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Arrowsmith CH
(3)
Bountra C
(3)
Edwards AM
(3)
Savitsky P
(3)
von Delft F
(3)
Chan C
(2)
Fedorov O
(2)
Gamblin SJ
(2)
Knapp S
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Newman JA
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Nunez-Alonso G
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Rubin SM
(2)
Structural Genomics Consortium (SGC)
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Tallant C
(2)
Abdouni H
(1)
Ali-Khan N
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Bandeira N
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Cheng KY
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Clements A
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Da Luz RF
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Emanuele MJ
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Filippakopoulos P
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Ford DJ
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Fujisawa T
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Gall AL
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Gamblin S
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Gul S
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Gupta GD
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Hou H
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Krojer T
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Lambert JP
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Lin ZY
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Low JKK
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Lowe ED
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Mittnacht S
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Patel K
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Xiao B
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E2F-1
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Retinoblastoma-associated protein 1
(8)
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(8)
pRB-binding protein E2F-1
(8)
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E2F1
(8)
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(9)
Bromodomain-containing protein 4
(2)
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(2)
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(1)
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(1)
Cyclin-dependent kinase 2
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S-phase kinase-associated protein 1
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Staphylococcal nuclease domain-containing protein 1
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Tudor domain-containing protein 1
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RNA polymerase II cis-regulatory region sequence-specific DNA binding
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protein dimerization activity
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regulation of transcription by RNA polymerase II
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Single alpha-helices involved in coiled-coils or other helix-helix interfaces
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PF16421 : E2F_CC-MB
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(7)
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Representative Structures
Representative Structures
Entries
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Entries 1 to 8 of 8
Select all entries on this page
Crystal structure of human SND1 extended Tudor domain in complex with a symmetrically dimethylated E2F peptide
Tallant C, Savitsky P, Moehlenbrink J, Chan C, Nunez-Alonso G, Siejka P, Sorrell FJ, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Fedorov O, La Thangue NB, Knapp S, Structural Genomics Consortium (SGC)
To be published
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Transcription factor E2F1 and Staphylococcal nuclease domain-containing protein 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-169517 (Preferred)
search this ID
Crystal structure of human TDRD1 extended Tudor domain in complex with a symmetrically dimethylated E2F peptide
Tallant C, Savitsky P, Moehlenbrink J, Chan C, Nunez-Alonso G, Newman JA, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Fedorov O, La Thangue NB, Knapp S, Structural Genomics Consortium (SGC)
To be published
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Transcription factor E2F1 and Tudor domain-containing protein 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-169518 (Preferred)
search this ID
E2F1-Cyclin F Interface
Ngoi P, Serrao VH, Rubin SM
bioRxiv
(2025)
[PMID: 39868286 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
PDBe complex ID:
PDB-CPX-285222 (Preferred)
search this ID
BRD4-BD1 in complex with the a diacetylated-E2F1 peptide
Patel K, Low JKK, Mackay JP
Biochemistry
(2021)
[PMID: 33620209 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Transcription factor E2F1 and Bromodomain-containing protein 4
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-130130 (Preferred)
search this ID
Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
Rubin SM, Gall AL, Zheng N, Pavletich NP
Cell
(2005)
[PMID: 16360038 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
RB1-E2F1-DP1 transcriptional repressor complex
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-139031 (Preferred)
search this ID
Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide
Xiao B, Spencer J, Clements A, Ali-Khan N, Mittnacht S, Broceno C, Burghammer M, Perrakis A, Marmorstein R, Gamblin SJ
Proc Natl Acad Sci U S A
(2003)
[PMID: 12598654 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Transcription factor E2F1 and Retinoblastoma-associated protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-139026 (Preferred)
search this ID
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated E2F1 peptide (K117ac/K120ac)
Filippakopoulos P, Picaud S, Krojer T, Sorrell F, Pike ACW, von Delft F, Arrowsmith CH, Edwards AM, Bountra C
Mol Cell
(2019)
[PMID: 30554943 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Bound ligands:
EDO
Assembly name:
Transcription factor E2F1 and Bromodomain-containing protein 4
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-130130 (Preferred)
search this ID
CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F
Tews I, Cheng KY, Lowe ED, Noble MEM, Brown NR, Gul S, Gamblin S, Johnson LN
Biochemistry
(2002)
[PMID: 12501191 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Cyclin A2-CDK2 complex and Transcription factor E2F1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-148904 (Preferred)
search this ID
Entries 1 to 8 of 8