Uniprot accession / id : Q60793  OR   Uniprot accession / id : O43474  OR   Uniprot accession / id : B7ZBT2
 
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Entry Information
Entry status  (1)
REL
(10)
 
Experimental methods  (1)
X-ray diffraction
(10)
 
Authors  (31)
Blumenthal RM
(7)
Cheng X
(7)
Hashimoto H
(7)
Zhang X
(7)
Jin P
(6)
Steves AN
(6)
Wang D
(6)
Blasig R
(2)
Carstanjen D
(2)
Heinemann U
(2)
Koenigsmann J
(2)
Milanovic M
(2)
Nana D
(2)
Rose C
(2)
Schuetz A
(2)
Zocher G
(2)
Choi KJ
(1)
Ferreon ACM
(1)
Ferreon JC
(1)
Kim C
(1)
Kim JJ
(1)
LaGrone A
(1)
Liu Y
(1)
MacKenzie KR
(1)
Olanrewaju YO
(1)
Park H
(1)
Quan MD
(1)
Sankaran B
(1)
Sharma R
(1)
Sharma S
(1)
Zheng Y
(1)
 
Homo / hetero assembly  (1)
hetero
(10)
 
Assembly composition  (1)
DNA/protein complex
(10)
 
Assembly polymer count  (1)
trimer
(10)
 
Resolution distribution
1.5 - 2
(3)
2.0 - 2.5
(7)
 
Release year distribution
2005 - 2010
(2)
2010 - 2015
(3)
2015 - 2020
(6)
2020 - 2025
(1)
 
Journal  (3)
Nucleic Acids Res
(7)
Cell Mol Life Sci
(2)
Nat Commun
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(10)
 
Organism name  (2)
Mus musculus
(9)
Homo sapiens
(1)
 
Molecule name  (3)
Epithelial zinc finger protein EZF
(10)
Gut-enriched krueppel-like factor
(10)
Krueppel-like factor 4
(10)
 
Molecule type  (1)
Protein
(10)
 
Gene names  (7)
Ezf
(9)
Gklf
(9)
Klf4
(9)
Zie
(9)
EZF
(1)
GKLF
(1)
KLF4
(1)
 
Interacting Molecules  (13)
DNA (5'-D(*GP*AP*GP*GP*TP*GP*TP*GP*GP*C)-3')
(3)
DNA (5'-D(*GP*AP*GP*GP*(5CM)P*GP*TP*GP*GP*C)-3')
(2)
DNA (5'-D(*GP*AP*GP*GP*CP*GP*TP*GP*GP*C)-3')
(2)
DNA (5'-D(*GP*CP*CP*AP*(5CM)P*GP*CP*CP*TP*C)-3')
(2)
DNA (5'-D(*GP*CP*CP*AP*CP*AP*CP*CP*TP*C)-3')
(2)
DNA (5'-D(*GP*CP*CP*AP*CP*GP*CP*CP*TP*C)-3')
(2)
5'-D(*DGP*DAP*DGP*DGP*DCP*DGP*DTP* DGP*DGP*DC)-3'
(1)
5'-D(*DGP*DCP*DCP*DAP*DCP*DGP*DCP* DCP*DTP*DC)-3'
(1)
5'-D(*GP*AP*GP*GP*CP*GP*CP)-3'
(1)
5'-D(*GP*CP*GP*CP*CP*TP*CP)-3'
(1)
DNA (5'-D(*AP*GP*GP*GP*GP*GP*TP*GP*TP*GP*CP*C)-3')
(1)
DNA (5'-D(*GP*CP*CP*AP*(5CM)P*AP*CP*CP*TP*C)-3')
(1)
DNA (5'-D(*GP*GP*CP*AP*CP*AP*CP*CP*CP*CP*CP*T)-3')
(1)
 
Interacting ligands  (4)
ZN : ZINC ION
(10)
GOL : GLYCEROL
(2)
ACT : ACETATE ION
(1)
EDO : 1,2-ETHANEDIOL
(1)
 
Sequence and Structure classification
CATH class  (1)
Alpha Beta
(2)
 
CATH topology  (1)
Double Stranded RNA Binding Domain
(2)
 
Pfam accession / name  (1)
PF00096 : zf-C2H2
(10)
 
Experimental Information
Diffraction protocol  (2)
Single wavelength
(9)
MAD
(1)
 
Diffraction radiation source type  (1)
Synchrotron
(10)
 
Diffraction source  (5)
APS BEAMLINE 22-ID
(4)
APS BEAMLINE 22-BM
(3)
ALS BEAMLINE 5.0.1
(1)
BESSY BEAMLINE 14.1
(1)
BESSY BEAMLINE 14.2
(1)
 
Synchrotron site  (3)
APS
(7)
BESSY
(2)
ALS
(1)
 
Diffraction detector type  (1)
CCD
(10)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 10
Entries 1 to 10 of 10
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mouse Klf4 E446P ZnF1-3 and MpG/MpG sequence DNA complex structure
Hashimoto H, Cheng X
Nucleic Acids Res (2016) [PMID: 27596594  ]
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
Modified residues: 5CM    5CM   
Assembly name: Krueppel-like factor 4 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-118905 (Preferred)   search this ID
PDBe-KB: Q60793   
X-ray diffraction
2.45Å resolution
Released: 14 Sep 2016
Model geometry
Fit model/data
5ke8
5ke8
5ke8
mouse Klf4 ZnF1-3 and TpG/MpA sequence DNA complex structure
Hashimoto H, Cheng X
Nucleic Acids Res (2016) [PMID: 27596594  ]
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN    EDO   
Modified residues: 5CM    5CM   
Assembly name: Krueppel-like factor 4 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-118904 (Preferred)   search this ID
PDBe-KB: Q60793   
X-ray diffraction
2.06Å resolution
Released: 14 Sep 2016
Model geometry
Fit model/data
5ke7
5ke7
5ke7
mouse Klf4 E446P ZnF1-3 and TpG/CpA sequence DNA complex structure
Hashimoto H, Cheng X
Nucleic Acids Res (2016) [PMID: 27596594  ]
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
Assembly name: Krueppel-like factor 4 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-118906 (Preferred)   search this ID
PDBe-KB: Q60793   
X-ray diffraction
2.336Å resolution
Released: 14 Sep 2016
Model geometry
Fit model/data
5ke9
5ke9
5ke9
mouse Klf4 ZnF1-3 (E446D) and CpG/CpG sequence DNA complex structure: Form I
Hashimoto H, Cheng X
Nucleic Acids Res (2016) [PMID: 27596594  ]
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
Assembly name: Krueppel-like factor 4 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-118907 (Preferred)   search this ID
PDBe-KB: Q60793   
X-ray diffraction
2.458Å resolution
Released: 14 Sep 2016
Model geometry
Fit model/data
5kea
5kea
5kea
mouse Klf4 ZnF1-3 and TpG/CpA sequence DNA complex structure
Hashimoto H, Cheng X
Nucleic Acids Res (2016) [PMID: 27596594  ]
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
Assembly name: Krueppel-like factor 4 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-118903 (Preferred)   search this ID
PDBe-KB: Q60793   
X-ray diffraction
1.99Å resolution
Released: 14 Sep 2016
Model geometry
Fit model/data
5ke6
5ke6
5ke6
mouse Klf4 ZnF1-3 (E446D) and CpG/CpG sequence DNA complex structure: Form II
Hashimoto H, Cheng X
Nucleic Acids Res (2016) [PMID: 27596594  ]
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
Assembly name: Krueppel-like factor 4 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-118908 (Preferred)   search this ID
PDBe-KB: Q60793   
X-ray diffraction
2.453Å resolution
Released: 14 Sep 2016
Model geometry
Fit model/data
5keb
5keb
5keb
Crystal structure of the zinc finger domain of Klf4 bound to its target DNA
Zocher G, Schuetz A, Carstanjen D, Heinemann U
Cell Mol Life Sci (2011) [PMID: 21290164  ]
Source organism: Mus musculus  
Assembly composition: DNA/protein complex
Bound ligands: GOL    ZN    ZN   
Assembly name: Krueppel-like factor 4 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-115905 (Preferred)   search this ID
PDBe-KB: Q60793   
X-ray diffraction
1.7Å resolution
Released: 7 Apr 2010
Model geometry
Fit model/data
2wbs
2wbs
2wbs
Crystal structure of human KLF4 zinc finger DNA binding domain in complex with NANOG DNA
Sharma R, Sharma S, Choi KJ, Ferreon ACM, Ferreon JC, Sankaran B, MacKenzie KR, Kim C
Nat Commun (2021) [PMID: 34552088  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: ZN    NA    ZN    NA   
Assembly name: Krueppel-like factor 4 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-120783 (Preferred)   search this ID
PDBe-KB: O43474   
X-ray diffraction
2.14Å resolution
Released: 1 Sep 2021
Model geometry
Data not analysed
Fit model/data
Data not analysed
6vtx
6vtx
6vtx
Structure of Klf4 zinc finger DNA binding domain in complex with methylated DNA
Liu Y, Olanrewaju YO, Blumenthal RM, Zhang X, Cheng X
Nucleic Acids Res (2014) [PMID: 24520114  ]
Source organisms: Synthetic construct, Mus musculus  
Assembly composition: DNA/protein complex
Bound ligands: ACT    GOL    ZN    ZN    ACT   
Modified residues: 5CM    5CM   
Assembly name: Krueppel-like factor 4 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-117835 (Preferred)   search this ID
PDBe-KB: Q60793   
X-ray diffraction
1.851Å resolution
Released: 12 Feb 2014
Model geometry
Fit model/data
4m9e
4m9e
4m9e
CRYSTAL STRUCTURE OF THE ZINC FINGER DOMAIN OF KLF4 BOUND TO ITS TARGET DNA
Schuetz A, Zocher G, Carstanjen D, Heinemann U
Cell Mol Life Sci (2011) [PMID: 21290164  ]
Source organisms: Synthetic construct, Mus musculus  
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
Assembly name: Krueppel-like factor 4 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-115906 (Preferred)   search this ID
PDBe-KB: Q60793   
X-ray diffraction
2.5Å resolution
Released: 7 Apr 2010
Model geometry
Fit model/data
2wbu
2wbu
2wbu
Entries 1 to 10 of 10
Entries 1 to 10 of 10