Uniprot accession / id : Q61187  OR   Uniprot accession / id : Q99816  OR   Uniprot accession / id : J3QRU6
 
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Entry Information
Entry status  (1)
REL
(21)
 
Experimental methods  (2)
X-ray diffraction
(15)
Solution NMR
(6)
 
Authors  (77)
Hurley JH
(7)
Burke TR
(6)
Freed EO
(6)
Im YJ
(6)
Liu F
(6)
Camara-Artigas A
(5)
Sundquist WI
(5)
Alam SL
(4)
Bonifacino JS
(4)
Burgos PV
(4)
Davis DR
(4)
Kuo L
(4)
Pornillos O
(4)
Ren X
(4)
Zhao XZ
(4)
Carter CA
(2)
Fisher RJ
(2)
Fivash MJ
(2)
Kim SE
(2)
Luque I
(2)
Martinez JC
(2)
Myszka DG
(2)
Palencia A
(2)
Rich RL
(2)
Stephen AG
(2)
Strickland M
(2)
Tjandra N
(2)
Waheed AA
(2)
Watanabe S
(2)
Andujar-Sanchez M
(1)
Arrowsmith CH
(1)
Avvakumov GV
(1)
Bacarizo J
(1)
Bochkarev A
(1)
Bonn SM
(1)
Bouamr F
(1)
Bountra C
(1)
Camara CM
(1)
Carter C
(1)
Dhe-Paganon S
(1)
Dupre E
(1)
Edwards AM
(1)
Ehrlich LS
(1)
Flower TG
(1)
Fushman D
(1)
Hanoulle X
(1)
Hill CP
(1)
Hill GC
(1)
Holton JM
(1)
Hudait A
(1)
Iglesias-Bexiga M
(1)
Kelly BN
(1)
Khan M
(1)
Leis J
(1)
Li Y
(1)
Liang X
(1)
Luan CH
(1)
Mateo PL
(1)
Moschidi D
(1)
Neculai D
(1)
Pak AJ
(1)
Powell MD
(1)
Rose K
(1)
Schubert HL
(1)
Strub M-P
(1)
Strub MP
(1)
Structural Genomics Consortium (SGC)
(1)
Takahashi Y
(1)
Tjahjono N
(1)
Villeret V
(1)
Voth GA
(1)
Walker JR
(1)
Wang HG
(1)
Weigelt J
(1)
Wernimont AK
(1)
Xue S
(1)
Yokom AL
(1)
 
Homo / hetero assembly  (2)
hetero
(13)
homo
(8)
 
Assembly composition  (2)
protein/protein complex
(13)
protein structure
(8)
 
Assembly polymer count  (4)
dimer
(11)
monomer
(7)
tetramer
(2)
trimer
(1)
 
Resolution distribution
1.0 - 1.5
(3)
1.5 - 2
(6)
2.0 - 2.5
(6)
 
Release year distribution
2000 - 2005
(5)
2005 - 2010
(6)
2010 - 2015
(7)
2015 - 2020
(4)
2020 - 2025
(4)
 
Journal  (9)
To be published
(6)
Structure
(5)
ACS Med Chem Lett
(2)
EMBO J
(2)
Nat Struct Biol
(2)
Acta Crystallogr D Biol Crystallogr
(1)
Mol Cell
(1)
Nat Commun
(1)
Nat Struct Mol Biol
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(21)
 
Organism name  (1)
Homo sapiens
(21)
 
Molecule name  (2)
ESCRT-I complex subunit TSG101
(21)
Tumor susceptibility gene 101 protein
(21)
 
Molecule type  (1)
Protein
(21)
 
Gene names  (1)
TSG101
(21)
 
Interacting Molecules  (10)
Gag polyprotein
(4)
Gag protein p6 domain-containing protein
(2)
Ubiquitin
(2)
Hepatocyte growth factor-regulated tyrosine kinase substrate
(1)
Matrix protein VP40
(1)
Matrix protein p19
(1)
Multivesicular body subunit 12A
(1)
Protein ORF3
(1)
Vacuolar protein sorting-associated protein 28 homolog
(1)
Vacuolar protein sorting-associated protein 37B
(1)
 
Interacting ligands  (6)
SO4 : SULFATE ION
(8)
CL : CHLORIDE ION
(2)
4N1 : 4-methoxy-1-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)-3,5-dimethyl-2-(sulfanylmethyl)pyridin-1-ium
(1)
ACY : ACETIC ACID
(1)
CU : COPPER (II) ION
(1)
NH4 : AMMONIUM ION
(1)
 
Function and Biology
Biological process  (2)
protein modification process
(19)
protein transport
(19)
 
Sequence and Structure classification
SCOP fold  (1)
UBC-like
(6)
 
SCOP family  (1)
UEV domain
(6)
 
CATH class  (2)
Alpha Beta
(16)
Special
(1)
 
CATH topology  (2)
Ubiquitin Conjugating Enzyme
(16)
Single alpha-helices involved in coiled-coils or other helix-helix interfaces
(1)
 
Pfam accession / name  (2)
PF05743 : UEV
(19)
PF09454 : Vps23_core
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(17)
 
Diffraction radiation source type  (2)
Synchrotron
(12)
Rotating anode
(3)
 
Diffraction source  (10)
APS BEAMLINE 22-ID
(3)
ALS BEAMLINE 8.3.1
(2)
ESRF BEAMLINE ID23-1
(2)
RIGAKU
(2)
APS BEAMLINE 19-ID
(1)
APS BEAMLINE 22-BM
(1)
BRUKER AXS MICROSTAR
(1)
ESRF BEAMLINE BM16
(1)
ESRF BEAMLINE ID23-2
(1)
SOLEIL BEAMLINE PROXIMA 2
(1)
 
Synchrotron site  (4)
APS
(5)
ESRF
(4)
ALS
(2)
SOLEIL
(1)
 
Diffraction detector type  (3)
CCD
(8)
Pixel
(5)
Image plate
(2)
 
Refinement software  (4)
CNS
(6)
PHENIX
(4)
REFMAC
(4)
BUSTER
(1)
 
NMR
NMR software packages  (12)
DYANA
(4)
CNS
(2)
CcpNmr Analysis
(2)
Felix
(2)
NMRPipe
(2)
Sparky
(2)
TopSpin
(2)
Xplor-NIH
(2)
Gaussian
(1)
NMRDraw
(1)
PSVS
(1)
TALOS-N
(1)
 
NMR Field Strength
500.0 - 600
(6)
600.0 - 700
(6)
700.0 - 800
(2)
800.0 - 900
(2)
900.0 - 1000
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 21
Entries 1 to 10 of 21
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Solution-state NMR structural ensemble of human Tsg101 UEV in complex with tenatoprazole
Strickland M, Ehrlich LS, Watanabe S, Khan M, Strub M-P, Luan CH, Powell MD, Leis J, Tjandra N, Carter C
Nat Commun (2017) [PMID: 29123089  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 4N1    4N1   
Assembly name: Tumor susceptibility gene 101 protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189274 (Preferred)   search this ID
PDBe-KB: Q99816   
Solution NMR
Released: 15 Nov 2017
Model geometry
Fit model/data
Data not analysed
5vkg
5vkg
5vkg
Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide
Moschidi D, Dupre E, Villeret V, Hanoulle X
To be published
Assembly composition: protein/protein complex
Bound ligands: NH4    SO4    CL    NH4   
Assembly name: Tumor susceptibility gene 101 protein and Protein ORF3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189276 (Preferred)   search this ID
PDBe-KB: Q99816    Q9YLR0   
X-ray diffraction
1.398Å resolution
Released: 2 Mar 2022
Model geometry
Fit model/data
7nlc
7nlc
7nlc
Solution-state NMR structural ensemble of human Tsg101 UEV in complex with K63-linked diubiquitin
Strickland M, Watanabe S, Bonn SM, Camara CM, Fushman D, Carter CA, Tjandra N
Structure (2021)
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Tumor susceptibility gene 101 protein and Ubiquitin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-279603 (Preferred)   search this ID
PDBe-KB: Q99816    P0CG47   
Solution NMR
Released: 17 Mar 2021
Model geometry
Fit model/data
Data not analysed
6ud0
6ud0
6ud0
Structure Of The Tsg101 UEV Domain In Complex With an Ebola PTAP late Domain Peptide
Camara-Artigas A
To be published
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Tumor susceptibility gene 101 protein and Matrix protein VP40 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-170147 (Preferred)   search this ID
PDBe-KB: Q99816    Q05128   
X-ray diffraction
2.2Å resolution
Released: 10 Apr 2013
Model geometry
Fit model/data
4eje
4eje
4eje
Crystal structure of the Tsg101 UEV domain in complex with a HIV-1 Gag P7A mutant peptide
Im YJ, Hurley JH
Structure (2010) [PMID: 21070952  ]
Assembly composition: protein/protein complex
Assembly name: Tumor susceptibility gene 101 protein and Gag Polyprotein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-180774 (Preferred)   search this ID
PDBe-KB: Q99816    Q72497   
X-ray diffraction
1.6Å resolution
Released: 1 Dec 2010
Model geometry
Fit model/data
3obx
3obx
3obx
STRUCTURE OF THE TSG101 UEV DOMAIN IN COMPLEX WITH A HIV-1 PTAP "LATE DOMAIN" PEPTIDE, CNS ENSEMBLE
Pornillos O, Alam SL, Davis DR, Sundquist WI
Nat Struct Biol (2002) [PMID: 12379843  ]
Assembly composition: protein/protein complex
Assembly name: Tumor susceptibility gene 101 protein and Gag protein p6 domain-containing protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189275 (Preferred)   search this ID
PDBe-KB: Q99816    Q9IF21   
Solution NMR
Released: 6 Nov 2002
Model geometry
Fit model/data
Data not deposited
1m4q
1m4q
1m4q
Crystal structure of the Tsg101 UEV domain in complex with a HIV-1 PTAP peptide
Im YJ, Hurley JH
Structure (2010) [PMID: 21070952  ]
Assembly composition: protein/protein complex
Assembly name: Tumor susceptibility gene 101 protein and Gag Polyprotein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-180774 (Preferred)   search this ID
PDBe-KB: Q99816    Q72497   
X-ray diffraction
1.6Å resolution
Released: 1 Dec 2010
Model geometry
Fit model/data
3obu
3obu
3obu
Structure of the Tsg101 UEV domain
Pornillos O, Alam SL, Rich RL, Myszka DG, Davis DR, Sundquist WI
EMBO J (2002) [PMID: 12006492  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Tumor susceptibility gene 101 protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189274 (Preferred)   search this ID
PDBe-KB: Q99816   
Solution NMR
Released: 25 May 2002
Model geometry
Fit model/data
Data not deposited
1kpq
1kpq
1kpq
TSG101(UEV) domain in complex with Ubiquitin
Sundquist WI, Schubert HL, Kelly BN, Hill GC, Holton JM, Hill CP
Mol Cell (2004) [PMID: 15053872  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CU    ACY    CU    SO4    ACY   
Modified residues: MSE    MSE   
Assembly name: Tumor susceptibility gene 101 protein and Ubiquitin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-143400 (Preferred)   search this ID
PDBe-KB: Q99816    P0CG48   
X-ray diffraction
2Å resolution
Released: 4 May 2004
Model geometry
Fit model/data
1s1q
1s1q
1s1q
Crystal Structure of the TSG101-UEV domain:space group P21
Camara-Artigas A
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SO4   
Assembly name: Tumor susceptibility gene 101 protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189274 (Preferred)   search this ID
PDBe-KB: Q99816   
X-ray diffraction
2.25Å resolution
Released: 22 Jun 2022
Model geometry
Fit model/data
7zlx
7zlx
7zlx
Entries 1 to 10 of 21
Entries 1 to 10 of 21