-interacting protein 1
(10)
Pre-mRNA-processing factor 17
(9)
Peptidyl-prolyl cis-trans isomerase H
(8)
RING-type E3 ubiquitin-protein ligase PPIL2
(8)
Serine/arginine repetitive matrix protein 1
(8)
Pre-mRNA-processing factor 19
(7)
Pre-mRNA-splicing factor SPF27
(7)
17S U2 SnRNP complex component HTATSF1
(6)
Microfibrillar-associated protein 1
(6)
Peptidyl-prolyl cis-trans isomerase-like 4
(6)
Pre-mRNA-splicing factor 38A
(6)
Probable ATP-dependent RNA helicase DDX46
(6)
RNA-binding protein 42
(6)
Serine/threonine-protein kinase PRP4 homolog
(6)
Spliceosome-associated protein CWC27 homolog
(6)
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
(6)
Zinc finger matrin-type protein 2
(6)
Ubiquitin-like protein 5
(5)
WD40 repeat-containing protein SMU1
(5)
WW domain-binding protein 4
(5)
Pre-mRNA
(4)
U2snRNA
(4)
5'ss oligo
(3)
DNA/RNA-binding protein KIN17
(3)
G-patch domain and KOW motifs-containing protein
(3)
MINX M3 pre-mRNA
(3)
U1 small nuclear ribonucleoprotein 70 kDa
(3)
U1 snRNA
(3)
U6snRNA
(3)
MINX
(2)
Pre-mRNA-splicing factor ISY1 homolog
(2)
Pre-mRNA-splicing factor SYF2
(2)
Protein Red
(2)
Serine/arginine-rich splicing factor 1
(2)
Skip
(2)
Sodium channel modifier 1
(2)
Transcription elongation regulator 1
(2)
U1 small nuclear ribonucleoprotein A
(2)
U1 small nuclear ribonucleoprotein C
(2)
U12 snRNA
(2)
More...
Function and Biology
Biological function
(2)
RNA binding
(43)
protein binding
(43)
Biological process
(4)
RNA splicing
(43)
U2-type prespliceosome assembly
(43)
mRNA processing
(43)
mRNA splicing, via spliceosome
(43)
Biological cell component
(10)
U12-type spliceosomal complex
(43)
U2 snRNP
(43)
U2-type precatalytic spliceosome
(43)
U2-type spliceosomal complex
(43)
catalytic step 2 spliceosome
(43)
nuclear speck
(43)
nucleoplasm
(43)
nucleus
(43)
precatalytic spliceosome
(43)
spliceosomal complex
(43)
Sequence and Structure classification
Pfam accession / name
(3)
PF02037 : SAP
(44)
PF04037 : DUF382
(43)
PF04046 : PSP
(43)
Experimental Information
Refinement software
(3)
PHENIX
(10)
REFMAC
(3)
phenix.real_space_refine
(1)
EM microscope model
(2)
FEI TITAN KRIOS
(40)
TFS KRIOS
(3)
EM detector name
(4)
FEI FALCON III (4k x 4k)
(16)
GATAN K3 (6k x 4k)
(16)
GATAN K2 SUMMIT (4k x 4k)
(8)
GATAN K3 BIOQUANTUM (6k x 4k)
(3)
NMR
NMR software packages
(6)
CYANA
(1)
KUJIRA
(1)
NMRPipe
(1)
NMRView
(1)
Olivia
(1)
XwinNMR
(1)
NMR Field Strength
700.0 - 800
(1)
800.0 - 900
(1)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 10 of 44
Select all entries on this page
The cryo-EM structure of human post-Bact complex
Zhan X, Lu Y, Shi Y
Nat Commun
(2024)
[PMID: 39068178 ]
Source organism: Homo sapiens
Assembly composition: RNA/protein complex
PDBe complex ID:
PDB-CPX-289408 (Preferred)
search this ID
The cryo-EM structure of human pre-Bact complex
Zhan X, Lu Y, Shi Y
Nat Commun
(2024)
[PMID: 39068178 ]
Source organisms: unidentified adenovirus , Homo sapiens
Assembly composition: RNA/protein complex
PDBe complex ID:
PDB-CPX-289410 (Preferred)
search this ID
The cryo-EM structure of human Bact-IV complex
Zhan X, Lu Y, Shi Y
Nat Commun
(2024)
[PMID: 39068178 ]
Source organism: Homo sapiens
Assembly composition: RNA/protein complex
PDBe complex ID:
PDB-CPX-289365 (Preferred)
search this ID
Cryo-EM structure of the cross-exon pre-B+ATP complex
Zhang Z, Kumar V, Dybkov O, Will CL, Zhong J, Ludwig S, Urlaub H, Kastner B, Stark H, Luehrmann R
Nature
(2024)
[PMID: 38778104 ]
Source organism: Homo sapiens
Assembly composition: RNA/protein complex
PDBe complex ID:
PDB-CPX-271693 (Preferred)
search this ID
Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex)
Bai R, Wan R, Wang L, Xu K, Zhang Q, Lei J, Shi Y
Science
(2021)
[PMID: 33509932 ]
Source organism: Homo sapiens
Assembly composition: RNA/protein complex
PDBe complex ID:
PDB-CPX-289369 (Preferred)
search this ID
cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom.
Zhang X, Yan C, Zhan X, Li L, Lei J, Shi Y
Cell Res
(2018)
[PMID: 29360106 ]
Source organisms: unidentified adenovirus , Homo sapiens
Assembly composition: RNA/protein complex
PDBe complex ID:
PDB-CPX-289363 (Preferred)
search this ID
Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom.
Zhang X, Yan C, Zhan X, Li L, Lei J, Shi Y
Cell Res
(2018)
[PMID: 29360106 ]
Source organisms: unidentified adenovirus , Homo sapiens
Assembly composition: RNA/protein complex
PDBe complex ID:
PDB-CPX-289368 (Preferred)
search this ID
Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom
Zhang X, Yan C, Zhan X, Li L, Lei J, Shi Y
Cell Res
(2018)
[PMID: 29360106 ]
Source organisms: unidentified adenovirus , Homo sapiens
Assembly composition: RNA/protein complex
PDBe complex ID:
PDB-CPX-289407 (Preferred)
search this ID
The cryo-EM structure of the human 17S U2 snRNP
Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex
Zhang Z, Kumar V, Dybkov O, Will CL, Zhong J, Ludwig S, Urlaub H, Kastner B, Stark H, Luehrmann R
Nature
(2024)
[PMID: 38778104 ]
Source organism: Homo sapiens
Assembly composition: RNA/protein complex
PDBe complex ID:
PDB-CPX-271694 (Preferred)
search this ID
Entries 1 to 10 of 44