Uniprot accession / id : Q61096  OR   Uniprot accession / id : P24158
 
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Entry Information
Entry status  (1)
REL
(1)
 
Experimental methods  (1)
X-ray diffraction
(1)
 
Authors  (6)
Chernaia MM
(1)
Fujinaga M
(1)
Halenbeck R
(1)
James MN
(1)
James MNG
(1)
Koths K
(1)
 
Homo / hetero assembly  (1)
homo
(1)
 
Assembly composition  (1)
protein structure
(1)
 
Assembly polymer count  (1)
tetramer
(1)
 
Resolution distribution
2.0 - 2.5
(1)
 
Release year distribution
1995 - 2000
(1)
 
Journal  (1)
J Mol Biol
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(1)
 
Organism name  (1)
Homo sapiens
(1)
 
Molecule name  (10)
AGP7
(1)
C-ANCA antigen
(1)
Leukocyte proteinase 3
(1)
Myeloblastin
(1)
NP-4
(1)
Neutrophil proteinase 4
(1)
P29
(1)
PR-3
(1)
PR3
(1)
Wegener autoantigen
(1)
 
Molecule type  (1)
Protein
(1)
 
Gene names  (2)
MBN
(1)
PRTN3
(1)
 
Interacting ligands  (2)
FUC : alpha-L-fucopyranose
(1)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(1)
 
Function and Biology
EC number / name  (1)
3.4.21.76 : Myeloblastin
(1)
 
Biological function  (7)
enzyme binding
(1)
hydrolase activity
(1)
peptidase activity
(1)
protein binding
(1)
serine-type endopeptidase activity
(1)
serine-type peptidase activity
(1)
signaling receptor binding
(1)
 
Biological process  (10)
antimicrobial humoral response
(1)
cell-cell junction maintenance
(1)
collagen catabolic process
(1)
mature conventional dendritic cell differentiation
(1)
membrane protein ectodomain proteolysis
(1)
negative regulation of phagocytosis
(1)
neutrophil extravasation
(1)
positive regulation of GTPase activity
(1)
positive regulation of cell population proliferation
(1)
proteolysis
(1)
 
Biological cell component  (11)
azurophil granule lumen
(1)
collagen-containing extracellular matrix
(1)
cytosol
(1)
extracellular exosome
(1)
extracellular region
(1)
extracellular space
(1)
intracellular membrane-bounded organelle
(1)
membrane
(1)
membrane raft
(1)
plasma membrane
(1)
plasma membrane raft
(1)
 
Sequence and Structure classification
SCOP fold  (1)
Trypsin-like serine proteases
(1)
 
SCOP family  (1)
Eukaryotic proteases
(1)
 
CATH class  (1)
Mainly Beta
(1)
 
CATH topology  (1)
Thrombin, subunit H
(1)
 
Pfam accession / name  (1)
PF00089 : Trypsin
(1)
 
Experimental Information
Refinement software  (1)
TNT
(1)
 
Representative Structures
Representative Structures
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PR3 (MYELOBLASTIN)
Fujinaga M, Chernaia MM, Halenbeck R, Koths K, James MNG
J Mol Biol (1996) [PMID: 8757293  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Carbohydrate polymer components:
Molecule 1 - FUC(1), NAG(1)
Assembly name: Myeloblastin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150162 (Preferred)   search this ID
PDBe-KB: P24158   
X-ray diffraction
2.2Å resolution
Released: 11 Jul 1996
Model geometry
Fit model/data
Data not analysed
1fuj
1fuj
1fuj
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