Uniprot accession / id : Q61686  OR   Uniprot accession / id : P45973
 
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Entries released this week  (1)
revised
(1)
 
Entry Information
Entry status  (1)
REL
(6)
 
Experimental methods  (3)
Solution NMR
(3)
X-ray diffraction
(2)
Electron Microscopy
(1)
 
Authors  (35)
Hashiguchi N
(3)
Hiragami-Hamada K
(3)
Kawaguchi A
(3)
Kidera A
(3)
Moritsugu K
(3)
Nakayama J
(3)
Nishimura Y
(3)
Oda T
(3)
Omori S
(3)
Sato M
(3)
Shimojo H
(3)
Amaya MF
(2)
Arrowsmith CH
(2)
Bochkarev A
(2)
Bountra C
(2)
Edwards AM
(2)
Kozieradzki I
(2)
Li Z
(2)
Min J
(2)
Ouyang H
(2)
Structural Genomics Consortium (SGC)
(2)
Weigelt J
(2)
Amaya M
(1)
Duan S
(1)
Kaustov L
(1)
Lemak A
(1)
Li Y
(1)
Loppnau P
(1)
Nady N
(1)
Ravichandran M
(1)
Schapira M
(1)
Sokolova V
(1)
Tan D
(1)
Vedadi M
(1)
Wasney GA
(1)
 
Homo / hetero assembly  (2)
hetero
(3)
homo
(3)
 
Assembly composition  (3)
protein structure
(3)
protein/protein complex
(2)
DNA/protein complex
(1)
 
Assembly polymer count  (3)
monomer
(3)
dimer
(2)
dodecamer
(1)
 
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(1)
6.0 - 6.5
(1)
 
Release year distribution
2005 - 2010
(2)
2015 - 2020
(3)
2020 - 2025
(1)
 
Journal  (3)
Sci Rep
(3)
To be published
(2)
J Biol Chem
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(6)
 
Organism name  (2)
Homo sapiens
(3)
Mus musculus
(3)
 
Molecule name  (4)
Chromobox protein homolog 5
(6)
HP1 alpha
(6)
Heterochromatin protein 1 homolog alpha
(6)
Antigen p25
(3)
 
Molecule type  (1)
Protein
(6)
 
Gene names  (4)
CBX5
(3)
Cbx5
(3)
HP1A
(3)
Hp1a
(3)
 
Interacting Molecules  (8)
DNA Widom601 (208bp) strand1
(1)
DNA Widom601 (208bp) strand2
(1)
Histone H2A.Z
(1)
Histone H2B 1.1
(1)
Histone H3.1
(1)
Histone H3.2
(1)
Histone H3.3
(1)
Histone H4
(1)
 
Interacting ligands  (1)
NA : SODIUM ION
(1)
 
Function and Biology
Biological function  (11)
DNA-binding transcription factor binding
(1)
chromatin binding
(1)
histone H3K9me2/3 reader activity
(1)
histone deacetylase binding
(1)
histone reader activity
(1)
identical protein binding
(1)
methylated histone binding
(1)
protein binding
(1)
protein-containing complex binding
(1)
protein-macromolecule adaptor activity
(1)
ribonucleoprotein complex binding
(1)
 
Biological process  (4)
DNA damage response
(1)
heterochromatin formation
(1)
negative regulation of DNA-templated transcription
(1)
negative regulation of transcription by RNA polymerase II
(1)
 
Biological cell component  (18)
nucleus
(2)
PML body
(1)
chromocenter
(1)
chromosome
(1)
chromosome, centromeric region
(1)
chromosome, telomeric region
(1)
heterochromatin
(1)
histone deacetylase complex
(1)
histone methyltransferase complex
(1)
kinetochore
(1)
nuclear envelope
(1)
nucleolus
(1)
nucleoplasm
(1)
pericentric heterochromatin
(1)
protein-containing complex
(1)
ribonucleoprotein complex
(1)
site of DNA damage
(1)
transcription repressor complex
(1)
 
Sequence and Structure classification
CATH class  (1)
Mainly Beta
(3)
 
CATH topology  (1)
OB fold (Dihydrolipoamide Acetyltransferase, E2P)
(3)
 
Pfam accession / name  (2)
PF00385 : Chromo
(5)
PF01393 : Chromo_shadow
(2)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(2)
 
Diffraction radiation source type  (1)
Synchrotron
(2)
 
Diffraction source  (2)
APS BEAMLINE 23-ID-B
(1)
CLSI BEAMLINE 08ID-1
(1)
 
Synchrotron site  (2)
APS
(1)
CLSI
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 6 of 6
Entries 1 to 6 of 6
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Structure of Heterochromatin Protein 1 (HP1) alpha in complex with an H2A.Z nucleosome
Tan D, Sokolova V
To be published
Assembly composition: DNA/protein complex
PDBe complex ID: PDB-CPX-270852 (Preferred)   search this ID
PDBe-KB: P45973    P02281    P84233    P0C0S6    P62799   
Electron Microscopy
6.3Å resolution
Released: 25 Sep 2024
Model geometry
Fit model/data
Data not analysed
8uxq
8uxq
8uxq
Solution structure of the chromodomain of HP1alpha with the phosphorylated N-terminal tail
Kawaguchi A, Nishimura Y
Sci Rep (2016) [PMID: 26934956  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Modified residues: SEP    SEP   
Assembly name: Chromobox protein homolog 5 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-178897 (Preferred)   search this ID
PDBe-KB: Q61686   
Solution NMR
Released: 16 Mar 2016
Model geometry
Fit model/data
Data not analysed
2rvm
2rvm
2rvm
Crystal Structural of CBX5 Chromo Shadow Domain
Amaya MF, Li Z, Li Y, Kozieradzki I, Edwards AM, Arrowsmith CH, Weigelt J, Bountra C, Bochkarev A, Min J, Ouyang H, Structural Genomics Consortium (SGC)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NA    NA   
Assembly name: Chromobox protein homolog 5 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155375 (Preferred)   search this ID
PDBe-KB: P45973   
X-ray diffraction
2.48Å resolution
Released: 18 Aug 2009
Model geometry
Fit model/data
3i3c
3i3c
3i3c
Crystal structure of the complex of human chromobox homolog 5 (CBX5) with H3K9(me)3 peptide
Amaya MF, Ravichandran M, Loppnau P, Kozieradzki I, Edwards AM, Arrowsmith CH, Weigelt J, Bountra C, Bochkarev A, Min J, Ouyang H, Structural Genomics Consortium (SGC)
J Biol Chem (2011) [PMID: 21047797  ]
Assembly composition: protein/protein complex
Modified residues: M3L    M3L   
Assembly name: Chromobox protein homolog 5 and Histone H3.1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155376 (Preferred)   search this ID
PDBe-KB: P45973    P68431   
X-ray diffraction
2Å resolution
Released: 13 Jan 2009
Model geometry
Fit model/data
3fdt
3fdt
3fdt
Solution structure of the chromodomain of HP1alpha with the N-terminal tail
Kawaguchi A, Nishimura Y
Sci Rep (2016) [PMID: 26934956  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Assembly name: Chromobox protein homolog 5 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-178897 (Preferred)   search this ID
PDBe-KB: Q61686   
Solution NMR
Released: 16 Mar 2016
Model geometry
Fit model/data
Data not analysed
2rvl
2rvl
2rvl
Solution structure of the chromodomain of HP1a with the phosphorylated N-terminal tail complexed with H3K9me3 peptide
Kawaguchi A, Nishimura Y
Sci Rep (2016) [PMID: 26934956  ]
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Modified residues: M3L    SEP    M3L    SEP   
Assembly name: Histone H3.3 and Chromobox protein homolog 5 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-160875 (Preferred)   search this ID
PDBe-KB: Q61686    P84244   
Solution NMR
Released: 16 Mar 2016
Model geometry
Fit model/data
Data not analysed
2rvn
2rvn
2rvn
Entries 1 to 6 of 6
Entries 1 to 6 of 6