Uniprot accession / id : Q61501  OR   Uniprot accession / id : Q01094
 
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Entry Information
Entry status  (1)
REL
(8)
 
Experimental methods  (2)
X-ray diffraction
(7)
Electron Microscopy
(1)
 
Authors  (78)
Arrowsmith CH
(3)
Bountra C
(3)
Edwards AM
(3)
Savitsky P
(3)
von Delft F
(3)
Chan C
(2)
Fedorov O
(2)
Gamblin SJ
(2)
Knapp S
(2)
La Thangue NB
(2)
Moehlenbrink J
(2)
Newman JA
(2)
Nunez-Alonso G
(2)
Rubin SM
(2)
Structural Genomics Consortium (SGC)
(2)
Tallant C
(2)
Abdouni H
(1)
Ali-Khan N
(1)
Bandeira N
(1)
Broceno C
(1)
Broceño C
(1)
Brown NR
(1)
Burghammer M
(1)
Cheng KY
(1)
Clements A
(1)
Da Luz RF
(1)
Emanuele MJ
(1)
Filippakopoulos P
(1)
Ford DJ
(1)
Fujisawa T
(1)
Gall AL
(1)
Gamblin S
(1)
Gingras AC
(1)
Gonzalez-Badillo B
(1)
Gul S
(1)
Gupta GD
(1)
Hou H
(1)
Johnson LN
(1)
Knight JDR
(1)
Krojer T
(1)
Lambert JP
(1)
Lin ZY
(1)
Low JKK
(1)
Lowe ED
(1)
Mackay JP
(1)
Marmorstein R
(1)
Mittnacht S
(1)
Ngoi P
(1)
Noble ME
(1)
Noble MEM
(1)
Patel K
(1)
Pavletich NP
(1)
Payne RJ
(1)
Pelletier L
(1)
Perrakis A
(1)
Picaud S
(1)
Pike ACW
(1)
Putta S
(1)
Serrao VH
(1)
Serrao VHB
(1)
Serrão VHB
(1)
Siejka P
(1)
Solomon PD
(1)
Sorrell F
(1)
Sorrell FJ
(1)
Spencer J
(1)
St-Denis N
(1)
Stucki M
(1)
Tews I
(1)
Tucholska M
(1)
Uuskula-Reimand L
(1)
Uusküla-Reimand L
(1)
Walshe JL
(1)
Wang X
(1)
Wilkinson-White L
(1)
Wilson MD
(1)
Xiao B
(1)
Zheng N
(1)
 
Homo / hetero assembly  (1)
hetero
(8)
 
Assembly composition  (1)
protein/protein complex
(8)
 
Assembly polymer count  (2)
dimer
(4)
trimer
(4)
 
Resolution distribution
1.0 - 1.5
(3)
1.5 - 2
(1)
2.0 - 2.5
(1)
2.5 - 3
(2)
3.0 - 3.5
(1)
 
Release year distribution
2000 - 2005
(2)
2005 - 2010
(1)
2015 - 2020
(4)
2020 - 2025
(2)
2025 - 2030
(1)
 
Journal  (6)
Biochemistry
(2)
To be published
(2)
Cell
(1)
Mol Cell
(1)
Proc Natl Acad Sci U S A
(1)
bioRxiv
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(8)
 
Organism name  (1)
Homo sapiens
(8)
 
Molecule name  (8)
E2F-1
(8)
PBR3
(8)
RBAP-1
(8)
RBBP-3
(8)
Retinoblastoma-associated protein 1
(8)
Retinoblastoma-binding protein 3
(8)
Transcription factor E2F1
(8)
pRB-binding protein E2F-1
(8)
 
Molecule type  (1)
Protein
(8)
 
Gene names  (2)
E2F1
(8)
RBBP3
(8)
 
Interacting Molecules  (9)
Bromodomain-containing protein 4
(2)
Retinoblastoma-associated protein
(2)
Cyclin-A2
(1)
Cyclin-F
(1)
Cyclin-dependent kinase 2
(1)
S-phase kinase-associated protein 1
(1)
Staphylococcal nuclease domain-containing protein 1
(1)
Transcription factor Dp-1
(1)
Tudor domain-containing protein 1
(1)
 
Function and Biology
Biological function  (2)
RNA polymerase II cis-regulatory region sequence-specific DNA binding
(1)
protein dimerization activity
(1)
 
Biological process  (1)
regulation of transcription by RNA polymerase II
(1)
 
Sequence and Structure classification
SCOP fold  (1)
E2F-DP heterodimerization region
(1)
 
SCOP family  (1)
E2F dimerization segment
(1)
 
CATH class  (1)
Special
(1)
 
CATH topology  (1)
Single alpha-helices involved in coiled-coils or other helix-helix interfaces
(1)
 
Pfam accession / name  (1)
PF16421 : E2F_CC-MB
(1)
 
Experimental Information
Diffraction protocol  (2)
Single wavelength
(7)
MAD
(1)
 
Diffraction radiation source type  (1)
Synchrotron
(7)
 
Diffraction source  (7)
DIAMOND BEAMLINE I04
(2)
APS BEAMLINE 24-ID-C
(1)
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
(1)
DIAMOND BEAMLINE I03
(1)
ESRF BEAMLINE ID13
(1)
ESRF BEAMLINE ID14-1
(1)
NSLS BEAMLINE X4A
(1)
 
Synchrotron site  (5)
Diamond
(3)
ESRF
(2)
APS
(1)
Australian Synchrotron
(1)
NSLS
(1)
 
Diffraction detector type  (2)
Pixel
(4)
CCD
(2)
 
Refinement software  (3)
REFMAC
(5)
CNS
(1)
PHENIX
(1)
 
EM microscope model  (1)
TFS KRIOS
(1)
 
EM detector name  (1)
GATAN K3 (6k x 4k)
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 8 of 8
Entries 1 to 8 of 8
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Crystal structure of human SND1 extended Tudor domain in complex with a symmetrically dimethylated E2F peptide
Tallant C, Savitsky P, Moehlenbrink J, Chan C, Nunez-Alonso G, Siejka P, Sorrell FJ, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Fedorov O, La Thangue NB, Knapp S, Structural Genomics Consortium (SGC)
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: 2MR    2MR   
Assembly name: Transcription factor E2F1 and Staphylococcal nuclease domain-containing protein 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-169517 (Preferred)   search this ID
PDBe-KB: Q01094    Q7KZF4   
X-ray diffraction
1.45Å resolution
Released: 7 Dec 2016
Model geometry
Fit model/data
5m9o
5m9o
5m9o
Crystal structure of human TDRD1 extended Tudor domain in complex with a symmetrically dimethylated E2F peptide
Tallant C, Savitsky P, Moehlenbrink J, Chan C, Nunez-Alonso G, Newman JA, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Fedorov O, La Thangue NB, Knapp S, Structural Genomics Consortium (SGC)
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: 2MR    EDO    2MR   
Modified residues: 2MR    2MR   
Assembly name: Transcription factor E2F1 and Tudor domain-containing protein 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-169518 (Preferred)   search this ID
PDBe-KB: Q01094    Q9BXT4   
X-ray diffraction
1.95Å resolution
Released: 16 Nov 2016
Model geometry
Fit model/data
5m9n
5m9n
5m9n
E2F1-Cyclin F Interface
Ngoi P, Serrao VH, Rubin SM
bioRxiv (2025) [PMID: 39868286  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-285222 (Preferred)   search this ID
PDBe-KB: Q01094    P41002    P63208   
Electron Microscopy
3.47Å resolution
Released: 12 Feb 2025
Model geometry
Fit model/data
Data not analysed
9cb3
9cb3
9cb3
BRD4-BD1 in complex with the a diacetylated-E2F1 peptide
Patel K, Low JKK, Mackay JP
Biochemistry (2021) [PMID: 33620209  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: ALY    NH2    ALY    NH2   
Assembly name: Transcription factor E2F1 and Bromodomain-containing protein 4 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-130130 (Preferred)   search this ID
PDBe-KB: Q01094    O60885   
X-ray diffraction
1.5Å resolution
Released: 19 Aug 2020
Model geometry
Fit model/data
6uls
6uls
6uls
Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
Rubin SM, Gall AL, Zheng N, Pavletich NP
Cell (2005) [PMID: 16360038  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: RB1-E2F1-DP1 transcriptional repressor complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-139031 (Preferred)   search this ID
PDBe-KB: Q01094    P06400    Q14186   
X-ray diffraction
2.55Å resolution
Released: 31 Jan 2006
Model geometry
Fit model/data
2aze
2aze
2aze
Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide
Xiao B, Spencer J, Clements A, Ali-Khan N, Mittnacht S, Broceno C, Burghammer M, Perrakis A, Marmorstein R, Gamblin SJ
Proc Natl Acad Sci U S A (2003) [PMID: 12598654  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Transcription factor E2F1 and Retinoblastoma-associated protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-139026 (Preferred)   search this ID
PDBe-KB: Q01094    P06400   
X-ray diffraction
2.6Å resolution
Released: 6 Mar 2003
Model geometry
Fit model/data
1o9k
1o9k
1o9k
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated E2F1 peptide (K117ac/K120ac)
Filippakopoulos P, Picaud S, Krojer T, Sorrell F, Pike ACW, von Delft F, Arrowsmith CH, Edwards AM, Bountra C
Mol Cell (2019) [PMID: 30554943  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: EDO   
Modified residues: ALY    ALY   
Assembly name: Transcription factor E2F1 and Bromodomain-containing protein 4 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-130130 (Preferred)   search this ID
PDBe-KB: Q01094    O60885   
X-ray diffraction
1.3Å resolution
Released: 28 Nov 2018
Model geometry
Fit model/data
6g0p
6g0p
6g0p
CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F
Tews I, Cheng KY, Lowe ED, Noble MEM, Brown NR, Gul S, Gamblin S, Johnson LN
Biochemistry (2002) [PMID: 12501191  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: TPO    TPO   
Assembly name: Cyclin A2-CDK2 complex and Transcription factor E2F1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-148904 (Preferred)   search this ID
PDBe-KB: Q01094    P20248    P24941   
X-ray diffraction
2.5Å resolution
Released: 1 Feb 2003
Model geometry
Fit model/data
1h24
1h24
1h24
Entries 1 to 8 of 8
Entries 1 to 8 of 8