Uniprot accession / id : Q4VGL6  OR   Uniprot accession / id : Q5TC82  OR   Uniprot accession / id : B9EGU6
 
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Entry Information
Entry status  (1)
REL
(13)
 
Experimental methods  (2)
X-ray diffraction
(12)
Solution NMR
(1)
 
Authors  (69)
Schlundt A
(7)
Janowski R
(6)
Niessing D
(6)
Heissmeyer V
(5)
Heinz GA
(4)
Sattler M
(4)
Tants JN
(3)
Weigand JE
(3)
Babon JJ
(2)
Binas O
(2)
Blank M
(2)
Braun J
(2)
Brenner S
(2)
Buch T
(2)
Buhmann R
(2)
Davydova E
(2)
Geerlof A
(2)
Gruber AR
(2)
Kershaw NJ
(2)
Kiledjian M
(2)
Peter SA
(2)
Schwalbe H
(2)
Stehle R
(2)
Tan D
(2)
Tants J-N
(2)
Tong L
(2)
Vinuesa CG
(2)
Wommelsdorf N
(2)
Zavolan M
(2)
Zhou M
(2)
Alderton D
(1)
Arrowsmith CH
(1)
Athanasopoulos V
(1)
Berrow NS
(1)
Bountra C
(1)
Brown SH
(1)
Brown SHJ
(1)
Chong MM
(1)
Chong MMW
(1)
Cockburn JB
(1)
Dixon NE
(1)
Dong A
(1)
Duan G
(1)
Edwards AM
(1)
Heinemann U
(1)
Hu D
(1)
Jergic S
(1)
Jones EY
(1)
Landthaler M
(1)
Li Y
(1)
Murakawa Y
(1)
Oberstrass L
(1)
Ose T
(1)
Owens RJ
(1)
Patel HR
(1)
Pratama A
(1)
Preiss T
(1)
Richards S
(1)
Rosenbaum E
(1)
Schuetz A
(1)
Srivastava M
(1)
Structural Genomics Consortium (SGC)
(1)
Stuart D
(1)
Tempel W
(1)
Tong Y
(1)
Verma A
(1)
Yeo JH
(1)
Zhang Q
(1)
kershaw NJ
(1)
 
Homo / hetero assembly  (2)
hetero
(7)
homo
(6)
 
Assembly composition  (2)
RNA/protein complex
(7)
protein structure
(6)
 
Assembly polymer count  (3)
dimer
(7)
monomer
(5)
trimer
(1)
 
Resolution distribution
1.5 - 2
(5)
2.0 - 2.5
(3)
2.5 - 3
(4)
 
Release year distribution
2010 - 2015
(8)
2015 - 2020
(8)
2020 - 2025
(3)
 
Journal  (4)
Nat Commun
(4)
Nat Struct Mol Biol
(4)
Nucleic Acids Res
(3)
To be published
(2)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(13)
 
Organism name  (2)
Mus musculus
(7)
Homo sapiens
(6)
 
Molecule name  (6)
RING finger and C3H zinc finger protein 1
(13)
RING finger and CCCH-type zinc finger domain-containing protein 1
(13)
Roquin
(13)
Roquin-1
(13)
Protein Sanroque
(7)
RING finger protein 198
(6)
 
Molecule type  (1)
Protein
(13)
 
Gene names  (6)
Gm551
(7)
Kiaa2025
(7)
Rc3h1
(7)
KIAA2025
(6)
RC3H1
(6)
RNF198
(6)
 
Interacting Molecules  (7)
5'-R(*AP*C*AP*UP*GP*UP*UP*UP*UP*CP*UP*GP*UP*GP*AP*AP*AP*AP*CP*GP*GP*AP*G)-3'
(1)
5'-R(*CP*UP*CP*CP*CP*UP*UP*CP*UP*GP*UP*GP*AP*AP*GP*GP*GP*GP*A)-3'
(1)
RNA (5'-R(*AP*CP*AP*UP*GP*UP*UP*UP*UP*CP*UP*GP*UP*GP*AP*AP*AP*AP*CP*GP*GP*AP*G)-3')
(1)
RNA (5'-R(P*CP*CP*AP*CP*AP*CP*CP*GP*UP*UP*CP*UP*AP*GP*GP*UP*GP*CP*UP*GP*G)-3')
(1)
RNA (5'-R(P*GP*GP*AP*AP*AP*UP*UP*AP*UP*AP*UP*UP*AP*AP*UP*UP*UP*CP*C)-3')
(1)
RNA (5'-R(P*GP*GP*UP*GP*CP*CP*UP*AP*AP*UP*AP*UP*UP*UP*AP*GP*GP*CP*AP*CP*(CCC))-3')
(1)
RNA (5'-R(P*UP*GP*AP*CP*UP*GP*CP*GP*UP*UP*UP*UP*AP*GP*GP*AP*GP*UP*UP*A)-3')
(1)
 
Interacting ligands  (6)
CL : CHLORIDE ION
(4)
EDO : 1,2-ETHANEDIOL
(2)
GOL : GLYCEROL
(2)
ZN : ZINC ION
(2)
IOD : IODIDE ION
(1)
NA : SODIUM ION
(1)
 
Function and Biology
EC number / name  (1)
2.3.2.27 : RING-type E3 ubiquitin transferase
(13)
 
Biological function  (1)
metal ion binding
(2)
 
Sequence and Structure classification
CATH class  (1)
Mainly Alpha
(7)
 
CATH topology  (1)
Four Helix Bundle (Hemerythrin (Met), subunit A)
(7)
 
Pfam accession / name  (3)
PF18386 : ROQ_II
(12)
PF21206 : Roquin_1_2-like_ROQ
(12)
PF14634 : zf-RING_5
(1)
 
Experimental Information
Diffraction protocol  (2)
Single wavelength
(11)
MAD
(1)
 
Diffraction radiation source type  (1)
Synchrotron
(12)
 
Diffraction source  (9)
SLS BEAMLINE X06DA
(3)
ESRF BEAMLINE ID23-1
(2)
APS BEAMLINE 19-ID
(1)
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
(1)
BESSY BEAMLINE 14.2
(1)
ESRF BEAMLINE BM14
(1)
ESRF BEAMLINE ID29
(1)
NSLS BEAMLINE X25
(1)
NSLS BEAMLINE X29A
(1)
 
Synchrotron site  (6)
ESRF
(4)
SLS
(3)
NSLS
(2)
APS
(1)
Australian Synchrotron
(1)
BESSY
(1)
 
Diffraction detector type  (2)
Pixel
(7)
CCD
(5)
 
Refinement software  (2)
REFMAC
(8)
PHENIX
(4)
 
NMR
NMR software packages  (3)
CYANA
(1)
CcpNmr Analysis
(1)
TopSpin
(1)
 
NMR Field Strength
400.0 - 500
(1)
500.0 - 600
(1)
600.0 - 700
(1)
700.0 - 800
(1)
800.0 - 900
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 13
Entries 1 to 10 of 13
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Structure of the ZnF domain from human Roquin-1
Schlundt A, Tants JN
Nucleic Acids Res (2024) [PMID: 38953172  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Roquin-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-178321 (Preferred)   search this ID
PDBe-KB: Q5TC82   
Solution NMR
Released: 3 Jul 2024
Model geometry
Fit model/data
Data not deposited
8rhs
8rhs
8rhs
X-ray structure of Roquin ROQ domain in complex with a Selex-derived hexa-loop RNA motif
Janowski R, Schlundt A, Sattler M, Niessing D
Nat Commun (2016) [PMID: 27010430  ]
Source organism: Mus musculus  
Assembly composition: RNA/protein complex
Assembly name: Roquin-1 and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-175773 (Preferred)   search this ID
PDBe-KB: Q4VGL6   
X-ray diffraction
3Å resolution
Released: 6 Apr 2016
Model geometry
Fit model/data
5f5f
5f5f
5f5f
X-ray structure of Roquin ROQ domain in complex with Ox40 hexa-loop RNA motif
Janowski R, Schlundt A, Sattler M, Niessing D
Nat Commun (2016) [PMID: 27010430  ]
Source organism: Mus musculus  
Assembly composition: RNA/protein complex
Bound ligands: GOL   
Assembly name: Roquin-1 and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-175774 (Preferred)   search this ID
PDBe-KB: Q4VGL6   
X-ray diffraction
2.23Å resolution
Released: 6 Apr 2016
Model geometry
Fit model/data
5f5h
5f5h
5f5h
X-ray structure of Roquin ROQ domain in complex with a UCP3 CDE2 SL RNA motif
Binas O, Tants J-N, Peter SA, Janowski R, Davydova E, Braun J, Niessing D, Schwalbe H, Weigand JE, Schlundt A
Nucleic Acids Res (2020) [PMID: 32491174  ]
Source organism: Mus musculus  
Assembly composition: RNA/protein complex
Bound ligands: MG    CL    MG   
Modified residues: CCC    CCC   
Assembly name: Roquin-1 and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-175775 (Preferred)   search this ID
PDBe-KB: Q4VGL6   
X-ray diffraction
2.4Å resolution
Released: 27 May 2020
Model geometry
Fit model/data
6tqa
6tqa
6tqa
Crystal structure of N-terminus of Roquin
Kershaw NJ, Vinuesa CG, Babon JJ
To be published
Source organism: Mus musculus  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: Roquin-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-175771 (Preferred)   search this ID
PDBe-KB: Q4VGL6   
X-ray diffraction
2.75Å resolution
Released: 11 Mar 2015
Model geometry
Fit model/data
4txa
4txa
4txa
X-ray structure of Roquin ROQ domain in complex with a UCP3 CDE1 SL RNA motif
Binas O, Tants J-N, Peter SA, Janowski R, Davydova E, Braun J, Niessing D, Schwalbe H, Weigand JE, Schlundt A
Nucleic Acids Res (2020) [PMID: 32491174  ]
Source organism: Mus musculus  
Assembly composition: RNA/protein complex
Bound ligands: MG    NA    CL    MG    EDO    NA   
Assembly name: Roquin-1 and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-175776 (Preferred)   search this ID
PDBe-KB: Q4VGL6   
X-ray diffraction
1.6Å resolution
Released: 27 May 2020
Model geometry
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6tqb
6tqb
6tqb
Crystal structure of the ROQ domain of human Roquin in complex with the Hmg19 stem-loop RNA
Tan D, Tong L
Nat Struct Mol Biol (2014) [PMID: 25026078  ]
Source organisms: Synthetic construct, Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: CA    CA   
Assembly name: Roquin-1 and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-178323 (Preferred)   search this ID
PDBe-KB: Q5TC82   
X-ray diffraction
2.9Å resolution
Released: 16 Jul 2014
Model geometry
Fit model/data
4qil
4qil
4qil
Crystal structure of the ROQ domain of human Roquin in complex with the TNF23 RNA duplex
Tan D, Tong L
Nat Struct Mol Biol (2014) [PMID: 25026078  ]
Source organisms: Synthetic construct, Homo sapiens  
Assembly composition: RNA/protein complex
Bound ligands: GOL    CL   
Modified residues: MSE    MSE   
Assembly name: Roquin-1 and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-178322 (Preferred)   search this ID
PDBe-KB: Q5TC82   
X-ray diffraction
1.9Å resolution
Released: 16 Jul 2014
Model geometry
Fit model/data
4qik
4qik
4qik
X-ray structure of the ROQ domain from murine Roquin-1
Janowski R, Schlundt A, Sattler M, Niessing D
Nat Struct Mol Biol (2014) [PMID: 25026077  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Bound ligands: EDO   
Assembly name: Roquin-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-175771 (Preferred)   search this ID
PDBe-KB: Q4VGL6   
X-ray diffraction
1.94Å resolution
Released: 16 Jul 2014
Model geometry
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4qi0
4qi0
4qi0
Crystal structure of the ROQ domain of human Roquin
Ose T, Verma A, Cockburn JB, Berrow NS, Alderton D, Stuart D, Owens RJ, Jones EY
Nat Commun (2015) [PMID: 25697406  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: IOD   
Assembly name: Roquin-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-178321 (Preferred)   search this ID
PDBe-KB: Q5TC82   
X-ray diffraction
2.201Å resolution
Released: 11 Mar 2015
Model geometry
Fit model/data
3x1o
3x1o
3x1o
Entries 1 to 10 of 13
Entries 1 to 10 of 13