Uniprot accession / id : Q61084  OR   Uniprot accession / id : Q99759
 
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Entry Information
Entry status  (1)
REL
(6)
 
Experimental methods  (2)
X-ray diffraction
(4)
Solution NMR
(2)
 
Authors  (43)
Arrowsmith C
(2)
Edwards A
(2)
Hu Q
(2)
Huang H
(2)
Huang X
(2)
Knapp S
(2)
Liu J
(2)
Shen W
(2)
Shi Y
(2)
Sundstrom M
(2)
Wu J
(2)
Zhang J
(2)
Zhang Y
(2)
von Delft F
(2)
Boggon TJ
(1)
Burgess N
(1)
Debreczeni JE
(1)
Deng H
(1)
Deng K
(1)
Deng Y
(1)
Ding J
(1)
Filippakopoulos P
(1)
Fisher OS
(1)
Gileadi O
(1)
Hou Y
(1)
Jiahai Z
(1)
Jihui W
(1)
Liu D
(1)
Louvi A
(1)
Papagrigoriou E
(1)
Qi H
(1)
Salah E
(1)
Savitsky P
(1)
Structural Genomics Consortium (SGC)
(1)
Su B
(1)
Turk BE
(1)
Ugochukwu E
(1)
Wang DC
(1)
Wang X
(1)
Wei R
(1)
Weigelt J
(1)
Yunyu S
(1)
Zhang F
(1)
 
Homo / hetero assembly  (2)
hetero
(3)
homo
(3)
 
Assembly composition  (2)
protein structure
(3)
protein/protein complex
(3)
 
Assembly polymer count  (2)
dimer
(3)
monomer
(3)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(1)
2.0 - 2.5
(2)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(4)
2010 - 2015
(2)
2015 - 2020
(2)
 
Journal  (4)
Biochemistry
(2)
To be published
(2)
Nat Commun
(1)
Structure
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(6)
 
Organism name  (1)
Homo sapiens
(6)
 
Molecule name  (4)
MAPK/ERK kinase kinase 3
(6)
MEK kinase 3
(6)
MEKK 3
(6)
Mitogen-activated protein kinase kinase kinase 3
(6)
 
Molecule type  (1)
Protein
(6)
 
Gene names  (3)
MAP3K3
(6)
MAPKKK3
(6)
MEKK3
(6)
 
Interacting Molecules  (2)
Cerebral cavernous malformations 2 protein
(2)
Dual specificity mitogen-activated protein kinase kinase 5
(1)
 
Interacting ligands  (2)
CA : CALCIUM ION
(1)
GOL : GLYCEROL
(1)
 
Function and Biology
EC number / name  (1)
2.7.11.25 : Mitogen-activated protein kinase kinase kinase
(6)
 
Sequence and Structure classification
SCOP fold  (1)
beta-Grasp (ubiquitin-like)
(2)
 
SCOP family  (1)
PB1 domain
(2)
 
CATH class  (1)
Alpha Beta
(4)
 
CATH topology  (1)
Ubiquitin-like (UB roll)
(4)
 
Pfam accession / name  (1)
PF00564 : PB1
(5)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(4)
 
Diffraction radiation source type  (2)
Rotating anode
(2)
Synchrotron
(2)
 
Diffraction source  (4)
APS BEAMLINE 24-ID-E
(1)
RIGAKU
(1)
RIGAKU FR-E SUPERBRIGHT
(1)
SLS BEAMLINE X10SA
(1)
 
Synchrotron site  (2)
APS
(1)
SLS
(1)
 
Diffraction detector type  (2)
CCD
(2)
Image plate
(2)
 
Refinement software  (2)
PHENIX
(2)
REFMAC
(2)
 
NMR
NMR software packages  (4)
CNS
(2)
MOLMOL
(2)
NMRPipe
(2)
CSI
(1)
 
NMR Field Strength
400.0 - 500
(2)
500.0 - 600
(2)
600.0 - 700
(2)
 
Representative Structures
Representative Structures
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Entries 1 to 6 of 6
Entries 1 to 6 of 6
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crystal structure of human mitogen-activated protein kinase kinase kinase 3 isoform 2 phox domain at 1.25 A resolution
Debreczeni JE, Salah E, Papagrigoriou E, Burgess N, von Delft F, Gileadi O, Sundstrom M, Edwards A, Arrowsmith C, Weigelt J, Knapp S
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CA    GOL    CA   
Modified residues: MSE    MSE   
Assembly name: Mitogen-activated protein kinase kinase kinase 3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189266 (Preferred)   search this ID
PDBe-KB: Q99759   
X-ray diffraction
1.25Å resolution
Released: 29 Nov 2005
Model geometry
Fit model/data
2c60
2c60
2c60
Solution structure of human MEKK3 PB1 domain cis isomer
Qi H, Jiahai Z, Jihui W, Yunyu S
Biochemistry (2007) [PMID: 17985933  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Mitogen-activated protein kinase kinase kinase 3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189266 (Preferred)   search this ID
PDBe-KB: Q99759   
Solution NMR
Released: 10 Jul 2007
Model geometry
Fit model/data
Data not analysed
2jrh
2jrh
2jrh
CCM2 HHD in complex with MEKK3 NPB1
Fisher OS, Boggon TJ
Nat Commun (2015) [PMID: 26235885  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Cerebral cavernous malformations 2 protein and Mitogen-activated protein kinase kinase kinase 3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189267 (Preferred)   search this ID
PDBe-KB: Q99759    Q9BSQ5   
X-ray diffraction
2.35Å resolution
Released: 1 Jul 2015
Model geometry
Fit model/data
4y5o
4y5o
4y5o
Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)
Filippakopoulos P, Savitsky P, Ugochukwu E, Edwards A, Arrowsmith C, Sundstrom M, von Delft F, Knapp S, Structural Genomics Consortium (SGC)
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Mitogen-activated protein kinase kinase kinase 3 and Dual specificity mitogen-activated protein kinase kinase 5 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171581 (Preferred)   search this ID
PDBe-KB: Q99759    Q13163   
X-ray diffraction
1.83Å resolution
Released: 12 Dec 2006
Model geometry
Fit model/data
2o2v
2o2v
2o2v
Crystal structure of truncated cerebral cavernous malformation 2 C-terminal adaptor domain in complex with an internal helix of mitogen-activated protein kinase kinase kinase 3
Ding J, Wang X, Wang DC
Structure (2015) [PMID: 25982527  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Cerebral cavernous malformations 2 protein and Mitogen-activated protein kinase kinase kinase 3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189267 (Preferred)   search this ID
PDBe-KB: Q99759    Q9BSQ5   
X-ray diffraction
2.1Å resolution
Released: 3 Jun 2015
Model geometry
Fit model/data
4yl6
4yl6
4yl6
solution structure of human MEKK3 PB1 domain
Hu Q, Zhang J, Wu J, Shi Y
Biochemistry (2007) [PMID: 17985933  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Mitogen-activated protein kinase kinase kinase 3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189266 (Preferred)   search this ID
PDBe-KB: Q99759   
Solution NMR
Released: 22 May 2007
Model geometry
Fit model/data
Data not analysed
2pph
2pph
2pph
Entries 1 to 6 of 6
Entries 1 to 6 of 6