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Miallau L
(2)
Nawrotek A
(2)
Talagas A
(2)
Vuillard LM
(2)
Arrial A
(1)
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(1)
Benz J
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Bonfil RD
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Faul C
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Georges GJ
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Hug MN
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Ichikawa O
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Kim JJ
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CD167 antigen-like family member B
(5)
Discoidin domain receptor 2
(5)
Discoidin domain-containing receptor 2
(5)
Discoidin domain-containing receptor tyrosine kinase 2
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Neurotrophic tyrosine kinase, receptor-related 3
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DDR2
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VHH
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4VD : N-[5-({[(3-fluorophenyl)carbamoyl]amino}methyl)-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide
(1)
D6Q : 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{H}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{N}-[2,2,2-tris(fluoranyl)ethyl]ethanamide
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2.7.10.1 : Receptor protein-tyrosine kinase
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cell surface receptor protein tyrosine kinase signaling pathway
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PF00754 : F5_F8_type_C
(3)
PF07714 : PK_Tyr_Ser-Thr
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Representative Structures
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Entries 1 to 5 of 5
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Structure of DDR2 DS domain in complex with VHH
Talagas A, Nawrotek A, Arrial A, Vuillard LM, Miallau L
To be published
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Discoidin domain-containing receptor 2 and IG-heavy chain
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-280179 (Preferred)
search this ID

Structure of DDR2 Kinase domain in complex with IBZ3
Nawrotek A, Talagas A, Vuillard LM, Miallau L
To be published
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Discoidin domain-containing receptor 2, Epithelial discoidin domain-containing receptor 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-170635 (Preferred)
search this ID
Crystal Structure of human DDR2 kinase in complex with 2-[4,5-difluoro-2-oxo-1'-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide
Stihle M, Richter H, Benz J, Kuhn B, Rudolph MG
ACS Chem Biol
(2019)
[PMID: 30452219 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Bound ligands:
D6Q
Assembly name:
Discoidin domain-containing receptor 2
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-172591 (Preferred)
search this ID

Crystal structure of the DDR2 discoidin domain bound to a triple- helical collagen peptide
Carafoli F, Bihan D, Stathopoulos S, Konitsiotis AD, Kvansakul M, Farndale RW, Leitinger B, Hohenester E
Structure
(2009)
[PMID: 20004161 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Discoidin domain-containing receptor 2
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-163301 (Preferred)
search this ID

Solution structure of the Discoidin Domain of DDR2
Ichikawa O, Osawa M, Nishida N, Goshima N, Nomura N, Shimada I
EMBO J
(2007)
[PMID: 17703188 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Discoidin domain-containing receptor 2
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-172591 (Preferred)
search this ID

Entries 1 to 5 of 5