Entry status  (1)

REL

(24)

Experimental methods  (1)

X-ray diffraction

(24)

Authors  (179)

Gurbani D

(8)

Westover KD

(8)

Gray NS

(7)

Hunter JC

(7)

Tan L

(7)

Du G

(6)

Ficarro SB

(6)

Fukami TA

(6)

Griffin JD

(6)

Ide M

(6)

Irie M

(6)

Jones DS

(6)

Kashiwagi H

(6)

Li L

(6)

Marto JA

(6)

Matsuura T

(6)

Miura T

(6)

Morikami K

(6)

Morishima K

(6)

Mowafy S

(6)

Muraoka T

(6)

Nakamura M

(6)

Nishihara M

(6)

Rao S

(6)

Sorger PK

(6)

Tam CP

(6)

Weisberg EL

(6)

Mulvihill MJ

(5)

Albertella M

(3)

Bittner M

(3)

Cooke A

(3)

Crew AP

(3)

Hornberger KR

(3)

Kamikawa T

(3)

Kleinberg A

(3)

Liu J

(3)

Maresca P

(3)

Maskos K

(3)

May E

(3)

Meyn P

(3)

Moertl M

(3)

Romashko D

(3)

Tokar B

(3)

Wang J

(3)

Wilde VL

(3)

Babiss L

(2)

Berger DM

(2)

Bruseker YB

(2)

Cuozzo JW

(2)

Damen E

(2)

Dong H

(2)

Gray MJ

(2)

Heijne EH

(2)

Hekking KFW

(2)

Hupp CD

(2)

Jestel A

(2)

Keefe AD

(2)

Li AH

(2)

McRiner AJ

(2)

Medeiros MR

(2)

Mueller G

(2)

Muller G

(2)

Müller G

(2)

Peick W

(2)

Renzetti LM

(2)

Siu K

(2)

Tanowitz M

(2)

Tarrant J

(2)

Thomson HA

(2)

Veerman JJN

(2)

Weng F

(2)

Winkel R

(2)

Zech B

(2)

Zhang Y

(2)

van Bruggen W

(2)

van Rijnsbergen P

(2)

Bell A

(1)

Bera AK

(1)

Bess K

(1)

Bodoor K

(1)

Bouzan A

(1)

Brenneisen S

(1)

Brown DG

(1)

Brown K

(1)

Buhrlage SJ

(1)

Byth KF

(1)

Campany K

(1)

Campbell PL

(1)

Carlson DA

(1)

Cheetham GM

(1)

Chen H

(1)

Chen X

(1)

Chen Z

(1)

Chenal G

(1)

Choi HG

(1)

Cohen P

(1)

Dedi N

(1)

Demirci S

(1)

Deng X

(1)

Derbyshire ER

(1)

 

More...

Homo / hetero assembly  (1)

homo

(24)

Assembly composition  (1)

protein structure

(24)

Assembly polymer count  (1)

monomer

(24)

Resolution distribution

1.5 - 2

(4)

2.0 - 2.5

(11)

2.5 - 3

(8)

3.0 - 3.5

(1)

Release year distribution

2005 - 2010

(1)

2010 - 2015

(6)

2015 - 2020

(13)

2020 - 2025

(4)

Journal  (9)

Bioorg Med Chem

(9)

Bioorg Med Chem Lett

(3)

Chem Pharm Bull (Tokyo)

(3)

ACS Med Chem Lett

(2)

J Med Chem

(2)

To be published

(2)

ACS Chem Biol

(1)

Cell Chem Biol

(1)

J Mol Biol

(1)

Organism superkingdom  (1)

Eukaryota

(24)

Organism name  (1)

Homo sapiens

(24)

Molecule name  (7)

Mitogen-activated protein kinase kinase kinase 7

(24)

TGF-beta-activated kinase 1

(24)

Transforming growth factor-beta-activated kinase 1

(24)

Mitogen-activated protein kinase kinase kinase 7-interacting protein 1

(23)

TAK1-binding protein 1

(23)

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

(23)

TGF-beta-activated kinase 1-binding protein 1

(23)

Molecule type  (1)

Protein

(24)

Gene names  (4)

MAP3K7

(24)

TAK1

(24)

MAP3K7IP1

(23)

TAB1

(23)

Interacting ligands  (26)

EDO : 1,2-ETHANEDIOL

(3)

DMS : DIMETHYL SULFOXIDE

(2)

GOL : GLYCEROL

(2)

1FM : (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione

(1)

1UH : 2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[2,3-c]pyridin-7-amine

(1)

1UL : 1-(4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2,3-c]pyridin-4-yl]-1H-pyrazol-1-yl}piperidin-1-yl)ethanone

(1)

1UO : trans-4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)-3-chlorofuro[2,3-c]pyridin-4-yl]-1H-pyrazol-1-yl}cyclohexanol

(1)

5KW : 2-chloro-N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}acetamide

(1)

6H3 : N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide

(1)

6H4 : N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide

(1)

6HF : N-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

(1)

6JV : N-(2-methoxy-4-{[3-(4-methylpiperazin-1-yl)propyl]carbamoyl}phenyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamide

(1)

6KC : N-[5-(4-methylpiperazine-1-carbonyl)[1,1'-biphenyl]-2-yl]-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamide

(1)

6KD : N-(2-isopropoxy-3-(4-methylpiperazine-1-carbonyl)phenyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamide

(1)

6L4 : ~{N}-[2-[5-chloranyl-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

(1)

6V3 : 1-(4-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-3-(5-(4-methylpiperazin-1-yl)naphthalen-2-yl)urea

(1)

6V4 : N-(2-isopropoxy-4-(4-methylpiperazine-1-carbonyl)phenyl)-2-(3-(3-phenylureido)phenyl)thiazole-4-carboxamide

(1)

6V5 : N-(2-isopropoxy-4-(4-methylpiperazine-1-carbonyl)phenyl)-2-(3-(phenylcarbamoyl)phenyl)thiazole-4-carboxamide

(1)

A1IED : 6-[5-[6-(4-oxidanylcyclohexyl)oxy-1~{H}-pyrrolo[2,3-b]pyridin-5-yl]-1,2-oxazol-3-yl]pyridine-2-carboxamide

(1)

ADN : ADENOSINE

(1)

EDH : N~1~-(1-propyl-1,3-dihydro-2H-benzimidazol-2-ylidene)benzene-1,3-dicarboxamide

(1)

NG2 : N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide

(1)

T92 : 2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl prop-2-enoate

(1)

URW : 2-[[5-[[2-[bis(fluoranyl)methoxy]phenyl]methyl-[(2~{R})-1-(methylamino)-1-oxidanylidene-propan-2-yl]carbamoyl]-1~{H}-imidazol-2-yl]carbonyl]isoindole-5-carboxamide

(1)

UWZ : ~{N}-[[2-[bis(fluoranyl)methoxy]phenyl]methyl]-~{N}-[2-(methylamino)-2-oxidanylidene-ethyl]-2-pyrrolidin-1-ylcarbonyl-1~{H}-imidazole-4-carboxamide

(1)

YIY : (1E)-1-[5-TERT-BUTYL-2-(3-FLUOROPHENYL)-1H-PYRAZOL-3-YLIDENE]-3-(4-PYRIDIN-3-YLOXYPHENYL)UREA

(1)

EC number / name  (1)

2.7.11.25 : Mitogen-activated protein kinase kinase kinase

(24)

Biological function  (2)

ATP binding

(24)

protein kinase activity

(24)

Biological process  (1)

protein phosphorylation

(24)

CATH class  (2)

Alpha Beta

(20)

Mainly Alpha

(20)

CATH topology  (2)

Phosphorylase Kinase; domain 1

(20)

Transferase(Phosphotransferase); domain 1

(20)

Pfam accession / name  (1)

PF07714 : PK_Tyr_Ser-Thr

(24)

Diffraction protocol  (1)

Single wavelength

(24)

Diffraction radiation source type  (2)

Synchrotron

(23)

Rotating anode

(1)

Diffraction source  (11)

APS BEAMLINE 19-ID

(8)

SLS BEAMLINE X06SA

(3)

SLS BEAMLINE X10SA

(3)

ESRF BEAMLINE MASSIF-1

(2)

PHOTON FACTORY BEAMLINE BL-17A

(2)

APS BEAMLINE 17-ID

(1)

PHOTON FACTORY BEAMLINE AR-NW12A

(1)

PHOTON FACTORY BEAMLINE BL-5A

(1)

RIGAKU FR-E+ DW

(1)

SRS BEAMLINE PX14.1

(1)

SSRF BEAMLINE BL19U1

(1)

Synchrotron site  (6)

APS

(9)

SLS

(6)

Photon Factory

(4)

ESRF

(2)

SRS

(1)

SSRF

(1)

Diffraction detector type  (2)

CCD

(16)

Pixel

(8)

Refinement software  (4)

REFMAC

(11)

PHENIX

(9)

BUSTER

(3)

CNS

(1)

Representative Structures

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95%

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