Uniprot accession / id : Q62371  OR   Uniprot accession / id : Q16832
 
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Entry Information
Entry status  (1)
REL
(5)
 
Experimental methods  (2)
X-ray diffraction
(4)
Solution NMR
(1)
 
Authors  (50)
Miallau L
(2)
Nawrotek A
(2)
Talagas A
(2)
Vuillard LM
(2)
Arrial A
(1)
Bedoucha M
(1)
Benz J
(1)
Bihan D
(1)
Bonfil RD
(1)
Buettelmann B
(1)
Burger D
(1)
Carafoli F
(1)
Farndale RW
(1)
Faul C
(1)
Fornoni A
(1)
Fridman R
(1)
Gasser R
(1)
Georges GJ
(1)
Goshima N
(1)
Gsell B
(1)
Harmeier A
(1)
Hermosilla R
(1)
Hochstrasser R
(1)
Hohenester E
(1)
Huber S
(1)
Hug MN
(1)
Ichikawa O
(1)
Kim JJ
(1)
Kocer B
(1)
Konitsiotis AD
(1)
Kuhn B
(1)
Kvansakul M
(1)
Leitinger B
(1)
Molina-David J
(1)
Moll S
(1)
Nishida N
(1)
Nomura N
(1)
Osawa M
(1)
Petersen AC
(1)
Prunotto M
(1)
Richter H
(1)
Ritter M
(1)
Rudolph MG
(1)
Santos JV
(1)
Satz AL
(1)
Shimada I
(1)
Stathopoulos S
(1)
Stihle M
(1)
Uhles S
(1)
Weibel F
(1)
 
Homo / hetero assembly  (2)
homo
(3)
hetero
(2)
 
Assembly composition  (2)
protein structure
(3)
protein/protein complex
(2)
 
Assembly polymer count  (3)
monomer
(3)
dimer
(1)
tetramer
(1)
 
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(1)
2.5 - 3
(2)
 
Release year distribution
2005 - 2010
(2)
2015 - 2020
(3)
2020 - 2025
(2)
 
Journal  (4)
To be published
(2)
ACS Chem Biol
(1)
EMBO J
(1)
Structure
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(5)
 
Organism name  (1)
Homo sapiens
(5)
 
Molecule name  (20)
CD167 antigen-like family member B
(5)
Discoidin domain receptor 2
(5)
Discoidin domain-containing receptor 2
(5)
Discoidin domain-containing receptor tyrosine kinase 2
(5)
Neurotrophic tyrosine kinase, receptor-related 3
(5)
Receptor protein-tyrosine kinase TKT
(5)
Tyrosine-protein kinase TYRO10
(5)
CD167 antigen-like family member A
(1)
Cell adhesion kinase
(1)
Discoidin receptor tyrosine kinase
(1)
Epithelial discoidin domain receptor 1
(1)
Epithelial discoidin domain-containing receptor 1
(1)
HGK2
(1)
MCK-10
(1)
Mammary carcinoma kinase 10
(1)
Protein-tyrosine kinase 3A
(1)
Protein-tyrosine kinase RTK-6
(1)
TRK E
(1)
Tyrosine kinase DDR
(1)
Tyrosine-protein kinase CAK
(1)
 
Molecule type  (1)
Protein
(5)
 
Gene names  (12)
DDR2
(5)
NTRKR3
(5)
TKT
(5)
TYRO10
(5)
CAK
(1)
DDR1
(1)
EDDR1
(1)
NEP
(1)
NTRK4
(1)
PTK3A
(1)
RTK6
(1)
TRKE
(1)
 
Interacting Molecules  (2)
COLLAGEN PEPTIDE
(1)
VHH
(1)
 
Interacting ligands  (2)
4VD : N-[5-({[(3-fluorophenyl)carbamoyl]amino}methyl)-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide
(1)
D6Q : 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{H}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{N}-[2,2,2-tris(fluoranyl)ethyl]ethanamide
(1)
 
Function and Biology
EC number / name  (1)
2.7.10.1 : Receptor protein-tyrosine kinase
(5)
 
Biological function  (4)
ATP binding
(2)
protein kinase activity
(2)
protein tyrosine kinase activity
(2)
transmembrane receptor protein tyrosine kinase activity
(2)
 
Biological process  (2)
cell surface receptor protein tyrosine kinase signaling pathway
(2)
protein phosphorylation
(2)
 
Biological cell component  (1)
membrane
(2)
 
Sequence and Structure classification
CATH class  (3)
Mainly Beta
(2)
Alpha Beta
(1)
Mainly Alpha
(1)
 
CATH topology  (3)
Jelly Rolls
(2)
Phosphorylase Kinase; domain 1
(1)
Transferase(Phosphotransferase); domain 1
(1)
 
Pfam accession / name  (2)
PF00754 : F5_F8_type_C
(3)
PF07714 : PK_Tyr_Ser-Thr
(2)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(4)
 
Diffraction radiation source type  (1)
Synchrotron
(4)
 
Diffraction source  (3)
SOLEIL BEAMLINE PROXIMA 2
(2)
DIAMOND BEAMLINE I02
(1)
SLS BEAMLINE X10SA
(1)
 
Synchrotron site  (3)
SOLEIL
(2)
Diamond
(1)
SLS
(1)
 
Diffraction detector type  (2)
Pixel
(3)
CCD
(1)
 
Refinement software  (3)
BUSTER
(2)
CNS
(1)
PHENIX
(1)
 
NMR
NMR software packages  (1)
CYANA
(1)
 
NMR Field Strength
400.0 - 500
(1)
500.0 - 600
(1)
600.0 - 700
(1)
 
Representative Structures
Representative Structures
100%
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90%
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Entries 1 to 5 of 5
Entries 1 to 5 of 5
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Structure of DDR2 DS domain in complex with VHH
Talagas A, Nawrotek A, Arrial A, Vuillard LM, Miallau L
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Discoidin domain-containing receptor 2 and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-280179 (Preferred)   search this ID
PDBe-KB: Q16832   
X-ray diffraction
2.62Å resolution
Released: 25 Nov 2020
Model geometry
Fit model/data
7azb
7azb
7azb
Structure of DDR2 Kinase domain in complex with IBZ3
Nawrotek A, Talagas A, Vuillard LM, Miallau L
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 4VD    4VD   
Assembly name: Discoidin domain-containing receptor 2, Epithelial discoidin domain-containing receptor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-170635 (Preferred)   search this ID
PDBe-KB: Q08345    Q16832   
X-ray diffraction
2.12Å resolution
Released: 16 Dec 2020
Model geometry
Fit model/data
7aym
7aym
7aym
Crystal Structure of human DDR2 kinase in complex with 2-[4,5-difluoro-2-oxo-1'-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide
Stihle M, Richter H, Benz J, Kuhn B, Rudolph MG
ACS Chem Biol (2019) [PMID: 30452219  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: D6Q   
Assembly name: Discoidin domain-containing receptor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172591 (Preferred)   search this ID
PDBe-KB: Q16832   
X-ray diffraction
2.87Å resolution
Released: 28 Nov 2018
Model geometry
Fit model/data
6fer
6fer
6fer
Crystal structure of the DDR2 discoidin domain bound to a triple- helical collagen peptide
Carafoli F, Bihan D, Stathopoulos S, Konitsiotis AD, Kvansakul M, Farndale RW, Leitinger B, Hohenester E
Structure (2009) [PMID: 20004161  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: ACE    HYP    NLE    ACE    HYP    NLE   
Assembly name: Discoidin domain-containing receptor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-163301 (Preferred)   search this ID
PDBe-KB: Q16832   
X-ray diffraction
1.6Å resolution
Released: 29 Dec 2009
Model geometry
Fit model/data
2wuh
2wuh
2wuh
Solution structure of the Discoidin Domain of DDR2
Ichikawa O, Osawa M, Nishida N, Goshima N, Nomura N, Shimada I
EMBO J (2007) [PMID: 17703188  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Discoidin domain-containing receptor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172591 (Preferred)   search this ID
PDBe-KB: Q16832   
Solution NMR
Released: 4 Sep 2007
Model geometry
Fit model/data
Data not analysed
2z4f
2z4f
2z4f
Entries 1 to 5 of 5
Entries 1 to 5 of 5